Abstract: Disclosed are methods and compositions related to polypeptides comprising a fusion of the needle tip protein and translocator protein of a type III secretion apparatus (T3SA) from a type III secretion system (T3SS) of a Gram negative bacteria. Disclosed herein are fusion polypeptides comprising a fusion of a needle tip protein, such as, Bsp22, LcrV, BipD, PcrV, CT053, or CT668, or anantigenic fragment thereof; and a translocator protein, such as, BopB, YopB, BipB, PopB, CopB, or CopB2, or anantigenic fragment thereof from a Type III secretion system (T3SS) of a Gram negative bacteria, such as, Bordetella, Burkholderia, Chlamydia, Pseudomonas, Vibrio, or Yersinia.
Abstract: An implant can include a plurality of polymeric fibers associated together into a fibrous body. The fibrous body is capable of being shaped to fit a tracheal defect and capable of being secured in place by suture or by bioadhesive. The fibrous body can have aligned fibers (e.g., circumferentially aligned) or unaligned fibers. The fibrous body can be electrospun. The fibrous body can have a first characteristic in a first gradient distribution across at least a portion of the fibrous body. The fibrous body can include one or more structural reinforcing members, such as ribbon structural reinforcing members, which can be embedded in the plurality of fibers. The fibrous body can include one or more structural reinforcing members bonded to the fibers with liquid polymer as an adhesive, the liquid polymer having a substantially similar composition of the fibers.
Type:
Grant
Filed:
November 2, 2021
Date of Patent:
September 6, 2022
Assignees:
The University of Kansas, The Children's Mercy Hospital
Inventors:
Michael Detamore, Lindsey Ott, Robert Weatherly
Abstract: The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs, where they will cross link in situ, thus increasing their viscosity and/or form a gel and blocking thief zones. Methods of making and using such polymers are also provided.
Type:
Grant
Filed:
September 12, 2021
Date of Patent:
August 2, 2022
Assignees:
CONOCOPHILLIPS COMPANY, UNIVERSITY OF KANSAS
Inventors:
Huili Guan, Cory Berkland, Ahmad Moradi-Araghi, Jenn-Tai Liang, Terry M. Christian, Riley B. Needham, James H. Hedges, Min Cheng, Faye L. Scully
Abstract: The instant application relates to nanogels or compositions that hold multivalent metal ions until some level of nanogel degradation has occurred, then slowly release the multivalent metal ions for gelation with carboxylate containing polymers. Compositions comprising such nanogels, together with polymers that can be crosslinked with multivalent metal ions, allow the deployment of such mixtures in various applications, and greatly increased gelation times.
Type:
Grant
Filed:
July 24, 2020
Date of Patent:
July 26, 2022
Assignees:
CONOCOPHILIPS COMPANY, UNIVERSITY OF KANSAS
Inventors:
Huili Guan, Cory Berkland, Ahmad Moradi-Araghi, Jenn-Tai Liang, Terry M. Christian, Riley B. Needham, Min Cheng, Faye Lynn Scully, James H. Hedges
Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.
Type:
Grant
Filed:
December 4, 2020
Date of Patent:
July 19, 2022
Assignee:
UNIVERSITY OF KANSAS
Inventors:
Brian S. J. Blagg, Bhaskar Reddy Kusuma, Teather Sundstrom
Abstract: The invention is directed to delayed gelation agents comprising a degradable polymeric cage containing therein one or more gelation agents. The cage degrades in situ, e.g, in an oil reservoir, thus releasing the gelation agent(s), which can then crosslink second polymers in situ to form a gel.
Type:
Grant
Filed:
April 30, 2019
Date of Patent:
July 19, 2022
Assignees:
CONOCOPHILLIPS COMPANY, UNIVERSITY OF KANSAS
Inventors:
Huili Guan, Cory Berkland, Ahmad Moradi-Araghi, Jenn-Tai Liang, David R. Zornes, Riley B Needham, James H. Hedges, Min Cheng, James P. Johnson, Faye L. Scully
Abstract: Cosmetic and dietary supplement compositions containing silymarin and sulfoalkyl ether cyclodextrin, particularly sulfobutyl ether cyclodextrin, are described. The compositions and methods are useful in reducing appearance of facial redness in rosacea-prone skin, rejuvenating skin, preventing skin aging, inhibiting oxidative stress in epidermal and dermal cells, increasing collagen production, reducing the likelihood of skin cancer, treating or reducing liver damage from a toxin, or treating a liver disease.
Type:
Grant
Filed:
July 2, 2020
Date of Patent:
July 12, 2022
Assignees:
CyDex Pharmaceuticals, Inc., University of Kansas
Inventors:
James D. Pipkin, Roger A. Rajewski, Beau Mainous
Abstract: The present technology is directed to compounds that inhibit of the interaction of RNA-binding proteins with RNA, intermediates thereof, compositions thereof, and methods of treatment utilizing such compounds, where the compounds are of Formula (I).
Type:
Application
Filed:
May 1, 2020
Publication date:
July 7, 2022
Applicants:
The University of North Carolina at Chapel Hill, University of Kansas
Inventors:
Jeff Aube, Sudeshna Roy, Liang XU, Xiaoqing WU, Lan LAN
Abstract: The present disclosure is directed to method of treatment for treating or ameliorating various conditions caused by radiation exposure such as RIGS, enteritis, oral mucositis, mucositis, and proctitis by the administration of a compound Yel002/BCN057 or an analog thereof.
Type:
Grant
Filed:
May 8, 2020
Date of Patent:
June 21, 2022
Assignees:
University of Kansas, BCN Biosciences L.L.C.
Abstract: The present technology is directed to TLR7 and TLR8 agonist compounds, compositions, and methods of using the same for the treatment of cancers and as vaccine adjuvants.
Type:
Application
Filed:
April 16, 2020
Publication date:
June 9, 2022
Applicants:
UNIVERSITY OF KANSAS, HYLAPHARM, LLC.
Inventors:
Laird Forrest, Daniel Aires, Ryan Moulder, Ruolin Lu, Jordan Hunt, Peter Kleindl, Ti Zhang, Chad Groer, Shuang Cai
Abstract: A computer vision-based fastener loosening detection approach is described. A first image is captured at a first time and a second image is captured at a second time. A feature-based image registration is performed to create a third image. An intensity-based image registration is performed to create a fourth image. Registration errors are determined based on a comparison of the first and fourth images. A feature enhancement process is performed on the registration errors to determine whether the fastener has loosened between the first time and the second time.
Abstract: Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and com positions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.
Type:
Grant
Filed:
September 30, 2019
Date of Patent:
May 17, 2022
Assignee:
University of Kansas
Inventors:
Russell Swerdlow, Laird Forrest, Jordan Hunt, Heather Wilkins, Eli Michaelis
Abstract: The present invention relates generally to methods of using nalfurafine for treating and/or preventing demyelinating disease in a subject, and in particular for treating and/or preventing multiple sclerosis (MS). Also disclosed is nalfurafine for use in treating and/or preventing MS as well as pharmaceutical compositions and unit dosage forms comprising nalfurafine for use for treating and/or preventing demyelinating disease in a subject, and in particular for treating and/or preventing MS.
Type:
Grant
Filed:
July 23, 2020
Date of Patent:
May 10, 2022
Assignees:
Victoria Link Ltd., University of Kansas
Inventors:
Thomas Edward Prisinzano, Bronwyn Maree Kivell, Anne Camille La Flamme
Abstract: The present invention relates to methods of using a therapeutic system. In particular, the present invention relates to procedures and methods of using a system having hardware, software, and appliance components for assessing and entraining a non-nutritive suck (NNS) pattern in a patient. The methods include configuring the hardware and software systems to receive data from an orofacial stimulation appliance and to generate a precise therapeutic pulse profile that is actuated as a tactile stimulus. The methods also include collecting data using the orofacial stimulation appliance and delivering the tactile stimulus via the orofacial stimulation appliance to entrain an organized NNS pattern.
Type:
Application
Filed:
January 14, 2022
Publication date:
May 5, 2022
Applicants:
Innara Health, Inc., University of Kansas
Inventors:
Steven M. Barlow, David L. Stalling, Kenneth Aron
Abstract: Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308.
Type:
Grant
Filed:
February 23, 2018
Date of Patent:
May 3, 2022
Assignees:
University of South Florida, University of Kansas
Inventors:
Chad Dickey, Lindsey Shelton, Brian Blagg, John Koren, Laura Blair
Abstract: The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I: wherein R1-5 are defined herein.
Type:
Application
Filed:
October 15, 2021
Publication date:
April 21, 2022
Applicants:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Kansas, Oklahoma State University
Inventors:
Mario Rivera, Huili Yao, Richard A. Bunce, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Kate Eshelman, Achala N.D. Punchi Hewage, Scott Lovell, Anabel Soldano
Abstract: Disclosed herein are devices having both imaging components and cell collection apparatuses. More specifically, the various embodiments disclosed herein include swallowable capsules having deployable collection structures, expansion structures to deploy the collection structures, and imaging components.
Type:
Grant
Filed:
January 31, 2018
Date of Patent:
April 12, 2022
Assignees:
University of Kansas, Department of Veterans Affairs
Inventors:
Ajay Bansal, Lane Christenson, Nick Baker, Ryan Baskins, John Stark, Nourouddin Sharifi, Hadi Kh A Kh Alzuabi, Parker Gill
Abstract: The present disclosure generally relates to chimeric antigen receptors, more specifically to chimeric antigen receptor compositions and methods for use of the same. The present disclosure also provides for nucleic acid molecules and expression vectors for making and using the chimeric antigen receptors and for co-receptor signaling using such chimeric antigen receptors. The present disclosure also provides methods of treatment using such compositions. The chimeric antigen receptors of the present disclosure interact with the endogenous T-cell receptor complex enabling physiological control of signaling and T-cell response and can be combined with ligands such as co-stimulatory ligands for further controlling and influencing T-cell activation and response.
Abstract: Embodiments of the present disclosure relate generally to the production of therapeutic mesenchymal stem cells (MSCs). More particularly, the present disclosure relates to the use of cell culture compositions and methods for generating MSCs that secrete neurotrophic factors and synaptic organizing agents for the treatment of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). As such, the present disclosure addresses the need for establishing a reliable source of therapeutic stem cells useful for the treatment of neurodegenerative diseases.
Type:
Grant
Filed:
September 14, 2018
Date of Patent:
March 29, 2022
Assignee:
University of Kansas
Inventors:
Hiroshi Nishimune, Richard Barohn, Buddhadeb Dawn, Yomna Badawi, James W. Mitchell, Rupal Soder