Abstract: A printed structure including a plurality of overlying layers of elongate polymeric filaments stacked on a surface of a substrate. The elongate polymeric filaments are stacked on each other along their lengths to form a liquid impermeable, self-supporting wall. The liquid impermeable self-supporting wall forms a wall angle of about 30° to about 90° with respect to a plane of the surface of the substrate.

Abstract: Fully electrified microwave (MW) hydrogen (H2) plasma reduction systems and methods. With some embodiments, a plasma-flash ironmaking process is provided in which iron ore fines or particles are reduced.

Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.

Abstract: Multi-echo radio frequency (“RF”) gradient based magnetic resonance imaging (“MRI”) is described. A gradient is established in the B1 RF field to enable B1-encoded pulse sequences, such as B1-encoded spin-echo pulse sequences. As a non-limiting example, the B1-field gradient can be established using a multi-echo frequency-modulated Rabi encoded echoes (“ME-FREE”) technique.

Abstract: Systems and techniques are described for additive manufacturing, e.g., 3D printing, a component on an unconstrained freeform build surface. The systems and techniques may allow determining a 3D trajectory and/or deformation of a target deposition region on the build surface by determining a relative location of at least one registration feature on the build surface. Control circuitry may control, based on the 3D trajectory and/or deformation and based on a build model of the component, at least one dispenser to cause dispensing of at least one composition from the at least one dispenser in a predetermined pattern on or adjacent to the target deposition region. The predetermined pattern of the composition defines at least one portion of the component.

Abstract: Disclosed are compositions and methods for treating autoimmune diseases such as lupus, including immune cells expressing at least a chimeric antigen receptor (CAR) polypeptides that binds CD83 and uses thereof for suppressing and/or killing autoreactive cells in a subject having an autoimmune disease.

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.

Abstract: A 3D-printed in vitro model biological microenvironment in examples discussed below may have one or more of the following features: (a) a gel matrix 3D-printed scaffold, wherein the gel matrix comprises a chemical composition configured to culture a first type of live cells, (b) a target chemical disposed at one or more locations within the gel matrix, the target chemical forming a chemical depot from which a chemical gradient is created within the gel matrix, (c) a conduit disposed within the gel matrix and defining a lumen comprising a second type of live cells, wherein the conduit is configured to enable at least some of the first type of live cells to migrate through the conduit and facilitate flow of at least: some of the live cells to an outlet of the conduit, or enable introduction of at least one of other cells, Achemical mediators, or drugs into the 3D-printed microenvironment.

Abstract: Provided herein are TLR7/8 agonists to enhance immune responses or for use as adjuvants in fentanyl vaccines in opioid-using individuals.

Abstract: Certain embodiments of the invention provide helix sequences that have affinity for Death Receptor 5 (DR5). Certain embodiments of the invention provide an isolated anti-DR5 polypeptide (e.g., affibody for DR5) that modulates the activity and/or conformation of DR5. Certain embodiments of the invention provide methods of noncompetitively inhibiting DR5 and/or treating a fatty liver disorder.

Abstract: A housing includes a cavity portion and a cover portion configured for rotary motion. The cover portion can include a receiver port configured to engage with a fitting configured for coupling to an end of a first tube. At a first alignment position of the cavity portion relative to the cover portion, the receiver port is aligned with a first retention cleat. At a second alignment position of the cavity portion relative to the cover portion, the receiver port is aligned with a fluid coupler. At a third alignment position of the cavity portion relative to the cover portion, the fitting is aligned with a second cap.

Abstract: A method includes setting an output of each memory cell in an array of memory cells to a same first value, decreasing power to the array of memory cells and then increasing power to the array of memory cells. Memory cells in the array of memory cells with outputs that switched to a second value different from the first value are then identified in response to decreasing and then increasing the power. A set of memory cells is then selected from the identified memory cells to use in hardware security.

Abstract: Provided herein are synthetic size standards that allow one to detect size bias in a sample that includes a plurality of polynucleotides. The size standards can provide an internal control to detect and correct for size bias in data obtained after manipulating and/or processing of sample polynucleotide. Also provided herein are methods for detecting size bias in a sample or in a sequencing run.

Abstract: An example wearable respiratory motion sensor system includes a plurality of inertial measurement units (IMUs) to be positioned on a subject and generate accelerometer and gyroscope signals. The wearable respiratory motion sensor system also includes a processor to compute three-dimensional displacements of a rib cage and an abdomen of the subject based on the generated accelerometer and gyroscope signals.

Abstract: A hydraulic pump-motor includes a cylinder block including a plurality of fluid chambers, a piston in each of the fluid chambers, a cam, a fixed valve area profile, and a timing adjustment actuator. The cam includes a cam surface that engages the pistons and drives movement of the pistons relative to the fluid chambers in response to relative rotation between the cam and the fluid chambers. The fixed valve area profile is configured to control fluid flows between the fluid chambers and first and second ports. The timing adjustment actuator is configured to adjust an angular orientation of the fixed valve area profile relative to an angular orientation of the cam based on a pressure differential between a pressure at the first port and a pressure at the second port.

Abstract: A hearing system to activate an auditory system using cerebrospinal fluids includes at least one processor configured to receive an audio signal captured using a sound sensor (e.g., a microphone), extract temporal and spectral features from the audio signal, and create modulated ultrasound signals in a range of 20 Hz to 20 kHz with ultrasound carrier frequencies in the range of 50 kHz to 4 MHz, which are ultrasound frequencies that are well-suited to reach the cerebrospinal fluids (e.g., can pass across the skull/bones to reach the cerebrospinal fluids). The system further includes at least one ultrasonic transducer which receives the modulated signal and delivers the modulated signal to the body and activates the auditory system via vibration of cerebrospinal fluids that vibrate cochlear fluids, bypassing the normal conductive pathway that uses middle ear bones and minimizing bone conduction and distortion through the skull.

Abstract: A method includes receiving a first polynomial and a second polynomial, both of order n?1 and forming d polynomial segments from both the first polynomial and the second polynomial such that each polynomial segment is of order (n/d)?1. The polynomial segments of the first polynomial and the d polynomial segments of the second polynomial are used to form segment products. Each segment product is divided into a first polynomial substructure of order n/d and a second polynomial substructure of order (n/d)?1. A first polynomial substructure containing the first n/d coefficients of a product of the first polynomial and the second polynomial is summed with a second polynomial substructure to form a sum substructure. The sum substructure is used multiple times to determine coefficients of a polynomial representing the modulo xn+1 of the product of the first polynomial and the second polynomial.

Abstract: The techniques and systems described herein relate to manufacturing, characterizing, and/or identifying one or more types of magnetic nanowires (MNWs). One or more types of MNWs may be associated with different objects, and a system may identify the objects based on the magnetic nanowires associated with the objects. For example, such techniques may involve characterizing the types of MNWs based on magnetic field transmission characteristics and ferromagnetic resonance characteristics of each type of MNW. In some examples, the techniques described herein may enable the identification of each of a plurality of types of MNWs present in a sample or object based on a combined transmission value of the sample. Such techniques may enable the development and use of barcode-like systems of different types of MNWs for labeling and identifying objects of interest.

Abstract: A process comprises feeding a stream of reactant compounds to a reactor and discharging a liquid plasma into the reactant stream in the reactor, wherein the plasma initiates or accelerates a reaction of the reactant compounds to form a product composition. The reactor can comprise one or more chambers, a high-voltage electrode positioned at a first portion of the one or more chambers, a ground electrode positioned at a second portion of the one or more chambers, and a dielectric plate between the ground electrode and the high-voltage electrode that comprises openings through which the reactant stream can pass from the first portion to the second portion or from the second portion to the first portion. Discharging the plasma can include supplying electrical power to the high-voltage electrode such that plasma is discharged where the reactant stream flows through the openings.

Abstract: A removable partial denture comprises a frame sized and shaped to conform to a mouth inner surface, the frame including a projecting mounting structure; and a segment having a slot for slidably receiving the projecting mounting structure when the segment is assembled to the frame. A method of fabricating a removable partial denture comprises: acquiring 3D digital image data of a patient's mouth and dentition; creating a 3D digital model of a removable partial denture; fabricating a frame shaped to conform to an inner surface of the mouth from the 3D digital model, the frame including a mounting structure; fabricating a segment from the 3D digital model, the segment having a slot for slidably receiving the mounting structure; and inserting the mounting structure of the frame into the slot of the segment to assemble the segment to the frame. The segment can be a tooth segment or a base segment.