Patents Assigned to University of Glasgow
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Patent number: 9828604Abstract: The present invention relates to phosphodiesterase 9A (PDE9A) for use as a marker for prostate cancer, and the use of PDE9A as a marker for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer. The present invention also relates to a composition for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer, a corresponding method and immunoassay, a method for diagnosing, monitoring or prognosticating hormone-resistant prostate cancer vs. hormone-sensitive prostate cancer, a corresponding immunoassay, a method of data acquisition, an immunoassay for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer, a method of identifying an individual for eligibility for prostate cancer therapy, an immunoassay for stratifying an individual or cohort of individuals with a prostate cancer disease, an immunoassay for stratifying an individual with prostate cancer.Type: GrantFiled: May 11, 2010Date of Patent: November 28, 2017Assignees: Koninklijke Philips N.V., The University Court of the University of GlasgowInventors: Ralf Hoffmann, Miles Douglas Houslay, David James Peter Henderson
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Patent number: 9757706Abstract: The invention provides a method for preparing a compound or a product having one or more characteristics that meet or exceed a user specification, the process comprising the step of selecting a first combination of chemical inputs, optionally together with physical inputs, and supplying those inputs to a reaction space, thereby to generate a first product; analyzing one or more characteristics of the product generated; comparing the one or more characteristics against a user specification; using a genetic algorithm selecting a second combination of chemical inputs, optionally together with physical inputs, wherein the second combination differs from the first combination, and supplying those inputs to the reaction space, thereby to generate a second product; analyzing one or more characteristics of the second product generated; comparing the one or more characteristics generated against the user specification; repeating the selecting and analyzing steps for further individual combinations of chemical and/or pType: GrantFiled: May 24, 2013Date of Patent: September 12, 2017Assignee: The University Court of The University of GlasgowInventor: Leroy Cronin
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Patent number: 9751057Abstract: A method of using a fluidics apparatus for lysing a cell. In the method, the cell is placed in a fluid sample contacting a substrate surface. The method further includes providing surface acoustic waves (SAWs) at the substrate surface, causing cell lyses.Type: GrantFiled: May 27, 2016Date of Patent: September 5, 2017Assignee: The University Court of the University of GlasgowInventors: Rab Wilson, Jonathan M. Cooper, Julien Reboud
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Publication number: 20170246634Abstract: The present invention generally relates to the manipulation of fluids using acoustic waves such as surface acoustic waves. In some aspects, one fluid may be introduced into another fluid via application of suitable acoustic waves. For example, a fluid may be added or injected into another fluid by applying acoustic waves where, in the absence of the acoustic waves, the fluid cannot be added or injected, e.g., due to the interface or surface tension between the fluids. Thus, for example, a fluid may be injected into a droplet of another fluid. Other embodiments of the invention are generally directed to systems and methods for making or using such systems, kits involving such systems, or the like.Type: ApplicationFiled: June 25, 2015Publication date: August 31, 2017Applicants: President and Fellows of Harvard College, The University Court of the University of GlasgowInventors: David A. Weitz, Thomas Franke
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Publication number: 20170240602Abstract: The invention relates to the treatment of bacterial respiratory infections using the bacterially-originating antibiotics known as pyocins. In particular, the invention provides the use of S-type pyocins, administered by pulmonary administration, for the treatment of such infections.Type: ApplicationFiled: September 22, 2015Publication date: August 24, 2017Applicant: The University Court of the University of GlasgowInventors: Daniel Walker, Laura McCaughey
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Patent number: 9677051Abstract: This invention provides method and media suitable for inducing and supporting the differentiation of stem cells into erythroid cells.Type: GrantFiled: July 18, 2013Date of Patent: June 13, 2017Assignees: The Common Services Agency, University Court of the University of GlasgowInventors: Joanne Mountford, Emmanuel Oliver
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Patent number: 9642875Abstract: The invention provides a propionate inulin ester for the reduction of appetite, food intake and/or calorie intake and/or to improve insulin sensitivity in a subject, and for the treatment or prevention of obesity or diabetes. The invention also provides compositions comprising a propionate inulin ester, methods using propionate inulin esters, functional food containing propionate inulin ester and methods of making propionate inulin esters.Type: GrantFiled: July 31, 2013Date of Patent: May 9, 2017Assignees: The University Court of the University of Glasgow, Imperial Innovations LimitedInventors: Gary Frost, Douglas Morrison, Thomas Preston
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Patent number: 9643152Abstract: Provided are methods for preparing and using reaction vessels obtained or obtainable by 3D-printing methods, including a method for preparing a product compound, the method comprising the steps of: (i) providing a reaction vessel that is obtained by a 3-D printing method, wherein the reaction vessel has a reaction space; (ii) providing one or more reagents, optionally together with a catalyst or a solvent, for use in the synthesis of the product compound; and (iii) permitting the one or more reagents to react in the reaction space, optionally in the presence of the catalyst and the solvent, in the reaction vessel, thereby to form the product compound.Type: GrantFiled: February 18, 2013Date of Patent: May 9, 2017Assignee: The University Court of the University of GlasgowInventor: Leroy Cronin
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Patent number: 9598386Abstract: This invention relates to compounds and uses thereof in the treatment or prophylaxis of diseases associated with inflammation.Type: GrantFiled: July 25, 2013Date of Patent: March 21, 2017Assignees: University of Strathclyde, University of GlasgowInventors: Margaret Harnett, William Harnett, Colin J. Suckling, Fraser Scott, Judith K. Huggan, Abedawn I. Khalaf
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Publication number: 20160333345Abstract: The invention relates to the use of microRNA 29 and precursors and mimics thereof for the modulation of tendon injury and the biomechanical properties of tendon. In particular, the invention derives from the finding that synthesis of type 1 collagen in tenocytes is less sensitive to miR-29 than is synthesis of type 3 collagen, thus enabling the balance between the collagen subtypes to be modulated in favour of type 1 collagen, mitigating reduction in biomechanical properties during healing.Type: ApplicationFiled: January 14, 2015Publication date: November 17, 2016Applicant: The University Court of the University of GlasgowInventors: Derek Stewart GILCHRIST, Neal Lindsay MILLAR
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Patent number: 9410873Abstract: A fluidics apparatus for manipulation of at least one fluid sample is disclosed. A manipulation surface locates the fluid sample. A surface acoustic wave (SAW) generation material layer is provided. This is a polycrystalline material, textured polycrystalline material, biaxially textured polycrystalline material, microcrystalline material, nanocrystalline material, amorphous material or composite material. A transducer electrode structure arranged at the SAW generation material layer provides SAWs at the manipulation surface for interaction with the fluid sample. The manipulation surface has a phononic structure, for affecting the transmission, distribution and/or behavior of SAWs at the manipulation surface. The apparatus is typically manufactured by reel-to-reel processes, to reduce the unit cost to a level at which the apparatus can be considered to be disposable after a single use.Type: GrantFiled: February 24, 2012Date of Patent: August 9, 2016Assignee: The University Court of the University of GlasgowInventors: Rab Wilson, Jonathan M. Cooper, Julien Reboud
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Publication number: 20160206679Abstract: The invention relates to the finding that turnover of DISC1 (Disrupted in schizophrenia 1) is mediated by the F-box-containing protein FBXW7 (F-box/WD repeat-containing protein 7). The sequence within DISC1 that binds to FBXW7 and targets DISC1 for turnover by the ubiquitin-proteasome system is identified. The invention provides antagonists that inhibit this interaction and methods of using these antagonists to decrease DISC1 turnover, for example in treatment of neuropsychiatric disorders, as well as methods of identifying new antagonists.Type: ApplicationFiled: September 29, 2014Publication date: July 21, 2016Applicant: The University Court of the University of GlasgowInventor: George BAILLIE
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Patent number: 9375690Abstract: A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location of the fluid sample. A transducer arrangement such as an interdigitated electrode structure on a piezoelectric body provides surface acoustic waves at the substrate surface for manipulation of the fluid sample. The substrate surface has an arrangement of surface acoustic wave scattering elements forming a phononic crystal structure for affecting the transmission, distribution and/or behavior of surface acoustic waves at the substrate surface. Also disclosed is a method for lysing a cell. In this method, the cell is comprised in a fluid sample contacting a substrate surface, the method comprising providing surface acoustic waves at the substrate surface, such that the cell lyses.Type: GrantFiled: August 24, 2010Date of Patent: June 28, 2016Assignee: The University Court of the University of GlasgowInventors: Rab Wilson, Jonathan M. Cooper, Julien Reboud
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Patent number: 9370557Abstract: The invention relates to the use of bacterial cytolysin proteins, such as pneumolysin, as adjuvants for stimulating or enhancing immune responses against co-administered target antigens. Desirably, the target antigen is provided as a fusion protein with the cytolysin. The inventors have found that cytolysins may be particularly effective for stimulation of mucosal immune responses against the target antigen.Type: GrantFiled: June 15, 2007Date of Patent: June 21, 2016Assignee: The University Court of the University of GlasgowInventors: Timothy John Mitchell, Lea-Ann Kirkham, Graeme James Cowan, Gillian Douce
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Patent number: 9322895Abstract: The present invention provides a novel lactate difference imaging (LDI) technique, allowing assessment of the metabolic responses of tissue over a period of time. This approach utilizes lactate change over a time period as an indicator of viable tissue, and offers benefits in the management and treatment of the effects of many common diseases, in particular stroke.Type: GrantFiled: September 3, 2010Date of Patent: April 26, 2016Assignees: Greater Glasgow Health Board, The University Court of the University of GlasgowInventors: Celestine Santosh, William Holmes, Rosario Lopez
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Patent number: 9267134Abstract: The present invention provides a method of treating or preventing pulmonary arterial hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors for treating pulmonary arterial hypertension are also disclosed.Type: GrantFiled: May 9, 2012Date of Patent: February 23, 2016Assignees: The University Court of the University of Glasgow, Cambridge Enterprise LimitedInventors: Andrew Baker, Margaret MacLean, Nicholas Morrell
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Publication number: 20150164984Abstract: The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli infections, including Crohns' disease. In particular, the invention relates to the use of colicins and bacteria producing colicins, for the treatment of such conditions.Type: ApplicationFiled: July 12, 2013Publication date: June 18, 2015Applicant: The University Court of the University of GlasgowInventors: Daniel Walker, Karen Smith
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Patent number: 8888674Abstract: Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the treatment of diseased areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas deep within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.Type: GrantFiled: December 10, 2008Date of Patent: November 18, 2014Assignees: University of Maryland College Park, University of GlasgowInventors: Benjamin Shapiro, Andreas Lüebbe, Declan Diver, Hugh Potts, Roland Probst
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Publication number: 20140234263Abstract: The present invention provides, among other things, improved compositions and methods for the treatment of tissue damage (e.g., acute or chronic) and related diseases, disorders or conditions based on the use of pathfinder cells, extracellular secretomes thereof, and/or pathfinder cell-associated microRNAs. In some embodiments, the present invention provides a method for treating tissue damage (e.g., acute or chronic) comprising a step of administering a population of cells to an individual suffering from a disease, disorder or condition characterized by acute damage to one or more tissues, wherein the cells are originated from an adult tissue and wherein the cells induce tissue repair, regeneration, remodeling, reconstitution or differentiation.Type: ApplicationFiled: February 13, 2013Publication date: August 21, 2014Applicant: The University Court of the University of GlasgowInventor: Paul Shiels
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Publication number: 20130330247Abstract: A fluidics apparatus for manipulation of at least one fluid sample is disclosed. A manipulation surface locates the fluid sample. A surface acoustic wave (SAW) generation material layer is provided. This is a polycrystalline material, textured polycrystalline material, biaxially textured polycrystalline material, microcrystalline material, nanocrystalline material, amorphous material or composite material. A transducer electrode structure arranged at the SAW generation material layer provides SAWs at the manipulation surface for interaction with the fluid sample. The manipulation surface has a phononic structure, for affecting the transmission, distribution and/or behaviour of SAWs at the manipulation surface. The apparatus is typically manufactured by reel-to-reel processes, to reduce the unit cost to a level at which the apparatus can be considered to be disposable after a single use.Type: ApplicationFiled: February 24, 2012Publication date: December 12, 2013Applicant: The University Courrt of the University of GlasgowInventors: Rab Wilson, Jonathan M. Cooper, Julien Reboud