Abstract: The invention relates to a composition for preparing a 3D scaffold for culturing cells and tissue, such as human cells and tissue. In particular embodiments, the present invention relates to a composition comprising a biocompatible polymer suitable for the preparation of a hydrogel, and a modified extracellular matrix (ECM) protein that is unreactive towards the biocompatible polymer, such that, after preparation of a hydrogel, the modified ECM protein is not covalently bound to the hydrogel. Compositions of the invention are suitable for use in 3D bioprinting, tissue engineering, drug screening, disease modelling and methods of treatment such as tissue regeneration.

Abstract: The invention provides means of diagnosing and treating microvascular angina (MVA). Diagnostic applications of intra-coronary guidewires are provided. Treatment of MVA patients with zibotentan is disclosed. The MVA patient can be identified and selected for treatment via the diagnostic applications provided.

Abstract: Provided are novel naphthalene diimide (NDI) compound of Formula 1. The compounds may exhibit colour change from substantially transparent to substantially black upon electrochemical or photochemical stimulus and may be useful in smart windows.

Abstract: Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

Abstract: The treatment of bacterial respiratory infections using bacterially-originating antibiotics known as pyocins are provided. In particular, S-type pyocins are administered by pulmonary administration for the treatment of bacterial infections such as Pseudomonas aeruginosa infections. Methods of using S-type pyocin proteins, particularly those comprising an S2, SD2, S5 or AP41 targeting portion or an S2, SD2, S5 or AP41 effector portion are provided.

Abstract: The invention discloses a device (1) for characterizing in real time the actimetry of a subject, having: a radar (2) emitting and receiving radar signals, and having a software interface for configuring the shape of the signal emitted; processing and computing means (3) coupled to the radar (2), having a trained classifier (3a) using a database, said processing and computing means (3) being configured to perform in real time: —a capture of color micro-Doppler images (6) having several color channels (R, V, B), each having micro-Doppler signatures (6a) with color pixels the value of which is a function of a reflectivity and a speed of the subject; —a processing of the micro-Doppler images (6) for: computing a so-called monochromatic image having monochromatic pixels, each having a given monochromatic intensity, on the basis of the color pixels of each color micro-Doppler image; transforming the monochromatic image into a binary image by segmentation, according to a binary luminous intensity threshold, of the m

Abstract: The present invention relates to analogues of insect neuropeptides having activity against hemipteran and dipteran insects, such as aphids and fruit flies, and their use as insect control agents (e.g. insecticides) and plant protection agents.

Abstract: A single photon avalanche diode (SPAD) device is presented. The SPAD device comprising: a Si-based avalanche layer formed over an n-type semiconductor contact layer; a p-type charge sheet layer formed in or on the avalanche layer, the p-type charge sheet layer having an in-plane width; a Ge-based absorber layer, formed over the charge sheet layer and/or the avalanche layer, and overlapping the charge sheet layer, the Ge-based absorber layer having an in-plane width; wherein, at least in one in-plane direction, the in-plane width of the Ge-based absorber layer is greater than the in-plane width of the p-type charge sheet layer.

Abstract: The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.

Abstract: Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

Abstract: A readout integrated circuit (IC) architecture for a tunnelling magnetoresistive (TMR) sensor which uses common mode feedback to achieve a performance level suitable for accurate detection of biomagnetic signals. The architecture uses a three-operational amplifier configuration with chopper stabilization. The architecture may form part of a fully integrated biomagnetic sensor electronics package that includes an array of TMR sensors together with modules for signal amplification and conditioning, data conversion and communication.

Abstract: The present invention concerns a structurally distinct immunosuppressive mimic of TGF-? that is a potent inducer of murine and human regulatory T cells and provides a therapeutic agent for the treatment of inflammatory disorders. Disclosed herein is a novel parasite TGF-? mimic which fully replicates the biological and functional properties of TGF-?, including binding to mammalian TGF-? receptors and inducing Foxp3+ Treg in both murine and human CD4+ T cells. This TGF-? mimic shares no homology to mammalian TGF-? or other members of the TGF-? family, but s distinctly related to the component control protein (CCP) superfamily.

Abstract: The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.

Abstract: The invention provides materials presenting a biologically active matrix comprising a physiological fibrillar fibronectin network, such as implantable constructs, and their use for modulating cell behaviour and fate, including cell growth, proliferation and/or differentiation, such as for promoting tissue regeneration, for example, bone regeneration or vascularization. Also provided are constructs presenting a biologically active matrix comprising a physiological fibrillar fibronectin network for sustaining growth of stem cells or maintaining stem cells (maintaining stemness).

Abstract: The present invention concerns a structurally distinct immunosuppressive mimic of TGF-? that is a potent inducer of murine and human regulatory T cells and provides a therapeutic agent for the treatment of inflammatory disorders. Disclosed herein is a novel parasite TGF-? mimic which fully replicates the biological and functional properties of TGF-?, including binding to mammalian TGF-? receptors and inducing Foxp3+ Treg in both murine and human CD4+ T cells. This TGF-? mimic shares no homology to mammalian TGF-? or other members of the TGF-? family, but s distinctly related to the component control protein (CCP) superfamily.

Abstract: A method is disclosed of manufacturing a semiconductor structure comprising an (001) oriented zincblende structure group III-nitride layer, such as GaN. The layer is formed on a 3C-SiC layer on a silicon substrate. A nucleation layer is formed, recrystallized and then the zincblende structure group III-nitride layer is formed by MOVPE at temperature T3 in the range 750-1000° C., to a thickness of at least 0.5?. There is also disclosed a corresponding semiconductor structure comprising a zincblende structure group III-nitride layer which, when characterized by XRD, shows that the substantial majority, or all, of the layer is formed of zincblende structure group III-nitride in preference to wurtzite structure group III-nitride. The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons.

Abstract: The disclosure is directed to an Echo-Planar-Imaging (EPI) magnetic resonance imaging techniques combined with a variable-density undersampling scheme. The technique comprises generating an RF pulse, applying a switched frequency-encoding read out gradient in a variable time interval, and applying simultaneously an intermittently blipped low-magnitude phase-encoding gradient with a variable value of an integral of the phase-encoding gradient. The aforementioned steps are carried out such that the k-space is at least partially undersampled and the time interval of one read out gradient is varied depending on the integral of the phase encoding gradient, such that a ratio between the variable time interval of the read out gradient and the integral of the corresponding phase encoding gradient is kept above or at a predetermined constant value, which is related to a predetermined criteria of image quality.

Abstract: A device is disclosed for the preparation of nebulised droplets, for inhalation. The device has: a surface acoustic wave (SAW) transmission surface; a SAW transducer adapted to generate and propagate SAWs along the SAW transmission surface; and an array of cavities opening at the SAW transmission surface for containing a liquid. In operation, SAWs propagating along the SAW transmission surface interact with the liquid in the cavities to produce nebulised droplets of the liquid. Operation of the device results in a nebulised plume of droplets of average diameter in the range 1-5 ?m.

Abstract: The treatment of bacterial respiratory infections using bacterially-originating antibiotics known as pyocins. In particular, S-type pyocins are administered by pulmonary administration for the treatment of such infections.

Abstract: A method and a system for controlling an output of an optical system, the method comprising generating a plurality of optical signal components having different optical properties and passing the generated optical signal components as input to an optical system comprising an optical device and/or an optical medium; an output of the optical system being based on interactions of the signal components within the optical device and/or the optical medium; and relative proportions of the optical signal components that are generated and individual optical properties thereof being selected to control the output of the optical system.