Patents Assigned to University of Saskatchewan
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Patent number: 5809759Abstract: A crop harvester has bristle guards (39) mounted on the cutter bar (14) as crop lifters and to capture fruit lost by dehiscence during cutting. Each bristle guard is a set of laterally oriented bristles (44). Dehisced fruit is swept into the header by a pickup reel (16) having bristle bats (74). The bristles (76) are supported on the leading side by a strip (78) of flexible belting. The belting protects the bristle against being cut by the cutter bar. The crops are supported against being pushed forward by the bristle bats (74) of the reel. The diameter is reduced to about one-half normal and the reel index in increased to provide an aggressive reel operation, ensuring that plants are properly engaged in the bristle guards for cutting.Type: GrantFiled: February 18, 1997Date of Patent: September 22, 1998Assignee: The University of SaskatchewanInventors: Lloyd E. Zyla, Lal R. Kushwaha, William B. Reed
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Patent number: 5801018Abstract: Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one A. pleuropneumoniae transferrin binding protein and/or one A. pleuropneumoniae cytolysin and/or one A. pleuropneumoniae APP4. Also disclosed are DNA sequences encoding these proteins, vectors including these sequences and host cells transformed with these vectors. The vaccines can be used to treat or prevent porcine respiratory infections.Type: GrantFiled: October 12, 1994Date of Patent: September 1, 1998Assignee: University of SaskatchewanInventors: Andrew A. Potter, Gerald F. Gerlach, Philip J. Willson, Amalia Rossi-Campos
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Patent number: 5747309Abstract: Vaccines are provided for vaccinating an animal against pathogenic bacteria, including E. coli. The invention also encompasses methods of preparing and methods of use of vaccine strains and compositions that result from or are used in these methods. In particular, pathogenic bacteria comprising at least one attenuating mutation selected from the group consisting of a pyrimidine pathway mutation, an iron metabolism mutation, and a colicin transport mutation which retain their immunogenicity so as to provide protective immunity are provided.Type: GrantFiled: April 7, 1995Date of Patent: May 5, 1998Assignee: University of SaskatchewanInventors: Brenda J. Allan, Andrew A. Potter
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Patent number: 5741818Abstract: A compound of general formula I below useful as an anticonvulsant for disorders of the central nervous system: ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen or halogen atom, or a C.sub.1-9 alkyl, C.sub.3-9 cycloalkyl, cyano, C.sub.1-9 alkoxy or C.sub.6-10 aryloxy group; R.sup.5 represents a hydrogen atom or a C.sub.1-9 alkyl, C.sub.3-9 cycloalkyl or C.sub.6-10 aryl group; and X is oxygen or sulfur; or a pharmaceutically-acceptable salt thereof. The compound may be adimistered orally for treating convulsions in humans or animals.Type: GrantFiled: June 7, 1995Date of Patent: April 21, 1998Assignee: University of SaskatchewanInventor: Jonathan Richard Dimmock
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Patent number: 5733544Abstract: The present invention relates to a newly discovered Bacillus sp. strain which exhibits pesticidal activity. The supernatant of cultures of this novel isolate are also effective pesticidal agents. Also provided are methods of using the novel strain or supernatant for treatment or prevention of disease in plants or animals.Type: GrantFiled: November 18, 1996Date of Patent: March 31, 1998Assignees: University of Saskatchewan, Agraquest, Inc.Inventors: Pamela Gail Marrone, Denise C. Manker, Sherry D. Heins, Desmond R. Jimenez, James J. Germida
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Patent number: 5723129Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected GnRH multimer which consists essentially of at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimer fused thereto.Type: GrantFiled: February 10, 1995Date of Patent: March 3, 1998Assignee: University of SaskatchewanInventors: Andrew A. Potter, John G. Manns
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Patent number: 5708155Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase the immunogenicity of the antigen fused thereto.Type: GrantFiled: May 31, 1995Date of Patent: January 13, 1998Assignee: University of SaskatchewanInventors: Andrew A. Potter, Mark J. Redmond, Huw P. A. Hughes
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Patent number: 5688772Abstract: Novel Quinoa saponin pharmaceutical compositions are disclosed. The compositions are useful for enhancing mucosal absorption of a drug administered therewith.Type: GrantFiled: July 27, 1995Date of Patent: November 18, 1997Assignee: University of SaskatchewanInventors: Alberto Estrada, Mark J. Redmond, Bernard Laarveld
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Patent number: 5597807Abstract: Novel Quinoa saponin pharmaceutical compositions are disclosed. The compositions are useful as immunological adjuvants, to stimulate nonspecific immunity, as well as to enhance an immunological response to a selected antigen. The Quinoa saponin compositions can also be used to enhance mucosal absorption of a drug administered therewith.Type: GrantFiled: August 1, 1994Date of Patent: January 28, 1997Assignee: University of SaskatchewanInventors: Alberto Estrada, Mark J. Redmond, Bernard Laarveld
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Patent number: 5594107Abstract: New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an RTX cytotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.Type: GrantFiled: December 20, 1993Date of Patent: January 14, 1997Assignees: University of Saskatchewan, Ciba-Geigy Canada Ltd.Inventors: Andrew Potter, Manuel Campos, Huw P. A. Hughes
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Patent number: 5585264Abstract: Recombinant subunit vaccines against bovine herpesvirus type 1 (BHV-1) are provided, as well as methods of vaccination, methods of recombinantly producing the subunit antigens or nucleotide sequences encoding the BHV-1 gI, gIII and gIV proteins employed in the vaccines.Type: GrantFiled: July 29, 1992Date of Patent: December 17, 1996Assignee: University of SaskatchewanInventors: Lorne Babiuk, Sylvia van den Hurk, Tim Zamb, David Fitzpatrick
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Patent number: 5534256Abstract: New subunit vaccines from Haemophilus somnus are disclosed. The vaccines include an outer membrane protein extract of H. somnus which is enriched with iron-regulated proteins. Additional antigens, such as antigens derived from Pasteurella haemolytica, can be included in the vaccine composition to provide protection against a variety of disease states.Type: GrantFiled: July 2, 1992Date of Patent: July 9, 1996Assignee: University of SaskatchewanInventors: Andrew A. Potter, Richard J. Harland
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Patent number: 5521072Abstract: Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one A. pleuropneumoniae transferrin binding protein and/or one A. pleuropneumoniae cytolysin and/or one A. pleuropneumoniae APP4. Also disclosed are DNA sequences encoding these proteins, vectors including these sequences and host cells transformed with these vectors. The vaccines can be used to treat or prevent porcine respiratory infections.Type: GrantFiled: March 22, 1994Date of Patent: May 28, 1996Assignee: University of SaskatchewanInventors: Andrew A. Potter, Gerald F. Gerlach, Philip J. Willson, Amalia Rossi-Campos
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Patent number: 5518710Abstract: Simple and efficient methods for extracting high levels of .beta.-glucans from cereal sources are disclosed. The method employs a strong base, such as sodium hydroxide as an initial solvent. If desired, the extract can be further purified to render a .beta.-glucan preparation which can be used directly or stored for future use.Type: GrantFiled: January 11, 1994Date of Patent: May 21, 1996Assignee: University of SaskatchewanInventor: Rattan S. Bhatty
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Patent number: 5508311Abstract: The invention relates to a series of propargylamines, their salts and pharmaceutical compositions containing a compound of formula (III) wherein R.sub.1, R.sub.3 and R.sub.4 are the same or different and represent hydrogen or a straight chain or branched lower alkyl; y is an integer ranging from 0 to 5; z is an integer ranging from 0 to 5; and R.sub.2 is a straight chain or branched alkyl, alkenyl, alkynyl, alkoxy, alkylthio or alkyl sulphinyl group having from 3 to 11 carbon atoms, said group being unsubstituted or substituted with at least one of the substituents selected from hydroxy, aldehyde, oxo, loweracyloxy, halogen, thio, sulfoxide, sulfone, phenyl, halogen-substituted phenyl, hydroxy-substituted phenyl, cycloalkyl having from 3 to 6 carbon atoms and heterocyclic substituents having between 3 and 6 atoms, of which form 1 to 3 are heteroatoms selected from O, S and/or N, and pharmaceutically acceptable salts thereof, in admixture with a pharmaceutically acceptable carrier, excipient or adjuvant.Type: GrantFiled: December 23, 1993Date of Patent: April 16, 1996Assignee: University of SaskatchewanInventors: Peter H. Yu, Bruce A. Davis, Alan A. Boulton
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Patent number: 5503833Abstract: Compositions and methods for preparing and delivering encapsulated biologically active agents to specific cell types are disclosed. Substances can be encapsulated in the VP6 inner capsid protein of rotavirus and delivered to selected cells, tissues and organs. Targeting agents can be linked to the surface of the VP6 sphere so that appropriate agents can be delivered to preselected cells and tissue types.Type: GrantFiled: September 6, 1994Date of Patent: April 2, 1996Assignee: University of SaskatchewanInventors: Mark J. Redmond, Manuel Campos
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Patent number: 5476657Abstract: New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. haemolytica fimbrial protein, P. haemolytica plasmin receptor protein, and P. haemolytica 50K outer membrane protein and P. haemolytica leukotoxin. The antigens can be used in a vaccine composition, either alone or in combination. Also disclosed are methods of vaccination as well as methods of making the subunit antigens employed in the vaccines.Type: GrantFiled: February 9, 1993Date of Patent: December 19, 1995Assignee: University of SaskatchewanInventor: Andrew A. Potter
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Patent number: 5464769Abstract: Conifer somatic embryos can be desiccated to a moisture content below 50%. A moisture content as low as 10% can be produced. The desiccated somatic conifer embryos have greatly increased ability to store lipids and other nutrients as compared to the corresponding zygotic embryo. The embryos are desiccated using a method which requires the utilization of ABA and PEG.Type: GrantFiled: December 1, 1993Date of Patent: November 7, 1995Assignee: University of SaskatchewanInventors: Stephen M. Attree, Lawrence C. Fowke
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Patent number: 5441736Abstract: Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one Actinobacillus pleuropneumoniae outer membrane lipoprotein A, or an immunogenic fragment thereof. Also disclosed are DNA sequences encoding these proteins, vectors including these sequences and host cells transformed with these vectors. The vaccines can be used to treat or prevent porcine respiratory infections.Type: GrantFiled: November 5, 1992Date of Patent: August 15, 1995Assignee: University of SaskatchewanInventors: Gerald F. Gerlach, Philip J. Willson, Amalia Rossi-Campos, Andrew A. Potter
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Patent number: 5437181Abstract: A slump tester for concrete includes a testing unit and a measuring unit. The testing unit includes a tube with a perforated lower section that is lowered into the concrete to be tested up to the level of a disc carried on the tube. A timer button on the measuring unit is pushed to initiate a timer. After a preset time, an alarm sounds and the rod-like measuring unit is lowered into the tube until contact is made with the concrete that has entered the testing unit. This is indicated by a dot appearing in a digital display on the upper end of the measuring unit. The depth to which the rod has been lowered into the tube is monitored using an induction coil wound on the upper part of the rod and a metal cylinder in the upper end of the testing unit. The inductance of the coil varies linearly with the degree of insertion and this is used to generate a signal representing the slump of the concrete, which is displayed on the measuring unit display.Type: GrantFiled: February 22, 1994Date of Patent: August 1, 1995Assignee: University of SaskatchewanInventor: Karim W. Nasser