Patents Assigned to University of Rhode Island
  • Patent number: 11932558
    Abstract: A piezoelectric polymer used as a piezocatalyst, and methods of manufacture and use therefor. A preferred piezoelectric polymer is poly(vinylidene difluoride) (PVDF) due to its piezoelectric response and good flexibility. The polymer can be doped with a metal, metal salt, metal carbonyl, metal oxide such as ZnO, Co2O3, or TiO2, or ion such as Cr3+, Co2+, or Zn2+. The dopant can be chosen so that when the polymer is PVDF the dopant increases the amount of ?-phase PVDF and/or ?-phase PVDF relative to ?-phase PVDF, thereby increasing the piezocatalytic response of the polymer. The compound to be decomposed can be adsorbed on the surface of the piezoelectric polymer. Applications include wastewater treatment, CO2 capture and reduction, hydroformylation, water splitting, and ammonia synthesis.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: March 19, 2024
    Assignee: University of Rhode Island Board of Trustees
    Inventors: William B. Euler, Angela Thach, Lasanthi Sumathirathne, Benjamin B. Cromwell, Mara Dubnicka
  • Patent number: 11857509
    Abstract: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: January 2, 2024
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • Patent number: 11851644
    Abstract: The invention provides a method and related compositions for preparing an effective probiotic bacteria formulation that can be stored, transported and used for protecting a variety of marine organisms against infection by potential pathogens.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: December 26, 2023
    Assignee: University of Rhode Island Board of Trustees
    Inventors: David R. Nelson, Jason LaPorte, David C Rowley, Marta Gomez-Chiarri
  • Publication number: 20230372551
    Abstract: The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.
    Type: Application
    Filed: September 21, 2021
    Publication date: November 23, 2023
    Applicants: MEMORIAL SLOAN-KETTERING CANCER CENTER, MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES, SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES, PHLIP, INC.
    Inventors: Jason S. LEWIS, Yana K. RESHETNYAK, Lukas M. CARTER, David BAUER
  • Publication number: 20230365818
    Abstract: Temperature measurements are critical in gas turbine engine design but difficult to obtain due to the extreme environment. Temperature indicating paints (thermal paints) have been used for decades to map maximum temperature fields on superalloy components but have numerous weaknesses. Disclosed herein are novel glass ceramic thermal paints that undergo viscous flow sintering to indicate temperatures up to 1000° C., with high resolution (±5° C.), by an optical transition. Disclosed paint formulations are designed to adhere to Nickel-based superalloys or SiC—SiC ceramic matrix composites (CMC) by closely matching coefficients of thermal expansion and may function for times above 60 hours. By utilizing automation and a UV:VIS spectrometer, quantitative temperature maps can be generated for easy comparison to theoretical models. A transient sintering energy model is disclosed to recover full thermal history information.
    Type: Application
    Filed: May 12, 2023
    Publication date: November 16, 2023
    Applicant: University of Rhode Island Board of Trustees
    Inventors: Noah Burke, Panagiotis Panoutsopoulos, Zachary Ahlquist, Otto J. Gregory
  • Patent number: 11779662
    Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: October 10, 2023
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • Patent number: 11738096
    Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: August 29, 2023
    Assignees: Yale University, University of Rhode Island Board of Trustees
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • Patent number: 11703471
    Abstract: Methods and apparatuses for highly sensitive detection of analytes using redox reactions. A library of heat reactions of analytes of interest with a variety of catalysts at a variety of temperatures is prepared. An array of sensors with low thermal mass heating elements is prepared, depositing the same or different catalysts, such as metal oxide catalysts that have multiple oxidation states, on each heating element. The low thermal mass heating elements are preferably not in thermal contact with a substrate, or a low mass substrate is used. The array is exposed to a sample at various temperatures. The sign and magnitude of the heat effect of the redox reaction of compounds in the sample or their decomposition products with each catalyst is measured and compared with the library. The catalysts and temperatures are chosen so that the desired analytes have a unique pattern of heat effect signs and magnitudes when reacted with those catalysts at those temperatures.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: July 18, 2023
    Assignee: University of Rhode Island Board of Trustees
    Inventors: Otto J. Gregory, Peter Ricci, III, Andrew Rossi
  • Patent number: 11662298
    Abstract: An accelerated life testing (ALT) system for the pressurization of corrosive media, such as seawater, at high pressures and at elevated temperatures (up to about 70° C.) for extended periods of time. The interior of a pressure vessel is coated in an inert ceramic/epoxy coating that provides adequate corrosion protection from the corrosive media. A fabric reinforced nitrile diaphragm separates the corrosive media from hydraulic actuating media, such as oil. The hydraulic actuating media is pressurized, which deforms the diaphragm into the corrosive media, thereby increasing the pressure. The diaphragm and supplementary flouroelastomer seals isolate the corrosive media from pressure generating, monitoring, and safety equipment. The temperature of the entire vessel and contents is maintained by complete immersion in a heated, filtered water bath. The system is particularly useful for ALT experiments on components intended for sea floor and long term deep ocean environment operations at about 6000 psi (41.4 MPa).
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: May 30, 2023
    Assignee: University of Rhode Island Board of Trustees
    Inventors: Dillon T. Fontaine, Anthony D. Marshall, Arun Shukla
  • Publication number: 20230144468
    Abstract: The present disclosure describes a unique, two-part, water-soluble polymer matrix material and a method of application that immobilizes a wide variety of loose powder or crystalline hazardous materials and renders them “safe” or at least “safer” for handling and transport. The polymer matrix material is a two-part polymer material comprising a liquid cross-linking polymer and a cross-linking agent, initiator, or biocide contained in a solution. The cross-linking agent functions to cross-link the polymer and cause it to harden in place.
    Type: Application
    Filed: November 18, 2022
    Publication date: May 11, 2023
    Applicant: University of Rhode Island Board of Trustees
    Inventors: Jimmie Oxley, James L. Smith, Robert Ichiyama, Gerald Kagan
  • Publication number: 20230050241
    Abstract: Method and apparatus for detecting in impedance change in a transmission line, such as a line in a computer bus. A CMOS-compatible time domain reflectometer circuit comprising a comparator is embedded in one or more chips and connected to the transmission line. The circuit measures the impedance inhomogeneity pattern (IIP) of the transmission line prior to use, and then repeatedly measures the HP during operation of the transmission line to detect a change in IIP, without Interfering with data transfer through the transmission line. The present invention can detect and locate wire-tapping magnetic probing or snooping, and Trojan and cold boot attacks on interconnecting buses between computer chips or integrated circuits in a computer system, such as on external memory buses.
    Type: Application
    Filed: January 29, 2021
    Publication date: February 16, 2023
    Applicant: University of Rhode Island Board of Trustees
    Inventors: Ken Qing Yang, Tao Wei, Zhenyu Xu
  • Patent number: 11572417
    Abstract: The invention provides a mild procedure for the functionalization of cellulose and other substrates with a detection reagent such as N-(1-naphthyl)ethylenediamine and is able to achieve much higher functionalization density than previously reported. A paper-based device created using cellulose functionalized according to the invention allowed for much lower detection limits for nitrite in various kinds of water samples than have been seen using paper-based devices. In addition, grafting of N-(1-naphthyl)ethylenediamine to cellulose improved the stability of the N-(1-naphthyl)ethylenediamine in the presence of moisture and light.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: February 7, 2023
    Assignee: University of Rhode Island Board of Trustees
    Inventors: Teresa L. Mako, Mindy Levine, Jason Dwyer
  • Patent number: 11474141
    Abstract: Methods and apparatuses for using the impedance inhomogeneity pattern (IIP) of a transmission line, or one or more segments thereof, to verify the identity of the transmission line and/or detect whether or not the transmission line has been altered or tampered with. Because the impedance inhomogeneity pattern of a transmission line is unique, unpredictable, and uncontrollable, it can be used as a physical unclonable function (PUF). The IIP can be obtained by a method such as frequency domain reflectometry or time domain reflectometry, and is then compared with a previously stored intrinsic IIP obtained from a transmission line (or segment(s)) prior to first use through the use of, for example, correlation or coherence functions. The method can be used on any transmission line, including electrical, optical and acoustic transmission lines.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: October 18, 2022
    Assignees: University of Rhode Island Board of Trustees, The Curators of the University of Missouri
    Inventors: Tao Wei, Jie Huang
  • Patent number: 11433026
    Abstract: The disclosure provides compositions and methods of use of formulations effective for the delivery of biologically active molecules and materials, including therapeutic and diagnostic agents, and combinations thereof, to cells, tissues, and living organisms. More particularly, the present invention is related to the incorporation of hydrophobic nanoparticles, such as hydrophobic metal nanoparticles, into the membranes of vesicular delivery vehicles. These hydrophobic nanoparticles enhance the endosomal membrane fusogenicity of the formulations through the promotion of inverted hexagonal phase formation in the lipid bilayers of the vesicular delivery vehicles. As a result, the vesicular delivery vehicles more readily fuse with the endosomal membranes, leading to enhanced endosomal escape of the vesicular delivery vehicle and its contents, thereby facilitating the delivery of the biologically active molecules and materials incorporated within the vesicular delivery vehicles to their sites of action.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: September 6, 2022
    Assignee: University of Rhode Island Board of Trustees
    Inventors: Ashish Sarode, Ruchi Verma, David Worthen, Ruitang Deng
  • Publication number: 20220259433
    Abstract: A composition and method of synthesizing a composition from organic oils and industrial byproducts for use as a corrosion inhibitor coating is disclosed. The synthesis of a rapid setting ionomer is the result of iron-induced polymerization of oleic and linoleic acids, where an alkaline ionomeric reaction is facilitated with a small fraction of pure aluminum leaf at room temperature. At least one alkaline reagent is employed with at least one metallic additive to form metal complex ionomers that form a solid polymer. The resulting ionomer is stirred and applied on the substrate as a surface coating and it starts setting in less than thirty minutes.
    Type: Application
    Filed: January 31, 2022
    Publication date: August 18, 2022
    Applicant: University of Rhode Island Board of Trustees
    Inventors: Sumeru Nayak, Sumanta Das
  • Publication number: 20220248983
    Abstract: An optical core-shell microfibrous textile incorporates single-walled carbon nanotubes (SWCNTs) for the real-time optical monitoring of hydrogen peroxide concentrations and other biochemicals in in vitro wounds. The environmentally sensitive and non-photo-bleachable fluorescence of SWCNTs enable continuous analyte monitoring without a decay in signal over time. The microfibrous textiles spatially resolve chemical indicator concentrations using a camera and are integrated into commercial wound bandages without significant degradation in their optical properties.
    Type: Application
    Filed: February 1, 2022
    Publication date: August 11, 2022
    Applicant: University of Rhode Island Board of Trustees
    Inventors: Daniel Roxbury, Mohammad Moein Safaee, Mitchell Gravely
  • Publication number: 20220229017
    Abstract: The present disclosure describes an improved sample preparation technique, swab, swab holder and solvent for the removal of trace chemical materials from swabs and delivery of the trace materials into a mass spectrometer (MS) or an ion mobility spectrometer (IMS). The devices and techniques aid the delivery of the analyte into the instrument inlet and concurrently serves as an ionization source. The technique includes the steps of positioning or shaping the swab so that a pointed analyte release area is directed toward the inlet of the MS or IMS, adding a solvent to the swab and charging the swab to create an ionized analyte spray (Taylor Cone spray) into the inlet of the detection instrument. Solvent may include a chemical for depressing the ionization of residual solvent or enhancing the ionization of the desired analyte and this chemical may serve as an internal standard or benchmark.
    Type: Application
    Filed: April 7, 2022
    Publication date: July 21, 2022
    Applicant: University of Rhode Island Board of Trustees
    Inventors: Jimmie Oxley, James L. Smith, Alexander Yevdokimov
  • Patent number: 11369628
    Abstract: The present invention provides compositions derived from cranberry including xyloglucan and pectic oligosaccharides, and iridoid terpene glycosides. These compositions can be used in conjunction with antibiotics to synergistically kill bacterial persister cells and inhibit bacterial quiescent phenotypes, thereby improving treatment outcomes in recurrent and other infections.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: June 28, 2022
    Assignee: University of Rhode Island Board of Trustees
    Inventors: David Rowley, Jiadong Sun, Robert Deering, Navindra Seeram, Paul Cohen
  • Publication number: 20220144396
    Abstract: Structures designed to mitigate implosion pressure spikes through the use of an external sacrificial confining structure. Such improved structures can, in some embodiments, completely surround the existing structures that are at a high risk of imploding. The improved structures can slow the rate at which the surrounding fluid media volume is consumed by providing resistance to flow into the enclosure.
    Type: Application
    Filed: November 1, 2021
    Publication date: May 12, 2022
    Applicant: University of Rhode Island Board of Trustees
    Inventors: Dillon Fontaine, Arun Shukla
  • Patent number: 11300542
    Abstract: The present disclosure describes an improved sample preparation technique and adapter device for the removal of trace materials from swabs and delivery of the trace materials into a mass spectrometer (MS) or an ion mobility spectrometer (IMS). The adapter device and technique aids the delivery of the analyte into the instrument inlet and concurrently serves as an ionization source. The technique includes the steps of positioning or shaping the swab so that a pointed analyte release corner or tip is directed toward the inlet of the MS or IMS, adding a solvent to the swab and charging the swab to create an ionized analyte spray pointed at or positioned within the inlet of the detection instrument.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: April 12, 2022
    Assignee: University of Rhode Island Board of Trustees
    Inventors: Jimmie Oxley, James L. Smith, Alexander Yevdokimov, Gerald Kagan