Abstract: Computer-implemented systems and methods for determining epidural spinal stimulation parameters that promote muscle activation use spectral analysis and machine learning techniques to characterize electromyography data.
Type:
Grant
Filed:
June 19, 2020
Date of Patent:
April 11, 2023
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
Susan J. Harkema, Enrico Rejc, Samineh Mesbah
Abstract: Microvesicle compositions and methods of use thereof are provided. The microvesicle composition includes a miRNA encapsulated by a microvesicle, wherein the microvesicle is derived from an edible plant. The method of use thereof includes treating a cancer in a subject by administering to the subject an effective amount of a microvesicle composition.
Type:
Application
Filed:
May 26, 2022
Publication date:
April 6, 2023
Applicant:
University of Louisville Research Foundation, Inc.
Abstract: Described herein are FasL-engineered biomaterials, as well as methods of making and using such FasL-engineered biomaterials, such as for immunomodulation, such as for inducing immunosuppression and specific immune tolerance, such as for preventing or reducing the risks of rejection of cellular or tissue grafts and/or the treatment of autoimmune disorders such as Type I diabetes. In specific embodiments, the FasL-engineered biomaterials are biotinylated microgels bound to SA-FasL.
Type:
Grant
Filed:
March 9, 2018
Date of Patent:
March 14, 2023
Assignees:
University of Louisville Research Foundation, Inc., Georgia Tech Research Corporation
Inventors:
Haval Shirwan, Andres J. Garcia, Esma S. Yolcu, Hong Zhao, Devon Headen
Abstract: Some embodiments of the invention include inventive catalysts (e.g., catalysts of Formula (I)). Other embodiments include compositions comprising the inventive catalysts. Some embodiments include methods of using the inventive catalysts (e.g., in hydrofluorination of an organic compound). Further embodiments include methods for making the inventive catalysts. Additional embodiments of the invention are also discussed herein.
Type:
Grant
Filed:
July 22, 2019
Date of Patent:
March 14, 2023
Assignee:
UNIVERSITY OF LOUISVILLE
RESEARCH FOUNDATION, INC.
Abstract: Some embodiments of the invention include virus-like particle (VLP) binding agents, and related polynucleotides, cells, methods of making, and compositions. Other embodiments of the invention include methods of detecting VLPs, parvovirus, erythrovirus or parvovirus B19 using a VLP binding agent and diagnostic methods for parvovirus, erythrovirus or parvovirus B19. Further embodiments include methods for administering VLP binding agents to an animal. Other embodiments include treating parvovirus, erythrovirus or parvovirus B19 infections and other diseases. Additional embodiments of the invention are also discussed.
Type:
Application
Filed:
December 30, 2020
Publication date:
February 16, 2023
Applicant:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
Inventors:
Shin-je GHIM, A. Bennett JENSON, Maryam ZAHIN
Abstract: Provided are composite electrolytes having a bio-based gel electrolyte in an ordered structure of a porous solid. In some embodiments, the gel electrolyte includes a glycolate gel, a glycerate gel, a bio-based compound-derived gel or a combination thereof. Also provided are electrochemical systems (electrodeposition), redox flow batteries, fuel cells, lithium-ion batteries and lithium-metal batteries including the composite electrolytes, and methods for producing gel electrolytes. In some embodiments, the methods including reacting a polyol, optionally ethylene glycol, propanediol, butanediol, pentanediol, diethylene glycol, glycerol, or any combination thereof, with a lithium metal and/or a lithium salt, optionally lithium hydroxide, a sodium salt, optionally sodium hydroxide (NaOH), NaTFSI, NaBF4, or NaPF6; an aluminum salt; a potassium salt, a magnesium salt; a calcium salt; a zinc salt; or any combination thereof.
Type:
Application
Filed:
November 27, 2020
Publication date:
January 5, 2023
Applicant:
University of Louisville Research Foundation, Inc.
Abstract: A multi-lumen arthroscopy cannula (MLAC) is described which may be used to contain and manage joint irrigation fluid as a means of improving the state of arthroscopic surgery. The MLAC includes an arrangement of components within a cannula housing. An internal passage (central lumen) through which surgical instruments may be inserted into the body includes a series of components which greatly reduce the leakage path of fluid through the central lumen while enabling manipulation of surgical instruments during arthroscopic procedures. A dual-tapered diaphragm seal grips the instruments as it is manipulated to prevent leakage. This works in concert with the consecutively placed multi-leaflet valves, which act to prevent internal leakage and maintain pressure within the surgical cavity. Unique features of this cannula, aside from the multiple valves and dual-tapered diaphragm seal, include bilateral lumens which provide infusion and withdrawal of irrigation inside the joint capsule.
Type:
Grant
Filed:
October 17, 2019
Date of Patent:
January 3, 2023
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
George Pantalos, Justin Heidel, David Caborn
Abstract: A robot skin apparatus includes polymer membranes encapsulating a pressure sensor. The sensor includes piezo-sensitive material in contact with a pair of electrodes in spaced relationship to form a circuit. The apparatus may include a flexible substrate, with the electrodes thereon. The piezo-sensitive material may be piezoresistive film. The electrodes may be symmetrically patterned on the substrate to form a substantially circular peripheral boundary. The apparatus may include pressure sensors on opposite sides of a plane for temperature compensation, a plurality of pressure sensors arrayed on the substrate, and a data acquisition system. A method of fabricating the apparatus includes a wet lithography process for patterning the piezoresistive film. A system includes a pair of gripper fingers, an actuator connected to the fingers, a robot skin apparatus positioned on one of the fingers, and an electronic unit for receiving data from the robot skin and controlling the fingers.
Type:
Grant
Filed:
April 6, 2018
Date of Patent:
January 3, 2023
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
Joshua R. Baptist, Mohammad Nasser Saadatzi, Zhong Yang, Ruoshi Zhang, Dan O. Popa
Abstract: Methods for automated segmentation system for retinal blood vessels from optical coherence tomography angiography images include a preprocessing stage, an initial segmentation stage, and a refining stage. Application of machine-learning techniques to segmented images allow for automated diagnosis of retinovascular diseases, such as diabetic retinopathy.
Type:
Grant
Filed:
June 20, 2018
Date of Patent:
December 27, 2022
Assignees:
University of Louisville Research Foundation, Inc., University of Massachusetts
Inventors:
Ayman El-Baz, Nabila Eldawi, Shlomit Schaal, Mohammed Elmogy, Harpal Sandhu, Robert S. Keynton, Ahmed Soliman
Abstract: Protein complex variants, compositions, and methods of use thereof are provided. The protein complex variant includes a cholera toxin B subunit variant having one or more modifications thereto. The method of use thereof includes treating a disease by administering an effective amount of a composition including a cholera toxin B subunit variant to a subject in need thereof.
Type:
Grant
Filed:
August 19, 2020
Date of Patent:
December 13, 2022
Assignee:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
Inventors:
Nobuyuki Matoba, Keegan Baldauf, Joshua Royal
Abstract: A flexible wire comprises a conductive core surrounded by one or more radial p-n diodes and alternating conductive and non-conductive bands along an outermost surface. Methods for producing the wire are also disclosed, as are textiles and other flexible materials comprising or consisting of such flexible wires.
Type:
Grant
Filed:
January 8, 2019
Date of Patent:
November 29, 2022
Assignee:
University of Louisville Research Foundation, Inc.
Abstract: An atrial appendage closure device is provided that includes an insertion rod having a first end and a second end. An occluding member having an outer surface and an inner surface is connected to the first end of the insertion rod. The occluding member is moveable between a retracted position and a deployed position such that, in the deployed position, the occluding member is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring member is further connected to the insertion rod and is configured to slide along the insertion rod to secure the device to a wall of a left atrial appendage. Methods for occluding a left atrial appendage that make use of the closure devices are also provided.
Type:
Grant
Filed:
December 4, 2019
Date of Patent:
November 15, 2022
Assignee:
University of Louisville Research Foundation
Inventors:
Mark S. Slaughter, Guruprasad A. Giridharan, Steven C. Koenig, Michael A. Sobieski, Kevin Soucy
Abstract: Systems and methods for diagnosing prostate cancer. Image sets (e.g., MRI collected at one or more b-values) and biological values (e.g., prostate specific antigen (PSA)) have features extracted and integrated to produce a diagnosis of prostate cancer. The image sets are analyzed primarily in three steps: (1) segmentation, (2) feature extraction, smoothing, and normalization, and (3) classification. The biological values are analyzed primarily in two steps: (1) feature extraction and (2) classification. Each analysis results in diagnostic probabilities, which are then combined to pass through an additional classification stage. The end result is a more accurate diagnosis of prostate cancer.
Type:
Grant
Filed:
July 9, 2018
Date of Patent:
November 8, 2022
Assignee:
University of Louisville Research
Foundation, Inc.
Inventors:
Ayman S. El-Baz, Ahmed Shalaby, Fahmi Khalifa, Islam Abdelmaksoud
Abstract: Disclosed herein are devices and methods used with neurostimulation therapy for spinal cord injury. More particularly, embodiments of the present invention relate to a sync pulse detector and methods for synchronizing signals from an implanted neurostimulator with measured physiological responses and other data.
Type:
Application
Filed:
February 11, 2022
Publication date:
October 27, 2022
Applicant:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
Inventors:
Susan J. Harkema, Yangsheng Chen, Douglas J. Jackson, Manikandan Ravi, Claudia Angeli
Abstract: A tissue construct is provided that comprises a pancreas derived microvessel fragment and a pancreatic islet cell. The pancreas derived microvessel fragment and the pancreatic islet cell can be incorporated into a biocompatible medium. Tissue constructs can be comprised of other cells, such as stem cells, combined with the pancreas derived microvascular fragment. Methods for isolating microvessel fragments from a pancreas are also provided and include enzymatic digestion of pancreatic tissue and separation of microvessel fragments from endocrine and exocrine tissue. Methods for treating diabetes are further provided and include administration of the tissue constructs.
Type:
Grant
Filed:
April 27, 2018
Date of Patent:
October 11, 2022
Assignee:
University of Louisville Research Foundation
Inventors:
Balamurugan Appakalai, Stuart K. Williams
Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
Type:
Application
Filed:
April 19, 2022
Publication date:
October 6, 2022
Applicants:
The United States of America,as represented by the Secretary,Department of Health and Human Services, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
Inventors:
Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
Abstract: Provided herein are GRFT variants and methods of using such GRFT variants. The GRFT variants described herein can be PEGylated, which significantly improves the pharmacokinetics and decreases the immunogenicity of the GFRT composition.
Type:
Application
Filed:
September 10, 2020
Publication date:
September 15, 2022
Applicants:
University of Louisville Research Foundation, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Servic
Inventors:
Joshua Fuqua, Krystal Hamorsky, Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer
Abstract: Provided are methods for increasing insulin sensitivity in subjects. In some embodiments, the method include administering to the subject an effective amount of a composition comprising a lipid bilayer, wherein the lipid bilayer is low in total phosphatidylcholine (PC) or has been treated to reduce total PC.
Type:
Application
Filed:
August 14, 2020
Publication date:
September 15, 2022
Applicant:
University of Louisville Research Foundation, Inc.
Abstract: Provided herein are methods of performing liquid phase epitaxy (LPE) of III-V compounds and alloys at low pressures using pulsed nitrogen plasma to form an epitaxial layer e.g. on a substrate. The pulse sequence of plasma (with on and off time scales) enables LPE but avoids crust formation on top of molten metal. The concentration of nitrogen inside the molten metal is controlled to limit spontaneous nucleation.
Type:
Grant
Filed:
October 12, 2020
Date of Patent:
September 13, 2022
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
Mahendra K. Sunkara, Daniel F. Jaramillo-Cabanzo, Sonia J. Calero-Barney