Patents Assigned to University of Massachusetts at Lowell
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Patent number: 7601378Abstract: The following is an examiner's statement of reasons for allowance: an antioxidant polymer and method of preparing, the antioxidant comprising repeat units that include one or both of Structural Formulas (I) and (II) wherein R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group is not taught nor fairly suggested by the prior art or any combination thereof.Type: GrantFiled: September 26, 2005Date of Patent: October 13, 2009Assignees: University of Massachusetts Lowell, The United States of America as represented by the Secretary of the ArmyInventors: Ashok L. Cholli, Vijayendra Kumar, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
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Patent number: 7595074Abstract: A method of preparing a phenolic polymer comprising: a) protecting at least one hydroxyl group of a substituted or unsubstituted phenol represented by Structural Formula (XXIX), wherein: R11, R12, R13, R14 and R15 are independently —H, —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, a substituted or unsubstituted alkoxycarbonyl or aryloxycarbonyl group, a substituted or unsubstituted alkoxy group or a saturated or unsaturated carboxylic acid group; or R11, R12, R13, R14 or R15, in conjunction with an adjacent R11, R12, R13, R14 or R15, forms a substituted or unsubstituted alkylene dioxy group; provided that at least one of R11, R12, R13, R14 or R15 is a tert-butyl group 1-ethenyl-2-carboxylic acid or ester thereof, a substituted or unsubstituted alkylene dioxy group or a substituted or unsubstituted n-alkoxycarbonyl group, at least one of R11, R12, R13, R14 or R15 is a hydroxyl group, and at least one of R11, R12, R13, R14 and R15 is —H; with a protecting group, wherein thereby obtaining onType: GrantFiled: January 21, 2004Date of Patent: September 29, 2009Assignees: University of Massachusetts Lowell, The United States of America as represented by the Secretary of the ArmyInventors: Ashok L. Cholli, Vijayendra Kumar, Ashish Dhawan, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
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Publication number: 20090190135Abstract: The invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell culture. In particular, the invention provides hydrogel materials, apparatus and methods for several non-invasive techniques of maintaining glucose and pH levels in cell cultures at near-optimal levels and the non-invasive measurement of pH levels in cell cultures.Type: ApplicationFiled: November 26, 2008Publication date: July 30, 2009Applicant: UNIVERSITY OF MASSACHUSETTS LOWELLInventors: Lisa-Jo Ann CLARIZIA, Daniel Schmidt, Emmanuelle Reynaud, Melisenda J. Mcdonald, Xingwei Wang
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Publication number: 20090163672Abstract: Methods are described herein for converting carbocationically terminated polymers to anionically terminated polymers. These methods comprise: (a) providing a carbocationically terminated polymeric moiety; (b) reacting the carbocationically terminated polymeric moiety with a heterocyclic compound of the formula where —X— is selected from —S—, —O—, —NH— and —NR—, and where R is an alkyl group or an aryl group, thereby providing an end-capped polymeric moiety; and (c) reacting the end-capped polymeric moiety with an organolithium compound to yield an anionically terminated polymeric moiety. Also described are block copolymers in which a first polymer block comprising cationically polymerized monomers is linked to a second polymer block comprising anionically polymerized monomers by a group, as well as a polymer in which a polymer block comprising cationically polymerized monomers is linked to a halogenated silane residue or a carbosilane residue by a group.Type: ApplicationFiled: July 30, 2008Publication date: June 25, 2009Applicant: UNIVERSITY OF MASSACHUSETTS LOWELLInventors: Rudolf FAUST, Axel H.E. Mueller
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Publication number: 20090110745Abstract: The present invention provides methods for improving cognitive function, improving mood, and decreasing aggression in a normal adult subject, and in a subject having symptoms characteristic of a neurological disorder, by administration of a nutriceutical formulation of the invention to the subject. The invention additionally features methods of treating neurological disorders, depression, and aggression using nutriceutical formulations. Nutriceutical compositions and formulations for use in the methods of the invention, and kits containing nutriceutical compositions and formulations, are also provided.Type: ApplicationFiled: April 4, 2008Publication date: April 30, 2009Applicant: UNIVERSITY OF MASSACHUSETTS LOWELLInventors: Thomas B. Shea, Amy Y. Chan-Daniels
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Patent number: 7507454Abstract: Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Rings A and B are each optionally substituted with one or more groups selected from the group consisting of —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, and a substituted or unsubstituted alkoxycarbonyl group; n is an integer equal to or greater than 2; and p is an integer equal to or greater than 0. The invention also includes methods of using and preparing these polymers.Type: GrantFiled: February 27, 2007Date of Patent: March 24, 2009Assignees: University of Massachusetts Lowell, United States of America as represented by the Secretary of the ArmyInventors: Ashok L. Cholli, Vijayendra Kumar, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
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Patent number: 7479329Abstract: Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.Type: GrantFiled: September 26, 2007Date of Patent: January 20, 2009Assignees: University of Massachusetts/Lowell, The United States of America as represented by the Secretary of the ArmyInventors: Susan Tripathy, legal representative, Lynne A. Samuelson, Ferdinando F. Bruno, Sucharita Roy, Ramaswamy Nagarajan, Jayant Kumar, Bon-Cheol Ku, Soo-Hyoung Lee, Sukant Tripathy
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Publication number: 20080274195Abstract: The present invention discloses an improved nanoemulsion comprising a uniform and discrete range of very small particle nano-sized diameters. This uniformity results in improved bioavailability of incorporated compounds (i.e., pharmaceuticals or nutraceuticals) as reflected in various pharmacokinetic parameters including, but not limited to, decreased Tmax, increased Cmax, and increased AUC. The improved method of making these uniform nanoemulsions utilizes microfluidization which differs in both process and mechanics when compared to conventional milling and grinding techniques used to generate nanoparticulate compositions. Further, the improvement results, in part, from a novel step of mixing a substantially soluble compound into a heated dispersion medium. This is unlike current nanoparticulate composition methods that mix an insoluble compound with an unheated dispersion medium. Further, these nanoemulsions are observed to be bacterial-resistant and stable to extremes in both temperature and pH changes.Type: ApplicationFiled: July 11, 2006Publication date: November 6, 2008Applicant: University of Massachusetts LowellInventors: Robert Nicolosi, Thomas Wilson
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Publication number: 20080234754Abstract: The invention relates to novel internal fixation devices, such as bone plates, generally and novel craniomaxillofacial bone plates more specifically and systems for bonding the same. More specifically, the invention relates to bone plates made of a polymer blend of (poly)lactic acid and Ecoflex as well as a novel hot-melt adhesive polymer blend of the same material.Type: ApplicationFiled: April 13, 2007Publication date: September 25, 2008Applicant: University of Massachusetts - LowellInventors: Stephen McCarthy, Jeffrey Weinzweig
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Publication number: 20080218732Abstract: Methods and systems for generating near-infrared (NIR) images of biological targets are discussed. In one aspect, one or more radiation sources illuminate a target, with one or more detectors receiving the transmitted radiation. Such equipment can be used to generate a plurality of NIR images of a target. The images can be converted into frequency space, combined using chosen weighting factors, and deconvoluted into the spatial domain to provide a composite image. The composite image can have enhanced quality relative to the individual images, allowing for a richer set of information to be displayed. Other aspects such as scanning, background illumination correction, the use of filters, and additional techniques are also discussed.Type: ApplicationFiled: July 24, 2006Publication date: September 11, 2008Applicant: University of Massachusetts LowellInventors: Samson Mil'shtein, Niyom Lue
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Patent number: 7417092Abstract: Methods are described herein for converting carbocationically terminated polymers to anionically terminated polymers. These methods comprise: (a) providing a carbocationically terminated polymeric moiety; (b) reacting the carbocationically terminated polymeric moiety with a heterocyclic compound of the formula where —X— is selected from —S—, —O—, —NH— and —NR—, and where R is an alkyl group or an aryl group, thereby providing an end-capped polymeric moiety; and (c) reacting the end-capped polymeric moiety with an organolithium compound to yield an anionically terminated polymeric moiety. Also described are block copolymers in which a first polymer block comprising cationically polymerized monomers is linked to a second polymer block comprising anionically polymerized monomers by a group, as well as a polymer in which a polymer block comprising cationically polymerized monomers is linked to a halogenated silane residue or a carbosilane residue by a group.Type: GrantFiled: June 18, 2004Date of Patent: August 26, 2008Assignee: University of Massachusetts LowellInventors: Rudolf Faust, Axel H. E. Mueller
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Publication number: 20080090103Abstract: Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.Type: ApplicationFiled: September 26, 2007Publication date: April 17, 2008Applicants: University of Massachusetts Lowell, Government of the United States, as Represented by the Secretary of the ArmyInventors: Sukant Tripathy, Susan Tripathy, Lynne Samuelson, Ferdinando Bruno, Sucharita Roy, Ramaswamy Nagarajan, Jayant Kumar, Bon-Cheol Ku, Soo-Hyoung Lee
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Patent number: 7323511Abstract: A method of preparing an antioxidant polymer includes forming or obtaining a first polymer having reactive pendant groups, where the first polymer does not include cyclic anhydride repeat units, and derivatizing the first polymer with an antioxidant. Another method of preparing an antioxidant polymer includes forming or obtaining a first polymer having reactive pendant groups and derivatizing the first polymer with an antioxidant, where the antioxidant is attached to the first polymer by an acetal, amide, amine, carbamate, carbonate, ester, ether or thioether linkage or by a carbon-carbon bond. The invention is also directed to polymers that are generally prepared by these methods, compositions that include such polymers and methods of using such polymers.Type: GrantFiled: January 21, 2005Date of Patent: January 29, 2008Assignee: University of Massachusetts LowellInventors: Ashok L. Cholli, Ashish Dhawan, Vijayendra Kumar
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Patent number: 7294686Abstract: Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.Type: GrantFiled: January 23, 2006Date of Patent: November 13, 2007Assignees: University of Massachusetts Lowell, United States of America as Represented by the Secretary of the ArmyInventors: Susan Tripathy, legal representative, Lynne A. Samuelson, Ferdinando F. Bruno, Sucharita Roy, Ramaswamy Nagarajan, Jayant Kumar, Bon-Cheol Ku, Soo-Hyoung Lee, Sukant Tripathy, deceased
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Patent number: 7226979Abstract: Novel copolymers, including block copolymers, which comprise: (a) a plurality of constitutional units that correspond to one or more olefin monomer species and (b) a plurality of constitutional units that correspond to one or more protected or unprotected hydroxystyrene monomer species.Type: GrantFiled: February 11, 2004Date of Patent: June 5, 2007Assignee: University of Massachusetts LowellInventors: Rudolf Faust, Laszlo Sipos
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Publication number: 20060223946Abstract: According to an aspect of the present invention, a method is provided in which a double diphenylethylene compound is reacted with a polymer that contains a carbocationically terminated chain thereby providing a 1,1-diphenylene end-functionalized chain. Subsequently, an alkylating agent is reacted with the 1,1-diphenylene end-functionalized chain, thereby providing an alkylated 1,1-diphenylene end-functionalized chain. In some embodiments, the method further comprises (a) optionally combining a 1,1-diphenylorganolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer followed by (b) reacting an organolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer. This provides an anionically terminated polymer, which can be used, for example, in subsequent anionic polymerization and coupling reactions.Type: ApplicationFiled: June 5, 2006Publication date: October 5, 2006Applicant: University of Massachusetts LowellInventors: Rudolf Faust, Jae Cho
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Patent number: 7056985Abstract: According to an aspect of the present invention, a method is provided in which a double diphenylethylene compound is reacted with a polymer that contains a carbocationically terminated chain thereby providing a 1,1-diphenylene end-functionalized chain. Subsequently, an alkylating agent is reacted with the 1,1-diphenylene end-functionalized chain, thereby providing an alkylated 1,1-diphenylene end-functionalized chain. In some embodiments, the method further comprises (a) optionally combining a 1,1-diphenylorganolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer followed by (b) reacting an organolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer. This provides an anionically terminated polymer, which can be used, for example, in subsequent anionic polymerization and coupling reactions.Type: GrantFiled: February 11, 2004Date of Patent: June 6, 2006Assignee: University of Massachusetts LowellInventors: Rudolf Faust, Jae Cheol Cho
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Patent number: 7031502Abstract: A guide can provide proper registration of an object such as a hand above a scanner device for imaging. The guide can include windows or slits so that the scanner device can produce an image such as a finger or palm in a natural state rather than being pressed against, for example, a flat surface such as glass. Thus, registration of a palm and/or a finger in the guide can be used to produce non-distorted high quality images of biometric patterns in their natural 3-dimensional state.Type: GrantFiled: January 25, 2002Date of Patent: April 18, 2006Assignee: University of Massachusetts LowellInventors: Samson Mil'shtein, Jason Pinsonnault, Craig M. LaBrecque
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Patent number: 6961449Abstract: A method and apparatus for computing correlating images for image recognition is provided. In particular, the method is used to compare images of a biometric object to authorize an individual or verify whether an individual is the person he claims to be. The biometric objects may include fingerprints, hand or palm prints, and retina scans. The method uses a deviation of symmetry of correlation functions to determine whether the images are of a same object.Type: GrantFiled: January 16, 2002Date of Patent: November 1, 2005Assignee: University of Massachusetts LowellInventors: Samson Mil'shtein, Joel Therrien
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Publication number: 20050238789Abstract: A method of preparing an antioxidant polymer includes forming or obtaining a first polymer having reactive pendant groups, where the first polymer does not include cyclic anhydride repeat units, and derivatizing the first polymer with an antioxidant. Another method of preparing an antioxidant polymer includes forming or obtaining a first polymer having reactive pendant groups and derivatizing the first polymer with an antioxidant, where the antioxidant is attached to the first polymer by an acetal, amide, amine, carbamate, carbonate, ester, ether or thioether linkage or by a carbon-carbon bond. The invention is also directed to polymers that are generally prepared by these methods, compositions that include such polymers and methods of using such polymers.Type: ApplicationFiled: January 21, 2005Publication date: October 27, 2005Applicant: University of Massachusetts LowellInventors: Ashok Cholli, Ashish Dhawan, Vijayendra Kumar