Patents Assigned to University of Iowa
  • THERAPEUTIC COMPOUNDS
    Publication number: 20100179217
    Abstract: The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. Compounds of the invention are useful to modulate (e.g. agonize or antagonize) opioid receptor function.
    Type: Application
    Filed: November 2, 2007
    Publication date: July 15, 2010
    Applicant: University of Iowa Research Foundation
    Inventor: Thomas Prisinzano
  • 2,4,6-TRISUBSTITUTED PHENOLS HAVING ANESTHETIC PROPERTIES
    Publication number: 20100173997
    Abstract: Trisubstituted phenol compounds and methods of using the compounds, e.g., for anesthetizing a subject, are disclosed.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 8, 2010
    Applicant: University of Iowa Research Foundatiion
    Inventor: Max T. Baker
  • Compounds and methods to enhance rAAV transduction
    Patent number: 7749491
    Abstract: Agents and methods to alter rAAV transduction are provided.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: July 6, 2010
    Assignees: University of Iowa Research Foundation, Targeted Genetics Corporation
    Inventors: John F. Engelhardt, Keith L. Munson, Ziying Yan
  • Methods for treatment of age-related macular degeneration
    Patent number: 7745389
    Abstract: The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: June 29, 2010
    Assignee: University of Iowa Research Foundation
    Inventor: Gregory S. Hageman
  • Compositions for treating hearing loss and methods of use thereof
    Patent number: 7741469
    Abstract: This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of genes encoding proteins involved in deafness caused by dominant negative mechanism of action by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of genes involved in deafness caused by dominant negative mechanism of action.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: June 22, 2010
    Assignee: University of Iowa Research Foundation
    Inventor: Richard J. Smith
  • Opioid receptor ligands and methods for their preparation
    Patent number: 7728001
    Abstract: The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. The invention also provides an improved method for isolating intermediate materials useful for obtaining compounds of formula I.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: June 1, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: Thomas Prisinzano, Richard Brian Rothman
  • Immunostimulatory nucleic acid molecules
    Patent number: 7723500
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: May 25, 2010
    Assignees: University of Iowa Research Foundation, The United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg
  • Immunostimulatory nucleic acid molecules
    Patent number: 7723022
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: May 25, 2010
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Assessing response to anti-CD20 therapy by genotyping C1q components
    Patent number: 7723036
    Abstract: The present invention encompasses methods for predicting metastasis in cancer by assessing the structure of the complement protein C1qA. The methods may encompass examining either protein or nucleic acids, and may further include making treatment decisions based on the predictive methods.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: May 25, 2010
    Assignee: The University of Iowa Research Foundation
    Inventors: Emilian V. Racila, George J. Weiner
  • Bipolar spin transistors and the applications of the same
    Patent number: 7719071
    Abstract: A bipolar spin transistor is provided. In one embodiment of the present invention, the bipolar spin transistor includes a first semiconductor region having a first conductivity type, a second semiconductor region having a second conductivity type that is different from the first conductivity type and also having a spin polarization, and a third semiconductor region having a conductivity type that is the same conductivity type of the first semiconductor region. The first semiconductor region and the second semiconductor region are adjacent to each other so as to form a first charge depletion layer therebetween, the first charge depletion layer having a first side facing the first semiconductor region and an opposing second side facing the second semiconductor region.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: May 18, 2010
    Assignee: University of iowa Research Foundation
    Inventors: Michael Edward Flatté, Zhi Gang Yu, Ezekiel Johnston-Halperin, David Awschalom
  • Non-magnetic semiconductor spin transistor
    Patent number: 7719070
    Abstract: A nonmagnetic semiconductor device which may be utilized as a spin resonant tunnel diode (spin RTD) and spin transistor, in which low applied voltages and/or magnetic fields are used to control the characteristics of spin-polarized current flow. The nonmagnetic semiconductor device exploits the properties of bulk inversion asymmetry (BIA) in (110)-oriented quantum wells. The nonmagnetic semiconductor device may also be used as a nonmagnetic semiconductor spin valve and a magnetic field sensor. The spin transistor and spin valve may be applied to low-power and/or high-density and/or high-speed logic technologies. The magnetic field sensor may be applied to high-speed hard disk read heads. The spin RTD of the present invention would be useful for a plurality of semiconductor spintronic devices for spin injection and/or spin detection.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: May 18, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: Kimberley C. Hall, Wayne H. Lau, Kenan Gündo{hacek over (g)}du, Michael E. Flatté, Thomas F. Boggess
  • Methods and systems for optic nerve head segmentation
    Patent number: 7712898
    Abstract: A method of classifying an optic nerve cup and rim of an eye from a retinal image comprising receiving a retinal image, determining a feature vector for a candidate pixel in the retinal image, and classifying the candidate pixel as a cup pixel or a rim pixel based on the feature vector using a trained classifier. The retinal image can be a stereo pair, the retinal image can be color or monochrome. The method disclosed can further comprise identifying an optic nerve, identifying an optic nerve cup and optic nerve rim, and determining a cup-to-disc ratio.
    Type: Grant
    Filed: April 3, 2007
    Date of Patent: May 11, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: Michael D. Abramoff, Young Kwon
  • Methods for treating and preventing infectious disease
    Patent number: 7713529
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: May 11, 2010
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Methods for forming magnetically modified electrodes and articles produced thereby
    Patent number: 7709115
    Abstract: The present invention is directed to methods for making magnetically modified electrodes and electrodes made according to the method. Such electrode are useful as electrodes in batteries, such as Ni-MH batteries, Ni—Cd batteries, Ni—Zn batteries and Ni—Fe batteries.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: May 4, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: Johna Leddy, Pengcheng Zou
  • Hydrofluoroalkyl phenols having anesthetic properties
    Patent number: 7705191
    Abstract: Substituted hydrofluoroalkylphenol compounds and methods of using the compounds, e.g., for anesthetizing a subject, are disclosed.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: April 27, 2010
    Assignee: University of Iowa Research Foundation
    Inventor: Max T. Baker
  • Interior tomography and instant tomography by reconstruction from truncated limited-angle projection data
    Patent number: 7697658
    Abstract: A system and method for tomographic image reconstruction using truncated limited-angle projection data that allows exact interior reconstruction (interior tomography) of a region of interest (ROI) based on the linear attenuation coefficient distribution of a subregion within the ROI, thereby improving image quality while reducing radiation dosage. In addition, the method includes parallel interior tomography using multiple sources beamed at multiple angles through an ROI and that enables higher temporal resolution.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: April 13, 2010
    Assignees: Virginia Tech Intellectual Properties, Inc., University of Iowa Research Foundation
    Inventors: Ge Wang, Yangbo Ye, Hengyong Yu
  • Methods for determining electron transfer rates in metalloproteins
    Patent number: 7691638
    Abstract: The present invention is directed to methods for determining electron transfer rates in systems involving metalloproteins. Metalloprotein/substrate electron transfer rates as well as metalloprotein self exchange rates may be modeled. Such electron transfer rates are useful in smart drug design and enzyme engineering.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: April 6, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: Johna Leddy, Shelley D. Minteer
  • IMMUNOMODULATORY OLIOGONUCLEOTIDES AND METHODS OF USE THEREFOR
    Publication number: 20100081706
    Abstract: The present invention is drawn a new class of oligodeoxynucleotides (ODNs) that inhibit ODN-activation of Toll-like receptor (TLR) 9. Particular 4-5 base extensions at the 5? and of the previously described core inhibitory ODN sequence enhances their inhibitory activity against human cells expressing human TLR9. Methods of use also are provided.
    Type: Application
    Filed: August 4, 2008
    Publication date: April 1, 2010
    Applicant: University of Iowa Research Foundation
    Inventors: ROBERT ASHMAN, Petar Lenert
  • Purification of Heparinase I, II and III from Flavobacterium heparinum
    Patent number: RE41328
    Abstract: A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: May 11, 2010
    Assignees: Massachusetts Institute of Technology, University of Iowa Research Foundation
    Inventors: Ramnath Sasisekharan, Charles L. Cooney, Robert S. Langer, Daniel L. Lohse, Robert J. Linhardt
  • Purification, composition and specificity of Heparinase I, II, and III from Flavobacterium heparinum
    Patent number: RE41461
    Abstract: A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Mono-clonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: July 27, 2010
    Assignees: Massachusetts Institute of Technology, University of Iowa Research Foundation
    Inventors: Daniel L. Lohse, Robert J. Linhardt, Ramnath Sasisekharan, Charles L. Cooney, Robert S. Langer