Patents Assigned to University of Minnesota
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Publication number: 20240384448Abstract: Advances in actuating fabrics could enable a paradigm shift in the field of smart wearables by dynamically fitting themselves to the unique topography of the human body. Active fabrics and fitting mechanisms are described herein that enable garments to conform around surface concavities without requiring high elasticity or a multiplicity of closure devices. Advanced materials and systems innovations (1) enable novel garment manufacturing and application strategies, (2) facilitate topographical fitting (spatial actuation) through garment architectural design, and (3) provide tunable NiTi-based SMA actuation temperatures to enable actuation on the surface of human skin. Such fabrics and garments are usable in a variety of fields including medical compression, technical sportswear, exosuits, space suits and components thereof, or non-garment applications.Type: ApplicationFiled: May 20, 2024Publication date: November 21, 2024Applicant: Regents of the University of MinnesotaInventors: Kevin ESCHEN, Julianna ABEL, Bradley Thomas HOLSCHUH, Rachael Margaret GRANBERRY
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Patent number: 12137886Abstract: According to embodiments, a substantially coaxial arrangement of a camera, a light source, and an ultrasonic sensor can be positioned in an housing of a system that can be deployed from the tool port of a standard bronchoscope. Illumination from the light source facilitates positioning of the system by an operator using information from the camera. The ultrasonic system can determine when an object to be biopsied is adjacent to a biopsy needle.Type: GrantFiled: April 15, 2022Date of Patent: November 12, 2024Assignee: Regents of the University of MinnesotaInventors: Michael A. Greminger, Anastasia Zink, Brian Krohn, Amit Goyal, Roy Joseph Cho, H. Erhan Dincer, Felix Zamora, Gills Fai, Sarah Ostlie
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Patent number: 12139722Abstract: This disclosure describes methods for organoid generation including, for example, for generation of a multi-tissue organoid. The multi-tissue organoid may include cartilage, bone, epithelium, and/or fibrous connective tissue. This disclosure further describes methods for isolating cells from the organoids and methods of using the organoids and cells of the organoids.Type: GrantFiled: June 10, 2021Date of Patent: November 12, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Timothy D. O'Brien, Beth Lindborg, Amanda Vegoe
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Patent number: 12142805Abstract: A complementary metal-oxide-semiconductor (CMOS) device includes a metal oxide layer comprising anodic aluminum oxide (AAO) and one or more nanowires (NW) of an electrically conducting material each formed within a corresponding pore extending through the AAO from a first side of the layer to a second side of the layer opposite the first side, a first electrically conducting layer disposed on the first side of the metal oxide layer, and a second electrically conducting layer disposed on the second side of the metal oxide layer. The nanowires form a via electrically connecting first electrically conducting layer and the second electrically conducting layer.Type: GrantFiled: June 4, 2021Date of Patent: November 12, 2024Assignees: Regents of the University of Minnesota, Board of Regents, The University of Texas SystemInventors: Rhonda Franklin, Yali Zhang, Joseph Um, Bethanie Joyce Hills Stadler, Rashaunda Henderson
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Patent number: 12138150Abstract: Systems and methods for performing transcatheter coronary artery bypass grafting procedures are provided. The methods generally involve passing the graft from the aorta to the coronary artery through the pericardial space. The systems include poke-out wires, a coring device, and devices for forming anastomoses at the proximal and distal ends of a vascular graft.Type: GrantFiled: December 5, 2019Date of Patent: November 12, 2024Assignees: BOSTON SCIENTIFIC SCIMED, INC., REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Annamaria Szabolcs, Jeffrey W. Reineke, Andrew Bicek, John R. Ballard, Steven Kangas
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Patent number: 12138456Abstract: The invention provides methods for treating a neurological disorder or deficit, such as tinnitus and phantom limb pain.Type: GrantFiled: February 11, 2021Date of Patent: November 12, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Hubert H. Lim, Craig D. Markovitz, Sarah J. Offutt
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Publication number: 20240365738Abstract: The present disclosure generally relates to Camelina sativa plants exhibiting facultative wintering. Provided herein are methods and compositions for producing plants exhibiting facultative wintering. Also provided herein are exemplary plants exhibiting this trait, including, for example, Camelina sativa line ‘CMN2207’.Type: ApplicationFiled: May 3, 2024Publication date: November 7, 2024Applicant: Regents of the University of MinnesotaInventors: James Allan ANDERSON, Matthew Ames OTT, Ratan CHOPRA, Katherine FRELS, Michael David MARKS
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Patent number: 12134751Abstract: Bioactive coatings that include a base and a protein associated with the base for actively promoting the removal of organic stains are provided. In aspects, bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.Type: GrantFiled: June 1, 2023Date of Patent: November 5, 2024Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, TOYOTA MOTOR CORPORATIONInventors: Andreas Buthe, Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Minjuan Zhang
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Publication number: 20240363269Abstract: In general, the disclosure is directed to bulk iron-nitride materials having a polycrystalline microstructure having pores including a plurality of crystallographic grains surrounded by grain boundaries, where at least one crystallographic grain includes an iron-nitride phase including any of a body centered cubic (bcc) structure, a body centered tetragonal (bct), and a martensite structure. The disclosure further describes techniques producing a bulk iron-nitride material having a polycrystalline microstructure, including: melting an iron source to obtain a molten iron source; fast belt casting the molten iron source to obtain a cast iron source; cooling and shaping the cast iron source to obtain a bulk iron-containing material having a body-centered cubic (bcc) structure; annealing the bulk iron-containing material at an austenite transformation temperature and subsequently cooling the bulk iron-containing material; and nitriding the bulk iron-containing material to obtain the bulk iron-nitride material.Type: ApplicationFiled: May 15, 2024Publication date: October 31, 2024Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Jian-Ping WANG, Jinming LIU, Bin MA, Fan ZHANG, Guannan GUO, Yiming WU, Xiaowei ZHANG
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Publication number: 20240353097Abstract: Disclosed herein are methods and systems for burning gaseous ammonia, including receiving a oxidizer gas into a chamber body such that the oxidizer gas generally flows in direction that extends along a longitudinal axis of the chamber body; introducing gaseous ammonia into the chamber body such that swirl is introduced into the gaseous ammonia; mixing the oxidizer gas and the gaseous ammonia to form a combustion mixture; igniting the combustion mixture; and combusting the combustion mixture for a duration such that the gaseous ammonia is converted to combustion products.Type: ApplicationFiled: April 19, 2024Publication date: October 24, 2024Applicant: Regents of the University of MinnesotaInventors: Seamus Patrick Kane, William F. Northrop, Clifford Goertemiller
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Publication number: 20240355227Abstract: Example artificial dental calculus models are described. In one example, an in vitro artificial dental calculus includes a dental substrate and a mineralized biofilm comprising an extracellular support material and at least one bacterial species. In one example, a method for creating an in vitro dental calculus model includes applying saliva to a dental substrate in a production environment, applying a mixture of an extracellular support material and at least one bacterial species to the dental substrate, applying a solution comprising calcium and phosphate to the mixture on the dental substrate, and removing the dental substrate from the production environment after a period of time during which a mineralized biofilm comprising the extracellular support material and the at least one bacterial species forms on the dental substrate.Type: ApplicationFiled: April 23, 2024Publication date: October 24, 2024Applicant: Regents of the University of MinnesotaInventors: Alex Siu Lun Fok, Anqi Zhang, Ruoqiong Chen, Tamer Abdelrehim, Bruno Pierre Lima, Stephanie Porter, Hooi Pin Chew, Dina Elsherbini, Saba Tohidkhah
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Patent number: 12121288Abstract: In some aspects, the present disclosure pertains to methods of treating a tissue volume comprising (a) administering an implantable composition comprising a releasable membrane-active agent to a target site such that the membrane-active agent is locally released to the tissue volume and (b) performing irreversible, reversible and/or thermal treatment by application of a pulsed electric field to the tissue volume. In other aspects, the present disclosure pertains to embolic compositions that comprise releasable membrane-active agents.Type: GrantFiled: March 17, 2021Date of Patent: October 22, 2024Assignees: Boston Scientific Scimed, Inc., Regents of the University of MinnesotaInventors: Bruce R. Forsyth, Chun Wang, Samuel Hanson
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Patent number: 12121567Abstract: A method to prevent, inhibit or treat one or more symptoms associated with a disease of the central nervous system by intrathecally, intracerebroventricularly or endovascularly administering a rAAV encoding a gene product associated with the disease, e.g., a mammal in which the gene product is absent or present at a reduced level relative to a mammal without the disease.Type: GrantFiled: September 27, 2017Date of Patent: October 22, 2024Assignees: Regents of the University of Minnesota, REGENXBIO Inc.Inventors: R. Scott McIvor, Lalitha R. Belur, Walter Low, Carolyn Fairbanks, Karen Kozarsky
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Publication number: 20240342222Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.Type: ApplicationFiled: February 21, 2024Publication date: October 17, 2024Applicant: Regents of the University of MinnesotaInventors: Michael J. SADOWSKY, Alexander KHORUTS, Alexa R. WEINGARDEN, Matthew J. HAMILTON
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Publication number: 20240343753Abstract: The invention provides a compound of formula (I): or a salt thereof, wherein R1, R2, R3, B, X, and Y have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as TET inhibitors, epigenetic modulators, and for treating cancer, eating disorders, and as adjuvants in cancer immunotherapy.Type: ApplicationFiled: April 12, 2024Publication date: October 17, 2024Applicant: Regents of the University of MinnesotaInventor: Natalia Tretyakova
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Patent number: 12109236Abstract: Provided herein are methods of manipulating ARID5B expression in immune cells such NK cells, T cells, and T cell and NK cell progenitors to enhance their persistence and function in vivo. Also provided herein are modified immune cells and compositions comprising such modified cells for anti-cancer, anti-viral, and other immunotherapies. In some embodiments, immune cells are genetically modified to increase ARID5B expression and, thus, improve persistence, increase in vivo anti-tumor efficacy, and increase viability and functionality of the modified cells after freezing and thawing.Type: GrantFiled: May 8, 2019Date of Patent: October 8, 2024Assignee: Regents of the University of MinnesotaInventors: Jeffrey Steven Miller, Frank Martin Cichocki
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Publication number: 20240327804Abstract: Certain embodiments of the invention provide conjugates, chemically self-assembled nanoring (CSAN), and cell modified with CSAN as described herein. Certain embodiments of the invention provide a method for cell-based drug delivery. Certain embodiments of the invention provide a method of transferring a cargo from a sender cell to a receiver cell as described herein.Type: ApplicationFiled: March 1, 2024Publication date: October 3, 2024Applicant: Regents of the University of MinnesotaInventors: Carston R. Wagner, Yiao Wang, Mark Distefano
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Patent number: 12106401Abstract: Self-supervised training of machine learning (“ML”) algorithms for reconstruction in inverse problems are described. These techniques do not require fully sampled training data. As an example, a physics-based ML reconstruction can be trained without requiring fully-sampled training data. In this way, such ML-based reconstruction algorithms can be trained on existing databases of undersampled images or in a scan-specific manner.Type: GrantFiled: October 20, 2020Date of Patent: October 1, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Mehmet Akcakaya, Burhaneddin Yaman, Seyed Amir Hossein Hosseini
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Patent number: 12100879Abstract: A method for forming anodic aluminum oxide (AAO) on a substrate includes disposing an Al layer on the substrate, there being a Cu layer between the substrate and the Al layer, and a TiW alloy layer between and in contact with the Cu layer and the Al layer, anodizing the Al layer to provide an AAO layer comprising nanopores extending into the AAO layer to a barrier layer of the AAO at a base of each nanopore and converting at least some of the TiW alloy layer to TiW oxide, over-anodizing the barrier layer to remove at least a portion of the AAO of the barrier layer at the base of each nanopore, and exposing the AAO layer, the TiW oxide, and the TiW to a chemical etchant sufficient to extend the nanopores through the AAO layer to a surface of the Cu layer.Type: GrantFiled: June 4, 2021Date of Patent: September 24, 2024Assignees: Regents of the University of Minnesota and Board of Regents, The University of Texas SystemInventors: Bethanie Joyce Hills Stadler, Joseph Um, Yali Zhang, Rhonda Franklin, Rashaunda Henderson
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Patent number: 12098118Abstract: The invention provides a compound of formula I and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the formula I compounds, as well as methods of using such as therapeutic agents for the treatment of pain-related disorders and diseases and in combination with other therapeutic agents.Type: GrantFiled: November 6, 2019Date of Patent: September 24, 2024Assignee: Regents of the University of MinnesotaInventors: Carolyn A. Fairbanks, Herbert T. Nagasawa, George L. Wilcox, Cristina D. Peterson, Kelley F. Kitto