Abstract: The present disclosure provides modified cells including pluripotent stem cells, hematopoietic precursor cells, and hematopoietic cells (e.g., modified Tregs) that are steroid and/or calcineurin inhibitor-resistant. The present disclosure provides methods for generating steroid and/or calcineurin inhibitor-resistant modified cells including pluripotent stem cells, hematopoietic precursor cells, and hematopoietic cells. Also provided herein are compositions and methods of treatment.

Abstract: A system and method for implanting heart assist devices. A model of a heart of a patient is formed based on images taken of the cardiothoracic cavity of the patient. A point is selected for insertion of the heart assist device based on the model. A graft location is selected on the aorta and a graft length for the graft is determined as a function of the implant location and the selected graft location.

Abstract: The invention provides a compound of formula (I) or a salt thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and methods of inhibiting an MPC and treating an MPC related disease or condition.

Abstract: A method may include annealing a material including iron and nitrogen in the presence of an applied magnetic field to form at least one Fe16N2 phase domain. The applied magnetic field may have a strength of at least about 0.2 Tesla (T).

Abstract: This invention relates to a polymerization process for producing a polyketoester, or an olefin-polyketoester utilizing a hydroesterification catalyst and an olefin-CO copolymerization catalyst in a reaction medium. Polyketoester copolymers and olefin-polyketoester copolymers are also disclosed.

Abstract: Disclosed herein are methods for reprocessing polyurethane compositions such as polyurethane foams. The method comprises introducing a polyurethane composition into a compounding device, heating the polyurethane composition to an effective bond-exchange temperature, and compounding the polyurethane composition for an effective bond-exchange time.

Abstract: A dielectrophoretic (DEP) sensor includes a graphene electrode adjacent a channel for confining a target particle in a liquid, a surface probe attached to a surface of the graphene electrode, the surface probe having a selective reaction with the target particle, and a voltage source electrically connected to the graphene electrode and configured to apply a voltage to the graphene electrode to cause DEP trapping of the target particle at the graphene electrode.

Abstract: A method of determining when to increase an amount electrical energy available to a vehicle includes setting a parameter for a function describing a reference state of charge as a function of distance traveled, wherein the reference state of charge represents a state of charge of the vehicle at which the amount of electrical energy available to the vehicle should be increased. For each trip of the vehicle, the parameter for the function is modified so that different trips of a same vehicle use different functions for the reference state of charge.

Abstract: Provided are compositions for activating NK cells to stimulate an immune response for treating cancer and other disorders. In one embodiment, the invention provides a compound comprising an NK engaging domain that binds to CD 16; an NK activating domain operably linked to the NK engaging domain; and a targeting domain that selectively binds to a target cell and is operably linked to the NK activating domain and the NK engaging domain, wherein the targeting domain binds to CLEC12A.

Abstract: A feed stream is contacted with a metal oxide catalyst disposed within a reactor. The feed stream includes a mixture of gases. The mixture of gases includes acetylene. The metal oxide catalyst includes a metal oxide. In response to contacting the feed stream with the metal oxide catalyst, the acetylene of the feed stream is selectively oxidized to produce at least one of carbon monoxide or carbon dioxide. A product stream is discharged from the reactor. The product stream includes the at least one of the carbon monoxide or the carbon dioxide produced.

Abstract: A system includes a database, a memory storing instructions, and a processor communicatively coupled to the memory and the database. The database stores a dataset comprising previous patient hospital stay data for a plurality of patients. The processor is configured to execute the instructions to generate training data based on the dataset, train a prediction model based on the training data, receive current patient hospital stay data for a current patient, generate a risk score of health deterioration for the current patient based on the prediction model and the current patient hospital stay data, and determine a likelihood of the current patient being transferred to an ICU within a selected period based on the risk score.

Abstract: A device includes a porous substrate that include a plurality of pores and a plurality of nanodevices dispersed in at least a portion of the plurality of pores. Each of the plurality of nanodevices includes a magnetic nanowire and a solder nanoparticle. The magnetic nanowires are configured to generate heat in response to an alternating magnetic field. The solder nanoparticles are configured to receive a portion of the heat and reflow to connect to one or more devices or surfaces.

Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.

Abstract: Yarns incorporating filaments of shape memory materials are described herein that enable the creation of fabrics, garments, and other materials with tunable force absorption or exertion capabilities, as well as creating complex shapes and structures upon actuation. Systems and methods described herein enable selective buckling, recruitment, compression, and other desirable phenomena by actuating fibers in knitted patterns, whether used as isolated filaments or in twisted yarns.

Abstract: A vision-aided inertial navigation system (VINS) implements a square-root multi-state constraint Kalman filter (SR-MSCKF) for navigation. In one example, a processor of a VINS receives image data and motion data for a plurality of poses of a frame of reference along a trajectory. The processor executes an Extended Kalman Filter (EKF)-based estimator to compute estimates for a position and orientation for each of the plurality of poses of the frame of reference along the trajectory. For features observed from multiple poses along the trajectory, the estimator computes constraints that geometrically relate the multiple poses of the respective feature. Using the motion data and the computed constraints, the estimator computes state estimates for the position and orientation of the frame of reference. Further, the estimator determines uncertainty data for the state estimates and maintains the uncertainty data as a square root factor of a covariance matrix.

Abstract: This document provides multiblock copolymers comprising: at least one block obtained from a polyester having an average MN of from about 2,000 to about 200,000, wherein the polyester contains one or more terephthalate units; and at least one block obtained from a polyolefin having an average MN of from about 2,000 to about 200,000. This document further provides methods of making and using the multiblock copolymers, and multilayer films, polymer blends, and molded articles comprising the multiblock copolymers.

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.

Abstract: The article includes a porous scaffold structure comprising a plurality of supports. The article further includes a plurality of metallic or non-metallic nanomaterials disposed on at least one of the supports. Each of the plurality of metallic or non-metallic nanomaterials is directly bound to at least one of the supports.

Abstract: The invention provides competitive inhibitors of farnesyl transferase, compositions comprising the competitive inhibitors of farnesyl transferase, and their use as antifungal agents and as agents for the prevention of the formation or growth of biofilms.

Abstract: A coupled ring oscillator circuit includes a first ring oscillator, a second ring oscillator and a coupling circuit. The first ring oscillator includes a series of delay stages, each delay stage including an inverter gate. The second ring oscillator includes a series of delay stages, each delay stage including an inverter gate. The coupling circuit includes a coupling cell having a first modified tri-state inverter connected in parallel with one of the inverter gates of the first ring oscillator, and a second modified tri-state inverter connected in parallel with one of the inverter gates of the second ring oscillator.