Patents Assigned to University of Iowa
  • Correlation-based motion estimation of object to be imaged
    Patent number: 7587022
    Abstract: An imaging system in an example comprises an x-ray source, a detector, a data acquisition system (DAS), and a computer. The x-ray source emits a beam of x-rays toward an object to be imaged. The detector receives x-rays emitted by the x-ray source. The DAS is operably connected to the detector. The computer is operably connected to the DAS and programmed to estimate motion of the object on a correlation-basis and through employment of earlier-collected data.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: September 8, 2009
    Assignees: General Electric Company, University of Iowa Research Foundation
    Inventors: Jiang Hsieh, Yuchuan Wei, Ge Wang
  • Magnetic materials and metallic particles and methods of making same
    Patent number: 7585543
    Abstract: New magnetic materials and new metallic particles, new methods of making and using same, for example, to prepare magnetically modified electrodes and fuel cells, and coated metallic particles in general. The present invention discloses methods of preparation of cheaper and more uniformly sized magnetic and metallic microparticles formed from the exemplary materials magnetite, nickel, samarium cobalt and neodymium iron boron. In addition, the present invention discloses methodology for preparation and use of coated magnetic and metallic microparticles, in particular, exemplary siloxyl coating of magnetic particles, metallic particles, and magnetic and metallic microparticles with an exemplary silane, 3-aminopropyltrimethoxysilane, that is cross linked thereon. In addition, methods and results are described for preparing and using larger siloxyl coated samarium cobalt milliparticles.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: September 8, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Johna Leddy, Shelley D. Minteer, Wayne L. Gellett
  • Synthesis and use of nanocrystalline zeolites
    Patent number: 7585490
    Abstract: Embodiments of the present invention relate to a method for synthesizing nanocrystalline zeolites, the method comprising contacting starting products that comprise a solvent, a silicon source, a cation base, an organic template, and an aluminum source, or any combination thereof sufficient to produce a zeolite gel by hydrolysis, heating the zeolite gel sufficient to produce a first batch of zeolite crystals and a first clear solution, separating the first batch of zeolite crystals from the first clear solution, heating the first clear solution sufficient to produce a second batch of zeolite crystals and second clear solution and separating the second batch of zeolite crystals from the second clear solution.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: September 8, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Sarah Larsen, Vicki Grassian, Weiguo Song, Gonghu Li
  • IMMUNOSTIMULATORY NUCLEIC ACID MOLECULES
    Publication number: 20090202575
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Application
    Filed: October 9, 2008
    Publication date: August 13, 2009
    Applicants: University of Iowa Research Foundation, The US, as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Joel N. Kline, Dennis Klinman
  • Immunogenic Compositions for Activating Gamma Delta T Cells
    Publication number: 20090196887
    Abstract: Disclosed are compositions, kits, and methods for activating, expanding, or stimulating ?? T cells that include recombinant attenuated microbes. The compositions may include pharmaceutical compositions that are used as ?? T cell stimulating vaccines or immunogenic compositions for preventing or treating microbial infections and hyperplasias such as cancer.
    Type: Application
    Filed: January 30, 2009
    Publication date: August 6, 2009
    Applicant: The University of Iowa Research Foundation
    Inventors: Craig T. Morita, Bradley D. Jones
  • IMMUNOSTIMULATORY NUCLEIC ACIDS
    Publication number: 20090191188
    Abstract: The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.
    Type: Application
    Filed: February 26, 2009
    Publication date: July 30, 2009
    Applicants: University of Iowa Research Foundation, Coley Pharmaceutical GmbH
    Inventors: Arthur M. Krieg, Christian Schetter, Jorg Vollmer
  • Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
    Patent number: 7553646
    Abstract: The present invention provides novel methods for the synthesis of racemic and enantiomers of modafinil via microbial oxidation-amidation transformation. The methods include the successive oxidation-amidation of benzhydrylsulfanyl carboxylic acid to produce racemic and enantiomers of modafinil using at least one microorganism of yeast, bacteria, or fungus. Also disclosed are pharmaceutical compositions of racemic and enantiomers of modafinil along with their use in the treatment of diseases, including attention deficit hyperactivity disorder and drug addiction.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: June 30, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Horacio F. Olivo, Antonio Victor Osorio-Lozada
  • Method and system for optimal bitloading in communication and data compression systems
    Patent number: 7539254
    Abstract: This invention provides a method and system for determining the number of bits to assign to a frequency range in a signal. The present invention is capable of bit allocation, with B total bits, among a plurality of N frequency ranges in time a time O(N log N), which is independent of the size of B. Embodiments of the present invention have many practical applications, including allocating bits among sub-channels in a multi-carrier communication system, and allocating bits among sub-bands in a signal representing digital multimedia, such as in JPEG or MPEG compressed files.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: May 26, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Soura Dasgupta, Manish Vemulapalli, Ashish Pandharipande
  • Treatment and prevention of abnormal cellular proliferation
    Patent number: 7538096
    Abstract: This invention provides a method for inhibiting or preventing the abnormal growth of cells, including transformed cells, by administering an effective amount of O-acylated heparin derivative. Abnormal growth of cells refers to cell growth independent of normal regulatory mechanism (e.g. loss of contact inhibition). This includes the abnormal growth of: (1) tumor cells (tumors); (2) benign and malignant cells of other proliferative disease in which aberrant cellular proliferation occurs; (3) aberrant smooth muscle cell proliferation, such as might occur following treatment for coronary atherosclerosis such as angioplasty or the insertion of a stent into an occluded vessel.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: May 26, 2009
    Assignees: The General Hospital Corporation, The University of Iowa Research Foundation
    Inventors: Charles A. Hales, Hari G. Garg, Lunyin Yu, Robert J Linhardt
  • Methods for enhancing antibody-induced cell lysis and treating cancer
    Patent number: 7534772
    Abstract: The invention relates to methods and products for treating cancer. In particular the invention relates to combinations of nucleic acids and antibodies for the treatment and prevention of cancer. The invention also relates to diagnostic methods for screening cancer cells.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: May 19, 2009
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical GmbH
    Inventors: George Weiner, Gunther Hartmann
  • METHODS AND REAGENTS FOR TREATMENT AND DIAGNOSIS OF AGE-RELATED MACULAR DEGENERATION
    Publication number: 20090124542
    Abstract: The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD.
    Type: Application
    Filed: February 14, 2006
    Publication date: May 14, 2009
    Applicant: University of Iowa Research Foundation
    Inventors: Gregory S. Hageman, Richard J. Smith
  • Method for preparing ladderanes
    Patent number: 7524966
    Abstract: Ditopic molecules in the form of linear reaction templates have been used to construct ladder-like hydrocarbons known as [n]-ladderanes (n=3,5). The templates assemble and position reactant molecules in the solid state by way of hydrogen bonds for [2+2] photodimerization. The products, which are based on recently identified naturally occurring frameworks, form stereospecifically, in gram quantities, and in quantitative yield. The control of reactivity achieved using linear templates provides a basis for the development of molecular tools, termed assemblers, that could be used to manufacture, with atomic-level precision, a wide range of products (e.g. molecular nanostructures) with unique properties.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: April 28, 2009
    Assignee: University of Iowa Research Foundation
    Inventor: Leonard R. MacGillivray
  • Apparatus and semiconductor co-crystal
    Patent number: 7524373
    Abstract: The invention provides a method to enforce face-to-face stacking of organic semiconductors in the solid state that employs semiconductor co-crystal formers (SCCFs), to align semiconductor building blocks (SBBs). Single-crystal X-ray analysis reveals n-orbital overlap optimal for organic semiconductor device applications.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: April 28, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Leonard R. MacGillivray, Anatoliy N. Sokolov
  • Immunostimulatory nucleic acid molecules
    Patent number: 7524828
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: April 28, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel N. Kline
  • System and method for adaptive bolus chasing computed tomography (CT) angiography
    Patent number: 7522744
    Abstract: A method of utilizing bolus propagation and control for contrast enhancement comprises measuring with an imaging device a position of a bolus moving along a path in a biological structure. The method further comprises predicting a future position of the bolus using a simplified target model and comparing the predicted future position of the bolus with the measured position of the bolus. A control action is determined to eliminate a discrepancy, if any, between the predicted position of the bolus and the measured position of the bolus and the relative position of the imaging device and the biological structure is adaptively adjusted according to the control action to chase the motion of the bolus.
    Type: Grant
    Filed: August 29, 2005
    Date of Patent: April 21, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Er-wei Bai, Ge Wang, Michael W. Vannier
  • Immunostimulatory nucleic acid molecules
    Patent number: 7517861
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: April 14, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel N. Kline
  • Methods of inhibiting COX-2
    Patent number: 7514548
    Abstract: The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for COX-2, and further provides methods of reducing expression of COX-2 in cells (e.g., cancer cells).
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: April 7, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Douglas K. Trask, Jonathan Bock
  • Non-toxic mutants of pathogenic gram-negative bacteria
    Patent number: 7510717
    Abstract: A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a mutant that lacks one or more secondary acyl chains contained in the wild type gram-negative bacterial pathogen, and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, the endotoxin isolated therefrom, or the endotoxin isolated therefrom which is then conjugated to a carrier protein, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically effective amount of the vaccine formulation.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: March 31, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Michael A. Apicella, Melvin G. Sunshine, Na-Gyong Lee, Rasappa Arumugham, Bradford W. Gibson
  • Variant TLR4 nucleic acid and uses thereof
    Patent number: 7498151
    Abstract: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: March 3, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: David A. Schwartz, Brian C. Schutte
  • Non-magnetic semiconductor spin transistor
    Patent number: 7492022
    Abstract: A nonmagnetic semiconductor device which may be utilized as a spin resonant tunnel diode (spin RTD) and spin transistor, in which low applied voltages and/or magnetic fields are used to control the characteristics of spin-polarized current flow. The nonmagnetic semiconductor device exploits the properties of bulk inversion asymmetry (BIA) in (110)-oriented quantum wells. The nonmagnetic semiconductor device may also be used as a nonmagnetic semiconductor spin valve and a magnetic field sensor. The spin transistor and spin valve may be applied to low-power and/or high-density and/or high-speed logic technologies. The magnetic field sensor may be applied to high-speed hard disk read heads. The spin RTD of the present invention would be useful for a plurality of semiconductor spintronic devices for spin injection and/or spin detection.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: February 17, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Kimberley C. Hall, Wayne H. Lau, Kenan Gündo{hacek over (g)}du, Michael E. Flatté, Thomas F. Boggess