Abstract: The invention provides methods for treating a hyperproliferative disorder in a mammal in need thereof comprising, administering to the mammal a combination of (a) an anti-cancer antibody and (b) a T cell activating agent for the prophylactic or therapeutic treatment of the hyperproliferative disorder. The invention further provides methods for maintaining long-term natural killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC) in the treatment of a hyperproliferative disorder in a mammal in need thereof comprising, administering to the mammal a combination of (a) an anti-cancer antibody, and (b) a T cell activating agent for the prophylactic or therapeutic treatment of the hyperproliferative disorder.

Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, an anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.

Abstract: Vectors having a nucleotide sequence having SEQ ID NO:1 or a nucleotide sequence having at least 85% identity to SEQ ID NO:1, or a portion thereof, that is capable of regulating bocaparvovirus replication, or vectors having the complement of the nucleotide sequence, and methods of using the vectors, are provided.

Abstract: An example of subject may deliver a therapy by delivering energy to tissue. The system may comprise a magnetic field system and an electric field system. The magnetic field system may be configured to provide a magnetic field in a first direction to the tissue. The magnetic field system may include at least one magnetic field source to produce the magnetic field. The magnetic field produced by the at least one magnetic field source may include a magnetic field produced by at least one of a permanent magnet, a temporary magnet or electric current flow through a conductor. The electric field system may be configured to provide an electric field in a second direction to the tissue. The electric field system may include at least one electric field source to provide the electric field and the second direction is non-parallel to the first direction.

Abstract: The spinal cord stimulation device of this invention is configured for implantation into a patient so as to traverse the dura mater that surrounds the spinal cord. Placing the device in this location provides direct contact between the electrode and the cerebrospinal fluid (CSF), in close proximity to the spinal cord. The device has an intradural portion and an extradural portion that compresses and seals the dural membrane between them, securing the device in position and preventing leakage of CSF. The position of the device may be stabilized in relation to the spinal cord by way of a laminoplasty plate, bridging between the device and a vertebra. The device is electronically powered by an implanted pulse generator that produces a spectrum of signals to interrupt or otherwise attenuate transmission of pain mediating neural signals through the spinal cord.

Abstract: The present disclosure provides CAPN5 substrates and CAPN5 inhibitors, nucleic acids encoding CAPN5 substrates or CAPN5 inhibitors, methods to deliver CAPN5 substrate or CAPN5 inhibitor agents to the eye, and methods of identifying inhibitors of CAPN5.

Abstract: An apparatus for reconstructing or filtering medical image data is provided. The apparatus includes processing circuitry to receive a first medical image data and meta-parameters related to the first medical image data; apply the received meta-parameters to inputs of a first trained machine-learning (ML) network, e.g., a multilayer perceptron, to obtain, from outputs of the first trained ML network, tuning parameters of a second ML network (e.g., a convolutional neural network) different from the first ML network; apply the received first medical image data to inputs of the second ML network, as tuned by the obtained tuning parameters output from the first ML network, to obtain, from outputs of the second ML network, second medical image data; and output the second medical image data. In one embodiment, the first medical image data is magnetic-resonance k-space data and the second medical data is a magnetic-resonance image.

Abstract: Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional glaucoma damage from retinal optical coherence image data. In an aspect, the systems and methods can map regions and layers of the eye to determine structural characteristics to compare to functional characteristics.

Abstract: A method can include receiving (1) images of at least one subject and (2) at least one total mass value for the at least one subject. The method can further include executing a first machine learning model to identify joints of the at least one subject. The method can further include executing a second machine learning model to determine limbs of the at least one subject based on the joints and the images. The method can further include generating three-dimensional (3D) representations of a skeleton based on the joints and the limbs. The method can further include determining a torque value for each limb, based on at least one of a mass value and a linear acceleration value, or a torque inertia and an angular acceleration value. The method can further include generating a risk assessment report based on at least one torque value being above a predetermined threshold.

Abstract: The invention provides a method and kits for inhibiting integrin ?9?1 activity comprising contacting integrin ?9?1 or a binding partner of integrin ?9?1 with an isolated anti-integrin ?9 inhibitor, wherein the integrin ?9?1 activity is inhibited. In certain aspects, the present invention provides a novel intervention by targeting integrin ?9?1 with a functional blocking inhibitor (e.g., peptides or antibodies) to limit brain damage following reperfusion after ischemic stroke.

Abstract: A method of identifying an object of interest can comprise obtaining first samples of an intensity distribution of one or more object of interest, obtaining second samples of an intensity distribution of confounder objects, transforming the first and second samples into an appropriate first space, performing dimension reduction on the transformed first and second samples, whereby the dimension reduction of the transformed first and second samples generates an object detector, transforming one or more of the digital images into the first space, performing dimension reduction on the transformed digital images, whereby the dimension reduction of the transformed digital images generates one or more reduced images, classifying one or more pixels of the one or more reduced images based on a comparison with the object detector, and identifying one or more objects of interest from the classified pixels.

Abstract: The invention provides methods, compositions, and kits that are useful for treating cancer (e.g., endometrial cancer).

Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1-R4 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful in immunotherapy as a potential treatment, or co-treatment, for cancer or infectious diseases.

Abstract: Methods for isolating viable cancer cells from a sample that comprises a mixture of cancerous cells and normal (non-cancerous) cells are provided. In the methods, a fluid preparation comprising a mixture of cancerous and normal cells is repeatedly exposed to fluid shear stresses, whereby the repeated exposure to the fluid shear stresses preferentially imparts fluid shear stress-resistance to the cancerous cells.

Abstract: Described herein is a method for treating or restoring loss of hearing and balance in a subject in need thereof. In certain aspects, the disclosed method is comprised of transplanting a humanized otocyst to a target delivery site in the subject. According to certain aspects, the otocyst is obtained from a humanized non-human mammal embryo. In certain exemplary aspects, the non-human mammal is a pig. In certain embodiments, prior to transplantation, the otocyst is cultured in a species-specific tissue culture buffer.

Abstract: A bioprinter and methods of using the bioprinter. The bioprinter permits selective three-dimensional movement of multiple nozzle assemblies during operation of the bioprinter. The bioprinter can be used to produce scaffold-free tissue constructs having a plurality of cellular elements interspersed among a semi-permeable vascular network. The bioprinter can also be used to print a tissue construct directly onto a tissue defect of a subject. The bioprinter can be provided as part of a bioprinting system that includes a scanner for imaging the tissue defect.

Abstract: A composition comprising particles formed of poly(diaminosulfide) and one or more leptospiral antigens, and methods of making and using the composition, are provided.

Abstract: The disclosed apparatus, systems and methods relate to a framelet-based iterative algorithm for polychromatic CT which can reconstruct two components using a single scan. The algorithm can have various steps including a scaled-gradient descent step of constant or variant step sizes; a non-negativity step; a soft thresholding step; and a color reconstruction step.

Abstract: A system for simulating surgery includes an electromagnetic tracking system comprising an emitter and a plurality of electromagnetic sensors and a plurality of model bone fragments, each of the model bone fragments operatively connected to one of the plurality of electromagnetic sensors. A method for simulating surgery includes electromagnetically tracking position of a plurality of model bone fragments and a model bone shaft using an electromagnetic tracking system and displaying virtual fluoroscopic images based on sensed position of the model bone fragments and the model bone shaft.

Abstract: The invention provides a method and materials for removing a metal contaminant from a water sample, as well as composites and methods for making composites.