Patents Assigned to University of Glasgow
  • Patent number: 9828604
    Abstract: The present invention relates to phosphodiesterase 9A (PDE9A) for use as a marker for prostate cancer, and the use of PDE9A as a marker for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer. The present invention also relates to a composition for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer, a corresponding method and immunoassay, a method for diagnosing, monitoring or prognosticating hormone-resistant prostate cancer vs. hormone-sensitive prostate cancer, a corresponding immunoassay, a method of data acquisition, an immunoassay for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer, a method of identifying an individual for eligibility for prostate cancer therapy, an immunoassay for stratifying an individual or cohort of individuals with a prostate cancer disease, an immunoassay for stratifying an individual with prostate cancer.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: November 28, 2017
    Assignees: Koninklijke Philips N.V., The University Court of the University of Glasgow
    Inventors: Ralf Hoffmann, Miles Douglas Houslay, David James Peter Henderson
  • Patent number: 9757706
    Abstract: The invention provides a method for preparing a compound or a product having one or more characteristics that meet or exceed a user specification, the process comprising the step of selecting a first combination of chemical inputs, optionally together with physical inputs, and supplying those inputs to a reaction space, thereby to generate a first product; analyzing one or more characteristics of the product generated; comparing the one or more characteristics against a user specification; using a genetic algorithm selecting a second combination of chemical inputs, optionally together with physical inputs, wherein the second combination differs from the first combination, and supplying those inputs to the reaction space, thereby to generate a second product; analyzing one or more characteristics of the second product generated; comparing the one or more characteristics generated against the user specification; repeating the selecting and analyzing steps for further individual combinations of chemical and/or p
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: September 12, 2017
    Assignee: The University Court of The University of Glasgow
    Inventor: Leroy Cronin
  • Patent number: 9751057
    Abstract: A method of using a fluidics apparatus for lysing a cell. In the method, the cell is placed in a fluid sample contacting a substrate surface. The method further includes providing surface acoustic waves (SAWs) at the substrate surface, causing cell lyses.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: September 5, 2017
    Assignee: The University Court of the University of Glasgow
    Inventors: Rab Wilson, Jonathan M. Cooper, Julien Reboud
  • Publication number: 20170246634
    Abstract: The present invention generally relates to the manipulation of fluids using acoustic waves such as surface acoustic waves. In some aspects, one fluid may be introduced into another fluid via application of suitable acoustic waves. For example, a fluid may be added or injected into another fluid by applying acoustic waves where, in the absence of the acoustic waves, the fluid cannot be added or injected, e.g., due to the interface or surface tension between the fluids. Thus, for example, a fluid may be injected into a droplet of another fluid. Other embodiments of the invention are generally directed to systems and methods for making or using such systems, kits involving such systems, or the like.
    Type: Application
    Filed: June 25, 2015
    Publication date: August 31, 2017
    Applicants: President and Fellows of Harvard College, The University Court of the University of Glasgow
    Inventors: David A. Weitz, Thomas Franke
  • Publication number: 20170240602
    Abstract: The invention relates to the treatment of bacterial respiratory infections using the bacterially-originating antibiotics known as pyocins. In particular, the invention provides the use of S-type pyocins, administered by pulmonary administration, for the treatment of such infections.
    Type: Application
    Filed: September 22, 2015
    Publication date: August 24, 2017
    Applicant: The University Court of the University of Glasgow
    Inventors: Daniel Walker, Laura McCaughey
  • Patent number: 9677051
    Abstract: This invention provides method and media suitable for inducing and supporting the differentiation of stem cells into erythroid cells.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: June 13, 2017
    Assignees: The Common Services Agency, University Court of the University of Glasgow
    Inventors: Joanne Mountford, Emmanuel Oliver
  • Patent number: 9642875
    Abstract: The invention provides a propionate inulin ester for the reduction of appetite, food intake and/or calorie intake and/or to improve insulin sensitivity in a subject, and for the treatment or prevention of obesity or diabetes. The invention also provides compositions comprising a propionate inulin ester, methods using propionate inulin esters, functional food containing propionate inulin ester and methods of making propionate inulin esters.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: May 9, 2017
    Assignees: The University Court of the University of Glasgow, Imperial Innovations Limited
    Inventors: Gary Frost, Douglas Morrison, Thomas Preston
  • Patent number: 9643152
    Abstract: Provided are methods for preparing and using reaction vessels obtained or obtainable by 3D-printing methods, including a method for preparing a product compound, the method comprising the steps of: (i) providing a reaction vessel that is obtained by a 3-D printing method, wherein the reaction vessel has a reaction space; (ii) providing one or more reagents, optionally together with a catalyst or a solvent, for use in the synthesis of the product compound; and (iii) permitting the one or more reagents to react in the reaction space, optionally in the presence of the catalyst and the solvent, in the reaction vessel, thereby to form the product compound.
    Type: Grant
    Filed: February 18, 2013
    Date of Patent: May 9, 2017
    Assignee: The University Court of the University of Glasgow
    Inventor: Leroy Cronin
  • Patent number: 9598386
    Abstract: This invention relates to compounds and uses thereof in the treatment or prophylaxis of diseases associated with inflammation.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: March 21, 2017
    Assignees: University of Strathclyde, University of Glasgow
    Inventors: Margaret Harnett, William Harnett, Colin J. Suckling, Fraser Scott, Judith K. Huggan, Abedawn I. Khalaf
  • Publication number: 20160333345
    Abstract: The invention relates to the use of microRNA 29 and precursors and mimics thereof for the modulation of tendon injury and the biomechanical properties of tendon. In particular, the invention derives from the finding that synthesis of type 1 collagen in tenocytes is less sensitive to miR-29 than is synthesis of type 3 collagen, thus enabling the balance between the collagen subtypes to be modulated in favour of type 1 collagen, mitigating reduction in biomechanical properties during healing.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 17, 2016
    Applicant: The University Court of the University of Glasgow
    Inventors: Derek Stewart GILCHRIST, Neal Lindsay MILLAR
  • Patent number: 9410873
    Abstract: A fluidics apparatus for manipulation of at least one fluid sample is disclosed. A manipulation surface locates the fluid sample. A surface acoustic wave (SAW) generation material layer is provided. This is a polycrystalline material, textured polycrystalline material, biaxially textured polycrystalline material, microcrystalline material, nanocrystalline material, amorphous material or composite material. A transducer electrode structure arranged at the SAW generation material layer provides SAWs at the manipulation surface for interaction with the fluid sample. The manipulation surface has a phononic structure, for affecting the transmission, distribution and/or behavior of SAWs at the manipulation surface. The apparatus is typically manufactured by reel-to-reel processes, to reduce the unit cost to a level at which the apparatus can be considered to be disposable after a single use.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: August 9, 2016
    Assignee: The University Court of the University of Glasgow
    Inventors: Rab Wilson, Jonathan M. Cooper, Julien Reboud
  • Publication number: 20160206679
    Abstract: The invention relates to the finding that turnover of DISC1 (Disrupted in schizophrenia 1) is mediated by the F-box-containing protein FBXW7 (F-box/WD repeat-containing protein 7). The sequence within DISC1 that binds to FBXW7 and targets DISC1 for turnover by the ubiquitin-proteasome system is identified. The invention provides antagonists that inhibit this interaction and methods of using these antagonists to decrease DISC1 turnover, for example in treatment of neuropsychiatric disorders, as well as methods of identifying new antagonists.
    Type: Application
    Filed: September 29, 2014
    Publication date: July 21, 2016
    Applicant: The University Court of the University of Glasgow
    Inventor: George BAILLIE
  • Patent number: 9375690
    Abstract: A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location of the fluid sample. A transducer arrangement such as an interdigitated electrode structure on a piezoelectric body provides surface acoustic waves at the substrate surface for manipulation of the fluid sample. The substrate surface has an arrangement of surface acoustic wave scattering elements forming a phononic crystal structure for affecting the transmission, distribution and/or behavior of surface acoustic waves at the substrate surface. Also disclosed is a method for lysing a cell. In this method, the cell is comprised in a fluid sample contacting a substrate surface, the method comprising providing surface acoustic waves at the substrate surface, such that the cell lyses.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: June 28, 2016
    Assignee: The University Court of the University of Glasgow
    Inventors: Rab Wilson, Jonathan M. Cooper, Julien Reboud
  • Patent number: 9370557
    Abstract: The invention relates to the use of bacterial cytolysin proteins, such as pneumolysin, as adjuvants for stimulating or enhancing immune responses against co-administered target antigens. Desirably, the target antigen is provided as a fusion protein with the cytolysin. The inventors have found that cytolysins may be particularly effective for stimulation of mucosal immune responses against the target antigen.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: June 21, 2016
    Assignee: The University Court of the University of Glasgow
    Inventors: Timothy John Mitchell, Lea-Ann Kirkham, Graeme James Cowan, Gillian Douce
  • Patent number: 9322895
    Abstract: The present invention provides a novel lactate difference imaging (LDI) technique, allowing assessment of the metabolic responses of tissue over a period of time. This approach utilizes lactate change over a time period as an indicator of viable tissue, and offers benefits in the management and treatment of the effects of many common diseases, in particular stroke.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: April 26, 2016
    Assignees: Greater Glasgow Health Board, The University Court of the University of Glasgow
    Inventors: Celestine Santosh, William Holmes, Rosario Lopez
  • Patent number: 9267134
    Abstract: The present invention provides a method of treating or preventing pulmonary arterial hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors for treating pulmonary arterial hypertension are also disclosed.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: February 23, 2016
    Assignees: The University Court of the University of Glasgow, Cambridge Enterprise Limited
    Inventors: Andrew Baker, Margaret MacLean, Nicholas Morrell
  • Publication number: 20150164984
    Abstract: The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli infections, including Crohns' disease. In particular, the invention relates to the use of colicins and bacteria producing colicins, for the treatment of such conditions.
    Type: Application
    Filed: July 12, 2013
    Publication date: June 18, 2015
    Applicant: The University Court of the University of Glasgow
    Inventors: Daniel Walker, Karen Smith
  • Patent number: 8888674
    Abstract: Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the treatment of diseased areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas deep within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: November 18, 2014
    Assignees: University of Maryland College Park, University of Glasgow
    Inventors: Benjamin Shapiro, Andreas Lüebbe, Declan Diver, Hugh Potts, Roland Probst
  • Publication number: 20140234263
    Abstract: The present invention provides, among other things, improved compositions and methods for the treatment of tissue damage (e.g., acute or chronic) and related diseases, disorders or conditions based on the use of pathfinder cells, extracellular secretomes thereof, and/or pathfinder cell-associated microRNAs. In some embodiments, the present invention provides a method for treating tissue damage (e.g., acute or chronic) comprising a step of administering a population of cells to an individual suffering from a disease, disorder or condition characterized by acute damage to one or more tissues, wherein the cells are originated from an adult tissue and wherein the cells induce tissue repair, regeneration, remodeling, reconstitution or differentiation.
    Type: Application
    Filed: February 13, 2013
    Publication date: August 21, 2014
    Applicant: The University Court of the University of Glasgow
    Inventor: Paul Shiels
  • Publication number: 20130330247
    Abstract: A fluidics apparatus for manipulation of at least one fluid sample is disclosed. A manipulation surface locates the fluid sample. A surface acoustic wave (SAW) generation material layer is provided. This is a polycrystalline material, textured polycrystalline material, biaxially textured polycrystalline material, microcrystalline material, nanocrystalline material, amorphous material or composite material. A transducer electrode structure arranged at the SAW generation material layer provides SAWs at the manipulation surface for interaction with the fluid sample. The manipulation surface has a phononic structure, for affecting the transmission, distribution and/or behaviour of SAWs at the manipulation surface. The apparatus is typically manufactured by reel-to-reel processes, to reduce the unit cost to a level at which the apparatus can be considered to be disposable after a single use.
    Type: Application
    Filed: February 24, 2012
    Publication date: December 12, 2013
    Applicant: The University Courrt of the University of Glasgow
    Inventors: Rab Wilson, Jonathan M. Cooper, Julien Reboud