Patents Assigned to University of Medicine and Dentistry of New Jersey
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Patent number: 9102617Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R3-R8 and X and Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.Type: GrantFiled: June 24, 2011Date of Patent: August 11, 2015Assignees: Rutgers, The State University of New Jersey, University of Medicine and Dentistry of New JerseyInventors: Edmond J. Lavoie, Ajit Parhi, Daniel S. Pilch
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Patent number: 9017935Abstract: Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I derived vector pro virus, which upon activation expresses a marker for late viral gene expression due to the insertion of the marker gene in the position of HIV-I envelope.Type: GrantFiled: July 17, 2012Date of Patent: April 28, 2015Assignee: University of Medicine and Dentistry of New JerseyInventors: Joseph P. Dougherty, Sofiya Micheva-Viteva, Stuart W. Peltz, Yacov Ron, Annmarie Pacchia
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Publication number: 20150018274Abstract: The present invention provides isolated stabilized EPO-derived peptides and their mimics that protect against tissue damage in subjects having diverse forms of neural and non-neural organ system injury, pharmaceutical compositions containing the isolated stabilized EPO-derived peptides, methods for treating symptoms of a disease, disorder or condition having an inflammatory or an autoimmune component in a subject in need thereof, and methods for downregulating immune mediator activity in a subject in need thereof.Type: ApplicationFiled: January 23, 2014Publication date: January 15, 2015Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEYInventors: Yasuhiro Maeda, Rui Rong Yuan, Joseph Menonna, Wei Ping Li, Peter Dowling
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Patent number: 8933096Abstract: The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein R1, R4-R8, R10, R2?-R6?, W, and A have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents.Type: GrantFiled: June 9, 2011Date of Patent: January 13, 2015Assignees: Rugers, The State University of New Jersey, University of Medicine and Dentistry of New JerseyInventors: Edmond J. Lavoie, Ajit Parhi, Daniel S. Pilch
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Publication number: 20140295416Abstract: The invention relates to pharmaceutical compositions comprising of FRY polypeptides and nucleotides, methods to treat cancer, methods to diagnose cancer, and methods to determine the effectiveness of the treatment of cancer, as well as methods to differentiate stem cells.Type: ApplicationFiled: December 6, 2011Publication date: October 2, 2014Applicant: University of Medicine and Dentistry of New JerseyInventors: Helmut Zarbl, Jessica Graham
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Publication number: 20140256720Abstract: Methods for regulating cancer cell growth and survival, inhibiting cancer cell growth, promoting cancer cell death, and/or treating a cancer make use of antagonists of a type I BMP receptor. In some embodiments the cancer is a lung cancer and the cancer cell is a lung cancer cell.Type: ApplicationFiled: July 25, 2012Publication date: September 11, 2014Applicants: UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY, VANDERBILT UNIVERSITYInventors: Charles C. Hong, John Langenfeld
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Patent number: 8821862Abstract: The present invention provides compositions comprising an antibiofilm enzyme, a soluble ?-N-acetylglucosaminidase similar to the dspB gene (DispersinB®), and an antimicrobial for preventing growth and proliferation of biofilm-embedded microorganisms in acute and chronic wounds, and methods of treatment. The invention further provides methods for preparing medical devices, and in particular, wound care devices using soluble ?-N-acetylglucosaminidase based antimicrobial compositions.Type: GrantFiled: March 9, 2012Date of Patent: September 2, 2014Assignees: Kane Biotech Inc., University of Medicine and Dentistry of New JerseyInventors: Srinivasa Madhyastha, Nanda Yakandawala, Purushottam V. Gawande, Karen Lovetri, Jeffrey B. Kaplan, Daniel Rhoads, Lasha Gogokhia
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Publication number: 20140243381Abstract: Nitric oxide biosynthesis-inhibiting anti-inflammatory and anti-microbial compounds of Formula (3) and Formula (4) wherein R1 and R2 are independently selected from optionally substituted thienyl, optionally substituted furyl, optionally substituted —CH?CH-thienyl and optionally substituted provided that R2 is substituted with as nitro group Treatment methods utilizing the compounds, and methods of synthesis of the compounds are also disclosed.Type: ApplicationFiled: February 22, 2013Publication date: August 28, 2014Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEYInventor: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
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Publication number: 20140234258Abstract: The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase nucleic and amino acid sequences, and compositions thereof may be used to advantage. The invention also encompasses screening methods to identify compounds/agents capable of modulating mRNA interferase activity and methods for using such compounds/agents. Also provided is a kit comprising mRNA interferase nucleic and/or amino acid sequences, mRNA interferase activity compatible buffers, and instruction materials.Type: ApplicationFiled: March 27, 2014Publication date: August 21, 2014Applicant: University of Medicine and Dentistry of New JerseyInventors: Masayori Inouye, Junjie Zhang, Yong Long Zhang
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Publication number: 20140228355Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.Type: ApplicationFiled: February 11, 2013Publication date: August 14, 2014Applicants: University of Medicine and Dentistry New Jersey Medical School, Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventors: Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine, University of Medicine and Dentistry New Jersey Medical School
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Publication number: 20140228380Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.Type: ApplicationFiled: August 2, 2013Publication date: August 14, 2014Applicants: University of Medicine and Dentistry New Jersey Medical School, Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventors: Sandhya Kortagere, Eldo V. Kuzhikandahil
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Publication number: 20140220108Abstract: The present invention provides, in part, cochleate compositions and methods for making and using same.Type: ApplicationFiled: May 4, 2012Publication date: August 7, 2014Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, COORDINATED PROGRAM DEVELOPMENT, LLCInventors: Ruying Lu, Raphael Mannino
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Patent number: 8796300Abstract: The invention provides compounds of formula (I) wherein u, d, v, m, n, R1, W, X, Y, and Z have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.Type: GrantFiled: November 5, 2010Date of Patent: August 5, 2014Assignees: Rutgers, the State University of New Jersey, University of Medicine and Dentistry of New JerseyInventors: Edmond J. LaVoie, Joseph E. Rice, Suzanne G. Rzuczek, Daniel S. Pilch
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Publication number: 20140193878Abstract: A regulated deployment of a toxin gene for developmental programmed cell death in bacteria is described. M. xanthus is demonstrated to have a solitary mazF gene that lacks a cotranscribed antitoxin gene. Deletion of mazF results in elimination of the obligatory cell death during development causing dramatic reduction in spore formation. Surprisingly, MrpC functions as a MazF antitoxin and a mazF transcription activator. Transcription of mrpC and mazF is negatively regulated via MrpC phosphorylation by a Ser/Thr kinase cascade. Various methods of exploiting this novel pathway are described herein.Type: ApplicationFiled: July 1, 2013Publication date: July 10, 2014Applicant: University of Medicine and Dentistry of New JerseyInventors: Masayori Inouye, Hirofumi Nariya
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Publication number: 20140170131Abstract: The present invention relates to antimicrobial deoxyribonuclease-based compositions that inhibit growth and proliferation of Staphylococcus aureus bacteria. The present invention also relates to methods of administering the compositions in the treatment and prevention of S. aureus infections. The present invention also relates to methods of administering the compositions in the eradication of S. aureus nasal carriage, in order to prevent the transmission of S.Type: ApplicationFiled: September 11, 2012Publication date: June 19, 2014Applicant: University of Medicine and Dentistry of New JerseyInventor: Jeffrey B. Kaplan
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Publication number: 20140073560Abstract: Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter freundii colicin A polypeptide, wherein the polypeptide has an antibacterial activity against the planktonic bacteria or the biofilm. Methods are also provided herein for treating a subject that has a bacterial infection, for example caused by a biofilm. The methods can be used to treat a biofilm on a living or non-living surface. Also provided herein are Citrobacter freundii colicin A polypeptides that have an antibacterial activity against planktonic bacteria or surface attached bacteria, and nucleic acid sequences encoding the polypeptides. Medical devices comprising a surface having an antimicrobial effective amount of a Citrobacter freundii colicin A polypeptide, or a nucleic acid molecule encoding the polypeptide, are also disclosed.Type: ApplicationFiled: November 13, 2013Publication date: March 13, 2014Applicants: University of Medicine and Dentistry of New Jersey, University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Robert Michael Queen Shanks, Daniel E. Kadouri
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Publication number: 20140044768Abstract: The present invention discloses vanadium-based insulin-mimetic agent composite coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The invention also encompasses methods of manufacturing implantable devices coated with vanadium-based insulin-mimetic agent composite coatings and the implantable devices so manufactured. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities.Type: ApplicationFiled: December 9, 2011Publication date: February 13, 2014Applicant: University of Medicine and Dentistry of New JerseyInventors: Sheldon S. Lin, David N. Paglia, Eric Breitbart, Joseph Benevenia
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Patent number: 8642073Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.Type: GrantFiled: January 11, 2007Date of Patent: February 4, 2014Assignees: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New JerseyInventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
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Publication number: 20140031933Abstract: A meniscus implant including a c-shaped scaffold having an arcuate middle section extending between an anterior end and a posterior end. A reinforcing network of fibers independent from the scaffold is embedded therein. Fibers of said network fibers exit each end of the scaffold to form respective anterior and posterior attachment segments which extend parallel to a central axis of the scaffold. The network of fibers is configured to convert an axial compressive force on said scaffold to tensile loads on said attachment points.Type: ApplicationFiled: March 15, 2013Publication date: January 30, 2014Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEYInventors: Charles J. Gatt, Aaron S. Merriam, Michael G. Dunn
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Publication number: 20140020138Abstract: Methods and compositions for producing genetically transformed plants exhibiting antibiofilm activity against bacterial pathogens are disclosed. Bacterial cells and plant transformation vectors include dspB genes encoding DispersinB antibiofilm enzymes of Aggregatibacter actinomycetemcomitans.Type: ApplicationFiled: March 23, 2012Publication date: January 16, 2014Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEYInventors: Chandran Ragunath, Mayilvahanan Shanmugam, Jeffrey B. Kaplan, Narayanan Ramasubbu