Patents Assigned to University of Minnesota
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Publication number: 20250130045Abstract: A vision-aided inertial navigation system (VINS) implements a square-root multi-state constraint Kalman filter (SR-MSCKF) for navigation. In one example, a processor of a VINS receives image data and motion data for a plurality of poses of a frame of reference along a trajectory. The processor executes an Extended Kalman Filter (EKF)-based estimator to compute estimates for a position and orientation for each of the plurality of poses of the frame of reference along the trajectory. For features observed from multiple poses along the trajectory, the estimator computes constraints that geometrically relate the multiple poses of the respective feature. Using the motion data and the computed constraints, the estimator computes state estimates for the position and orientation of the frame of reference. Further, the estimator determines uncertainty data for the state estimates and maintains the uncertainty data as a square root factor of a covariance matrix.Type: ApplicationFiled: May 24, 2024Publication date: April 24, 2025Applicant: Regents of the University of MinnesotaInventors: Stergios I. Roumeliotis, Kejian J. Wu
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Patent number: 12281204Abstract: This document provides multiblock copolymers comprising: at least one block obtained from a polyester having an average MN of from about 2,000 to about 200,000, wherein the polyester contains one or more terephthalate units; and at least one block obtained from a polyolefin having an average MN of from about 2,000 to about 200,000. This document further provides methods of making and using the multiblock copolymers, and multilayer films, polymer blends, and molded articles comprising the multiblock copolymers.Type: GrantFiled: April 1, 2020Date of Patent: April 22, 2025Assignees: Regents of the University of Minnesota, Murray State UniversityInventors: Christopher John Ellison, Kevin Michael Miller
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Patent number: 12281105Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.Type: GrantFiled: August 11, 2023Date of Patent: April 22, 2025Assignee: Regents of the University of MinnesotaInventors: Ingrid Gunda Georg, Narsihmulu Cheryala
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Patent number: 12274995Abstract: The article includes a porous scaffold structure comprising a plurality of supports. The article further includes a plurality of metallic or non-metallic nanomaterials disposed on at least one of the supports. Each of the plurality of metallic or non-metallic nanomaterials is directly bound to at least one of the supports.Type: GrantFiled: March 23, 2018Date of Patent: April 15, 2025Assignee: Regents of the University of MinnesotaInventors: Abdennour Abbas, John Brockgreitens, Snober Ahmed, Fatemeh Heidari
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Publication number: 20250114350Abstract: The invention provides competitive inhibitors of farnesyl transferase, compositions comprising the competitive inhibitors of farnesyl transferase, and their use as antifungal agents and as agents for the prevention of the formation or growth of biofilms.Type: ApplicationFiled: October 4, 2024Publication date: April 10, 2025Applicants: Regents of the University of Minnesota, Duke UniversityInventors: Mark Dewey Distefano, Feng Xu, Lorena S. Beese, Homme W. Hellinga, You Wang, Andrew A. Alspaugh
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Patent number: 12261598Abstract: A coupled ring oscillator circuit includes a first ring oscillator, a second ring oscillator and a coupling circuit. The first ring oscillator includes a series of delay stages, each delay stage including an inverter gate. The second ring oscillator includes a series of delay stages, each delay stage including an inverter gate. The coupling circuit includes a coupling cell having a first modified tri-state inverter connected in parallel with one of the inverter gates of the first ring oscillator, and a second modified tri-state inverter connected in parallel with one of the inverter gates of the second ring oscillator.Type: GrantFiled: July 10, 2023Date of Patent: March 25, 2025Assignee: Regents of the University of MinnesotaInventors: Hyung-il Kim, William Moy
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Patent number: 12255108Abstract: A device includes a substrate and at least one electrically conducting portion supported by the substrate, the at least one electrically conducting portion including a signal line and a ground plane electrically isolated from the signal line. The electrically conducting portion includes a layer of a first electrically conducting material and a layer of a metal oxide material including anodic aluminum oxide (AAO) and one or more nanowires (NW) of a second electrically conducting material each formed within a corresponding pore extending through the AAO from a first side of the layer to a second side of the layer of the metal oxide material opposite the first side.Type: GrantFiled: June 17, 2022Date of Patent: March 18, 2025Assignees: Regents of the University of Minnesota, The University of Texas at DallasInventors: Rhonda Franklin, Aditya Dave, Yali Zhang, Bethanie Joyce Hills Stadler, Allison Harpel, Rashaunda Henderson, Nikita Mahjabeen
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Patent number: 12253063Abstract: A method includes determining, by a control system, from among a plurality of categories, a current category of an incoming wind approaching a wind turbine, and setting, by the control system, a yaw bias of the wind turbine based on the current category. In some examples, the plurality of categories includes two or more wind conditions, such as a first wind condition in which wind contacting an upper rotor of the wind turbine is veering and wind contacting a lower rotor of the wind turbine is veering, a second wind condition in which the wind contacting the upper rotor of the wind turbine is veering and the wind contacting the lower rotor of the wind turbine is backing, and so on.Type: GrantFiled: January 26, 2022Date of Patent: March 18, 2025Assignee: Regents of the University of MinnesotaInventors: Jiarong Hong, Linyue Gao
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Publication number: 20250083123Abstract: Articles and method of making articles including a solid porous material having a selenium nanomaterial bound to a surface of and within the solid porous material. The article may be a include no polymeric stabilizer or proteinaceous stabilizer. The solid porous material may be a sponge, a film, a fabric, a non-woven material, or a metal-organic framework (MOF), or a combination thereof. The article may be produced by treating a solid porous material with an aqueous selenous acid solution and heating the solid porous material to form the selenium nanomaterial on the surface of and within the solid porous material.Type: ApplicationFiled: November 22, 2024Publication date: March 13, 2025Applicant: Regents of the University of MinnesotaInventors: Abdennour Abbas, Snober Ahmed
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Patent number: 12246597Abstract: A system includes a display and a processor coupled to the display. The processor determines a position of a vehicle relative to a road lane and causes the display to depict a set of position indicators to convey the position of the vehicle relative to the road lane. In one state, the set of position indicators include a plurality of empty shape outlines and at least one filled shape outline. The processor also determines a position of a hazard relative to the vehicle and causes the display to depict a set of hazard position indicators to convey the position of the hazard relative to the vehicle. In one state, the set of hazard position indicators include a plurality of empty shape outlines and at least one filled shape outline.Type: GrantFiled: May 4, 2023Date of Patent: March 11, 2025Assignee: Regents of the University of MinnesotaInventors: Max Donath, Brian Davis, Chen-Fu Liao, Nichole Morris, Katelyn Schwieters
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Patent number: 12248613Abstract: A method includes storing a value in data storage so that a third party is prevented from accessing the value, retrieving the value and applying a first transform to the value to form a transformed value having a uniform distribution. Noise is added to the transformed value to form a sum and a second transform is applied to the sum to form a transformed sum having a uniform distribution. An inverse of the first transform is applied to the transformed sum to form a privatized value and the privatized value is provided to the third party.Type: GrantFiled: March 31, 2022Date of Patent: March 11, 2025Assignee: Regents of the University of MinnesotaInventors: Xuan Bi, Xiaotong Shen
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Publication number: 20250074956Abstract: The invention provides antibiotic BPI Fold Containing Family A Member 2 (BPIFA2) peptides, compositions comprising a BPIFA2 peptide, hydrogels comprising a BPIFA2 peptide, nanofibrillar networks comprising a BPIFA2 peptide, and tissue scaffolds comprising BPIFA2 peptides. The peptide, compositions, hydrogels nanofibrillar networks and tissue scaffolds are useful for medical therapy in an animal.Type: ApplicationFiled: June 5, 2024Publication date: March 6, 2025Applicant: Regents of the University of MinnesotaInventors: Sven-Ulrik Gorr, Conrado Aparicio, Zhou Ye
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Publication number: 20250068425Abstract: A system for Multi-Party Computation (MPC) includes a general-purpose programming language, an MPC processor, an MPC Instruction Set Architecture (ISA), and a compiler. The general-purpose programming language is used for writing an MPC application. The MPC processor executes the MPC application. The MPC ISA corresponds to the MPC processor. The compiler generates an intermediate representation for the MPC application and generates machine code for the intermediate representation by mapping and assembling MPC ISA instructions.Type: ApplicationFiled: August 21, 2024Publication date: February 27, 2025Applicant: Regents of the University of MinnesotaInventors: John Mario Sartori, Shashank Ganapathi Hegde
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Therapeutic methods involving modulating inflammasome activation of myeloid-derived suppressor cells
Patent number: 12234480Abstract: In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.Type: GrantFiled: December 11, 2020Date of Patent: February 25, 2025Assignees: Regents of the University of Minnesota, The University of North Carolina at Chapel Hill, Albert-Ludwigs-Universität Freiburg, St. Jude Children's Research Hospital, Inc.Inventors: Bruce R. Blazar, Brent Koehn, Peter J. Murray, Jenny P. Y. Ting, Robert Zeiser, Jeff S. Miller -
Patent number: 12233073Abstract: An example technique for treating a skin cancer condition includes administering a therapeutically effective amount of a p53-related protein kinase (PRPK) inhibitor to a patient having skin cancer or having a high risk of developing skin cancer. An example composition includes a therapeutically effective amount of a PRPK inhibitor for treating a skin cancer condition. An example composition includes a pharmaceutically effective amount of at least one anti-solar ultraviolet (anti-sUV) combination for preventing a skin cancer condition. The at least one anti-sUV combination is chosen from the combinations: avobenzone and octinoxate; octocrylene and zinc oxide; avobenzone, octocrylene, and titanium dioxide; or avobenzone, octocrylene, and zinc oxide.Type: GrantFiled: June 8, 2018Date of Patent: February 25, 2025Assignee: Regents of the University of MinnesotaInventors: Ann M. Bode, Zigang Dong, Eunmiri Roh
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Patent number: 12221612Abstract: This document relates to methods and materials for generating oilseed (e.g., pennycress) plants that have oil with reduced levels of polyunsaturated fatty acids (PUFAs) and/or increased levels of oleic acid. For example, oilseed plants having reduced expression levels of one or more polypeptides involved in fatty acid biosynthesis (e.g., fatty acid desaturase 2 (FAD2) and reduced oleate desaturation 1 (ROD1)), as well as methods and materials for making and using such oilseed plants are provided.Type: GrantFiled: February 12, 2019Date of Patent: February 11, 2025Assignees: Regents of the University of Minnesota, The Board of Trustees of Illinois State UniversityInventors: Michael David Marks, Ratan Chopra, Nicole Folstad, Donald L. Wyse, John C. Sedbrook
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Patent number: 12215642Abstract: A method of estimating in-cylinder pressure includes receiving a vibration signal from a vibration sensor mounted proximate a compression ignition (CI) engine, receiving angular position information for the CI engine, and determining in-cylinder pressure based on the angular position information and on a combustion component of the vibration signal.Type: GrantFiled: September 12, 2023Date of Patent: February 4, 2025Assignee: Regents of the University of MinnesotaInventors: Rajesh Rajamani, Woongsun Jeon
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Patent number: 12209140Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.Type: GrantFiled: November 21, 2022Date of Patent: January 28, 2025Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of MinnesotaInventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
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Patent number: 12209336Abstract: Garments having active and passive knitted rows can provide desired levels of compression. Garments made of active and passive knitted rows can provide dynamic levels of compression with respect to both location and over time to address a variety of conditions.Type: GrantFiled: February 24, 2022Date of Patent: January 28, 2025Assignee: Regents of the University of MinnesotaInventors: Rachael Margaret Granberry, Kevin Eschen, Julianna Abel, Bradley Holschuh
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Patent number: 12201509Abstract: This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts.Type: GrantFiled: March 6, 2023Date of Patent: January 21, 2025Assignee: Regents of the University of MinnesotaInventors: Robert Tranquillo, Zeeshan Syedain, Lee Meier