Patents Assigned to University of North Carolina
  • Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
    Patent number: 11067537
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: July 20, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Methods and compositions for treating mucosal tissue disorders
    Patent number: 11058743
    Abstract: The present invention provides compositions and formulations comprising glutathione with or without thiocyanate and methods of use thereof to treat diseases and disorders in mucosal/epithelial tissue.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: July 13, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Roland R. Arnold, David C. Henke
  • Systems and methods for modeling neural architecture
    Patent number: 11062450
    Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: July 13, 2021
    Assignees: Ohio State Innovation Foundation, The Penn State Research Foundation, University of North Carolina, University of San Francisco
    Inventors: Skyler Cranmer, Bruce Desmarais, Shankar Bhamidi, James Wilson, Matthew Denny, Zhong-Lin Lu, Paul Stillman
  • Methods and compositions for dual glycan binding AAV vectors
    Patent number: 11059862
    Abstract: The present invention provides methods and compositions comprising an adeno-associated virus (AAV) capsid protein, comprising one or more amino acids substitutions, wherein the substitutions introduce a new glycan binding site into the AAV capsid protein.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: July 13, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Aravind Asokan, Richard Samulski
  • Benzoylglycine Derivatives and Methods of Making and Using Same
    Publication number: 20210206715
    Abstract: Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1, R2, R3, R4, R5, R6, R7, R11, R12, R13, R14, R15, R16, R17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.
    Type: Application
    Filed: March 19, 2021
    Publication date: July 8, 2021
    Applicants: Duke University, The University of North Carolina at Chapel Hill
    Inventors: Pei Zhou, Eric J. Toone, Robert A. Nicholas, Ramesh Gopalaswamy, Xiaofei Liang, Frank Navas, III
  • INJECTABLE THERMORESPONSIVE HYDROGELS AS A COMBINATORY MODALITY FOR CONTROLLED DRUG DELIVERY, BIOMATERIAL IMPLANT AND 3D PRINTING BIOINK
    Publication number: 20210205459
    Abstract: Provided herein are pharmaceutical compositions that include a pharmaceutically active agent, a cellulose nanocrystal or a cellulose nanofiber, a thermogelling biocompatible polymer, and a gelling agent. Such pharmaceutical compositions can be configured as a bioink suitable for 3D printing. Such pharmaceutical compositions are suitable for treating bone disorders, including osteoporosis. Methods of treating Paget's disease, treating or preventing cancer, treating or preventing an infectious disease, and treating or preventing a disorder through regenerative medicine are also provided.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 8, 2021
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Soumya Rahima Benhabbour, Panita Maturavongsadit
  • SYSTEMS AND METHODS FOR MODELING NEURAL ARCHITECTURE
    Publication number: 20210209761
    Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.
    Type: Application
    Filed: March 5, 2021
    Publication date: July 8, 2021
    Applicants: Ohio State Innovation Foundation, The Penn State Research Foundation, University of North Carolina, University of San Francisco
    Inventors: Skyler Cranmer, Bruce Desmarais, Shankar Bhamidi, James Wilson, Matthew Denny, Zhong-Lin Lu, Paul Stillman
  • Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods
    Patent number: 11053535
    Abstract: Devices, such as chips for DNA analysis, have at least one fluid transport nanochannel with at least one intersecting (e.g., transverse) sensing nanochannel that can be monitored for change in ionic current to determine characteristics or parameters of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: July 6, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Jean Pierre Alarie, Laurent Menard
  • Gene-expression based subtyping of pancreatic ductal adenocarcinoma
    Patent number: 11053550
    Abstract: Methods for generating a prognostic and/or subtype signature for a subject with pancreatic ductal adenocarcinoma (PDAC) are provided. In some embodiments, the methods include determining expression levels for one or more genes listed in Tables 2-5, 9, 10, or 11, and/or the DE-S and/or DE-T subset of genes in PDAC cells obtained from the subject, wherein the determining provides a prognostic and/or subtype signature for the subject. Also provided are methods for classifying a subject diagnosed with pancreatic ductal adenocarcinoma (PDAC) as having an activated stroma subtype or a normal stroma subtype of PDAC and/or a basal subtype or a classical subtype of PDAC; and methods for identifying a differential treatment strategy for a subject diagnosed with pancreatic ductal adenocarcinoma (PDAC).
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: July 6, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Richard Moffitt, Jen Jen Yeh, Naim Ur Rashid
  • Methods and compositions for inducing an immune response
    Patent number: 11052149
    Abstract: The present invention provides a composition comprising a) a polyacetal polymer, a polyester polymer and/or a biodegradable polymer; b) a cyclic dinucleotide; and c) an antigen and/or an antibody, as well as methods of using same.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: July 6, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jenny P.-Y. Ting, Robert Junkins, Brandon Johnson, Kristy Ainslie, Eric Bachelder, Matthew Gallovic, Michael Collier, Ning Cheng
  • Array of micromolded structures for sorting adherent cells
    Patent number: 11046926
    Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: June 29, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah
  • Minimal-latency tracking and display for matching real and virtual worlds in head-worn displays
    Patent number: 11049476
    Abstract: Methods, systems, and computer readable media for minimal-latency tracking and display for matching real and virtual worlds in head-worn displays are disclosed. According to one aspect, a method for minimal-latency tracking and display for matching real and virtual worlds in head-worn displays includes calculating a desired image, calculating an error image as the difference between the desired image and an image currently being perceived by a user, identifying as an error portion a portion of the error image having the largest error, updating a portion of a projected image that corresponds to the error portion, and recalculating the image currently being perceived by a user based on the updated projected image.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: June 29, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Henry Fuchs, Anselmo A. Lastra, John Turner Whitted, Feng Zheng, Andrei State, Gregory Welch
  • Camera control unit (CCU) communications breakout box
    Patent number: 11050204
    Abstract: According to one aspect, the subject matter described herein includes a camera control unit (CCU) communications breakout box. The CCU communications breakout box includes a housing for mounting to an audio/visual equipment rack, the housing including a first surface having signal connector apertures. The CCU communications breakout box further includes a plurality of signal connectors mounted in the signal connector apertures, the signal connectors including a multi-conductor CCU connector having a plurality of conductors that are connectable to a CCU via a multi-conductor cable, the signal connectors further including CCU signal breakout connectors connected to predetermined ones of the conductors of the multi-conductor CCU connector for breaking out signals of the CCU accessible through the multi-conductor CCU connector.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: June 29, 2021
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventor: Kevin Gerard Tucker
  • System for removing bromide from a wastewater stream
    Patent number: 11040896
    Abstract: In one aspect, systems and methods for the efficient and cost-effective removal of bromide from wastewater streams are described herein. Briefly, a system for bromide removal comprises pretreatment apparatus operable for at least partial removal of background ionic species from the wastewater stream and/or dilution of the background ionic species in the wastewater stream. The system also comprises bromide capture apparatus operable for removal of bromide from the pretreated wastewater stream, wherein the system removes bromide from the wastewater stream at an efficiency of at least 80 percent. In some embodiments, bromide is recovered from the capture apparatus and reused in flue gas treatment applications.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: June 22, 2021
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE
    Inventors: James E. Amburgey, Olya Stepanovna Keen, Mei Sun
  • Benzimidazoles that enhance the activity of oligonucleotides
    Patent number: 11040056
    Abstract: This disclosure is directed to methods, compounds and compositions for delivering nucleic acids to a cell of interest. In particular, it provides salts that are particularly effective in delivering nucleic acids to cells in the lung for disorders such as cystic fibrosis (CF).
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: June 22, 2021
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Rudolph L. Juliano, Silvia M. Kreda, Ling Wang, Xin Ming, Lindsey Ingerman James, Ranathunga Arachchillage Yamuna Kumari Ariyarathna
  • Methods for subtyping of lung squamous cell carcinoma
    Patent number: 11041214
    Abstract: Methods and compositions are provided for determining a subtype of lung squamous cell carcinoma (SQ) of an individual by detecting the expression level of at least one classifier biomarker selected from a group of gene signatures for lung squamous cell carcinoma. Also provided herein are methods and compositions for determining the response of an individual with a squamous cell carcinoma subtype to a therapy such as immunotherapy.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: June 22, 2021
    Assignees: GeneCentric Therapeutics, Inc., The University of North Carolina at Chapel Hill
    Inventors: Hawazin Faruki, Myla Lai-Goldman, Greg Mayhew, Jonathan Serody, Charles Perou, David Neil Hayes
  • Benzoylglycine derivatives and methods of making and using same
    Patent number: 11034649
    Abstract: Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1, R2, R3, R4, R5, R6, R7, R11, R12, R13, R14, R15, R16, R17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: June 15, 2021
    Assignees: DUKE UNIVERSITY, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Pei Zhou, Eric J. Toone, Robert A. Nicholas, Ramesh Gopalaswamy, Xiaofei Liang, Frank Navas, III
  • P16 POSITIVE TUMOR STRATIFICATION ASSAYS AND METHODS
    Publication number: 20210172021
    Abstract: Described herein are assays and methods to detect and/or treat a non-responsive or treatment resistant p16 positive tumor in a subject in need thereof. The disclosed method can also involve determining if the subject is HPV positive or negative, whether the HPV is integrated or episomal, and selecting a suitable treatment based on these determinations. Also disclosed herein is a method of treating an oropharyngeal squamous cell carcinoma in a subject using the arrays and methods disclosed herein.
    Type: Application
    Filed: April 12, 2019
    Publication date: June 10, 2021
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Wesley Hunter STEPP, Travis Parke SCHRANK
  • Methods of identifying risk of vascular endothelial growth factor (VEGF) pathway inhibitor-induced hypertension
    Patent number: 11028448
    Abstract: The disclosure relates to methods of identifying subjects at risk of developing bevacizumab-induced toxicities such as proteinuria and/or hypertension involving measuring nucleic acid or gene mutations in a sample obtained from the subject.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: June 8, 2021
    Assignees: The University of North Carolina at Chapel Hill, Duke University
    Inventors: Federico Innocenti, Julia Quintanilha, Danyu Lin, Kouros Owzar, Jin Wang
  • Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto
    Patent number: 11026965
    Abstract: Disclosed herein are cyclodextrin molecules covalently modified to store and release nitric oxide, as well as methods of making and uses thereof. The covalently modified cyclodextrin molecules may be tailored, in several embodiments, to release nitric oxide in a controlled manner and are useful for reduction and/or eradication of bacteria and for the treatment of disease.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: June 8, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Haibao Jin