Patents Assigned to University of Louisville Research Foundation, Inc.
  • Noninvasive detection of cancer originating in tissue outside of the lung using exhaled breath
    Patent number: 11016082
    Abstract: Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: May 25, 2021
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Xiaoan Fu, Michael Nantz, Michael Bousamra, Victor van Berkel
  • Cosmetic compositions containing quinones and their topical use on skin and hair
    Patent number: 11013673
    Abstract: Described are compositions containing quinones that show activity in enhance DNA repair and/or prevent damage to DNA and/or upregulate genes associated with wound healing. The quinones are thymoquinone, lapachol, myrtucommulone C, or mixtures thereof, and can be formulated into cosmetic compositions for topical administration to a subject in need thereof. The cosmetic compositions can also include sunscreens, surfactants, sunless tanning agents, desquamation agents, antiperspirants, colorants, preservatives and mixtures; and a cosmetically acceptable carrier. The compositions should find use in methods for treating the signs of ageing in mammals, dermatitis and wound healing via topical application to a site in need thereof, such as the skin or hair of the mammals or a wound site.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: May 25, 2021
    Assignees: Repairogen Corp., University of Louisville Research Foundation, Inc., Cornell University
    Inventors: Michael Boice, Frank Borchetta, Albert Cunningham, John Trent, Pengbo Zhou, Chenyi Yang
  • COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20210145821
    Abstract: Methods and pharmaceutical compositions for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) and the treatment of cancer are described.
    Type: Application
    Filed: November 13, 2020
    Publication date: May 20, 2021
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Sucheta TELANG, Jason CHESNEY, John O. TRENT
  • Compositions and methods for treating, including preventing, parvovirus infections and related diseases
    Patent number: 11008367
    Abstract: Some embodiments of the invention include inventive polypeptides (e.g., mutant VP2 proteins) and virus-like particles made from the inventive polypeptides. Other embodiments of the invention include compositions for treating (e.g., preventing) parvovirus (e.g., erythrovirus or parvovirus B19) infection and other diseases. Further embodiments include methods for administering compositions to an animal. Other embodiments include treating (e.g., preventing) parvovirus (e.g., erythrovirus or parvovirus B19) infection and other diseases. Still other embodiments include nucleic acid sequences that encode the inventive polypeptides. Additional embodiments of the invention are also discussed.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: May 18, 2021
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Shin-je Ghim, A. Bennett Jenson, John O. Trent
  • Methods for providing optimized neurostimulation
    Patent number: 11007368
    Abstract: Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for providing multiple independent, simultaneous waveforms in neurostimulation therapy while minimizing or substantially eliminating undesirable interactions between the waveforms.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: May 18, 2021
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Susan J. Harkema, Yangshen Chen, Robert S. Keynton, Douglas J. Jackson, John Naber, Thomas Roussel, Manikandan Ravi
  • Micro-array devices for capturing cells in blood and methods of their use
    Patent number: 11002737
    Abstract: The present disclosure provides micro-array devices for capturing cells in blood and methods of their use. In some aspects, a method for counting cells in a blood sample is provided, the method comprising applying a blood sample onto a CNT device; allowing cells in the blood sample to differentially settle on the CNT device, and identifying and counting cells of preselected type in the blood sample.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: May 11, 2021
    Assignees: Worcester Polytechnic Institute, University of Louisville Research Foundation, Inc.
    Inventors: Balaji Panchapakesan, Farhad Khosravi, Shesh N. Rai
  • AUTOMATED METHODS FOR THE OBJECTIVE QUANTIFICATION OF RETINAL CHARACTERISTICS BY RETINAL REGION AND DIAGNOSIS OF RETINAL PATHOLOGY
    Publication number: 20210125336
    Abstract: Automated and objective methods for quantifying a retinal characteristic include segmenting an optical coherence tomography retinal image into a plurality of layered retinal regions, and quantifying the retinal characteristic for each region as normalized to a range defined by the characteristic value in the vitreous region and in the retinal pigment epithelium region. Such methods are useful for detecting occult ocular pathology, diagnosing ocular pathology, reducing age-bias in OCT image analysis, and monitoring efficacy ocular/retinal disease therapies.
    Type: Application
    Filed: December 30, 2020
    Publication date: April 29, 2021
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Shlomit Schaal, Ayman El-Baz, Amir Reza Hajrasouliha
  • METHOD AND SYSTEM FOR MONITORING AND EVALUATION OF PRESSURE ULCER SEVERITY
    Publication number: 20210106274
    Abstract: Evaluating a pressure ulcer includes: detecting in a color input image a boundary of the pressure ulcer to get a RGB region of interest (ROI) image; converting the RGB ROI image to a grayscale ROI image; processing the grayscale ROI image using a Linear Combination of Discrete Gaussians (LCDG) process to estimate three main class probabilities of the grayscale ROI image; processing the RGB ROI image using predetermined RGB values to estimate the three main class probabilities of the RGB ROI image; and combining the probabilities of the grayscale ROI image and the probabilities of the RGB ROI image to determine an estimated labeled image; and normalizing and refining the estimated labeled image using a Generalized Gauss-Markov Random Field (GGMRF) process to produce a final segmentation image.
    Type: Application
    Filed: May 18, 2018
    Publication date: April 15, 2021
    Applicant: University of Louisville Research Foundation, Inc.
    Inventors: Adel S. Elmaghraby, Maria Begoña García-Zapirain Soto, Ayman Sabry El-Baz
  • EDIBLE PLANT-DERIVED NANOPARTICLES FOR REGULATION OF GUT MICROBIOTA
    Publication number: 20210085744
    Abstract: Provided are methods for modulating gut microbiota in subjects. In some embodiments, the methods include administering to a subject an effective amount of a composition that includes a first edible plant-derived nanoparticle encapsulating an effective amount of RNA. Also provided are methods for preventing and/or treating gut dysbiosis, methods for modulating bacterial growth, methods for modulating inflammatory cytokines, methods for reducing migration of bacterial from the gut to gut-associated bloodstream, and compositions for use in the presently disclosed methods, including pharmaceutical compositions.
    Type: Application
    Filed: November 21, 2018
    Publication date: March 25, 2021
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Methods for forming a perovskite solar cell
    Patent number: 10950794
    Abstract: A perovskite thin film and method of forming a perovskite thin film are provided. The perovskite thin film includes a substrate, a hole blocking/electron transport layer, and a sintered perovskite layer. The method of forming the perovskite solar cell includes depositing a perovskite layer onto a substrate and processing (for example, by sintering) the perovskite layer with intense pulsed light to initiate a radiative thermal response that is enabled by an alkyl halide additive.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: March 16, 2021
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Thad Druffel, Brandon Lavery, Krishnamraju Ankireddy, Amir Hossein Ghahremani, Blake Martin, Gautam Gupta
  • COMPOSITIONS COMPRISING ENGINEERED EMBRYONIC STEM CELL-DERIVED EXOSOMES AND METHOD OF USE THEREFOR
    Publication number: 20210060148
    Abstract: Provided are compositions, optionally pharmaceutical compositions, that include a plurality of exosomes generated from stem cells, optionally ESCs and/or iPSCs, that have been modified to express a granulocyte-macrophage colony stimulating factor (GM-CSF) polypeptide, optionally a human GM-CSF polypeptide. Also provided are methods for employing the presently disclosed compositions for preventing and/or inhibiting tumor growth in subjects in need thereof, for preventing and/or inhibiting metastases in subject in need thereof, for inducing anti-tumor immune responses in subjects, and uses of the presently disclosed compositions for prevention and/or treatment of tumors and/or cancers and for the preparation of medicaments for treatment of tumors and/or cancers.
    Type: Application
    Filed: May 9, 2018
    Publication date: March 4, 2021
    Applicant: University of Louisville Research Foundation, Inc.
    Inventors: John W. Eaton, Kavitha Yaddanapudi, Chi Li
  • Methods for forming a perovskite solar cell
    Patent number: 10937978
    Abstract: A perovskite thin film and method of forming a perovskite thin film are provided. The perovskite thin film includes a substrate, a hole blocking/electron transport layer, and a sintered perovskite layer. The method of forming the perovskite solar cell includes depositing a perovskite layer onto a substrate and sintering the perovskite layer with intense pulsed light.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: March 2, 2021
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Thad Druffel, Brandon Lavery
  • Biopsy sampling device
    Patent number: 10932762
    Abstract: A biopsy sampling device comprises a handle with a flexible cannula extending from the handle. The flexible cannula includes: an inner catheter, which defines an opening in a lateral wall surface thereof, and further defines a central lumen in fluid communication with the opening; an outer catheter positioned around and moveable relative to the inner catheter; and a cutting element positioned at a distal end of the outer catheter. The flexible cannula is configured such that a vacuum can be applied through the central lumen of the inner catheter to create a suction that draws a piece of tissue into the opening defined in the lateral wall surface of the inner catheter. The handle is configured to move the inner catheter relative to the outer catheter, such that the cutting element shears and severs the piece of tissue that has been drawn into the opening.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: March 2, 2021
    Assignees: University of Louisville Research Foundation, Inc., Endoscopy Assist Devices, LLC
    Inventors: Gerald W. Dryden, Jr., Anthony Appling
  • Method and device for detecting cellular targets in bodily sources using carbon nanotube thin film
    Patent number: 10919759
    Abstract: A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (CNT's). When antibodies are absorbed by the CNT's, cellular targets having markers matching the antibodies may be detected in a bodily source placed upon the biofunctional pad by measuring the conductivity of the thin film using conductive contacts electrically coupled to the thin film, as the binding of the receptors in the cellular targets to the antibodies changes the free energy in the thin film. In many respects, the device functions as a Field Effect Transistor (FET) with the bodily source, e.g., blood, acting as a polyelectrolyte liquid gate electrode to create a varying electrostatic charge or capacitance in the thin film based upon the binding of cellular targets in the source to the antibodies present on the biofunctional pad.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: February 16, 2021
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventor: Balaji Panchapakesan
  • METHODS FOR TREATMENT OF CANCER AND ENHANCEMENT OF NANOPARTICLE ACCUMULATION IN TISSUES
    Publication number: 20210030829
    Abstract: Provided are methods for treating tumors and/or cancers. In some embodiments, the methods relate to administering to a subject in need thereof an effective amount of a nanoparticle derived from an edible plant and an effective amount of an autologous exosome. Also provided are methods for enhancing accumulation of nanoparticles in the lungs of subjects, methods for delivering agents to the liver, brain, and/or bones of subjects, and methods for delivering agents across the blood-brain barrier of subjects.
    Type: Application
    Filed: March 6, 2019
    Publication date: February 4, 2021
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Atrial appendage closure device and related methods
    Patent number: 10898202
    Abstract: An atrial appendage closure device is provided that includes an occluding portion having a distal surface and a proximal surface opposite the distal surface, the occluding portion being moveable between a retracted position and a deployed position such that, in the deployed position, the occluding portion is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring portion is operably connected to the occluding member with the anchoring portion being moveable between a retracted position and a deployed position. Methods for occluding a left atrial appendage that make use of the closure devices are also provided.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: January 26, 2021
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Mark S. Slaughter, Guruprasad A. Giridharan, Steven C. Koenig, Michael A. Sobieski, Kevin Soucy
  • SYSTEM AND METHOD FOR PERSONALIZED DOSING OF PHARMACOLOGIC AGENTS
    Publication number: 20210012872
    Abstract: A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile.
    Type: Application
    Filed: September 17, 2020
    Publication date: January 14, 2021
    Applicant: University of Louisville Research Foundation, Inc.
    Inventors: Adam E. GAWEDA, Michael E. BRIER, George R. ARONOFF, Alfred A. JACOBS
  • METHOD AND SYSTEM FOR PREDICTING RECURRENCE AND NON-RECURRENCE OF MELANOMA USING SENTINEL LYMPH NODE BIOMARKERS
    Publication number: 20210010090
    Abstract: A method of characterizing melanoma in a subject involves determining the presence or level of one or more biomarkers in a sample obtained from a sentenal lymph node (SLN) of a subject.
    Type: Application
    Filed: August 6, 2020
    Publication date: January 14, 2021
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Hongying Hao, Kelly M. McMasters
  • Automated methods for the objective quantification of retinal characteristics by retinal region and diagnosis of retinal pathology
    Patent number: 10891729
    Abstract: Automated and objective methods for quantifying a retinal characteristic include segmenting an optical coherence tomography image into a plurality of layered retinal regions, and quantifying the retinal characteristic for each region as normalized to a range defined by the characteristic value in the vitreous region and in the retinal pigment epithelium region. Such methods are useful for detecting occult ocular pathology, diagnosing ocular pathology, reducing age-bias in OCT image analysis, and monitoring efficacy ocular/retinal disease therapies.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: January 12, 2021
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Shlomit Schaal, Ayman El-Baz, Amir Reza Harjrasouliha
  • Methods of making spheroids including biologically-relevant materials
    Patent number: 10889799
    Abstract: Methods of making a spheroid are provided whereby a suspension is first produced including one or more biologically-relevant materials dispersed within a biocompatible medium. A droplet of the suspension is then bioprinted into a salt solution by bringing the droplet into contact with a surface of the salt solution in a controlled manner to reproducibly yield a spheroid containing a desired size and a desired amount of biologically-relevant materials.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: January 12, 2021
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Stuart K. Williams, Jeremy S. Touroo, James B. Hoying