Abstract: The present invention provides three-component compositions comprising microparticles, a tumor antigen, a first immune adjuvant, and a second immune adjuvant. Also provided are chemo-immunotherapeutic compositions comprising microparticles, a chemotherapeutic agent, and an immune adjuvant.
Type:
Grant
Filed:
October 18, 2011
Date of Patent:
February 21, 2017
Assignee:
The University of Iowa Research Foundation
Inventors:
Aliasger K. Salem, Sean M. Geary, George J. Weiner, Caitlin Lemke, Yogita Krishnamachari
Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The electrode array is maintained on the spinal cord by way of a spring or support structure that is anchored to an anatomical structure outside the spinal cord but near the site of implantation. Suitable anchoring structures include the vertebrae and the dura. Secured in this fashion, the support structure maintains a gentle pressure of the electrode array against the spinal cord so as to stay in electrical contact but minimize injury or inflammation. The device may accommodate and buffer movement of the spinal cord both laterally and in a caudal-rostral fashion so that the electrode array remains in place.
Type:
Grant
Filed:
January 22, 2016
Date of Patent:
February 21, 2017
Assignee:
University of Iowa Research Foundation
Inventors:
Matthew A. Howard, Hiroyuki Oya, Steve Viljoen, Chandan G. Reddy
Abstract: Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
Type:
Application
Filed:
November 19, 2015
Publication date:
February 2, 2017
Applicant:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Steven L. McKnight, Joseph M. Ready, Andrew A. Pieper, Gelin Wang, Ting Han
Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
Type:
Application
Filed:
August 27, 2013
Publication date:
January 26, 2017
Applicant:
University of Iowa Research Foundation
Inventors:
Beverly L. Davidson, Alejandro Mas Monteys, Jodi L. McBride, Ryan Boudreau
Abstract: Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional glaucoma damage from retinal optical coherence image data. In an aspect, the systems and methods can map regions and layers of the eye to determine structural characteristics to compare to functional characteristics.
Abstract: The present invention provides a gallium-containing composition for coating/impregnating a device or device surface to prevent biofilm growth formation. The present invention also provides a method of preventing or inhibiting biofilm growth formation. The present invention also provides methods for killing established biofilms.
Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using these RNAi molecules to treat Huntington's disease.
Type:
Grant
Filed:
May 20, 2015
Date of Patent:
December 20, 2016
Assignee:
University of Iowa Research Foundation
Inventors:
Beverly L. Davidson, Alejandro Mas Monteys
Abstract: The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules.
Abstract: A personally portable nanoparticle respiratory deposition (NRD) sampler configured to collect nanoparticles based upon a sampling criterion. In an aspect, the NRD sampler has an impactor stage, and a diffusion stage. In another aspect, the NRD sampler includes a particle size separator in addition to an impactor stage and a diffusion stage.
Abstract: A device comprising at least one electrode and at least one cell such as Anabaena variabilis cyanobacteria disposed on said electrode for producing ammonia. A layer of polymer, such as ion exchange polymer, can be used to help immobilize the cells. Whole cells or partially disrupted cells can be used. A method and a system for producing ammonia, comprising contacting at least one cyanobacteria such as Anabaena variabilis cyanobacteria with a media with an electrochemical perturbation is disclosed. The potential enhances ammonia production.
Type:
Grant
Filed:
June 28, 2013
Date of Patent:
November 29, 2016
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Johna Leddy, Timothy Michael Paschkewitz
Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.
Type:
Application
Filed:
February 9, 2015
Publication date:
November 24, 2016
Applicant:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
James O. McNamara, Katie R. Flenker, Hyeon Kim, Alexander R. Horswill, Frank J. Hernandez, Mark Behlke, Lingyan Huang, Richard Owczarzy, Elliot Burghardt, Karen Clark
Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
Type:
Grant
Filed:
June 5, 2014
Date of Patent:
November 8, 2016
Assignee:
University of Iowa Research Foundation
Inventors:
Beverly L. Davidson, Henry Paulson, Victor Miller, Cynthia Gouvion
Abstract: A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.
Type:
Grant
Filed:
August 7, 2015
Date of Patent:
November 8, 2016
Assignees:
University of Iowa Research Foundation, University of Virginia Patent Foundation
Inventors:
Matthew Howard, Timothy Brennan, Brian Dalm, Marcel Utz, George T. Gillies, Steven Scott, Randall S. Nelson, Robert Shurig
Abstract: A bioprinter and methods of using the bioprinter. The bioprinter permits selective three-dimensional movement of multiple nozzle assemblies during operation of the bioprinter. The bioprinter can be used to produce scaffold-free tissue constructs having a plurality of cellular elements interspersed among a semi-permeable vascular network. The bioprinter can also be used to print a tissue construct directly onto a tissue defect of a subject. The bioprinter can be provided as part of a bioprinting system that includes a scanner for imaging the tissue defect.
Type:
Application
Filed:
November 4, 2014
Publication date:
October 6, 2016
Applicant:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Ibrahim T. Ozbolat, Howard Chen, Yin Yu, Yahui Zhang, Nicholas Zavazava, Liu Hong, Aliasger K. Salem, Adil Akkouch, Kazim Kerim Moncal
Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
Type:
Application
Filed:
November 3, 2015
Publication date:
September 29, 2016
Applicant:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
Abstract: Provided herein are compositions and methods for reducing one or both of axonal degeneration and neuronal cell death associated with a disease or traumatic brain injury. An aminopropyl carbazole agent with potent neuroprotective properties is described. Specifically, (?)-(S)—N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine, is proposed as a new pharmacological agent for protecting patients against axonal degeneration and chronic consequences of TBI.
Type:
Application
Filed:
November 11, 2014
Publication date:
September 22, 2016
Applicant:
University of Iowa Research Foundation
Inventors:
Steven L. McKnight, Joseph M. Ready, Andrew A. Pieper
Abstract: Regulator of G Protein Signaling (RGS) proteins modulate the complex signaling pathways elicited by G protein coupled receptor activation. Recent studies have implicated RGS proteins in the development and progression of multiple cancers. Provided herein are inhibitors of RGS17, compositions thereof and methods of treating diseases using the inhibitors.
Abstract: Disclosed are pharmaceutical compositions and methods for treating or preventing muscle diseases or the symptoms thereof. The compositions typically include and the methods typically utilize phosphodiesterase type 5A inhibitors.
Type:
Application
Filed:
May 25, 2016
Publication date:
September 15, 2016
Applicant:
University of Iowa Research foundation
Inventors:
Kevin P. Campbell, Yvonne M. Kobayashi, Robert W. Crawford
Abstract: Methods for isolating viable cancer cells from a sample that comprises a mixture of cancerous cells and normal (non-cancerous) cells are provided. In the methods, a fluid preparation comprising a mixture of cancerous and normal cells is repeatedly exposed to fluid shear stresses, whereby the repeated exposure to the fluid shear stresses preferentially imparts fluid shear stress-resistance to the cancerous cells.