Abstract: Cyclic peptides inhibit LFA-1 interaction with ICAM-1 and are useful in treatment of hematopoietic neoplasms and in adjunct therapy in prevention of retinoic acid syndrome and diseases involving emigration of leukocytes into organ tissue.

Abstract: The invention relates to transgenic mammals characterized by 5-HT3 receptor over-expression in the central nervous system (CNS). The mammals have particular utility as models for studying the role of 5-HT3 receptors in the CNS, especially for the study of reward pathways for alcohol and other substances of abuse.

Abstract: The present invention provides a unipolar semiconductor structure comprising: at least one active layer comprising at least one group III-nitride; and at two barrier layers disposed on either side of the active layer, each of the two barrier layers comprising at least one group

Abstract: A Single Event Upset (SEU) resistant latch circuit that uses the Single Event Resistant Topology (SERT) comprises a first circuit module electrically coupled to a second circuit module. In the SERT-1 embodiment, the first circuit module has two output terminals, including four cross-coupled p-channel (PMOS) transistors coupled with two n-channel (NMOS) transistors. The second circuit module has two output terminals, including four cross-coupled p-channel (PMOS) transistors coupled with two n-channel (NMOS) transistors. These four output terminals satisfy a set of state equations that can be used to obtain the SERT-1 State Table. In the SERT-2 embodiment, the first circuit module has two output terminals, including four cross-coupled n-channel (NMOS) transistors coupled with two p-channel (PMOS) transistors. The second circuit module has two output terminals, including four cross-coupled n-channel (NMOS) transistors coupled with two p-channel (PMOS) transistors.

Abstract: A method of in situ biodenitrification of a contaminated site comprising providing to a contaminated site a phosphorous source, namely a polyphosphate or a trimetaphosphate. The phosphorous source is provided to a saturated zone or an unsaturated zone and a carbon source is also provided, most preferably acetate. The invention is also of an in situ biodenitrification apparatus (FIG. 3) comprising at least one extraction well for extracting subsurface water from a contaminated site, a container for mixing nutrients into the extracted water, and an injection well for re-introducing the extracted water to the subsurface. Preferably, at least three extraction wells are placed approximately on a circle having the injection well as a center, and a phosphorous source is introduced to the container, preferably a polyphosphate or a trimetaphosphate.

Abstract: A line of sight laser communication system includes a laser to generate a laser signal with femtosecond pulses. A first grating spectrally disperses the femtosecond pulses of the laser signal. A programmable mask converts the femtosecond pulses of the laser signal into coded words. A second grating spectrally recombines the coded words of the laser signal. A telescope then launches the laser signal. The launched laser signal is received at a receiving telescope. A second laser generates a set of reference pulses. A non-linear crystal combines the set of reference pulses and the laser signal to create an output signal only when the laser signal and the reference pulses temporally coincide. A camera records the output signal.

Abstract: The invention provides anti-thiol reagents which inhibit enzyme activity of cell-associated protein disulfide isomerase (PDI) by oxidizing or blocking PDI active site vicinal thiol groups which normally participate in disulfide bond rearrangement of PDI substrates. Inhibition of this PDI function is particularly useful in blocking PDI-mediated entry of HIV or other virions into a host cell, as well as inhibiting lymphocyte traffic through the lymph nodes. The invention further provides an assay for the identification of such PDI inhibitors based on the discovery that inhibitors of the invention also induce shedding of the leucocyte L-selectin adhesion molecule. The invention additionally provides for suppression of inflammation and of lymph node entry by calmodulin antagonists that, like PDI inhibition, cause leukocyte L-selectin shedding.

Abstract: The present invention provides a hybrid material and a method for forming a hybrid material comprising actuator made from a stimuli responsive polymer mounted in a porous framework. The present invention also provides devices employing the actuator of the present invention.

Abstract: The present invention provides a coating composition comprising: A coating composition comprising: TEOS; a surfactant; at least one organosilane; HCl; water; and ethanol. The present invention also provides films made from such a coating composition and a method for making such films.

Abstract: The present invention provides a heat shock protein immunotoxin comprising: at least a fragment of a heat shock protein, the fragment being capable of being bound by an immune cell; and a toxin bound to the fragment. The present invention also provides a method for decreasing the number of immune cells in an individual using the heat shock protein immunotoxins of the present invention. In addition, the present invention provides a method for decreasing the number of immune cells in an organ using the heat shock protein immunotoxins of the present invention.

Abstract: An electrical equivalent circuit is provided for an electrospray process. It is a series circuit which includes a power supply voltage (Vapp), a voltage (Vec) established at the electrochemical contact to the solution, a solution resistance (Rs), a constant current regulator which represents the processes of charge separation and charge transport in the gap between the spray needle aperture and the counter electrode, and a voltage (Vcn) caused by charge neutralization at the counter electrode. A current i, established by the constant current regulator flows throughout the entire circuit. Current-voltage curves are developed for each part of the circuit. From these it is shown that in the case where Rs is negligible (the power supply is connected directly to a conducting needle) the shape of the current-voltage curve is dictated by the constant current regulator established by the charge separation process, the gap, and the counter electrode.

Abstract: The present invention provides a method for inducing a refractive index change in a lead silicate glass material comprising: providing a lead silicate glass material; and irradiating the lead silicate glass material to increase the index of refraction of said lead silicate glass material. The present invention also provides a photo-induced lead silicate glass grating.

Abstract: A method for purifying heat shock protein complexes is provided which comprises the steps of adding a solution containing heat shock protein complexes, in which heat shock proteins are associated with peptides, polypeptides, denatured proteins or antigens, to a column containing an ADP matrix to bind the heat shock proteins complexes to the ADP matrix and adding a buffer containing ADP to the column to remove the heat shock protein complexes in an elution protein. Additionally a method for synthesizing heat shock protein complexes and purifying the complexes so produced is provided which comprises the steps of adding heat shock proteins to an ADP matrix column to bind them to the matrix, adding a solution of peptides, polypeptides, denatured proteins or antigens to the column to bind them to the heat shock proteins as heat shock protein complexes and adding a buffer containing ADP to the column to remove the complexes in an elution product.

Abstract: A high-speed, ultra-dense, via contact programmable ROM based on multiplexor cells is presented. High density is achieved by fully encoding n-bits of address space and programming the core with 2n bits of information per contact through the use of higher order logic techniques. Subfunction encoding is used to make substantial improvement to the area required for ROM structures. The programming is accomplished using via contacts between the top two metal layers. No transistors are used in the programmed core for the ROM, reducing the bit line load and helping to maintain a high level of performance.

Abstract: A system and method for misting a liquid agent to be used for fire suppression and inertion or explosion suppression and inertion are provided. The system includes a container of pressurized liquid agent, a way to convey a stream of the agent to a discharge nozzle, and a way to introduce pressurized gas to the stream of agent.

Abstract: A method and an apparatus for diagnosis of sensors and/or processes through use of Bayesian belief networks. More specifically, the method and apparatus of the present invention achieve sensor and/or process fault detection, isolation, and accommodation.

Abstract: The present invention provides a method of fabricating an electro-optically active fiber segment comprising the steps, in any order, of inducing a second-order nonlinearity in the fiber segment, and placing a portion of the fiber segment between and in contact with two electrodes. Also, the present invention provides an electro-optically active fiber segment comprising a second-order nonlinearity induced within the fiber segment, and a portion of the fiber segment being between and in contact with a first electrode and a second electrode.

Abstract: In one embodiment, the present invention provides a microlens having very small focal length. The present invention also provides a non-planar microstructure having a covering layer which is slowly oxidizing or substantially free of oxygen. The present invention also provides methods for forming such microlenses and microstructures. In addition, the present invention provides a VCSEL which includes one or more non-planar microstructures of the present invention.

Abstract: An improved highly doped waveguide is provided which comprises a waveguide employing an Er dopant and Pr sensitizer ions. The present invention also provides a method of efficient coupling from an optical source into a waveguide using a rotated optical element.

Abstract: The present invention involves a process and system for producing spherical BNxOy particles that are converted to crystalline BN. The process involves adding a boron compound to an aqueous solution, creating an aerosol spray from the solution in the form of aerosol droplets using an aerosol generator. The aerosol droplets are fed with an inert carrier gas into a heated furnace at a preset flow rate while simultaneously injecting a gaseous nitriding agent into the heated furnace in a direct proportion to the flow rate of the carrier gas containing the aerosol droplets whereby a precursor of spherically shaped BNxOy particles are formed which are further heat treated into particles of spherically shaped BN having a turbostratic or hexagonal structure.