Patents Assigned to University of Medicine and Dentistry of New Jersey
  • Patent number: 9102617
    Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R3-R8 and X and Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: August 11, 2015
    Assignees: Rutgers, The State University of New Jersey, University of Medicine and Dentistry of New Jersey
    Inventors: Edmond J. Lavoie, Ajit Parhi, Daniel S. Pilch
  • Patent number: 9017935
    Abstract: Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I derived vector pro virus, which upon activation expresses a marker for late viral gene expression due to the insertion of the marker gene in the position of HIV-I envelope.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: April 28, 2015
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Joseph P. Dougherty, Sofiya Micheva-Viteva, Stuart W. Peltz, Yacov Ron, Annmarie Pacchia
  • Publication number: 20150018274
    Abstract: The present invention provides isolated stabilized EPO-derived peptides and their mimics that protect against tissue damage in subjects having diverse forms of neural and non-neural organ system injury, pharmaceutical compositions containing the isolated stabilized EPO-derived peptides, methods for treating symptoms of a disease, disorder or condition having an inflammatory or an autoimmune component in a subject in need thereof, and methods for downregulating immune mediator activity in a subject in need thereof.
    Type: Application
    Filed: January 23, 2014
    Publication date: January 15, 2015
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Yasuhiro Maeda, Rui Rong Yuan, Joseph Menonna, Wei Ping Li, Peter Dowling
  • Patent number: 8933096
    Abstract: The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein R1, R4-R8, R10, R2?-R6?, W, and A have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: January 13, 2015
    Assignees: Rugers, The State University of New Jersey, University of Medicine and Dentistry of New Jersey
    Inventors: Edmond J. Lavoie, Ajit Parhi, Daniel S. Pilch
  • Publication number: 20140295416
    Abstract: The invention relates to pharmaceutical compositions comprising of FRY polypeptides and nucleotides, methods to treat cancer, methods to diagnose cancer, and methods to determine the effectiveness of the treatment of cancer, as well as methods to differentiate stem cells.
    Type: Application
    Filed: December 6, 2011
    Publication date: October 2, 2014
    Applicant: University of Medicine and Dentistry of New Jersey
    Inventors: Helmut Zarbl, Jessica Graham
  • Publication number: 20140256720
    Abstract: Methods for regulating cancer cell growth and survival, inhibiting cancer cell growth, promoting cancer cell death, and/or treating a cancer make use of antagonists of a type I BMP receptor. In some embodiments the cancer is a lung cancer and the cancer cell is a lung cancer cell.
    Type: Application
    Filed: July 25, 2012
    Publication date: September 11, 2014
    Applicants: UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY, VANDERBILT UNIVERSITY
    Inventors: Charles C. Hong, John Langenfeld
  • Patent number: 8821862
    Abstract: The present invention provides compositions comprising an antibiofilm enzyme, a soluble ?-N-acetylglucosaminidase similar to the dspB gene (DispersinB®), and an antimicrobial for preventing growth and proliferation of biofilm-embedded microorganisms in acute and chronic wounds, and methods of treatment. The invention further provides methods for preparing medical devices, and in particular, wound care devices using soluble ?-N-acetylglucosaminidase based antimicrobial compositions.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: September 2, 2014
    Assignees: Kane Biotech Inc., University of Medicine and Dentistry of New Jersey
    Inventors: Srinivasa Madhyastha, Nanda Yakandawala, Purushottam V. Gawande, Karen Lovetri, Jeffrey B. Kaplan, Daniel Rhoads, Lasha Gogokhia
  • Publication number: 20140243381
    Abstract: Nitric oxide biosynthesis-inhibiting anti-inflammatory and anti-microbial compounds of Formula (3) and Formula (4) wherein R1 and R2 are independently selected from optionally substituted thienyl, optionally substituted furyl, optionally substituted —CH?CH-thienyl and optionally substituted provided that R2 is substituted with as nitro group Treatment methods utilizing the compounds, and methods of synthesis of the compounds are also disclosed.
    Type: Application
    Filed: February 22, 2013
    Publication date: August 28, 2014
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventor: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
  • Publication number: 20140234258
    Abstract: The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase nucleic and amino acid sequences, and compositions thereof may be used to advantage. The invention also encompasses screening methods to identify compounds/agents capable of modulating mRNA interferase activity and methods for using such compounds/agents. Also provided is a kit comprising mRNA interferase nucleic and/or amino acid sequences, mRNA interferase activity compatible buffers, and instruction materials.
    Type: Application
    Filed: March 27, 2014
    Publication date: August 21, 2014
    Applicant: University of Medicine and Dentistry of New Jersey
    Inventors: Masayori Inouye, Junjie Zhang, Yong Long Zhang
  • Publication number: 20140228380
    Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
    Type: Application
    Filed: August 2, 2013
    Publication date: August 14, 2014
    Applicants: University of Medicine and Dentistry New Jersey Medical School, Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
    Inventors: Sandhya Kortagere, Eldo V. Kuzhikandahil
  • Publication number: 20140228355
    Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
    Type: Application
    Filed: February 11, 2013
    Publication date: August 14, 2014
    Applicants: University of Medicine and Dentistry New Jersey Medical School, Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
    Inventors: Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine, University of Medicine and Dentistry New Jersey Medical School
  • Publication number: 20140220108
    Abstract: The present invention provides, in part, cochleate compositions and methods for making and using same.
    Type: Application
    Filed: May 4, 2012
    Publication date: August 7, 2014
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, COORDINATED PROGRAM DEVELOPMENT, LLC
    Inventors: Ruying Lu, Raphael Mannino
  • Patent number: 8796300
    Abstract: The invention provides compounds of formula (I) wherein u, d, v, m, n, R1, W, X, Y, and Z have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: August 5, 2014
    Assignees: Rutgers, the State University of New Jersey, University of Medicine and Dentistry of New Jersey
    Inventors: Edmond J. LaVoie, Joseph E. Rice, Suzanne G. Rzuczek, Daniel S. Pilch
  • Publication number: 20140193878
    Abstract: A regulated deployment of a toxin gene for developmental programmed cell death in bacteria is described. M. xanthus is demonstrated to have a solitary mazF gene that lacks a cotranscribed antitoxin gene. Deletion of mazF results in elimination of the obligatory cell death during development causing dramatic reduction in spore formation. Surprisingly, MrpC functions as a MazF antitoxin and a mazF transcription activator. Transcription of mrpC and mazF is negatively regulated via MrpC phosphorylation by a Ser/Thr kinase cascade. Various methods of exploiting this novel pathway are described herein.
    Type: Application
    Filed: July 1, 2013
    Publication date: July 10, 2014
    Applicant: University of Medicine and Dentistry of New Jersey
    Inventors: Masayori Inouye, Hirofumi Nariya
  • Publication number: 20140170131
    Abstract: The present invention relates to antimicrobial deoxyribonuclease-based compositions that inhibit growth and proliferation of Staphylococcus aureus bacteria. The present invention also relates to methods of administering the compositions in the treatment and prevention of S. aureus infections. The present invention also relates to methods of administering the compositions in the eradication of S. aureus nasal carriage, in order to prevent the transmission of S.
    Type: Application
    Filed: September 11, 2012
    Publication date: June 19, 2014
    Applicant: University of Medicine and Dentistry of New Jersey
    Inventor: Jeffrey B. Kaplan
  • Publication number: 20140073560
    Abstract: Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter freundii colicin A polypeptide, wherein the polypeptide has an antibacterial activity against the planktonic bacteria or the biofilm. Methods are also provided herein for treating a subject that has a bacterial infection, for example caused by a biofilm. The methods can be used to treat a biofilm on a living or non-living surface. Also provided herein are Citrobacter freundii colicin A polypeptides that have an antibacterial activity against planktonic bacteria or surface attached bacteria, and nucleic acid sequences encoding the polypeptides. Medical devices comprising a surface having an antimicrobial effective amount of a Citrobacter freundii colicin A polypeptide, or a nucleic acid molecule encoding the polypeptide, are also disclosed.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 13, 2014
    Applicants: University of Medicine and Dentistry of New Jersey, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Robert Michael Queen Shanks, Daniel E. Kadouri
  • Publication number: 20140044768
    Abstract: The present invention discloses vanadium-based insulin-mimetic agent composite coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The invention also encompasses methods of manufacturing implantable devices coated with vanadium-based insulin-mimetic agent composite coatings and the implantable devices so manufactured. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities.
    Type: Application
    Filed: December 9, 2011
    Publication date: February 13, 2014
    Applicant: University of Medicine and Dentistry of New Jersey
    Inventors: Sheldon S. Lin, David N. Paglia, Eric Breitbart, Joseph Benevenia
  • Patent number: 8642073
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: February 4, 2014
    Assignees: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
    Inventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
  • Publication number: 20140031933
    Abstract: A meniscus implant including a c-shaped scaffold having an arcuate middle section extending between an anterior end and a posterior end. A reinforcing network of fibers independent from the scaffold is embedded therein. Fibers of said network fibers exit each end of the scaffold to form respective anterior and posterior attachment segments which extend parallel to a central axis of the scaffold. The network of fibers is configured to convert an axial compressive force on said scaffold to tensile loads on said attachment points.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 30, 2014
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Charles J. Gatt, Aaron S. Merriam, Michael G. Dunn
  • Publication number: 20140020138
    Abstract: Methods and compositions for producing genetically transformed plants exhibiting antibiofilm activity against bacterial pathogens are disclosed. Bacterial cells and plant transformation vectors include dspB genes encoding DispersinB antibiofilm enzymes of Aggregatibacter actinomycetemcomitans.
    Type: Application
    Filed: March 23, 2012
    Publication date: January 16, 2014
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Chandran Ragunath, Mayilvahanan Shanmugam, Jeffrey B. Kaplan, Narayanan Ramasubbu