Patents Assigned to University of Georgia Research Foundation, Inc.
  • Patent number: 11370934
    Abstract: Coating compositions, coated articles including the coating compositions, and methods of making the coating compositions and coated articles are provided. In some aspects, the coating compositions are applied to a substrate having nitric oxide-releasing properties. The coating compositions can include copolymers having crosslinking agents that can be activated with mild UV light (about 345 nm to 365 nm) to avoid damaging the substrate while creating strong covalent bonds to the substrate. The copolymers can include hydrophilic repeat units, and in particular zwitterionic repeat units such as repeat units containing phosphorylcholine groups. In some aspects, the coating compositions are applied to a surface of a polymer substrate, wherein the polymer substrate had nitric oxide releasing properties. The coating compositions and the coated articles can have antifouling, antithrombotic, and/or antibacterial properties.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: June 28, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Jason J. Locklin, Qiaohong Liu, Priyadarshini Singha, Hitesh Handa, Jitendra Pant, Marcus J. Goudie, Sean P. Hopkins
  • Patent number: 11332718
    Abstract: The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lig28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: May 17, 2022
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Steven L Stice, Franklin West, Yangqing Lu
  • Patent number: 11317570
    Abstract: The present disclosure provides peanut maturity grading systems and methods for quickly, efficiently, and objectively determining a peanut maturity grade for a crop of peanuts and determining an optimal harvest time for the crop. Embodiments of systems and methods of the present disclosure can be performed in the field or field-side and do not require assistance of a trained peanut grading specialist.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: May 3, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Tsz Ho Tse, Brian Boland, Donald Leo, Kyle Johnsen, Sahil Patel, Zhuo Zhao
  • Patent number: 11311916
    Abstract: The present disclosure provides peanut maturity grading systems and methods for quickly, efficiently, and objectively determining a peanut maturity grade for a crop of peanuts and determining an optimal harvest time for the crop. Embodiments of systems and methods of the present disclosure can be performed in the field or field-side and do not require assistance of a trained peanut grading specialist.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: April 26, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Tsz Ho Tse, Brian Boland, Donald Leo, Kyle Johnsen, Zhuo Zhao
  • Patent number: 11292000
    Abstract: A variety of devices, systems, kits, and methods are provided for separating or enriching circulating tumor cells in a biological sample such as whole blood. In some aspects, the devices are multi-stage devices including at least a filtering stage, and two separation stages for ferrohydrodynamic separation of magnetically labelled white blood cells and for marker-independent and size-independent focusing of magnetically labeled particles so as to separate or enrich unlabeled rare cells in the biological sample. The devices and methods are, in some aspects, capable of high throughput in excess of 6 milliliters per hour while achieving high separation (>97%) of the unlabeled rare cells.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: April 5, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Leidong Mao, Yang Liu, Wujun Zhao
  • Publication number: 20220096441
    Abstract: Compounds, compositions, and methods for the treatment of infections caused by Acanthamoeba or Balamuthia mandrillaris trophozoites and/or cysts and for the disinfection of solids and/or liquids, such as medical and personal care items, for example contact lenses, that may harbor Acanthamoeba trophozoites and/or cysts are provided.
    Type: Application
    Filed: October 17, 2019
    Publication date: March 31, 2022
    Applicants: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC., UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., UNIVERSITY OF SOUTH FLORIDA
    Inventors: David W. Boykin, Dennis E. Kyle, Christopher A. Rice, Abdelbasset A. Farahat
  • Publication number: 20220096665
    Abstract: Ligand-bimodal nanoparticle conjugates capable of crossing the blood-brain barrier are disclosed. Methods of making and using the conjugates also are disclosed. The bimodal nanoparticle includes a polymeric matrix, one or more magnetic particles disposed within the polymeric matrix or conjugated to an outer surface of the polymeric matrix, and a dye disposed within the polymeric matrix. A ligand for a blood-brain barrier amino acid transporter is conjugated to the outer surface of the bimodal nanoparticle.
    Type: Application
    Filed: November 20, 2019
    Publication date: March 31, 2022
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Puliyur Seshadri MohanKumar, Sheba M.J. MohanKumar, Yen-jun Chuang
  • Patent number: 11274329
    Abstract: Provided herein are plant/plant pathogen volatile compound electrochemical sensors, plant/plant pathogen volatile detection systems, and methods for detecting stress-induced plant volatile compounds and/or a plant-pathogen emitted volatile compounds.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: March 15, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Ramaraja P. Ramasamy, Yi Fang
  • Patent number: 11268041
    Abstract: The present application provides charcoal briquettes infused with a flammable composition including fusel oil and/or one or more dehydration products of fusel oil and the flammable compositions including one or more dehydration products of fusel oil.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: March 8, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Ryan B. Adolphson, Daniel P. Geller, Levi T. Mills, Marcus Leonard Smith, Fredrick W. Huszagh, II
  • Patent number: 11246965
    Abstract: Compositions, devices, grafts and methods for reducing or preventing anti-neointima following cardiovascular injuries and interventions are disclosed. The compositions, devices, and grafts typically include an effective amount of a CTP synthase 1 inhibitor to reduce proliferation of vascular smooth muscle cells, without substantial reducing the proliferation of endothelial cells. Methods of reducing neointima formation, accelerating re-endothelialization, and reducing restenosis in a subject using the compositions, devices, and grafts are also disclosed.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: February 15, 2022
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Shiyou Chen, Rui Tang
  • Publication number: 20220023410
    Abstract: Crimean-Congo hemorrhagic fever (CCHF) virus replicon particles (VRP) are described. These VRP are capable of undergoing a single round of virus replication, but are unable to produce new particles or spread to neighboring cells due to the lack of the glycoprotein-encoding M genome segment. In some instances, the VRP contain one or more mutations in the viral ovarian tumor domain protease encoded by the L genome segment or heterologous antigens within its S genome segment. The VRP are shown to elicit a protective immune response against lethal CCHF virus challenge in an animal model.
    Type: Application
    Filed: December 13, 2019
    Publication date: January 27, 2022
    Applicants: University of Georgia Research Foundation, Inc., THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Eric Bergeron, Scott D. Pegan, Stephen R. Welch, Florine E.M. Scholte, Christina F. Spiropoulou, Stuart T. Nichol, Jessica R. Spengler
  • Patent number: 11229690
    Abstract: The present invention provides genetically engineered strains of the Bordetella species to include one or more mutations preventing expression of the gene encoding the Bordetella Sigma Regulator (also referred to as “bsr,” “btrS,” and “brpL”), compositions and vaccines thereof, and the use of such engineered strains in methods to protect against Bordetella spp, including but not limited to Bordetella bronchiseptica, B. pertussis, B. parapertussis, B. homelsii, or B. avium. In some aspects, the present invention provides the Bordetella bronchiseptica strain RB50?bsr, compositions and vaccines thereof, and the use of Bordetella bronchiseptica strain RB50?fer in methods to protect against Bordetella spp, including but not limited to Bordetella bronchiseptica, B. pertussis, B. parapertussis, B. homelsii, or B. avium.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: January 25, 2022
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Eric T. Harvill, Monica Cartelle Gestal
  • Patent number: PP33868
    Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-920’, characterized by a combination of early-to-mid season ripening; large berries with good scar and flavor and high fruit quality; moderately vigorous growth suited to home gardens, soft pink flowers at opening, bronze coloring to newly emerging foliage, berries transitioning from pink hued to sky-blue during ripening; and a chilling requirement of about 500-550 hours below about 45° F.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: January 18, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Patent number: PP33869
    Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-889’, characterized by a combination of later season flowering and ripening; large berries with unique, vibrant light blue color and good flavor and firmness; vigorous growth; compact form; attractive fall foliage color; and a chilling requirement of about 500-600 hours below about 45° F.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: January 18, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Patent number: PP34162
    Abstract: A new and distinct cultivar of Vaccinium plant named ‘TO-3097’, characterized by a combination of unique pink-colored fruit, mid-season flowering and ripening, large berries with good firmness and flavor, high quality fruit production in conventional production areas, and a chilling requirement of about 450-500 hours below about 45° F.
    Type: Grant
    Filed: September 15, 2021
    Date of Patent: April 26, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Patent number: PP34167
    Abstract: A new and distinctive cultivar of Abelia plant named ‘00-BC-47-7R’ characterized by a combination of uniform, compact, mounding growth habit; glossy dark green foliage in the summer; relatively short height; white flowers and greyed-orange or yellow-green sepals; and heavy blooming from May to September.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: April 26, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Carol Robacker, Allen Byous, Sherrod Baden
  • Patent number: PP34180
    Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-1996’, characterized by a combination of early season ripening; large berries with good scar and flavor; moderately vigorous growth; and a low chilling requirement of about 100 hours, or less, below about 45° F.
    Type: Grant
    Filed: September 15, 2021
    Date of Patent: May 3, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Patent number: PP34193
    Abstract: A new and distinctive cultivar of Abelia plant named ‘00-BC-47-13R’ characterized by a combination of colorful display due to golden-yellow-green and green foliage that changes from early spring through late fall, relatively short height, and the abundant blooms of white flowers with greyed-orange or red sepals from June through September.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: May 3, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Carol Robacker, Allen Byous, Sherrod Baden
  • Patent number: PP34324
    Abstract: A new and distinct cultivar of Spiraea plant named ‘MAD-SP1’, characterized by a combination of deep pink, self-cleaning flowers with medium green colored foliage, a moderately vigorous growth rate with a compact, low-mounding growth habit, and superior leaf spot resistance.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: June 14, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Matthew A. Dirr
  • Patent number: PP34407
    Abstract: A new and distinct cultivar of Spiraea plant named ‘MAD-SP2’, characterized by its pure white colored flowers, medium green foliage and moderately vigorous, compact, low mounded growth habit. Also, for the last 5 years of its existence Spiraea ‘MAD-SP2’ has proven to be leaf spot resistant.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: July 5, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Matthew A. Dirr