Abstract: Methods of reducing oxidative damage to an eye of a subject are provided. Aspects of the method include intravitreal injection an antioxidant composition consisting essentially of a non-reducing sugar or a hydrate thereof. In some embodiments, the non-reducing sugar is trehalose. The methods can further include surgical removal of at least a portion of the subject's vitreous humor during a vitrectomy. Also provided are ophthalmic compositions, kits and pre-loaded injection devices for use in vitrectomy surgery which find use in the subject methods.

Abstract: Methods for wet chemical synthesis of lithium argyrodites are provided, which in some embodiments include includes dissolving a stoichiometric mixture of precursors in a small quantity of solvent in an argon atmosphere, drying the mixture under vacuum or an inert gas atmosphere to evaporate the solvent, and then annealing to obtain a final lithium argyrodite product. Further embodiments comprise synthesizing the precursors, and excess halide doping to achieve higher ionic conductivity.

Abstract: In certain embodiments, the present invention provides a method of modulating myocardial blood flow (MBF) as compared to a control in a patient in need thereof, comprising administering an agent that interacts with a Kv? protein.

Abstract: Systems and methods for the electrochemical conversion of COT to multi-carbon products are provided. Each system and method comprises a sequence of multiple, independently optimized electrochemical reaction steps that take place in separate reaction chambers.

Abstract: Provided are methods for producing levulinic acid from hemp hurds. In some embodiments, the methods include dissolving hemp hurds in an ionic liquid medium to produce a cellulose-rich product; hydrolyzing cellulose present in the cellulose-rich product to produce a glucose-rich product; dehydrating glucose present in the glucose-rich product, and/or fructose resulting from isomerization of the glucose, to produce 5-hydroxymethyl furfural (HMF); and hydrolyzing the HMF to levulinic acid.

Abstract: A closed loop system for control of spinal cord epidural stimulation includes a second controller hosting software for receiving, from at least one sensor, physiological data from a subject, generating a stimulation configuration based on the data, and transmitting the configuration to a first controller which operatively causes a neurostimulator to apply the stimulation configuration to the subject, the physiological results of such stimulation are monitored by the at least one sensor.

Abstract: Provided are methods, compositions, and kits that are useful for long-term stabilization of biospecimens at ambient and elevated temperatures that are resilient to degradation by environmental factors and contaminants In some embodiments, the presently disclosed subject matter can be employed for long-term storage of biospecimens that would typically require low and/or ultra-low storage conditions, but as a consequence of employing the presently disclosed compositions and/or methods, the need for cryo-and/or sub-zero refrigeration is not needed in order to get similar if not superior stability of the biospecimen.

Abstract: A composition comprises an anti-nucleolin agent conjugated to nanoparticles. The nanoparticles are non-magnetic, not iron oxide and not polyacrylamide. Furthermore, a pharmaceutical composition for treating cancer comprises a composition including an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier.

Abstract: This specification describes an adaptive robotic nursing assistant for physical tasks and patient observation and feedback. In some examples, the adaptive robotic nursing assistant includes an omni-directional mobile platform; a footrest on the omni-directional mobile platform; a handlebar located above the footrest such that a user standing on the footrest can grasp the handlebar; a display above the handlebar and at least one user input device; a robot manipulator comprising a robotic arm and an end effector on the robotic arm; and a control system coupled to the omni-directional mobile platform, the control system comprising at least one processor and memory storing executable instructions for the at least one processor to control the omni-directional mobile platform.

Abstract: Provided are methods for preventing and/or treating oral diseases, disorders, and/or conditions. In some embodiments, the methods relate to administering to the oral cavity of a subject in need thereof a composition that includes an effective amount of ginger-derived exosome-like nanoparticles (GELNs) or a biologically active component thereof. Also provided are methods for preventing and/or treating periodontitis, methods for reducing growth of and/or pathogenicity of microorganisms in the oral cavities of subjects, methods for reducing microorganismal motility, and methods for reducing bone loss in the oral cavities of subjects associated with infection with microorganisms. Also provided are compositions that can be employed in the disclosed methods.

Abstract: Provided are methods for isolating subpopulations of stem cells. In some embodiments, the presently disclosed methods include selecting subsets of cells that are positive for CD34 or Sca-1, are further positive for one or more of FSHR, LHCGR, PRLR, AR, ESR?, ESR?, and PGR; and are negative for each of CD45R/B220, Gr-1, TCR??, TCR??, CD11b, and Ter-119. In some embodiments, the subpopulations are further fractioning into CD45? and CD45+ fractions. Also provided are populations of stem cells isolated by the presently disclosed methods, compositions that include the presently disclosed subpopulations in pharmaceutically acceptable carriers, methods for expanding stem cells, methods for stimulating proliferation of MSCs, methods for treating subjects suffering from exposure to radiation, and methods for producing gametes in vitro.

Abstract: A perovskite-type oxide catalyst for water-splitting reactions is provided. The catalyst, Ca2-ySryFe1-xCo1-xMn2xO6-? where y=0.10-1.90 and x=0.05-0.95, has catalytic activity for both hydrogen- and oxygen-evolution reactions. An exemplary catalyst is CaSrFe0.75Co0.75Mn0.5O6-?.

Abstract: The present disclosure relates to human facilitating cells (hFC), and methods of isolating, characterizing, and using such hFCs.

Abstract: Methods for wet chemical synthesis of lithium argyrodites are provided, which in some embodiments include dissolving a stoichiometric mixture of precursors in a small quantity of solvent in an argon atmosphere, drying the mixture under vacuum or an inert gas atmosphere to evaporate the solvent, and then annealing to obtain a final lithium argyrodite product. Further embodiments comprise synthesizing the precursors, excess halide doping to achieve higher ionic conductivity, and the use of carboxylic acid esters to enhance the interfacial properties of high-performance lithium batteries.

Abstract: Methods for ex vivo expansion of very small embryonic like stem cells in the absence of feeder cells are provided. In some embodiments the methods include providing a plurality of VSELs; and growing the VSELs in a culture medium that includes a histone deacetylase inhibitor, luteinizing hormone, follicle-stimulating hormone, and optionally transforming growth factor beta in an amount that is sufficient to overcome quiescence of the VSELs. Also provided are feeder cell-free cell cultures, ex vivo expanded VSELs, pharmaceutical compositions that include the disclosed ex vivo expanded VSELs, methods for overcoming quiescence in VSELs, methods for re-establishing imprinting in VSELs, method for treating injuries to tissues in subjects, methods for repopulating cell types in subjects, methods for bone marrow transplantation, methods for treating radiation exposure in subjects, and methods that relate to regenerative medicine.

Abstract: A computer aided diagnostic system and automated method to classify a kidney utilizes medical image data and clinical biomarkers in evaluation of kidney function pre- and post-transplantation. The system receives image data from a medical scan that includes image data of a kidney, then segments kidney image data from other image data of the medical scan. The kidney is then classified by analyzing at least one feature determined from the kidney image data and the at least one clinical biomarker.

Abstract: Evaluating a pressure ulcer includes: detecting in a color input image a boundary of the pressure ulcer to get a RGB region of interest (ROI) image; converting the RGB ROI image to a grayscale ROI image; processing the grayscale ROI image using a Linear Combination of Discrete Gaussians (LCDG) process to estimate three main class probabilities of the grayscale ROI image; processing the RGB ROI image using predetermined RGB values to estimate the three main class probabilities of the RGB ROI image; and combining the probabilities of the grayscale ROI image and the probabilities of the RGB ROI image to determine an estimated labeled image; and normalizing and refining the estimated labeled image using a Generalized Gauss-Markov Random Field (GGMRF) process to produce a final segmentation image.

Abstract: Described herein are methods for treating and preventing cancer. In particular, described herein are methods using SA-4-1BBL as a monotherapy agent to treat, prevent or reduce the risk of cancer, treat, prevent, or reduce the risk of tumorigenesis, and treat, prevent, or reduce the risk of post-surgical tumor recurrence. SA-4-1BBL for use as a monotherapy in such methods also is provided.

Abstract: Methods to determine the absence or presence of one or more cancer types in an animal are disclosed herein. In some embodiments, amounts of lipids in a sample (e.g., a bodily fluid or treatment thereof) from the animal are used with a predictive model to make the determination. The lipid amounts can be measured, in some instances, using a mass spectrometry system.

Abstract: A system for intramedullary preparations comprises a directional reamer including a flexible drive shaft having a proximal end and a distal end, and a cutting head operably connected to the distal end of the flexible drive shaft. The system further includes a means of displacing the distal end of the flexible drive shaft and deflecting the cutting head to selectively shape a medullary canal in a bone. A follower sleeve is also include in the system and has a proximal end and a distal end in the form of a collar, with the follower sleeve being configured to accept the flexible drive shaft. The system additionally includes a reaming plunger that extends through the follower sleeve and is positioned adjacent to the flexible drive shaft such that the reaming plunger engages the collar of the follower sleeve to deflect the cutting head.