Patents Assigned to University of Kansas
  • Patent number: 12030867
    Abstract: Described are compounds of formula (I), based on an isoquinolin-1(2H)-one backbone, that function as Hsp90? selective inhibitors. Also described are pharmaceutical compositions thereof and methods of treating cancer by administering compounds of formula (I).
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: July 9, 2024
    Assignees: University of Notre Dame du Lac, University of Kansas
    Inventors: Brian Blagg, Sanket Mishra
  • Patent number: 12029460
    Abstract: Embodiments of the present invention relate to systems, methods, and apparatus for immobilizing and/or securing bone portions. Particularly, at least one embodiment involves a compact anti-rotation device that can secure adjacent bones and/or bone portions in a manner that prevents or limits relative rotational movement thereof.
    Type: Grant
    Filed: September 24, 2021
    Date of Patent: July 9, 2024
    Assignee: University of Kansas
    Inventors: Terence Edward McIff, Edward Bruce Toby
  • Patent number: 12024536
    Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.
    Type: Grant
    Filed: July 12, 2022
    Date of Patent: July 2, 2024
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Brian S. J. Blagg, Bhaskar Reddy Kusuma, Teather Sundstrom
  • Patent number: 12024515
    Abstract: The present disclosure relates to compounds according to Formula I (I) or a pharmaceutically acceptable salt and/or solvate thereof, as well as compositions including such compounds and uses thereof, where R1 is an unsubstituted C1-C12 alkyl; and R2, R3, and R4 are each independently H or —C(O)—(unsubstituted C1-C12 alkyl). Among other things, the present disclosure evidences that the significant upregulation of CD20 by the inhibition of a-mannosidase enzymes by compounds of the present technology potentiates the activity of anti-CD20 mAbs and importantly sensitize cell lines that are resistant to the action of these antibodies.
    Type: Grant
    Filed: January 22, 2022
    Date of Patent: July 2, 2024
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Mark Patrick Farrell, Suresh Eknath Kurhade, Patrick Andrew Ross, Jack Douglas Weiner, Fei Philip Gao
  • Patent number: 11999965
    Abstract: Vectors having a nucleotide sequence having SEQ ID NO:1 or a nucleotide sequence having at least 85% identity to SEQ ID NO:1, or a portion thereof, that is capable of regulating bocaparvovirus replication, or vectors having the complement of the nucleotide sequence, and methods of using the vectors, are provided.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: June 4, 2024
    Assignees: University of Iowa Research Foundation, University of Kansas
    Inventors: Ziying Yan, John F. Engelhardt, Jianming Qiu, Zekun Wang
  • Patent number: 12000949
    Abstract: Systems, methods, and computer-readable storage media for generating, transmitting, and utilizing a composite radar and communication waveform are disclosed. The composite radar and communication waveform may facilitate radar detection and data communication operations and may be generated from a frequency modulated (FM) radar waveform and a communication signal. In an aspect, the composite radar and communication waveform may be generated by iteratively executing a shaping process against the FM radar waveform and the communication signal until a first stop criterion is satisfied to produce an initial composite radar and communication waveform having the communication signal embedded therein, and then iteratively executing an enhancement process against the initial composite radar waveform and the communication signal until a second stop criterion is satisfied to produce a final composite radar and communication waveform suitable for both radar detection and data communication operations.
    Type: Grant
    Filed: September 21, 2019
    Date of Patent: June 4, 2024
    Assignees: University of Kansas, The United States of America as Represented by the Secretary of the Air Force
    Inventors: Gerald Brandon Ravenscroft, Patrick M. McCormick, Shannon D. Blunt, Erik S. Perrins, Justin G. Metcalf
  • Patent number: 11988787
    Abstract: A multipurpose front-end board for solid state sensors is described. In particular, the board is optimized for fast timing particle detection or for characterization and test of silicon and diamond detectors that produce a fast but small current signal at the passage of a particle. The multipurpose front-end board includes a sensor pad configured to receive a solid state sensor to be characterized, distribute a bias potential, and read out the current signal produced by the sensor. The board also includes an amplifier configured to read out the current signal from the sensor pad and convert the current signal to an output voltage signal and a discriminator configured to receive the output voltage signal from the amplifier. A threshold voltage of the discriminator can be controlled by a potentiometer, and the board includes at least one output port to provide data for characterization of the sensor.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: May 21, 2024
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Christophe Royon, Nicola Minafra
  • Publication number: 20240150803
    Abstract: A non-human organism for upgrading intermediate oxidation products formed by catalytic degradation of alkanes or polystyrenes is provided. The non-human organism is genetically modified to convert the intermediate oxidation products to secondary metabolites, and in particular to include a positive feedback loop construction in the promotor system. A method includes steps of catalytically degrading alkanes or polystyrene in an oxidizing environment to form intermediate products with one or more catalysts and contacting the intermediate products with the non-human organism such that intermediate oxidation products are converted to secondary metabolites.
    Type: Application
    Filed: October 16, 2023
    Publication date: May 9, 2024
    Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, UNIVERSITY OF KANSAS
    Inventors: Berl OAKLEY, Travis J. WILLIAMS, Yi-Ming CHIANG, Clay C. WANG, Yuhao CHEN, Swati BIJLANI, C. Elizabeth OAKLEY, Christian Anthony RABOT
  • Patent number: 11952337
    Abstract: Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and compositions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.
    Type: Grant
    Filed: May 16, 2022
    Date of Patent: April 9, 2024
    Assignee: University of Kansas
    Inventors: Russell Swerdlow, Laird Forrest, Jordan Hunt, Heather Wilkins, Eli Michaelis
  • Patent number: 11954844
    Abstract: An approach for fatigue crack detection is described. In one example, a first image of a structure is captured at a first time, and a second image of the structure is captured at a second time. A feature-based image registration is performed to align features of the second image with the first image, and an intensity-based image registration is performed to further align features of the second image with the first image. A registration error map is determined by performing a pixel-by-pixel intensity comparison of the first image and the second image. Additionally, an edge-aware noise reduction process can be performed on the registration error map. The registration error map can be referenced to identify certain fatigue cracks in the structure.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: April 9, 2024
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Xiangxiong Kong, Jian Li
  • Patent number: 11939291
    Abstract: The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: March 26, 2024
    Assignees: University of Kansas, University of South Florida
    Inventors: Sanket Jaiprakash Mishra, Brian S. J. Blagg, Chad Anthony Dickey
  • Patent number: 11931373
    Abstract: Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308.
    Type: Grant
    Filed: April 15, 2022
    Date of Patent: March 19, 2024
    Assignees: University of South Florida, University of Kansas
    Inventors: Chad Dickey, Lindsey Shelton, Brian Blagg, John Koren, Laura Jenelle Blair
  • Patent number: 11926532
    Abstract: Provided are processes for producing metal oxides, including pigmentary TiO2. In embodiments, a process for producing a metal oxide comprises combining a metal halide and an oxidant in a liquid phase medium under conditions to oxidize the metal halide in the liquid phase medium to produce a metal oxide therefrom.
    Type: Grant
    Filed: January 11, 2022
    Date of Patent: March 12, 2024
    Assignee: University of Kansas
    Inventors: Mark Brandon Shiflett, David Richard Corbin, Andrew M. Danby, Bala Subramaniam
  • Patent number: 11927494
    Abstract: Disclosed are functional materials for use in additive manufacturing (AM). The functional material can comprise an elastomeric composition (e.g., a silicone composite) for use in, for example, direct ink writing. The elastomeric composition can include an elastomeric resin, and a magnetic nanorod filler dispersed within the elastomeric resin. Nanorod characteristics (e.g., length, diameter, aspect ratio) can be selected to create 3D-printed constructs with desired mechanical properties along different axes. Furthermore, since nickel nanorods are ferromagnetic, the spatial distribution and orientation of nanorods within the continuous phase can be controlled with an external magnetic field. This level of control over the nanostructure of the material system offers another degree of freedom in the design of functional parts and components with anisotropic properties. Magnetic fields can be used to remotely sense compression of the constructs, or alternatively, control the stiffness of these materials.
    Type: Grant
    Filed: September 1, 2022
    Date of Patent: March 12, 2024
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Cory Berkland, Jonathan Whitlow, Jean Salash
  • Publication number: 20240067600
    Abstract: The present technology relates to compounds of any one of Formula I, II, IIa, III, IV, and/or V as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
    Type: Application
    Filed: March 16, 2023
    Publication date: February 29, 2024
    Applicants: UNIVERSITY OF KANSAS, Oregon Health & Science University
    Inventors: Sudeshna ROY, Paolo BERNARDI, Michael FORTE, Frank SCHOENEN, Justina SILEIKYTE
  • Patent number: 11911626
    Abstract: The present application relates to stacked piezoelectric composites comprising piezoelectric structures. Suitably, the composites are useful as tissue-stimulating implants, including spinal fusion implants. The present application also relates to methods of making stacked piezoelectric composites.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: February 27, 2024
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Elizabeth Annamaria Friis, John Patrick Domann, Paul M. Arnold
  • Patent number: 11908960
    Abstract: A method of making a plasmonic metal/graphene heterostructure comprises heating an organometallic complex precursor comprising a metal at a first temperature T1 for a first period of time t1 to deposit a layer of the metal on a surface of a heated substrate, the heated substrate in fluid communication with the precursor; and heating, in situ, the precursor at a second temperature T2 for a second period of time t2 to simultaneously form on the layer of the metal, a monolayer of graphene and a plurality of carbon-encapsulated metal nanostructures comprising the metal, thereby providing the plasmonic metal/graphene heterostructure. The heated substrate is characterized by a third temperature T3. The plasmonic metal/graphene heterostructures, devices incorporating the heterostructures, and methods of using the heterostructures are also provided.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: February 20, 2024
    Assignee: University of Kansas
    Inventors: Judy Z. Wu, Qingfeng Liu
  • Patent number: 11891668
    Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: February 6, 2024
    Assignees: The University of Kansas, Kansas State University Research Foundation
    Inventor: Mei He
  • Patent number: 11884881
    Abstract: The disclosure is directed to methods and compositions delaying the gelation of polymers in water flooding by sequentially or co-injecting a carboxylate-containing polymer solution, a gel-delaying polymer, and gelation agent into a hydrocarbon reservoir. Delays of weeks are observed.
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: January 30, 2024
    Assignees: CONOCOPHILLIPS COMPANY, UNIVERSITY OF KANSAS
    Inventors: Huili Guan, Cory Berkland, Ahmad Moradi-Araghi, Jenn-Tai Liang, Terry M. Christian, Riley B. Needham, Min Cheng
  • Patent number: 11885870
    Abstract: The present application discloses a new form of ?-STAP, referred to herein as post ?-STAP or P?-STAP, which overcomes the drawbacks associated with existing ?-STAP techniques. The P?-STAP techniques described herein facilitate the generation of additional training data and homogenization after pulse compression. For example, P?-STAP techniques may apply a plurality of homogenization filters to a pulse compressed datacube generated from an input radar waveform, which produces a plurality of new pulse compressed datacubes with improved characteristics. Unlike existing ?-STAP techniques described above, which require pre-pulse compressed data to operate, the P?-STAP techniques disclosed in the present application are designed to utilize pulse compressed data, and therefore may be readily applied to legacy radar systems.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: January 30, 2024
    Assignees: University of Kansas, The United States of America as Represented by the Secretary of the Air Force
    Inventors: Lumumba Harnett, Justin G. Metcalf, Shannon D. Blunt