Patents Assigned to University of Georgia Research Foundation, Inc.
  • Patent number: 11911615
    Abstract: In one embodiment, an assessment system includes an electrical stimulation device configured to generate current, stimulation electrodes configured to apply the current generated by the electrical stimulation device to a neck of a subject at a location that results in stimulation of a phrenic nerve of the subject, a movement sensor configured to sense movement of an upper abdomen of the subject caused by twitching of a diaphragm of the subject responsive to the stimulation of the phrenic nerve, and a controller configured to receive data sensed by the movement sensor, analyze the received data to evaluate the activity of the diaphragm, and generate an assessment of the subject's respiratory function or phrenic nerve.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: February 27, 2024
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventor: Kevin K. McCully
  • Patent number: 11912647
    Abstract: In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: February 27, 2024
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: David Crich, Asiri Hettikankanamalage, Jarvis Hill
  • Patent number: 11903916
    Abstract: Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: February 20, 2024
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Ralph A. Tripp, Jackelyn Murray, Robert Jeff Hogan
  • Patent number: 11897775
    Abstract: Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: February 13, 2024
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Hitesh Handa, Marcus Goudie, Jitendra Pant, Bryan Grommersch, Sean Hopkins
  • Patent number: 11872215
    Abstract: Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: January 16, 2024
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Geert-Jan Boons
  • Patent number: 11841365
    Abstract: The present disclosure provides devices, kits, and methods for focusing/enriching and/or separating/sorting submicron size particles, including biological entities such as exosomes and other submicron size extracellular vesicles. Devices, kits, and methods of the present disclosure utilize ferrohydrodynamic manipulation to focus populations of submicron particles into a stream for enrichment and/or further sort various sub-populations of submicron particles based on size differences.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: December 12, 2023
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Leidong Mao, Yang Liu
  • Patent number: 11814653
    Abstract: A heat attenuated infectious bronchitis virus (IBV) isolate of PDRC DMV/1639 deposited at the ATCC under Patent Designation PTA-126757 and progeny and derivatives thereof and compositions thereof are presented. Methods for administering the isolates and compositions as vaccines to prevent virulent IBV infection in birds of the order Galliformes are also presented.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: November 14, 2023
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Mark W. Jackwood, Brian J. Jordan
  • Patent number: 11788100
    Abstract: Methods and compositions disclosed herein generally relate to genes involved in plant reproduction and methods of using the same.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: October 17, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Peggy Ozias-Akins, Joann A. Conner
  • Patent number: 11780872
    Abstract: Disclosed herein are oligosaccharides and intermediates useful for the production thereof. The compounds are useful as analytical standards and as intermediates for the preparation of more complex oligosaccharide and N-glycan products. The compounds may be prepared in high purity using the selective stop/go synthetic methods disclosed herein.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: October 10, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Geert-Jan Boons, Anthony Robert Prudden, Lin Liu
  • Patent number: 11773146
    Abstract: As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein family member 3 (WASF3) leads to destabilization of WASF3 and suppression of invasion. Disclosed are stapled peptides that inhibit the binding of Cytoplasmic FMR1-interacting protein 1 (CYFIP1) to either WASF3 or NCK-associated protein (NCKAP1). Also disclosed are methods for treating or suppressing invasion and metastasis of a cancer in a subject that involve administering to the subject a therapeutically effective amount of a stapled peptide disclosed herein.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: October 3, 2023
    Assignees: University of Georgia Research Foundation, Inc., Augusta University Research Institute
    Inventors: Eileen J. Kennedy, John Cowell
  • Patent number: 11707768
    Abstract: Various examples of a system for peanut sorting and grading are disclosed herein. The system for grading peanut maturity, can include: a sample feeder configured to supply individual peanuts to an imaging area; a sorting board comprising a plurality of chutes and a plurality of gates, each chute of the plurality of chutes designated for a grade of peanut; and program instructions to obtain the digital image of the individual peanut; determine the grade of the individual peanut; and sort the individual peanut based on the grade of the individual peanut. A method for grading peanut maturity, can include feeding an individual peanut to an imaging area; obtaining a digital image of the individual peanut; determining a grade of the individual peanut based on an average color; and sorting the individual peanut in a chute of a sorting board based on the grade of the individual peanut.
    Type: Grant
    Filed: October 1, 2021
    Date of Patent: July 25, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Zhuo Zhao, Tsz Ho Tse, Don Leo, Kyle Johnsen, Rui Li, Brian L. Boland
  • Patent number: 11690900
    Abstract: Provided herein is a protein, referred to as a Pn3Pase protein, that degrades the capsular polysaccharide of serotype 3 Streptococcus pneumoniae. The disclosure includes a genetically modified cell that includes a Pn3Pase protein, and compositions that include the protein, the polynucleotide encoding the protein, the genetically modified cell, or a combination thereof. Also provided are methods for using a Pn3Pase protein, including methods for contacting a S. pneumoniae having a type III capsular polysaccharide with a Pn3Pase protein, increasing deposition of at least one complement component on the surface of a S. pneumoniae, treating an infection in a subject, treating a symptom in a subject, decreasing colonization of a subject by S. pneumoniae, or a combination thereof.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: July 4, 2023
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Fikri Y. Avci, Dustin Middleton, Amy Victoria Paschall
  • Patent number: 11686729
    Abstract: The present disclosure includes methods and systems of detecting bacteria in a sample using phage-functionalized sensors, methods of enriching a sample with phage-functionalized magnetic particles, phage-functionalized magnetic particles and methods of making phage-functionalized magnetic particles.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: June 27, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Ramaraja P. Ramasamy, Yan Zhou
  • Patent number: 11655471
    Abstract: Disclosed are compositions and methods for increasing virus production. In particular, disclosed herein are cell or cell line comprises reduced expression of one or more cellular genes selected from the group comprising COQ9, FGF2, NAT9, NDUFA9, NEU2, PLA2G1B, PYCR1, RAD51AP1, STRADA, SVOPL, and/or ZFYVE9 for use in increasing viral production.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: May 23, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Ralph A Tripp
  • Patent number: 11648559
    Abstract: A variety of devices and methods are provided for separating or enriching circulating tumor cells in a biological sample such as whole blood. In some aspects, the devices are multi-stage devices including at least (i) a filtering stage, (ii) a sheath flow stage for ferrohydrodynamic separation of magnetically labelled white blood cells, and (iii) a focusing stage for marker-independent and size-independent focusing of magnetically labeled particles so as to separate or enrich unlabeled rare cells in the biological sample. The devices and methods are, in some aspects, capable of high throughput in excess of 6 milliliters per hour while achieving high separation (>95%) of the unlabeled rare cells.
    Type: Grant
    Filed: August 4, 2018
    Date of Patent: May 16, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Leidong Mao
  • Patent number: PP35180
    Abstract: A new and distinct cultivar of Thuja plant named ‘RutThu5’, characterized by its nice, columnar form, dark green foliage that does not have chartreuse tips like Thuja occidentalis ‘Emerald Green’. ‘RutThu5’ can be grown with one cutting per pot compared to the industry standard of three cuttings per pot, and has similar growth rate in containers and field as three-cutting plants of ‘Emerald Green’. The new ‘RutThu5’ has demonstrated cold hardiness to about ?34° F. in trials conducted in Minnesota.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: May 23, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: John M. Ruter
  • Patent number: PP35198
    Abstract: A new and distinct cultivar of Ilex plant named ‘RutHol7’, characterized by its upright, elliptical growth habit; a height-to-width ratio of about 2.3; grayish-purple new growth, and narrower leaves than similar Ilex cultivars.
    Type: Grant
    Filed: August 8, 2022
    Date of Patent: May 30, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: John M. Ruter
  • Patent number: PP35206
    Abstract: A new and distinct cultivar of Thuja plant named ‘RutThu3’, characterized by its compact, rounding form and yellow foliage with orange tips; growth and heat tolerance in USDA Zone 8a, growth in full sun and afternoon shade conditions in landscape and full sun in container production, disease and insect resistance, and cold hardiness to about ?34° F. in Minnesota.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: June 6, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: John M. Ruter
  • Patent number: PP35227
    Abstract: A new and distinct cultivar of Ilex plant named ‘RutHol6’, characterized by its full, oval growth habit; a height-to-width ratio of about 1.3; grayish-red new growth, and wider leaves than similar Ilex cultivars.
    Type: Grant
    Filed: August 8, 2022
    Date of Patent: June 20, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: John M. Ruter
  • Patent number: PP35297
    Abstract: A new and distinct cultivar of Thuja plant named ‘RutThu4’, characterized by its compact, globose growth, similar in shape but larger in size and with a faster growth rate than some other Thuja occidentalis cultivars. ‘RutThu4’ also has disease resistance when grown in USDA Zone 8a, and has demonstrated both heat tolerance as well as cold hardiness to about ?34° F. in trials conducted in Minnesota.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: August 8, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: John M. Ruter