Abstract: This disclosure relates to variant AAVrh.10 and AAV3 particles engineered to escape host neutralizing antibodies but retain or improve transduction efficiency, and their use as gene delivery vehicles.

Abstract: Provided herein are compositions and methods for packaging a recombinant adeno-associated vims (rAAV) particle comprising using inverted terminal repeats (ITRs) and rep genes of different serotypes and/or using chimeric rep genes.

Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens from Clostridium Perfringens as vaccines to prevent necrotic enteritis (NE).

Abstract: The disclosure relates, in some aspects, to compositions and methods useful for production of nitrated aromatic molecules. The disclosure is based, in part, on whole cell systems expressing artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes. In some aspects, the disclosure relates to methods of producing nitrated aromatic molecules in whole cell systems having artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes.

Abstract: An apparatus and method is provided for finishing surfaces and edges of a stent. The apparatus may be capable of rotating a turning wheel, lowering the turning wheel onto a stent, tilting the stent, and polishing and deburring exterior, interior, and wall surfaces of the stent. An automated method is provided for polishing and deburring exterior, interior, and wall surfaces of a stent. Additionally, the automated method may include rotating a turning wheel, applying magnetic abrasive particles to the turning wheel, lowering the turning wheel onto the stent, tilting the stent, and polishing and deburring the exterior, interior, and wall surfaces of the stent.

Abstract: Disclosed herein are recombinant AAV variant (e.g., variant serotype 3B (AAV3B)) capsid proteins and variant capsid protein-containing viral particles with enhanced ability to transduce hepatic cells. Viral particles containing these capsid variants are capable of evading neutralization by the host humoral immune response. The recombinant AAV3B variant proteins and viral particles disclosed herein were identified from a variant AAV3B capsid library that was engineered by making substitutions in only the variable regions of the capsid. Some embodiments of the AAV3B capsid variants disclosed herein comprise the AAV3B-G3 variant and the AAV3B-E12 variant. Compositions of these variant AAV particles are provided that are useful for transducing and delivering therapeutic transgenes to cells, such as liver cells, and thus treat diseases and disorders pertaining to these cells.

Abstract: A water based paint that can be used to form a superhydrophobic coating includes a fluorinated particulate filler, a water soluble or water suspendable resin, and an aqueous solvent. The superhydrophobic paint can be applied to a surface where the loss of the solvent results in a superhydrophobic coating.

Abstract: Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and/or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest.

Abstract: A magnetic-field-guidance system and methods of finishing a workpiece using a magnetic-field-guidance system are provided. The magnetic-field-guidance system comprises a workpiece holder, one or more tooling magnets each comprising a finishing tip, and one or more flexible bags containing magnetic media. The workpiece holder is configured to (a) be secured to a base and (b) secure a workpiece relative to the base. The flexible bag(s) are configured to be disposed on the opposite side and/or same side of the workpiece relative to the one or more tooling magnets. In collaboration with the tooling magnets, the magnetic media contained with the flexible bag(s) direct a magnetic field which thereby guides a magnetic-abrasive slurry to finish the workpiece using Magnetic Abrasive Finishing (MAF).

Abstract: Example embodiments provide methods, apparatuses, systems, computing devices, and/or the like for vetting USB device firmware via a USB-specific firmware analysis framework. In one example, a method is provided for analyzing firmware of a Universal Serial Bus (USB) device. The example method includes steps of receiving a firmware image extracted from the USB device, identifying signatures from the firmware image relating to USB operation, and building an expected model of operation of the USB device using the identified signatures and a database of operational information regarding USB devices. The example method further includes the steps of generating a recovered model of operation of the USB device based on the firmware image and the identified signatures, and comparing the recovered model of operation with the expected model of operation to identify unexpected or unknown behaviors. The example method may further include generating a report comprising the identified unexpected or unknown behaviors.

Abstract: The invention provides compounds of formulae A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.

Abstract: Various examples are provided related to software and hardware architectures that enable a lightweight incremental encryption scheme that is implemented on a System-on-chip (SoC) resource such as a network interface. In one example, among others, a method for incremental encryption includes obtaining, by a network interface (NI) of a sender intellectual property (IP) core in a network-on-chip (NoC) based system-on-chip (SoC) architecture, a payload for communication to a receiver intellectual property (IP) core; identifying, by the NI, one or more different blocks between the payload and a payload of a previous packet communicated between the sender IP core and the receiver IP core; and encrypting, by the NI, the one or more different blocks to create encrypted blocks of an encrypted payload.

Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens from Clostridium Perfringens as vaccines to prevent necrotic enteritis (NE).

Abstract: Systems and methods are configured to control operation of an HVAC system providing climate control for a zone of a structure. In various embodiments, a constrained optimization problem is performed to set control commands for controlling operation of the HVAC system to achieve one or more objectives while providing a supply air flow at an air temperature and a humidity ratio for the zone at a future time. For instance, the optimization problem may include a cost function having constraints based on a desired temperature setpoint and a humidity ratio for the zone. A value is set for each control command based on the performance of the constrained optimization problem to achieve at least one of the objectives and as a result, the supply air flow at the air temperature and humidity ratio is provided by the HVAC system at the future time to the zone based on the values.

Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure provides methods of inhibiting RAN protein translation by contacting a cell with an effective amount of an inhibitor of eIF2 phosphorylation or an inhibitor of protein kinase R (PKR). In some embodiments, methods described by the disclosure are useful for treating diseases associated with RAN protein translation, such as certain neurodegenerative diseases.

Abstract: Disclosed herein are methods for removing acetylene from an ethylene gas stream wherein a catalyst reacts with the acetylene to polymerize said acetylene forming an ethylene gas stream substantially free of acetylene.

Abstract: Provided herein, in some embodiments, are nucleic acid constructs encoding RNA molecules comprising one or more introns that can be regulated (e.g., autoregulated), and that are useful for delivery in a recombinant viral vector. Aspects of the application provide compositions and methods for delivering regulated (e.g., auto-regulated) gem expression constructs to a subject.

Abstract: Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation.

Abstract: The subject invention provides therapeutic compositions and uses thereof for improving pulmonary function. In one embodiment, the therapeutic composition comprises one or more free amino acids selected from lysine, glycine, threonine, valine, tyrosine, aspartic acid, isoleucine, tryptophan, asparagine, and serine; and electrolytes. In one embodiment, the subject invention can be used to prevent or treat long-term lung complications induced by radiation.

Abstract: Systems and methods for a computer-based visual recognition based upon a spatially forked deep learning architecture, including unification of deep learning and reasoning. A method can include a primary learner with an adjacent structured memory bank that can not only predict the output from a given input, but also relate the input to all past memorized instances and help in creative understanding.