Patents Assigned to University of Medicine and Dentistry of New Jersey
  • ATTENUATED MYCOBACTERIAL STRAIN AS NOVEL VACCINE AGAINST TUBERCULOSIS
    Publication number: 20130101623
    Abstract: The present invention provides a novel attenuated vaccine for tuberculosis. Furthermore, when used as a subcutaneous vaccine, the present invention induces a higher level of protection than the current vaccine. Finally, the present invention results in less tissue damage and a lower number of colony forming units (CFU) in the lungs compared to subjects vaccinated with BCG.
    Type: Application
    Filed: October 3, 2012
    Publication date: April 25, 2013
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventor: UNIVERSITY OF MEDICINE AND DENTISTRY OF
  • Cytokines and Genes Differentially Affected by TNF Blockers
    Publication number: 20130095472
    Abstract: The present invention is directed to cytokines and genes that are differentially affected by TNF blockers and the use of these genes and cytokines to help asses the TB risks of new immunosuppressive therapies, to help evaluate the effects of new TB vaccines, and to help assess TB susceptibility in persons exposed to Mycobacterium tuberculosis.
    Type: Application
    Filed: September 13, 2012
    Publication date: April 18, 2013
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventor: Robert Wallis
  • Serum MG53 as a diagnostic marker for tissue injury
    Patent number: 8420338
    Abstract: Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a muscle-related disease or disorder. In addition, the invention relates to targeting the native MG53 found in the blood as a therapeutic approach.
    Type: Grant
    Filed: November 5, 2011
    Date of Patent: April 16, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Noah Weisleder, Jianjie Ma
  • Method for increasing bone mass
    Patent number: 8415316
    Abstract: The present invention features methods for promoting the differentiation of osteoblast bone forming cells to a mineralization phenotype and increasing bone mass using inhibitors of Brahma. Subjects benefiting from such treatment may have non-union fractures, osteopenia or osteoporosis, osteosarcoma, or a bone graft or bone fusion or orthopedic and dental implants, osteolytic bone disease, skeletal defects or deficiencies or periodontal disease.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: April 9, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Elizabeth Moran, Stephen Flowers
  • Compositions And Methods For Immunodominant Antigens of Mycobacterium Tuberculosis
    Publication number: 20130072398
    Abstract: Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.
    Type: Application
    Filed: November 19, 2012
    Publication date: March 21, 2013
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, IMMPORT THERAPEUTICS, INC.
    Inventors: Philip Felgner, Xiaowu Liang, Maria Laura Gennaro
  • RNA Interferases and Methods of Use Thereof
    Publication number: 20130071374
    Abstract: The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase nucleic and amino acid sequences, and compositions thereof may be used to advantage. The invention also encompasses screening methods to identify compounds/agents capable of modulating mRNA interferase activity and methods for using such compounds/agents. Also provided is a kit comprising mRNA interferase nucleic and/or amino acid sequences, mRNA interferase activity compatible buffers, and instruction materials.
    Type: Application
    Filed: April 17, 2012
    Publication date: March 21, 2013
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Masayori Inouye, Junjie Zhang, Yong Long Zhang
  • DENTINAL DRUG DELIVERY COMPOSITION AND SCREENING METHOD
    Publication number: 20130065866
    Abstract: The present invention is a dentinal drug delivery composition composed of cationic and/or neutral porous particles containing an effective amount of a therapeutic agent, a method for using the dentinal drug delivery to provide a dental treatment, and a method for identifying anti-inflammatory agents capable of diffusing through dentin.
    Type: Application
    Filed: November 7, 2012
    Publication date: March 14, 2013
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventor: University of Medicine and Dentistry of New Jersey
  • Salivary bioassay for early detection of bone loss
    Patent number: 8389015
    Abstract: The present invention is directed to methods to detect and diagnose osteoporosis and periodontal disease using salivary biomarkers.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: March 5, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Daniel H. Fine, David Furgang
  • Glutamate-enhanced cell-penetrating peptides and methods of using same
    Patent number: 8389481
    Abstract: Disclosed herein are novel glutamate-enhanced cell-penetrating peptides (CPPs) for use as delivery vehicles to mediate intracellular uptake of therapeutic payloads and methods of using the same.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: March 5, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Beverly E. Barton, H. Dan Lewis, Robert J. Donnelly, Ali Husain, Dimitrios Barlos, Sheraz Riaz
  • Method for Automated Autoantibody Detection and Identification
    Publication number: 20130052662
    Abstract: The present invention is a kit and method for detecting and identifying autoantibodies. The invention employs the use of indirect immunofluorescence, imaging flow cytometry and pattern recognition software to automatically identify autoantibodies associated with autoimmune disorders.
    Type: Application
    Filed: August 23, 2012
    Publication date: February 28, 2013
    Applicant: University of Medicine and Dentistry of New Jersey
    Inventors: Betsy J. Barnes, Di Feng, Rivka C. Stone
  • Method of reversing carboplatin resistance by inhibition of HGFIN
    Patent number: 8383806
    Abstract: The present invention discloses the cloning of a new cDNA, HGFIN, from stimulated bone marrow stromal cells that was retrieved with a probe specific for the neurokinin-1 (NK-1) receptor. The novel gene, HGFIN, encodes a protein receptor that is involved in the regulation of hematopoietic proliferation and differentiation. HGFIN is implicated in the treatment of hyperproliferative disorders, particularly bone and breast cancer, because it acts to suppress the proliferating cells.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: February 26, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventor: Pranela Rameshwar
  • Assay for the measurement of IGF type 1 receptor and insulin receptor expression
    Patent number: 8377655
    Abstract: This invention relates to a quantitative PCR assay that differentiates between IR-A, IR-B and IGF-IR mRNAs and compares expression of the three receptors on the same scale.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: February 19, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Teresa L. Wood, Anne M. Rowzee
  • Methods and means for increasing resistance to cell damage
    Publication number: 20130041009
    Abstract: Methods are provided to increase resistance to cell damage in a subject. The increase in resistance to cell damage in a subject in the subject is accomplished by decreasing activity of eEF2 kinase in the subject. The eEF2 kinase activity can be decreased by decreasing the amount of functional eEF2 kinase produced by the subject, including contacting the eEF2 kinase with a compound that inhibits phosphorylation of eEF2 kinase substrate or decreasing the amount of functional eEF2 kinase is decreased by reducing expression of a gene encoding the eEF2 kinase.
    Type: Application
    Filed: October 3, 2011
    Publication date: February 14, 2013
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Alexey G. Ryazanov, Hsueh-Ping Chu
  • HIV-1 LATENCY MODEL FOR HIGH THROUGHPUT SCREENING
    Publication number: 20130040385
    Abstract: Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I derived vector pro virus, which upon activation expresses a marker for late viral gene expression due to the insertion of the marker gene in the position of HIV-I envelope.
    Type: Application
    Filed: July 17, 2012
    Publication date: February 14, 2013
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Joseph P. Dougherty, Sofiya Micheva-Viteva, Stuart W. Peltz, Yacov Ron, Annmarie L. Pacchia
  • Dual Inducible System for the cSPP System
    Publication number: 20130029426
    Abstract: The present invention provides a dual inducible system for single protein production, as well as a method of inducing high level protein expression using amino acids.
    Type: Application
    Filed: July 23, 2012
    Publication date: January 31, 2013
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Masayori Inouye, Lili Mao, S. Thangminlal Vaiphei, Yojiro Ishida
  • Telomerase reverse transcriptase variant
    Patent number: 8362209
    Abstract: The present invention relates to nucleic and amino acid sequences of a novel variant of the telomerase reverse transcriptase. More particularly, the present invention is directed to a novel variant of human telomerase reverse transcriptase, which displays properties distinct from those of wildtype telomerase reverse transcriptase, and methods of use thereof.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: January 29, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventor: Janine H. Santos
  • Salivary Bioassay for Early Detection of Bone Loss
    Publication number: 20130022501
    Abstract: The present invention is directed to methods to detect and diagnose osteoporosis and periodontal disease using salivary biomarkers.
    Type: Application
    Filed: September 17, 2012
    Publication date: January 24, 2013
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventor: University of Medicine and Dentistry of New Jerse
  • eEF2K assays for identifying compounds that inhibit eEF2K activity
    Patent number: 8349576
    Abstract: Assays for identifying novel compounds for inhibiting eEF2 kinase and consequence peptides employed therein.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: January 8, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Alexey G. Ryazanov, Benjamin E. Turk
  • Pharmacologically-active vanilloid carbamates
    Patent number: 8343971
    Abstract: This application relates to pharmacologically-active vanilloid compounds which are useful for the treatment of various anti-inflammatory states characterized by inhibition of FAAH, such as, Alzheimer's dementia, Parkinson's disease, depression, pain, rheumatoid arthritis, pathophysiology of mood disorders, multiple sclerosis, and inflammation, or antagonism of TRPV1, such as, for example, Huntington's disease, hypertension, arthritis, allergic airway inflammation, Crohn's disease, ulcerative colitis, and neuropathic pain.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: January 1, 2013
    Assignees: Rutgers, The State University of New Jersey, The University of Medicine and Dentistry of New Jersey, Lehigh University
    Inventors: Jeffrey D. Laskin, Diane E. Heck, Carl Jeffrey Lacey, Erik Aponte, Mou-Tuan Huang, Ned D. Heindel
  • Dentinal Drug Delivery Composition
    Publication number: 20120329790
    Abstract: The present invention is a dentinal drug delivery composition composed of cationic and/or neutral porous particles containing an effective amount of a therapeutic agent and a method for using the same to provide a dental treatment.
    Type: Application
    Filed: November 23, 2010
    Publication date: December 27, 2012
    Applicant: University of Medicine and Dentistry of New Jersey
    Inventor: Kenneth Markowitz