Patents Assigned to University of Ottawa
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Patent number: 12195451Abstract: Provided are compounds of Formula III that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.Type: GrantFiled: March 31, 2022Date of Patent: January 14, 2025Assignee: Ottawa Hospital Research Institute and University of OttawaInventors: Jean-Simon Diallo, Christopher Noyce Boddy, Mark Dornan, Ramya Krishnan, Rozanne Arulanandam, Fabrice Le Boeuf, Jeffrey Smith, Andrew Macklin
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Patent number: 12138364Abstract: Provided herein are scaffold biomaterials comprising a decellularised fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for preparing such scaffold biomaterials, as well as uses thereof as an implantable scaffold for supporting animal cell growth, for promoting tissue regeneration, for promoting angiogenesis, for a tissue replacement procedure, and/or as a structural implant for cosmetic surgery are also provided. Therapeutic treatment and/or cosmetic methods employing such scaffolds are additionally described.Type: GrantFiled: September 29, 2021Date of Patent: November 12, 2024Assignee: University of OttawaInventors: Andrew Edward Pelling, Charles Michel Cuerrier, Daniel J. Modulevsky, Ryan Joseph Hickey
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Publication number: 20240371622Abstract: The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMC®) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.Type: ApplicationFiled: March 20, 2024Publication date: November 7, 2024Applicants: Standard BioTools Canada Inc., University of OttawaInventors: Paul Corkum, Alexander V. Loboda
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Publication number: 20240360115Abstract: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.Type: ApplicationFiled: July 4, 2024Publication date: October 31, 2024Applicants: Ottawa Hospital Research Institute, University of OttawaInventors: Jean-Simon Diallo, Christopher Noyce Boddy, Mark Dornan, Ramya Krishnan, Rozanne Arulanandam, Fabrice Le Boeuf, Jeffrey Smith, Andrew Macklin
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Patent number: 12013364Abstract: Described are various embodiments of a system and method for selectively identifying the presence of a designated chemical species within a chemical sample using a two-dimensional sensor, which, when exposed to illumination, provides a differentiable adsorption sensor response signal for chemical identification.Type: GrantFiled: October 15, 2020Date of Patent: June 18, 2024Assignee: University of OttawaInventors: Jean-Michel Ménard, Adina Anamaria Luican-Mayer, Ranjana Rautela
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Patent number: 11967496Abstract: The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMC™) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.Type: GrantFiled: January 21, 2022Date of Patent: April 23, 2024Assignees: University of OttawaInventors: Paul Corkum, Alexander V. Loboda
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Patent number: 11512262Abstract: The present disclosure relates generally to antioxidants. More particularly, the present disclosure relates to lubricating compositions comprising an antioxidant.Type: GrantFiled: March 15, 2018Date of Patent: November 29, 2022Assignee: University of OttawaInventors: Derek Andrew Pratt, Evan Haidasz
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Publication number: 20220220101Abstract: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.Type: ApplicationFiled: March 31, 2022Publication date: July 14, 2022Applicants: Ottawa Hospital Research Institute, University of OttawaInventors: Jean-Simon Diallo, Christopher Noyce Boddy, Mark Dornan, Ramya Krishnan, Rozanne Arulanandam, Fabrice Le Boeuf, Jeffrey Smith, Andrew Macklin
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Patent number: 11339146Abstract: Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.Type: GrantFiled: May 18, 2020Date of Patent: May 24, 2022Assignee: Ottawa Hospital Research Institute and University of OttawaInventors: Jean-Simon Diallo, Christopher Noyce Boddy, Mark Dornan, Ramya Krishnan, Rozanne Arulanandam, Fabrice Le Boeuf, Jeffrey Smith, Andrew Macklin
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Patent number: 11298402Abstract: Methods for modulating lysosome-mediated microautophagy of a lipid or protein substrate in a cell are provided herein. In certain embodiments, said methods may comprise increasing lysosome-mediated microautophagy by treating the cell with a microautophagy-enhancing agent which increases lysosomal association-dissociation events between lysosomes and the cellular lipid or protein substrate and/or increases lysosomal degradation capacity; or decreasing lysosome-mediated microautophagy by treating the cell with a microautophagy-reducing agent which reduces lysosomal association-dissociation events between lysosomes and the cellular lipid or protein substrate and/or decreases lysosomal degradation capacity; thereby modulating lysosome-mediated microautophagy of the lipid or protein substrate.Type: GrantFiled: July 8, 2016Date of Patent: April 12, 2022Assignee: University of OttawaInventors: Mohsen Amir Alipour, Zemin Yao
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Publication number: 20220016317Abstract: Provided herein are scaffold biomaterials comprising a decellularised fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for preparing such scaffold biomaterials, as well as uses thereof as an implantable scaffold for supporting animal cell growth, for promoting tissue regeneration, for promoting angiogenesis, for a tissue replacement procedure, and/or as a structural implant for cosmetic surgery are also provided. Therapeutic treatment and/or cosmetic methods employing such scaffolds are additionally described.Type: ApplicationFiled: September 29, 2021Publication date: January 20, 2022Applicant: University of OttawaInventors: Andrew Edward PELLING, Charles Michel CUERRIER, Daniel J. MODULEVSKY, Ryan Joseph HICKEY
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Patent number: 11175294Abstract: A method of isotope-labelling a microbiota sample. It involves providing a first microbiota sample that was obtained from a given source; exposing the first microbiota sample to an isotope enriched medium; and culturing the exposed first microbiota sample in the isotope enriched medium to obtain an isotope-labelled microbiota sample, wherein the isotope labelled metaproteome of the isotope-labelled microbiota sample is taxon specific for taxa present in the first microbiota sample when initially obtained from the given source.Type: GrantFiled: June 1, 2017Date of Patent: November 16, 2021Assignee: University Of OttawaInventors: Joseph Michel Daniel Figeys, Alain Christophe Stintzi, David R. Mack, Xu Zhang, Zhibin Ning
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Patent number: 11122830Abstract: Bacterial strains are provided that can be isolated from the microflora of lowbush blueberry (Vaccinium angustifolium), and that are capable of increasing the antioxidant content of their growth medium. The bacteria can be used, for example, to increase the antioxidant content of various foodstuffs, as probiotics or as additives to animal feed. Antioxidant-enriched compositions produced by fermentation processes utilising the bacteria are also provided. The antioxidant-enriched compositions can be used in the preparation of cosmetics and nutritional supplements. The antioxidant-enriched compositions also have therapeutic applications.Type: GrantFiled: February 5, 2019Date of Patent: September 21, 2021Assignee: University of OttawaInventors: Chantal Matar, Luc J. Martin
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Patent number: 11045582Abstract: Provided herein are scaffold biomaterials comprising a decellularised plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised plant or fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for preparing such scaffold biomaterials, as well as uses thereof as an implantable scaffold for supporting animal cell growth, for promoting tissue regeneration, for promoting angiogenesis, for a tissue replacement procedure, and/or as a structural implant for cosmetic surgery are also provided. Therapeutic treatment and/or cosmetic methods employing such scaffolds are additionally described.Type: GrantFiled: February 10, 2017Date of Patent: June 29, 2021Assignee: University of OttawaInventors: Andrew Edward Pelling, Charles Michel Cuerrier, Daniel J. Modulevsky, Ryan Joseph Hickey
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Publication number: 20210157179Abstract: A pixel for creating an optical phase change includes a transparent electrical insulator, a first electrical conductor disposed on the transparent electrical insulator, the first electrical conductor comprising an antenna component and a connector component, an electrical insulator disposed on the first electrical conductor, a transparent semiconductor disposed on the electrical insulator, and a second electrical conductor disposed on the transparent semiconductor. The transparent semiconductor is sufficiently thick to prevent plasmonic resonance from occurring at an interface between the transparent semiconductor and the second electrical conductor.Type: ApplicationFiled: November 23, 2020Publication date: May 27, 2021Applicants: Huawei Technologies Canada Co., Ltd., The University of OttawaInventors: Antonino CALA' LESINA, Pierre Simon Joseph BERINI, Lora RAMUNNO, Dominic John GOODWILL, Eric BERNIER
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Patent number: 10965370Abstract: An optical performance monitor comprises a first stage configured to receive a multiplexed optical signal. The first stage is tunable over a period. The first stage periodically filters the multiplexed optical signal over an optical channel to produce a fine filtered optical signal. A second stage is coupled to the first stage and has a second-stage transfer function. The second stage receives the fine filtered optical signal and produces one or a plurality of interfered optical signal pairs. A third stage is coupled to the second stage and has a third-stage transfer function. The third stage receives the optical signal pairs and demultiplexes the optical signal pairs to produce a plurality of demultiplexed optical signals. The combination of the second-stage transfer function and the third-stage transfer function is flatter over the optical channel than the third-stage transfer function.Type: GrantFiled: June 1, 2020Date of Patent: March 30, 2021Assignees: Huawei Technologies Canada Co., Ltd., The University of OttawaInventors: Mohammad Mehdi Mansouri Rad, Patrick Dumais, Trevor James Hall, Mehedi Hasan
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Publication number: 20210001007Abstract: Provided herein are scaffold biomaterials comprising a decellularised plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised plant or fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for preparing such scaffold biomaterials, as well as uses thereof as an implantable scaffold for supporting animal cell growth, for promoting tissue regeneration, for promoting angiogenesis, for a tissue replacement procedure, and/or as a structural implant for cosmetic surgery are also provided. Therapeutic treatment and/or cosmetic methods employing such scaffolds are additionally described.Type: ApplicationFiled: April 14, 2020Publication date: January 7, 2021Applicant: University of OttawaInventors: Andrew Edward PELLING, Charles Michel CUERRIER, Daniel J. MODULEVSKY, Ryan Joseph HICKEY
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Publication number: 20200412447Abstract: An optical performance monitor comprises a first stage configured to receive a multiplexed optical signal. The first stage is tunable over a period. The first stage periodically filters the multiplexed optical signal over an optical channel to produce a fine filtered optical signal. A second stage is coupled to the first stage and has a second-stage transfer function. The second stage receives the fine filtered optical signal and produces one or a plurality of interfered optical signal pairs. A third stage is coupled to the second stage and has a third-stage transfer function. The third stage receives the optical signal pairs and demultiplexes the optical signal pairs to produce a plurality of demultiplexed optical signals. The combination of the second-stage transfer function and the third-stage transfer function is flatter over the optical channel than the third-stage transfer function.Type: ApplicationFiled: June 1, 2020Publication date: December 31, 2020Applicants: Huawei Technologies Canada Co., Ltd., The University of OttawaInventors: Mohammad Mehdi MANSOURI RAD, Patrick DUMAIS, Trevor James HALL, Mehedi HASAN
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Patent number: 10851372Abstract: A method for preparing exosomes or exosome-like vesicles packaged with a nucleic acid of interest is provided. In certain embodiments, the method may comprise: introducing into an exosome-producing cell a nucleic acid construct comprising the nucleic acid sequence of interest incorporated in a pre-miR-451 structural mimic, and allowing the cell to produce exosomes. Nucleic acid constructs, compositions, and uses thereof are also provided.Type: GrantFiled: September 30, 2016Date of Patent: December 1, 2020Assignee: University of OttawaInventors: Derrick Gibbings, James Andrew Taylor
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Publication number: 20200354351Abstract: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.Type: ApplicationFiled: May 18, 2020Publication date: November 12, 2020Applicants: Ottawa Hospital Research Institute, University of OttawaInventors: Jean-Simon Diallo, Christopher Noyce Boddy, Mark Dornan, Ramya Krishnan, Rozanne Arulanandam, Fabrice Le Boeuf, Jeffrey Smith, Andrew Macklin