Patents Assigned to University of Iowa Research Foundation
  • LUNG INJURY REPAIR COMPOSITIONS AND METHODS
    Publication number: 20160120934
    Abstract: The present invention provides a pharmaceutical composition comprising Protein Kinase C Zeta (PKC-?) inhibitor and therapeutic methods for preventing or treating a pathological condition or symptom or for inducing proliferation of lung progenitor cells in a mammal by administering the PKC-? inhibitor.
    Type: Application
    Filed: October 28, 2015
    Publication date: May 5, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Alejandro P. Comellas Freymond, Xiaopeng Li, Joseph Zabner, Luis Guillermo Vargas Buonfiglio
  • METHOD OF REGULATING CFTR EXPRESSION AND PROCESSING
    Publication number: 20160108406
    Abstract: The present invention relates to methods of reducing ?F508-CFTR ubiquitination or degradation, or increasing ?F508-CFTR processing or function in a CF cell comprising contacting the cell with a therapeutic agent that inhibits NEDD8, FBXO2, and/or SYVN1 expression in the cell.
    Type: Application
    Filed: October 8, 2015
    Publication date: April 21, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Paul B. McCray, Shyam Ramachandran
  • NUCLEIC ACID APTAMERS
    Publication number: 20160108403
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Application
    Filed: August 18, 2015
    Publication date: April 21, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Paloma Giangrande, Francis Miller, William Thiel
  • MODULATION OF MITOCHONDRIAL CALCIUM UNIPORTER ACTIVITY FOR TREATING AND PREVENTING ARRHYTHMIAS
    Publication number: 20160095837
    Abstract: Disclosed are methods and compositions for treating or preventing diseases or disorders associated with mitochondrial calcium uniporter (MCU) activity. The methods may include administering a modulator of MCU activity to a patient in need thereof.
    Type: Application
    Filed: October 7, 2015
    Publication date: April 7, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Mark E. Anderson, Yuejin Wu
  • METHODS TO PREVENT AND TREAT AUTOSOMAL DOMINANT NON-SYNDROMIC HEARING LOSS
    Publication number: 20160090597
    Abstract: The present invention provides in certain embodiments a method of treating autosomal dominant non-syndromic hearing loss (ADNSHL) in a patient in need thereof comprising: (a) identifying a mutation in an ADNSHL-causing gene, (b) preparing a ADNSHL therapeutic miRNA, and (c) administering to the patient a pharmaceutical composition comprising the ADNSHL therapeutic miRNA and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: September 10, 2015
    Publication date: March 31, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Richard J.H. Smith, Seiji Shibata
  • Methods for lowering blood glucose
    Patent number: 9295664
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: March 29, 2016
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Treatment of chronic nephropathies using soluble complement receptor type I (sCR1)
    Patent number: 9295713
    Abstract: A method is disclosed for treating nephropathies involving undesired alternative pathway complement activation by administration of a complement inhibitory protein such as soluble complement receptor type I (sCR1).
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: March 29, 2016
    Assignees: CELLDEX THERAPEUTICS, INC., UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Richard J. H. Smith, Yuzhou Zhang, Henry C. Marsh
  • HUNTINGTON'S DISEASE THERAPEUTIC COMPOUNDS
    Publication number: 20160060624
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using these RNAi molecules to treat Huntington's disease.
    Type: Application
    Filed: May 20, 2015
    Publication date: March 3, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys
  • Methods to enhance RNAi oligonucleotide delivery to respiratory epithelial cells
    Patent number: 9272016
    Abstract: The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a sensitizing agent followed by contacting the cell with a therapeutic RNAi agent.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 1, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Paul B. McCray, Jr., Beverly L. Davidson, Sateesh Krishnamurthy
  • Method for producing layered materials using long-lived photo-induced active centers
    Patent number: 9274429
    Abstract: The invention relates to a method for applying a photo-activated layered polymer coating to a substrate material in which one or more layers do not contain photoinitiator, or are not exposed to initiating light, but cure due to migration of cationic active centers. At least two separate monomer layers are applied to the substrate material. At least one of the monomer layers includes a photoinitiator capable of producing cationic active centers. The at least one layer including the photoinitiator is exposed to a source of UV radiation at a desired wavelength forming cationic active centers. The at least two separate monomer layers react in a polymerization reaction forming a cured layered material. The cationic active centers of the exposed monomer layer migrate to the unexposed layer such that both layers cure via the polymerization reaction.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: March 1, 2016
    Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., University of Iowa Research Foundation
    Inventors: Cynthia G. Templeman, Alec B. Scranton, Beth Ann Rundlett, Cynthia Hoppe
  • RNA interference suppression of neurodegenerative diseases and methods of use thereof
    Patent number: 9260716
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: February 16, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • THERAPEUTIC METHODS
    Publication number: 20160038521
    Abstract: Certain embodiments of the present invention provide a method for treating or preventing juvenile neuronal ceroid lipofuscinosis (JNCL) in an animal comprising administering CBX, GRA, or GZA to the animal.
    Type: Application
    Filed: March 17, 2014
    Publication date: February 11, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Colleen S. Stein, Mark Schultz, Luis Tecedor, Tammy L. Kielian
  • SYSTEMS AND METHODS UTILIZING EXPANDABLE TRANSCATHETER VALVE
    Publication number: 20160038283
    Abstract: Apparatus and methods for transcatheter valves. Specific embodiments relate to transcatheter flutter valves configured for pediatric use.
    Type: Application
    Filed: August 6, 2015
    Publication date: February 11, 2016
    Applicant: THE UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Abhay DIVEKAR, Osamah ALDOSS, Joseph TUREK, Peter GRUBER
  • Tomatidine, analogs thereof, compositions comprising same, and uses for same
    Patent number: 9254295
    Abstract: In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: February 9, 2016
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Christopher M. Adams, Michael C. Dyle, Michael Welsh
  • System that secures an electrode array to the spinal cord for treating back pain
    Patent number: 9254379
    Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The electrode array is maintained on the spinal cord by way of a spring or support structure that is anchored to an anatomical structure outside the spinal cord but near the site of implantation. Suitable anchoring structures include the vertebrae and the dura. Secured in this fashion, the support structure maintains a gentle pressure of the electrode array against the spinal cord so as to stay in electrical contact but minimize injury or inflammation. The device may accommodate and buffer movement of the spinal cord both laterally and in a caudal-rostral fashion so that the electrode array remains in place.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: February 9, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Matthew A. Howard, Hiroyuki Oya, Steve Viljoen, Chandan G. Reddy
  • AUTOMATED SEPARATION OF BINARY OVERLAPPING TREES
    Publication number: 20160035088
    Abstract: Provided are systems and methods for analyzing images. An exemplary method can comprise receiving at least one image having one or more annotations indicating a feature. The method can comprise generating training images from the at least one image. Each training image can be based on a respective section of the at least one image. The training images can comprise positive images having the feature and negative images without the feature. The method can comprise generating a feature space based on the positive images and the negative images. The method can further comprise identifying the feature in one or more unclassified images based upon the feature space.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA, as Represented by THE SECRETARY OF THE DEPT. OF VETERANS AFFAIRS
    Inventors: Michael D. Abramoff, Mona K. Garvin, Hu Qiao
  • Compounds and methods to treat organophosphorus poisoning
    Patent number: 9249100
    Abstract: Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: February 2, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Daniel M. Quinn, Joseph John Topczewski
  • PROMOTER COMPOSITIONS
    Publication number: 20160022837
    Abstract: An isolated promoter sequence comprising a nucleic acid of between 600 and 1700 nucleotides in length having at least 90% identity to SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, or SEQ ID NO:7.
    Type: Application
    Filed: March 6, 2014
    Publication date: January 28, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Edgardo Rodriguez, Alejandro Mas Monteys
  • Chemoprevention of colorectal cancer by mesalamine/sulfasalazine
    Patent number: 9238040
    Abstract: A method for preventing colorectal cancer in a patient possessing human tropomyocin isoform TC22 is disclosed. The method comprises: (a) detecting a serum protein concentration of TC22 in a patient and (b) administering to said patient prior to detecting colorectal cancer in said patient a therapeutically effective amount of a chemotherapeutic composition comprising a chemotherapeutic compound that reduces the level of TC22, wherein the chemotherapeutic compound is selected from the group consisting of sulfasalazine, 5-amino-2-hydroxybenzoic acid, osalazine, and balsalazide.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: January 19, 2016
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Kiron M. Das, Jim Jung-Ching Lin
  • METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES
    Publication number: 20150374781
    Abstract: The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain.
    Type: Application
    Filed: April 6, 2015
    Publication date: December 31, 2015
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Yong Hong Chen