Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds and prodrugs thereof that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
Type:
Grant
Filed:
February 1, 2019
Date of Patent:
May 12, 2020
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
Type:
Grant
Filed:
February 12, 2018
Date of Patent:
February 18, 2020
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Inventors:
Katherine L. Radtke, Kartik Temburnikar
Abstract: A vibrating platform for the deploying of passive sampling devices in sediments and other media to be sampled. The vibrating platform can greatly enhance the rate of mass transfer of analytes, such as polycyclic aromatic hydrocarbons and polychlorinated biphenyls, into passive sampler material by disrupting the formation of a depletion layer in proximity of the passive sampler material.
Type:
Grant
Filed:
September 28, 2017
Date of Patent:
February 4, 2020
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Abstract: The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes of mRNA splicing in combination with a compound that modulates/inhibits activity of an RNA splicing factor protein. Further, changes in splicing of mRNAs and phosphorylation of RNA splicing factors can be used as biomarkers for patient responsiveness to anti-PIM treatment and also suggest effective combinatorial therapies, including synergistic combination.
Type:
Grant
Filed:
March 22, 2017
Date of Patent:
January 7, 2020
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Inventors:
Charles J. Bieberich, Xiang Li, Tejashree Joglekar
Abstract: The present invention discloses methods and systems to control magnetic fields and magnetic field induced currents, and more particularly to provide stimulations within a patient's body, such as deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. In accordance with certain aspects of an embodiment, an array of magnetic coils is provided and positionable about a portion of a patient's body. During operation, at least some of the magnetic coils function as DC coil pairs configured to generate a DC magnetic field, while at least some DC coil of the other magnetic coils function as transient magnetic field generators to generate an induced current within a portion of the patient's body, such as in a region of the patient's brain.
Type:
Grant
Filed:
April 2, 2015
Date of Patent:
December 31, 2019
Assignees:
University of Maryland, Baltimore, University of Maryland, Baltimore County
Abstract: Separation methods and systems for converting high concentrations of animal wastes into nutrients and other useful products such as struvite and potassium struvite. Advantageously, the system and methods do not require the addition of external chemicals other than an acid and a base.
Type:
Grant
Filed:
May 12, 2017
Date of Patent:
November 5, 2019
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
Type:
Grant
Filed:
April 30, 2018
Date of Patent:
October 8, 2019
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Abstract: Methods employed for the discovery, enrichment, and characterization of a marine consortium of fermentative and methanogenic microorganisms developed from the solid waste digestor of a fully contained, land-based, marine recirculating aquaculture system are described. The methanogenic microbial consortium discovered is capable of reducing over 90% of marine fish waste in an aquaculture system to biomethane and carbon dioxide at saline concentrations found in marine aquaculture. Systems and methods for the treatment of marine fish waste utilizing the methanogenic marine consortium are also disclosed.
Abstract: The present invention provides for a therapeutic cancer treatment using a soluble CD80 fusion protein that binds to PDL1 and inhibits PDL1-PD1 interactions thereby overcoming PDL1-induced immune suppression and restoring T cell activation.
Type:
Grant
Filed:
April 20, 2017
Date of Patent:
August 13, 2019
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Abstract: The present invention provides for excitable molecules positioned near metallic structures, wherein the metallic structures have a particles size from about 1 nm to 1000 nm and wherein the excitable molecules have fluorescence, phosphorescence or alpha-fluorescence emissions that are altered due to positioning near the metal structures. The emission spectra are distorted on either the blue or red edges in a range from 1 to 10 nm thereby changing the color of emissions. Further, the width of the emission spectrum is modified either by narrowing or broadening depending on the material of the metallic structures and type of excitable molecule.
Type:
Grant
Filed:
January 13, 2016
Date of Patent:
August 13, 2019
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Abstract: A turbulence-free CCD camera system with nonclassical imaging resolution, for applications in long-distance imaging, such as satellite and aircraft-to-ground based distant imaging, utilizing an intensity-fluctuation correlation measurement of thermal light. The proposed camera system has the following advantages over classic imaging technology: (1) it is turbulence-free; (2) its spatial resolution is mainly determined by the angular diameter of the light source. For example, using sun as the light source, this camera may achieve a spatial resolution of 200 micrometer for any object on Earth. 200-micrometer resolution is insignificant for short distance imaging, however, taking a picture of a target at 10-kilometer, a classic camera must have a lens of 90-meter diameter in order to achieve 200-micrometer resolution.
Abstract: The present invention provides for nutrient extraction and recovery devices that use the Donnan Membrane Principle (DMP) to cause spontaneous separation of dissolved ions along electrochemical potential gradients, wherein anions and cations such as H2PO4?, HPO42?, PO43?, Mg2+, Ca2+, NH4+, and K+ are moved from manure containing waste streams through cation and anion exchange membranes into a recovery stream thereby precipitating target compounds including but not limited to struvite, potassium struvite and hydroxyapatite.
Type:
Grant
Filed:
December 16, 2016
Date of Patent:
June 25, 2019
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Abstract: The present invention provides for novel fucosidase mutants that server as fuco-ligases for core fucosylation of a range of biological glycopeptides and glycoproteins including intact therapeutic antibodies. Several mutants with mutation at the general acid/base residue E274 of the Lactobacillus casei ?1,6-fucosidase, including E274A, E274S, and E274G, were able to efficiently fucosylate a wide variety of complex N-glycopeptides and intact glycoproteins. The site specific mutants enable the transfer of fucose to a core GlcNAc-Asn residue and useful for drug delivery and vaccine development.
Type:
Application
Filed:
August 10, 2017
Publication date:
June 20, 2019
Applicant:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Abstract: A camera and imaging method with nonclassical imaging resolution, for applications in long-distance imaging, such as satellite and aircraft-to-ground based distant imaging, utilizing an intensity-fluctuation correlation measurement of thermal light.
Abstract: The present invention provides for lysing systems and methods to rapidly lyse bugs, bacteria, viruses, cells and/or algae in an efficient manner in addition to fragmenting DNA and/or RNA onto smaller pieces. Solutions or gases containing the biological material to be lysed are introduced or pumped (flow) between two or more apexes of metallic triangles with microwave energy focused at the apexes. Subsequently, the rapid heating of fluid between the apexes lyses cells allows for increased collection of the lysate, the inner genetic materials or other components for further purification or isolating thereafter.
Type:
Grant
Filed:
April 21, 2016
Date of Patent:
May 21, 2019
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
Type:
Grant
Filed:
July 2, 2018
Date of Patent:
March 12, 2019
Assignees:
University of Maryland, Baltimore County, Katholieke Universiteit Leuven/Lieden University Medical Center, RC Leiden
Inventors:
Katherine L. Radtke, Hannah Peters, Johan Neyts, Dirk Jochmans, Eric J. Snijder
Abstract: Systems and methods for proximity-based position, movement and gesture detection are provided that utilize capacitive sensor arrays. In one embodiment, the system utilizes textile-based capacitive sensor arrays that can be integrated into other textiles, such as clothing, bed linens, etc., or that can be integrated into the environment (e.g., furniture, wheelchairs, car seats, etc.). The system recognizes gestures from detected movement by utilizing hierarchical signal processing techniques.
Type:
Grant
Filed:
October 24, 2014
Date of Patent:
March 12, 2019
Assignee:
University of Maryland, Baltimore County
Abstract: A mid-infrared cascading fiber amplifier device having a source configured to generate a first electromagnetic wave output at a first frequency, a fiber coupled to the source and a pump coupled to the fiber and configured to generate a second electromagnetic wave output at a second frequency, wherein the second frequency is higher than the first frequency and causes the fiber to undergo two or more transitions in response to stimulation by the first electromagnetic wave output at the first frequency, wherein the first transition generates the first electromagnetic wave output approximately at the first frequency and the second transition generates the first electromagnetic wave output approximately at the first frequency.
Type:
Grant
Filed:
March 11, 2016
Date of Patent:
December 25, 2018
Assignees:
BAYLOR UNIVERSITY, UNIVERSITY OF MARYLAND BALTIMORE COUNTY
Abstract: Methods for the production of reproductively sterile fish and aquatic animals for aquaculture, the aquarium trade, and control of invasive species are described. The methods include disruption of gonadal development through the administration of compounds that lead to the failure of fertile gonadal development. Compounds may be delivered to the eggs prior to fertilization or water activation or post fertilization and water activation by contacting unfertilized or pre-water-activated fertilized eggs or fertilized eggs in an immersion medium including the compound of interest. Compounds may be conjugated with a molecular transporter compound effective for chorionic transport of the conjugate. The compounds may be antisense Morpholino oligomers that are capable of effectively suppressing the expression of the dead end gene or other essential genes for germ cell development in fish and other egg-producing aquatic animals.