Patents Assigned to University of Iowa
  • Methods and compositions for treating brain diseases
    Patent number: 10391184
    Abstract: The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's cisterna magna and/or ventricle an rAAV particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner such that cells with access to the cerebrospinal fluid (CSF) express the therapeutic agent and in certain embodiments secretes the therapeutic agent into the CSF for distribution to the brain.
    Type: Grant
    Filed: July 20, 2014
    Date of Patent: August 27, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Luis Tecedor, Yong Hong Chen
  • Real-time applicator position monitoring system
    Patent number: 10376712
    Abstract: A real-time applicator position monitoring system (RAPS) measures brachytherapy applicator displacement in real-time by computing the relative displacement between two infrared reflective targets, one attached to the applicator and the other to the patient's skin. In an aspect, RAPS can be used with any brachytherapy application. RAPS measures the applicator motion during HDR brachytherapy treatment, as well as during the transfer of the patient from the imaging room (e.g., where the CT and MR scanners are located) to the HDR BT operating/treatment room.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: August 13, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Junyi Xia, Yusung Kim, Timothy J. Waldron
  • Automated separation of binary overlapping trees
    Patent number: 10360672
    Abstract: Provided are systems and methods for analyzing images. An exemplary method can comprise receiving at least one image having one or more annotations indicating a feature. The method can comprise generating training images from the at least one image. Each training image can be based on a respective section of the at least one image. The training images can comprise positive images having the feature and negative images without the feature. The method can comprise generating a feature space based on the positive images and the negative images. The method can further comprise identifying the feature in one or more unclassified images based upon the feature space.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 23, 2019
    Assignees: University of Iowa Research Foundation, The United States of America, as Represented by the Department of Veterans Affairs
    Inventors: Michael D. Abramoff, Mona K. Garvin, Hu Qiao
  • COMPOSITIONS AND METHODS FOR CANCER THERAPY
    Publication number: 20190216771
    Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, and one or more anti-cancer therapies.
    Type: Application
    Filed: June 6, 2017
    Publication date: July 18, 2019
    Applicant: University Of Iowa Research Foundation
    Inventors: Fenghuang ZHAN, Ivana FRECH, Guido TRICOT
  • Neuroprotective Compounds and Use Thereof
    Publication number: 20190218203
    Abstract: Provided herein is compositions and methods for reducing one or both of axonal degeneration and neuronal cell death associated with a disease.
    Type: Application
    Filed: February 12, 2018
    Publication date: July 18, 2019
    Applicant: University of Iowa Research Foundation
    Inventors: Steven L. McKnight, Joseph M. Ready, Andrew A. Pieper
  • MAGNETICALLY-ACTIVATED COATING FOR TREATING BIOFILMS, AND ASSOCIATED SYSTEMS AND METHODS
    Publication number: 20190209743
    Abstract: A system for disrupting a biofilm on a medical device that comprises an implantable medical device; a magnetically-sensitive coating on the surface of the implantable device comprising a polymer and magnetic particles embedded within the polymer; and a coil element capable of generating an alternating magnetic field, wherein the coil element is constructed and arranged to be capable of applying an alternating magnetic field to induce heating of the surface of the implantable device.
    Type: Application
    Filed: June 27, 2017
    Publication date: July 11, 2019
    Applicant: University of Iowa Research Foundation
    Inventors: Eric NUXOLL, Joel COFFEL, Erica RICKER
  • Miniature grism system for astronomical spectroscopy
    Patent number: 10345496
    Abstract: The invention is directed at a miniature grism system. The miniature grism system is a single compact device that comprises a grism with collimating and focusing optics. In an aspect, the grism includes at least one prism and a grating. In an aspect, the miniature grism system, and more specifically the grism, includes at least one prism which is placed on either side of the grating. The focusing optics and the collimating optics are found on opposite sides of the grism system, sandwiching the prism and grating of the grism. In an aspect, the miniature grism system is configured to be retained within a filter wheel. The miniature grism system is configured to be used with telescopes having a small focal ratio.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: July 9, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Dominic Ludovici, Robert Mutel
  • RNA based biomaterial for tissue engineering applications
    Patent number: 10335498
    Abstract: The present disclosure provides compositions and methods useful for tissue engineering including a composition having chemically modified RNA (cmRNA) encapsulated in or complexed with a non-viral delivery vehicle and a biocompatible, bioresorbable scaffold and methods of using the composition to regenerate, for example, bone tissue.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: July 2, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Satheesh Elangovan, Sheetal Reginald R D'mello, Anh-Vu T Do, Liu Hong, Behnoush Khorsand-Sourkohi, Aliasger K Salem, Michael Kormann
  • Lung injury repair compositions and methods
    Patent number: 10328114
    Abstract: The present invention provides a pharmaceutical composition comprising Protein Kinase C Zeta (PKC-?) inhibitor and therapeutic methods for preventing or treating a pathological condition or symptom or for inducing proliferation of lung progenitor cells in a mammal by administering the PKC-? inhibitor.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: June 25, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Alejandro P. Comellas Freymond, Xiaopeng Li, Joseph Zabner, Luis Guillermo Vargas Buonfiglio
  • Preventative therapy for post-traumatic osteoarthritis
    Patent number: 10314941
    Abstract: Compositions comprising a reverse-temperature sensitive hydrogel comprising a biopolymer such as a polysaccharide and a synthetic polymer, and a compound in an amount that reversibly inhibits respiratory enzyme complex I, and methods of using the composition, are provided.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: June 11, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Todd O. McKinley, James A. Martin, Mitchell Coleman, Tae-Hong Lim, Marc Brouillette
  • Methods for treating tumors in situ including intratumor injection of cytotoxic particles and immune checkpoint blockade therapy
    Patent number: 10314854
    Abstract: Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. The compositions, kits, and methods comprise or utilize cytotoxic particles, immune checkpoint inhibitors, and/or T-cell stimulatory agents.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: June 11, 2019
    Assignee: University of Iowa Foundation
    Inventors: Aliasger K. Salem, Amani Makkouk, Vijaya B. Joshi, George Weiner
  • COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS
    Publication number: 20190153412
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a SIN CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing SIN CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
    Type: Application
    Filed: January 30, 2019
    Publication date: May 23, 2019
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, University of Iowa Research Foundation
    Inventors: Feng ZHANG, Beverly Davidson, Chie-Yu Lin, Edgardo RODRIGUEZ
  • METHODS TO PREVENT OR TREAT PERIODONTITIS OR PERI-IMPLANTITIS
    Publication number: 20190144856
    Abstract: Compositions and methods to prevent, inhibit or treat aveolar or periodontal bone loss, enhance bone regeneration, prevent, inhibit or treat peri-implantitis or periodontitis, e.g., periodontitis or peri-implantitis associated with bone loss, or to prevent, inhibit or treat osteoarthritis are provided.
    Type: Application
    Filed: January 15, 2016
    Publication date: May 16, 2019
    Applicant: University of Iowa Research Foundation
    Inventors: Liu HONG, Brad A. AMENDT, Aliasger K. SALEM, Satheesh ELANGOVAN, Gustavo Avila Ortiz, Thad SHARP
  • MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
    Patent number: 10273476
    Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention provides the use of miR-200a inhibitor to stimulate bone regeneration.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: April 30, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Liu Hong, Brad Amendt, Thad Sharp, Aliasger Salem
  • AUTOMATED DETERMINATION OF ARTERIOVENOUS RATIO IN IMAGES OF BLOOD VESSELS
    Publication number: 20190059718
    Abstract: The methods and systems provided can automatically determine an Arteriolar-to-Venular diameter Ratio, AVR, in blood vessels, such as retinal blood vessels and other blood vessels in vertebrates. The AVR is an important predictor of increases in the risk for stroke, cerebral atrophy, cognitive decline, and myocardial infarct.
    Type: Application
    Filed: March 26, 2018
    Publication date: February 28, 2019
    Applicants: University of Iowa Research Foundation, The United States of America, as represented by the Secretary of the Department of Veterans Affair
    Inventors: Michael D. Abramoff, Meindert Niemeijer, Xiayu Xu, Milan Sonka, Joseph M. Reinhardt
  • Botanical extracts and compounds from plants and methods of use
    Patent number: 10195241
    Abstract: This disclosure relates to extracts from chestnut plants and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the leaves of a Castanea plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: February 5, 2019
    Assignees: Emory University, University of Iowa Research Foundation
    Inventors: Cassandra L. Quave, James Lyles, Alexander R. Horswill
  • CRISPR-related methods and compositions with governing gRNAS
    Patent number: 10190137
    Abstract: Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: January 29, 2019
    Assignees: Editas Medicine, Inc., The Broad Institute Inc., Massachusetts Institute of Technology, University of Iowa Research Foundation
    Inventors: Feng Zhang, Deborah Palestrant, Beverly Davidson, Jordi Mata-Fink, Edgardo Rodriguez, Alexis Borisy
  • FREIGHT AND WEATHER DECISION SUPPORT SYSTEM
    Publication number: 20190012606
    Abstract: A includes receiving data input from a plurality of sources wherein the data input comprises weather data and route data for a vehicle, applying the data input within a decision support system implemented by a computing system to determine an evidence-based probability of risk of delay and crash for the vehicle, and communicating the probability of risk of delay and crash or a decision based on the evidence-based probability of risk of delay and crash to the vehicle or a driver of the vehicle.
    Type: Application
    Filed: September 7, 2018
    Publication date: January 10, 2019
    Applicant: University of Iowa Research Foundation
    Inventors: Wilfrid A. Nixon, Anissa Jensen Gerard
  • Treating alcohol-mediated disorders by inhibition of RGS6
    Patent number: 10155807
    Abstract: The invention provides RGS6 antagonists and methods for their use in treating the effects of alcohol consumption.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: December 18, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Rory A. Fisher, Biswanath Maity, Adele M. Stewart, David Roman, Christopher R. Bodle
  • METHODS OF PRODUCING BIOSYNTHETIC BACTERIAL CELLULOSE MEMBRANES
    Publication number: 20180355393
    Abstract: Described herein are methods of producing biosynthetic bacterial cellulose membranes having improved characteristics that are advantageous for use in various biological applications, including medicine.
    Type: Application
    Filed: December 12, 2016
    Publication date: December 13, 2018
    Applicant: The University of Iowa Research Foundation
    Inventors: Chaid Schwarz, Vijay Kumar, Madhavan Raghavan