Abstract: Methods, systems, and computer readable media for controlling ventricular assist devices are disclosed. In some embodiments, the method includes receiving at least one reference pump speed differential associated with a pump of a ventricular assist device; determining a filtered pump speed differential associated with the pump of a ventricular assist device; and adjusting, using a feedback based controller algorithm, current to the pump based on the at least one reference pump speed differential and the filtered pump speed differential.
Type:
Grant
Filed:
November 8, 2019
Date of Patent:
August 23, 2022
Assignee:
University of Louisville Research Foundation, Inc.
Abstract: A method of making a spheroid is provided that includes the step of providing a suspension having one or more biologically-relevant materials dispersed within a biocompatible medium. An amount of a hydrophilic material is deposited on a defined area of a super-hydrophobic surface, and a droplet of the suspension is bioprinted onto the hydrophilic material positioned on the super-hydrophobic to thereby create the spheroid.
Type:
Grant
Filed:
June 27, 2017
Date of Patent:
August 23, 2022
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
Stuart K. Williams, Brian C. Gettler, Joseph S. Zakhari, Piyani S. Gandhi
Abstract: Methods of reducing oxidative damage to an eye of a subject are provided. Aspects of the method include intravitreal injection an antioxidant composition consisting essentially of a non-reducing sugar or a hydrate thereof. In some embodiments, the non-reducing sugar is trehalose. The methods can further include surgical removal of at least a portion of the subject's vitreous humor during a vitrectomy. Also provided are ophthalmic compositions, kits and pre-loaded injection devices for use in vitrectomy surgery which find use in the subject methods.
Type:
Grant
Filed:
February 8, 2016
Date of Patent:
August 9, 2022
Assignee:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
Inventors:
Ori Braun, Martin G. O'Toole, Shlomit Schaal
Abstract: In certain embodiments, the present invention provides a method of modulating myocardial blood flow (MBF) as compared to a control in a patient in need thereof, comprising administering an agent that interacts with a Kv? protein.
Type:
Application
Filed:
January 18, 2022
Publication date:
July 21, 2022
Applicant:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
Abstract: Methods for wet chemical synthesis of lithium argyrodites are provided, which in some embodiments include includes dissolving a stoichiometric mixture of precursors in a small quantity of solvent in an argon atmosphere, drying the mixture under vacuum or an inert gas atmosphere to evaporate the solvent, and then annealing to obtain a final lithium argyrodite product. Further embodiments comprise synthesizing the precursors, and excess halide doping to achieve higher ionic conductivity.
Type:
Application
Filed:
April 16, 2020
Publication date:
July 21, 2022
Applicants:
University of Louisville Research Foundation, Inc., Uniwersy tet Warszawski
Abstract: Systems and methods for the electrochemical conversion of COT to multi-carbon products are provided. Each system and method comprises a sequence of multiple, independently optimized electrochemical reaction steps that take place in separate reaction chambers.
Type:
Grant
Filed:
December 31, 2018
Date of Patent:
July 19, 2022
Assignee:
University of Louisville Research Foundation, Inc.
Abstract: Provided are methods for producing levulinic acid from hemp hurds. In some embodiments, the methods include dissolving hemp hurds in an ionic liquid medium to produce a cellulose-rich product; hydrolyzing cellulose present in the cellulose-rich product to produce a glucose-rich product; dehydrating glucose present in the glucose-rich product, and/or fructose resulting from isomerization of the glucose, to produce 5-hydroxymethyl furfural (HMF); and hydrolyzing the HMF to levulinic acid.
Type:
Application
Filed:
April 16, 2020
Publication date:
July 14, 2022
Applicant:
University of Louisville Research Foundation, Inc.
Abstract: A closed loop system for control of spinal cord epidural stimulation includes a second controller hosting software for receiving, from at least one sensor, physiological data from a subject, generating a stimulation configuration based on the data, and transmitting the configuration to a first controller which operatively causes a neurostimulator to apply the stimulation configuration to the subject, the physiological results of such stimulation are monitored by the at least one sensor.
Type:
Application
Filed:
April 4, 2020
Publication date:
June 23, 2022
Applicant:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
Inventors:
SUSAN J. HARKEMA, ENRICO REJC, CLAUDIA ANGELI, CHARLES H. HUBSCHER, APRIL N. HERRITY, YANGSHENG CHEN, SEVDA G. ASLAN
Abstract: Provided are methods, compositions, and kits that are useful for long-term stabilization of biospecimens at ambient and elevated temperatures that are resilient to degradation by environmental factors and contaminants In some embodiments, the presently disclosed subject matter can be employed for long-term storage of biospecimens that would typically require low and/or ultra-low storage conditions, but as a consequence of employing the presently disclosed compositions and/or methods, the need for cryo-and/or sub-zero refrigeration is not needed in order to get similar if not superior stability of the biospecimen.
Type:
Application
Filed:
April 13, 2020
Publication date:
June 16, 2022
Applicant:
University of Louisville Research Foundation, Inc.
Inventors:
Gautam Gupta, Robert S. Keynton, Rajat Chauhan, Theodore Kalbfleisch
Abstract: A composition comprises an anti-nucleolin agent conjugated to nanoparticles. The nanoparticles are non-magnetic, not iron oxide and not polyacrylamide. Furthermore, a pharmaceutical composition for treating cancer comprises a composition including an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
August 18, 2016
Date of Patent:
May 31, 2022
Assignee:
University of Louisville Research Foundation, Inc
Inventors:
Paula J. Bates, Mohammad Tariq Malik, Kyung A. Kang
Abstract: This specification describes an adaptive robotic nursing assistant for physical tasks and patient observation and feedback. In some examples, the adaptive robotic nursing assistant includes an omni-directional mobile platform; a footrest on the omni-directional mobile platform; a handlebar located above the footrest such that a user standing on the footrest can grasp the handlebar; a display above the handlebar and at least one user input device; a robot manipulator comprising a robotic arm and an end effector on the robotic arm; and a control system coupled to the omni-directional mobile platform, the control system comprising at least one processor and memory storing executable instructions for the at least one processor to control the omni-directional mobile platform.
Type:
Application
Filed:
April 16, 2020
Publication date:
May 19, 2022
Applicant:
University of Louisville Research Foundation, Inc.
Inventors:
Sumit Kumar Das, Mohammad Nasser Saadatzi, Indika B. Wijayasinghe, Shamsudeen Olawale Abubakar, Christopher Kevin Robinson, Dan O. Popa
Abstract: Provided are methods for preventing and/or treating oral diseases, disorders, and/or conditions. In some embodiments, the methods relate to administering to the oral cavity of a subject in need thereof a composition that includes an effective amount of ginger-derived exosome-like nanoparticles (GELNs) or a biologically active component thereof. Also provided are methods for preventing and/or treating periodontitis, methods for reducing growth of and/or pathogenicity of microorganisms in the oral cavities of subjects, methods for reducing microorganismal motility, and methods for reducing bone loss in the oral cavities of subjects associated with infection with microorganisms. Also provided are compositions that can be employed in the disclosed methods.
Type:
Application
Filed:
March 2, 2020
Publication date:
May 12, 2022
Applicant:
University of Louisville Research Foundation, Inc.
Abstract: Provided are methods for isolating subpopulations of stem cells. In some embodiments, the presently disclosed methods include selecting subsets of cells that are positive for CD34 or Sca-1, are further positive for one or more of FSHR, LHCGR, PRLR, AR, ESR?, ESR?, and PGR; and are negative for each of CD45R/B220, Gr-1, TCR??, TCR??, CD11b, and Ter-119. In some embodiments, the subpopulations are further fractioning into CD45? and CD45+ fractions. Also provided are populations of stem cells isolated by the presently disclosed methods, compositions that include the presently disclosed subpopulations in pharmaceutically acceptable carriers, methods for expanding stem cells, methods for stimulating proliferation of MSCs, methods for treating subjects suffering from exposure to radiation, and methods for producing gametes in vitro.
Type:
Grant
Filed:
August 31, 2016
Date of Patent:
April 26, 2022
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
Mariusz Z. Ratajczak, Janina Ratajczak, Magdalena Kucia
Abstract: A perovskite-type oxide catalyst for water-splitting reactions is provided. The catalyst, Ca2-ySryFe1-xCo1-xMn2xO6-? where y=0.10-1.90 and x=0.05-0.95, has catalytic activity for both hydrogen- and oxygen-evolution reactions. An exemplary catalyst is CaSrFe0.75Co0.75Mn0.5O6-?.
Type:
Grant
Filed:
May 7, 2020
Date of Patent:
April 26, 2022
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
Farshid Ramezanipour, Ram K. Hona, Surendra B. Karki
Abstract: Methods for wet chemical synthesis of lithium argyrodites are provided, which in some embodiments include dissolving a stoichiometric mixture of precursors in a small quantity of solvent in an argon atmosphere, drying the mixture under vacuum or an inert gas atmosphere to evaporate the solvent, and then annealing to obtain a final lithium argyrodite product. Further embodiments comprise synthesizing the precursors, excess halide doping to achieve higher ionic conductivity, and the use of carboxylic acid esters to enhance the interfacial properties of high-performance lithium batteries.
Type:
Application
Filed:
December 7, 2021
Publication date:
March 24, 2022
Applicant:
University of Louisville Research Foundation, Inc.
Abstract: Methods for ex vivo expansion of very small embryonic like stem cells in the absence of feeder cells are provided. In some embodiments the methods include providing a plurality of VSELs; and growing the VSELs in a culture medium that includes a histone deacetylase inhibitor, luteinizing hormone, follicle-stimulating hormone, and optionally transforming growth factor beta in an amount that is sufficient to overcome quiescence of the VSELs. Also provided are feeder cell-free cell cultures, ex vivo expanded VSELs, pharmaceutical compositions that include the disclosed ex vivo expanded VSELs, methods for overcoming quiescence in VSELs, methods for re-establishing imprinting in VSELs, method for treating injuries to tissues in subjects, methods for repopulating cell types in subjects, methods for bone marrow transplantation, methods for treating radiation exposure in subjects, and methods that relate to regenerative medicine.
Type:
Application
Filed:
July 26, 2021
Publication date:
February 24, 2022
Applicant:
University of Louisville Research Foundation, Inc.
Inventors:
Mariusz Z. Ratajczak, Janina Ratajczak, Magdalena Kucia, Donald Miller
Abstract: Evaluating a pressure ulcer includes: detecting in a color input image a boundary of the pressure ulcer to get a RGB region of interest (ROI) image; converting the RGB ROI image to a grayscale ROI image; processing the grayscale ROI image using a Linear Combination of Discrete Gaussians (LCDG) process to estimate three main class probabilities of the grayscale ROI image; processing the RGB ROI image using predetermined RGB values to estimate the three main class probabilities of the RGB ROI image; and combining the probabilities of the grayscale ROI image and the probabilities of the RGB ROI image to determine an estimated labeled image; and normalizing and refining the estimated labeled image using a Generalized Gauss-Markov Random Field (GGMRF) process to produce a final segmentation image.
Type:
Grant
Filed:
May 18, 2018
Date of Patent:
February 1, 2022
Assignees:
University of Louisville Research Foundation, Inc, Fundacion Deusto, Universidad de Deusto
Inventors:
Adel S. Elmaghraby, Maria Begoña García-Zapirain Soto, Ayman Sabry El-Baz
Abstract: A computer aided diagnostic system and automated method to classify a kidney utilizes medical image data and clinical biomarkers in evaluation of kidney function pre- and post-transplantation. The system receives image data from a medical scan that includes image data of a kidney, then segments kidney image data from other image data of the medical scan. The kidney is then classified by analyzing at least one feature determined from the kidney image data and the at least one clinical biomarker.
Type:
Grant
Filed:
February 22, 2019
Date of Patent:
February 1, 2022
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
Ayman S. El-Baz, Amy Dwyer, Ahmed Soliman, Mohamed Shehata, Hisham Abdeltawab, Fahmi Khalifa
Abstract: Described herein are methods for treating and preventing cancer. In particular, described herein are methods using SA-4-1BBL as a monotherapy agent to treat, prevent or reduce the risk of cancer, treat, prevent, or reduce the risk of tumorigenesis, and treat, prevent, or reduce the risk of post-surgical tumor recurrence. SA-4-1BBL for use as a monotherapy in such methods also is provided.
Type:
Application
Filed:
November 15, 2019
Publication date:
January 13, 2022
Applicants:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC., FASCURE THERAPEUTICS, LLC
Inventors:
Haval SHIRWAN, Esma S. YOLCU, Rajesh SHARM