Patents Assigned to University of North Carolina at CHapel Hill
  • Methods and treatments using toll-like receptor agonists to mitigate hematopoietic myeloid loss, increase gastrointestinal recovery and reduce tumor growth
    Patent number: 11918621
    Abstract: Provided herein are methods of mitigating and/or preventing side effects from chemotherapy and/or radiotherapy in a subject by administering a therapeutically effective amount of a toll-like receptor 2/6 (TLR 2/6) ligand, including fibroblast-stimulating lipopeptide 1 (FSL-1). Methods of treating and/or preventing gastrointestinal disorders are also disclosed. Additionally, methods of increasing granulocyte colony-stimulating factor (G-CSF) production in a subject undergoing a medical treatment, including administering FSL-1 compositions, are provided.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: March 5, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jenny P.-Y. Ting, Willie June Brickey, Hao Guo, Cathryn Julia Robbins
  • Compositions and methods for enhancing the biological response to chemical agents and physical stimuli
    Patent number: 11918822
    Abstract: The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.
    Type: Grant
    Filed: October 19, 2022
    Date of Patent: March 5, 2024
    Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Clinton Rubin, Janet Rubin
  • Array of micro-elements for high resolution and high content imaging and sorting of cells
    Patent number: 11920115
    Abstract: An array of magnetic or paramagnetic micro-elements comprised of polysilsesquioxane is described having ultra-low-autofluorescence and other optical properties to improve microscopic imaging of cells or other objects present on the array. These materials are also amenable to chemical modification allowing surface attachment of affinity capture moieties or chemical reporters for selective binding or analysis of cells, macromolecules or other targets.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: March 5, 2024
    Assignees: The University of North Carolina at Chapel Hill, Cell Microsystems, Inc.
    Inventors: Nancy L. Allbritton, Yuli Wang, Christopher E. Sims, Nicholas C. Dobes, Steven C. Gebhart, Nicholas C. Trotta
  • Bilateral amines for defect passivation and surface protection in perovskite solar cells
    Patent number: 11920042
    Abstract: Described herein is an ink solution, comprising: i. a composition having the formula ABX3; ii. a compound having the formula NH2—R1—NH2; and iii. a solvent. Methods for producing polycrystalline perovskite films using the ink solutions described herein in a fast blading process and the use of the films in photoactive and photovoltaic applications are additionally described.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: March 5, 2024
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Jinsong Huang, Guang Yang, Wuqiang Wu
  • SHORT-ACTING HEPARIN-BASED ANTICOAGULANT COMPOUNDS AND METHODS
    Publication number: 20240066048
    Abstract: Heparin compounds and synthetic heparin analogues having short acting anticoagulant activity are provided. Methods of synthesizing such heparin compounds, including chemoenzymatic pathways using sulfotransferase enzymes are provided. Methods of treating subjects in need of anticoagulant activity are provided.
    Type: Application
    Filed: July 17, 2023
    Publication date: February 29, 2024
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Jian Liu, Zhangjie Wang, Po-Hung Hsieh, Yongmei Xu
  • Compositions and methods for the selective detection of tumor-derived viral DNA
    Patent number: 11913080
    Abstract: The present disclosure provides methods and compositions of modified oligonucleotide primer and probe combinations, structurally modified with locked nucleic acids, quenchers, and dyes, effective to detect tumor-derived Human Papilloma Virus (HPV) and tumor-derived Epstein-Barr virus (EBV) and, especially, to distinguish viral DNA derived from tumors from viral DNA derived from infectious viral particles.
    Type: Grant
    Filed: February 15, 2022
    Date of Patent: February 27, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Gaorav Gupta, Bhishamjit S. Chera, Sunil Kumar
  • Short-acting heparin-based anticoagulant compounds and methods
    Patent number: 11903963
    Abstract: Heparin compounds and synthetic heparin analogues having short acting anticoagulant activity are provided. Methods of synthesizing such heparin compounds, including chemoenzymatic pathways using sulfotransferase enzymes are provided. Methods of treating subjects in need of anticoagulant activity are provided.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: February 20, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jian Liu, Zhangjie Wang, Po-Hung Hsieh, Yongmei Xu
  • Methods and compositions for gene transfer across the vasculature
    Patent number: 11905312
    Abstract: The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: February 20, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Aravind Asokan, Giridhar Murlidharan, Blake Albright
  • Methods and compositions for delivery of viral vectors across the blood-brain barrier
    Patent number: 11905533
    Abstract: Disclosed herein is an adeno-associated virus (AAV) particle comprising a surface-bound peptide that enhances transduction of cells across the blood-brain barrier (BBB). Also disclosed herein is a modified AAV capsid protein comprising an insertion of a polypeptide that enhances transduction of cells across the BBB, and an AAV particle comprising the modified AAV capsid protein. Specific peptides are provided. Pharmaceutical formulations and method of administering/delivering a nucleic acid to a cell of the brain and/or central nervous system are also disclosed.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: February 20, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Chengwen Li, Richard Jude Samulski
  • Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus
    Patent number: 11905306
    Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 21, 2022
    Date of Patent: February 20, 2024
    Assignees: Southern Research Institute, Vanderbilt University, University of North Carolina at Chapel Hill
    Inventors: Syed Kaleem Ahmed, Shilpa Dutta, John Phillip Tillotson, Corinne E. Augelli-Szafran, Ashish Kumar Pathak, Omar Moukha-Chafiq, Timothy Patrick Sheahan, Ralph S. Baric, Amy Catherine Sims, Mark R. Denison
  • Bifunction chemical epigenetic modifiers and methods of use
    Patent number: 11905537
    Abstract: The present disclosure relates to bifunctional chemical epigenetic modifiers, and methods of making, kits and using the bifunctional chemical epigenetic modifiers. The bifunctional chemical epigenetic modifiers can include a FK506 molecule or derivative thereof, a linker and a bifunctional ligand. The bifunctional ligand can be a histone deacetylase inhibitor.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: February 20, 2024
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Nate Hathaway, Jian Jin, Kyle Butler, Anna Chiarella
  • WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds and methods of use
    Patent number: 11905291
    Abstract: Disclosed herein are WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds including a WDR5 ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of WDR5-mediated diseases.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: February 20, 2024
    Assignees: Icahn School of Medicine at Mount Sinai, The University of North Carolina at Chapel Hill
    Inventors: Jian Jin, Gang Wang, Jing Liu, Xufen Yu, Dongxu Li
  • Compounds Useful in HIV Therapy
    Publication number: 20240051972
    Abstract: The invention relates to compounds of Formula (I), (Ia), (Ib), (II) or (III), salts thereof, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.
    Type: Application
    Filed: August 31, 2022
    Publication date: February 15, 2024
    Applicants: GlaxoSmithKline Intellectual Property Development Limited, The University of North Carolina at Chapel Hill, ViiV Healthcare Company
    Inventors: Martha DE LA ROSA, Richard M. DUNHAM, David MARGOLIS, Vincent Wing-Fai TAI, Jun TANG
  • Compositions and methods for inhibiting pathogen infection
    Patent number: 11897939
    Abstract: The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating virus infection in the respiratory tract and virus transmission through the respiratory tract. In particular, the presently-disclosed subject matter relates to inhibiting and treating virus infection in a subject using compositions and antibodies that trap viruses in mucus of the respiratory tract, thereby inhibiting transport of virus across or through mucus secretions.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: February 13, 2024
    Assignees: The University of North Carolina at Chapel Hill, The Johns Hopkins University
    Inventors: Samuel Lai, Ying-Ying Wang, Arthi Kannan, Kenetta Nunn, Durai Babu Subramani, Richard Cone, Bing Yang, Justin Mccallen
  • Methods and compositions for activation of T cells using nanoparticles conjugated with multiple ligands for binding receptors on T cells
    Patent number: 11884738
    Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: January 30, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Andrew Wang, Yu Mi
  • Compositions and methods comprising SFRP2 antagonists
    Patent number: 11873333
    Abstract: The present disclosure provides humanized antibodies and antigen-binding fragments thereof that specifically bind to SFRP2 and compositions comprising such humanized antibodies or antigen-binding fragments thereof. In some aspects, the humanized antibodies or antigen-binding fragments can be used to treat diseases or conditions associated with increased SFRP2, such as cancer. In some aspects, the antibodies or antigen-binding fragments can be used to treat osteosarcoma.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: January 16, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nancy Demore, Cam Patterson
  • Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders
    Patent number: 11872311
    Abstract: Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: January 16, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Wenbin Lin, Demin Liu, Joseph Della Rocca, Stephanie Kramer, Christopher Y. Poon
  • Sulfated oligosaccharides having anti-inflammatory activity
    Patent number: 11865137
    Abstract: Provided herein are small molecule compounds, including non-anticoagulant heparan sulfate oligosaccharide molecules, having anti-inflammatory properties and capable of interacting with high mobility group box 1 (HMGB1) proteins in a manner sufficient to affect an interaction between the HMGB1 protein and a receptor for advanced glycation end products (RAGE). Also provided herein are methods of treating Paracetamol (APAP) overdose in subjects.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: January 9, 2024
    Assignees: The University of North Carolina at Chapel Hill, The Research Foundation for the State University of New York
    Inventors: Katelyn Arnold, Ding Xu, Yongmei Xu, Rafal Pawlinski, Jian Liu
  • Vector-mediated immune tolerance in the eye
    Patent number: 11866480
    Abstract: This invention relates to vectors for delivery of human leukocyte antigen G to the eye and/or to cornea explants and methods of using the same for treatment and/or prevention of corneal transplant rejection and other disorders associated with an immune response and/or vascularization.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: January 9, 2024
    Assignees: The University of North Carolina at Chapel Hill, North Carolina State University
    Inventors: Matthew Louis Hirsch, Brian Christopher Gilger
  • Detecting cancer cell of origin
    Patent number: 11851715
    Abstract: Methods and compositions are provided for determining a pan-cancer clustering of cluster assignment (COCA) subtype of a cancer in an individual by detecting the expression level of at least one classifier biomarker selected from a group of classifier biomarkers for COCA subtypes. Also provided herein are methods and compositions for determining the response of an individual with a COCA subtype to a therapy such as immunotherapy.
    Type: Grant
    Filed: August 17, 2022
    Date of Patent: December 26, 2023
    Assignees: GeneCentric Therapeutics, Inc., The University of North Carolina at Chapel Hill
    Inventors: Greg Mayhew, Hawazin Faruki, Myla Lai-Goldman, Charles M. Perou, Joel S. Parker