Patents Assigned to University of Maryland Baltimore County
  • Patent number: 10136621
    Abstract: Methods for the production of reproductively sterile fish and aquatic animals for aquaculture, the aquarium trade, and control of invasive species are described. The methods include disruption of gonadal development through the administration of compounds that lead to the failure of fertile gonadal development. Compounds may be delivered to the eggs prior to fertilization or water activation or post fertilization and water activation by contacting unfertilized or pre-water-activated fertilized eggs or fertilized eggs in an immersion medium including the compound of interest. Compounds may be conjugated with a molecular transporter compound effective for chorionic transport of the conjugate. The compounds may be antisense Morpholino oligomers that are capable of effectively suppressing the expression of the dead end gene or other essential genes for germ cell development in fish and other egg-producing aquatic animals.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: November 27, 2018
    Assignee: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
    Inventors: Yonathan Zohar, Ten-Tsao Wong
  • Publication number: 20180295817
    Abstract: Methods are provided for delivery of at least one agent into egg(s) from an egg-producing aquatic animal including contacting fertilized or unfertilized egg(s) from said egg-producing aquatic animal with the at least one agent in the presence of a guanidine-containing compound capable of enhancing the permeability of the chorion of the egg(s). Methods are provided for the drug screening and compound toxicity assays. Methods are also provided for the production of reproductively sterile fish and aquatic animals for aquaculture, the aquarium trade, and control of invasive species are described. The methods include disruption of gonadal development through the administration of agents that lead to the failure of fertile gonadal development. Agents may be delivered to the eggs directly before the fertilization or post fertilization by contacting eggs in an immersion medium including the agent of interest.
    Type: Application
    Filed: May 17, 2016
    Publication date: October 18, 2018
    Applicant: University of Maryland Baltimore County
    Inventors: Ten-Tsao Wong, Yonathan Zohar
  • Patent number: 10078013
    Abstract: The invention provides methods and apparatus comprising a multi-wavelength laser source that uses a single unfocused pulse of a low intensity but high power laser over a large sample area to collect Raman scattered collimated light, which is then Rayleigh filtered and focused using a singlet lens into a stacked fiber bundle connected to a customized spectrograph, which separates the individual spectra from the scattered wavelengths using a hybrid diffraction grating for collection onto spectra-specific sections of an array photodetector to measure spectral intensity and thereby identify one or more compounds in the sample.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: September 18, 2018
    Assignee: University of Maryland Baltimore County
    Inventors: Bradley Arnold, Christopher Cooper, John Cataldi
  • Patent number: 10058516
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: August 28, 2018
    Assignees: University of Maryland Baltimore County, Katholieke Universiteit Leuven, Leiden University Medical Center
    Inventors: Katherine L. Radtke, Hannah L. Peters, Johan Neyts, Dirk Jochmans, Eric J. Snijder
  • Patent number: 10060923
    Abstract: The present invention provides for a system and method to detect low levels of the anthrax protective antigen (PA) exotoxin in biological fluids, wherein the system uses a metal-enhanced fluorescence (MEF)-PA assay in combination with microwave-accelerated PA protein surface absorption. Microwave irradiation rapidly accelerates PA deposition onto the surface adjacent to deposited metallic particles and significantly speeding up the MEF-PA assay and resulting in a total assay run time of less than 40 min with an analytical sensitivity of less than 1 pg/ml PA.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: August 28, 2018
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Chris D. Geddes
  • Patent number: 10024850
    Abstract: The present invention relates to surface plasmon-coupled bioluminescence, wherein bioluminescent emission from a bioluminescent chemical reaction couples to surface plasmons in metallized particles thereby enhancing the signal. Importantly, these plasmonic emissions emitted from metallic particles generated without an external excitation source but instead from induced electronically excited states caused by the bioluminescent chemical reaction.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: July 17, 2018
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Chris D. Geddes
  • Patent number: 10024794
    Abstract: Nickel, iron and palladium thin films thermally evaporated onto glass supports are used to demonstrate surface plasmon coupled fluorescence (SPCF) and surface plasmon couple chemiluminescence (SPCC) over a broad wavelength range (400-800 nm) for potential assays or other detection systems. Nickel, iron and palladium thin films used in SPCF and SPCC convert otherwise isotropic emission into highly directional and polarized emission, an attractive concept for surface assays. The emission angles of detected emissions occur over a 10 degree range for tested emitted wavelengths.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: July 17, 2018
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Chris D. Geddes
  • Patent number: 9999208
    Abstract: Methods for the production of reproductively sterile fish and aquatic animals for aquaculture, the aquarium trade, and control of invasive species are described. The methods include disruption of gonadal development through the administration of compounds that lead to the failure of fertile gonadal development. Compounds may be delivered to the eggs prior to fertilization or water activation or post fertilization and water activation by contacting unfertilized or pre-water-activated fertilized eggs or fertilized eggs in an immersion medium including the compound of interest. Compounds may be conjugated with a molecular transporter compound effective for chorionic transport of the conjugate. The compounds may be antisense Morpholino oligomers that are capable of effectively suppressing the expression of the dead end gene or other essential genes for germ cell development in fish and other egg-producing aquatic animals.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: June 19, 2018
    Assignee: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
    Inventors: Yonathan Zohar, Ten-Tsao Wong
  • Patent number: 9991771
    Abstract: This invention relates to an active control system for a variable electromotive-force generator (VEG) for use in wind turbines, ships, hybrid vehicles, and related applications.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: June 5, 2018
    Assignee: THE UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Weidong Zhu, Navid Goudarzi, Xuefeng Wang
  • Patent number: 9982227
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: May 29, 2018
    Assignee: University of Maryland, Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Xudong Ge, Douglas Frey
  • Patent number: 9895374
    Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: February 20, 2018
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Katherine L. Radtke, Kartik Temburnikar
  • Patent number: 9883823
    Abstract: Systems and methods for determining an in vivo concentration of a small molecule substance of interest is provided that takes advantage of the semi-permeable nature of skin, which allows small molecules to passively diffuse through the skin and onto the skin surface. The systems and methods of the present invention allow for the collection of these small molecules that have passively diffused through the skin without skin disruption or breaking of the skin. The systems and methods of the present invention are noninvasive, painless and safe even for delicate newborns, and are particularly suited for the determination of blood glucose in newborns and infants in a noninvasive manner.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: February 6, 2018
    Assignee: University of Maryland Baltimore County
    Inventors: Leah Tolosa, Xudong Ge, Yordan Kostov, Michael Tolosa, Govind Rao
  • Patent number: 9816990
    Abstract: The present invention provides for a system and method to detect low levels of the anthrax protective antigen (PA) exotoxin in biological fluids, wherein the system uses a metal-enhanced fluorescence (MEF)-PA assay in combination with microwave-accelerated PA protein surface absorption. Microwave irradiation rapidly accelerates PA deposition onto the surface adjacent to deposited metallic particles and significantly speeding up the MEF-PA assay and resulting in a total assay run time of less than 40 min with an analytical sensitivity of less than 1 pg/ml PA.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: November 14, 2017
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Chris D. Geddes
  • Patent number: 9810637
    Abstract: The present invention relates to detection systems and methods that detect fluorescence, luminescence, chemiluminescence or phosphorescence signatures in the form of an electrical signal conducted and emitted from metallic containing surfaces. Thus, the present invention provides for detecting fluorescence digitally and directly without the need for expensive detectors.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: November 7, 2017
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Chris D. Geddes
  • Patent number: 9784682
    Abstract: The present invention relates to an optical imaging system communicatively connected to a microwave energy producing source wherein the combination provides for increases in chemical reaction times and the ability to monitor the reactions in real time with sufficient resolution to view the location of intracellular components labeled with luminescent molecules as well as interaction with other biomolecules and responses to localized environmental variables in living cells and tissues during the application of a microwave field.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: October 10, 2017
    Assignee: University of Maryland, Baltimore County
    Inventors: Chris D. Geddes, Michael J. R. Previte
  • Patent number: 9719923
    Abstract: The present invention provides for the surface plasmon-enhancement of long lived luminescent compounds, thereby providing for methods and systems having enhanced and controllable rates of the radiative emission of such relaxation of long lived luminescent compounds. The present invention achieves acceleration of the radiative processes by the interaction of the long lived luminescent compounds with surface plasmons of the metal surfaces.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: August 1, 2017
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Chris D. Geddes
  • Patent number: 9708494
    Abstract: The present invention relates to a method for fabricating a new silver coating/nanoparticle scaffold that significantly enhances the luminescence of near-field fluorophores via the metal enhanced fluorescence phenomenon. The silver coating/nanoparticle scaffold can be used for numerous applications in metal-enhanced fluorescence.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: July 18, 2017
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Chris D. Geddes, Anatoliy I. Dragan
  • Publication number: 20170166929
    Abstract: Methods employed for the discovery, enrichment, and characterization of a marine consortium of fermentative and methanogenic microorganisms developed from the solid waste digestor of a fully contained, land-based, marine recirculating aquaculture system are described. The methanogenic microbial consortium discovered is capable of reducing over 90% of marine fish waste in an aquaculture system to biomethane and carbon dioxide at saline concentrations found in marine aquaculture. Systems and methods for the treatment of marine fish waste utilizing the methanogenic marine consortium are also disclosed.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 15, 2017
    Applicant: University of Maryland Baltimore County
    Inventor: Kevin R. Sowers
  • Patent number: 9650429
    Abstract: The present invention provides for a therapeutic cancer treatment using a soluble CD80 fusion protein that binds to PDL1 and inhibits PDL1-PD1 interactions thereby overcoming PDL1-induced immune suppression and restoring T cell activation.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: May 16, 2017
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Suzanne Ostrand-Rosenberg
  • Patent number: 9637402
    Abstract: A process for treatment of sludge made up of saline organic solids or organic waste produced in a saltwater or brackish aquaculture system is described. The process includes use of a modified reactor, operating under anaerobic conditions, which yields methane from the digestion of the saline organic solids. Modification of a traditional reactor to include a packing substrate provides for saline waste digestion not previously known. Additionally provided is a process for producing methane from the digestion of organic solids. Inclusion of and use of modified reactors in aquaculture systems is also provided.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: May 2, 2017
    Assignee: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
    Inventors: Yossi Tal, Kevin R. Sowers