Patents Assigned to University of Saskatchewan
  • Immunization of dairy cattle with GapC protein against Streptococcus infection
    Patent number: 6866855
    Abstract: The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S. iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: March 15, 2005
    Assignee: University of Saskatchewan
    Inventors: Alexandra J. Bolton, Jose Perez-Casal, Michael Fontaine, Andrew A. Potter
  • Modified bovine adenovirus having altered tropism
    Patent number: 6849446
    Abstract: The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is associated with altered tropism. The present invention provides adenovirus vectors and host cells comprising such vectors. The present invention also provides methods of making and using such adenoviruses.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: February 1, 2005
    Assignee: University of Saskatchewan
    Inventors: Suresh K. Tikoo, Lorne A. Babiuk, Linong Zhang, Qiaohua Wu
  • Camp factor of streptococcus uberis
    Publication number: 20040219639
    Abstract: The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs, including CAMP factor epitopes from more than one bacterial species. The CAMP factors and chimeras including the same can be used in immunogenic compositions for the prevention and treatment of bacterial infections.
    Type: Application
    Filed: June 8, 2004
    Publication date: November 4, 2004
    Applicant: University of Saskatchewan
    Inventors: Andrew A. Potter, Jose Perez-Casal, Michael Fontaine, Xinming Song
  • Composition containing propargylamine for enhancing cancer therapy
    Patent number: 6809120
    Abstract: Antineoplastic drug modulators are described. The specific modulators referred to are propargylamines which can enhance the cytotoxic effects of antineoplastic drugs on cancer cells while protecting normal cells from damage. The propargylamine modulators can be used to increase the selectivity and effectiveness of conventional antineoplastic drugs, to reduce the unwanted side-effects of cancer chemotherapy, to improve effectiveness of cancer chemotherapy, to improve treatment of cancers for which treatment is otherwise ineffective, to improve therapy of cancers otherwise unresponsive or poorly responsive due to drug-resistance and/or toxicity limited treatment regimens and to render effective chemotherapy for previously untreatable cancers.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: October 26, 2004
    Assignee: University of Saskatchewan Technologies Inc.
    Inventors: R. C. Warrington, I. Alick Paterson, Alan A. Boulton
  • Fractionation and processing of oilseed meal
    Patent number: 6800308
    Abstract: The present invention relates to a process for the aqueous extraction, fractionation and enzymatic treatment of oilseed materials to generate valued products with no significant low value by-product or waste streams. In particular, the fractionation scheme generates a protein-fiber feed ingredient principally for use with ruminant animals and a second dephytinized high protein fraction. The dephytinized high protein fraction has value as feed ingredient for a variety of species of animals.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: October 5, 2004
    Assignee: University of Saskatchewan Technologies Inc.
    Inventors: David D. Maenz, Rex W. Newkirk, Henry L. Classen, Robert T. Tyler
  • Enhanced immunogenicity using leukotoxin chimeras
    Patent number: 6797272
    Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase the immunogenicity of the antigen fused thereto.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: September 28, 2004
    Assignee: University of Saskatchewan
    Inventors: Andrew A. Potter, Mark J. Redmond, Huw P. A. Hughes
  • Methods to culture circovirus
    Patent number: 6794163
    Abstract: The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 functional protein.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: September 21, 2004
    Assignee: University of Saskatchewan
    Inventors: Qiang Liu, Suresh K. Tikoo, Philip Willson, Lorne A. Babiuk
  • Immunization of dairy cattle with Mig protein
    Patent number: 6740322
    Abstract: The Mig protein gene of Streptococcus dysgalactiae, and the correspondingamino acid sequence, is described, as is the use of the Mig protein in vaccine compositions to prevent and treat bacterial infections in general, and mastitis in particular.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: May 25, 2004
    Assignee: University of Saskatchewan
    Inventors: Andrew A. Potter, Alexandra J. Bolton, Xin Ming Song
  • Immunization of dairy cattle with chimeric GapC protein against streptococcus infection
    Publication number: 20040062774
    Abstract: The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.
    Type: Application
    Filed: August 27, 2003
    Publication date: April 1, 2004
    Applicant: University of Saskatchewan
    Inventors: Andrew A. Potter, Jose Perez-Casal, Michael Fontaine
  • Lignan complex derived from flaxseed as hypercholesterolemic and anti-atherosclerotic agent
    Patent number: 6673773
    Abstract: A method is described for treating hypercholesterolemic atherosclerosis or for reducing total cholesterol while raising high-density lipoportoein cholesterol. It involves administering to a patient a substantially pure complex derived from flaxseed and containing secoisolariciresinol diglucoside (SDG), cinnamic acid glucosides and hydroxymethyl glutaric acid.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: January 6, 2004
    Assignee: University of Saskatchewan Technologies Incorporated
    Inventor: Kailash Prasad
  • Immunization of dairy cattle with chimeric GapC protein against Streptococcus infection
    Patent number: 6660270
    Abstract: The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberisand Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: December 9, 2003
    Assignee: University of Saskatchewan
    Inventors: Andrew A. Potter, Jose Perez-Casal, Michael Fontaine
  • Process for producing an antioxidant extract from the bearberry plant
    Patent number: 6660320
    Abstract: An antioxidant extracted from the bearberry plant (Arctostaphylos uva-ursi), particularly for use as a food preservative, and a process of extracting it from the bearberry plant are disclosed. The process includes grinding the leaves of the bearberry, mixing the ground leaves with ethanol, shaking the resulting slurry, filtering the slurry, evaporating the supernatant to dryness and dechlorophyllyzing the resulting precipitate using a silicic acid column with hexane as the mobile phase and recovering the dechlorophyllyzed extract using ethanol as the mobile phase.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: December 9, 2003
    Assignee: University of Saskatchewan Technologies Inc.
    Inventors: Ronald Bruce Pegg, Branka Barl, Ryszard Amarowicz
  • Porcine circoviruses, vaccines and diagnostic reagents
    Patent number: 6660272
    Abstract: The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It relates to purified preparations of these strains, conventional attenuated or inactivated vaccines, recombinant live vaccines, plasmid vaccines and subunit vaccines, as well as reagents and diagnostic methods. It also relates to the DNA fragments which can be used for the production of subunits in an in vitro expression vector or as sequences to be integrated into a virus or plasmid type in vivo expression vector.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: December 9, 2003
    Assignees: Merial, The Queen's University of Belfast, University of Saskatchewan
    Inventors: Gordon Allan, Brian Meehan, Edward Clark, John Ellis, Deborah Haines, Lori Hassard, John Harding, Catherine Elisabeth Charreyre, Gilles Emile Chappuis, Francis McNeilly
  • Transferrin binding proteins of Pasteurella haemolytica and vaccines containing same
    Patent number: 6610506
    Abstract: Novel transferrin binding proteins from Pasteurella haemolytica, and nucleic acid molecules encoding the novel proteins are disclosed. Antibodies against the novel proteins are disclosed. The invention also relates to vaccines containing the novel proteins of the invention. The invention also provides methods for identifying substances which affect the binding of transferrin to the proteins and methods for screening for agonists or antagonists of the binding of the proteins and transferrin.
    Type: Grant
    Filed: November 29, 1996
    Date of Patent: August 26, 2003
    Assignees: University Technologies International, Inc., University of Guelph, University of Saskatchewan
    Inventors: Reggie Y. C. Lo, Anthony Bernard Schryvers, Andrew Allan Potter
  • Internal artificial vagina for collecting animal semen
    Patent number: 6554811
    Abstract: An internal artificial vagina for collecting animal semen including a stiff support frame comprising a straight bar portion having at one end thereof a generally circular ring portion substantially perpendicular to the axis of the bar portion and an attachment means at the other end of the bar portion. An elastomeric tube open at both ends is adapted to slide within the frame ring portion with an end portion of the elastomeric tube stretched and pulled outwardly around the frame ring portion whereby the ring portion is retained within the folded portion of the elastomeric tube. The other end portion of the elastomeric tube is fixed to the attachment means of the frame. A replaceable semen collection bag is also provided in the form of an elongated generally cylindrical thin, flexible plastic member having a closed end and an open end.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: April 29, 2003
    Assignee: University of Saskatchewan Technologies Inc.
    Inventor: Albert D. Barth
  • Polynucleotides encoding LKT 111
    Patent number: 6521746
    Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to one or more selected GnRH multimers which comprise at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimers fused thereto.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: February 18, 2003
    Assignee: University of Saskatchewan
    Inventors: Andrew A. Potter, John G. Manns
  • Reduction of porcine circovirus-2 viral load with inactivated PCV-2
    Patent number: 6517843
    Abstract: Porcine circovirus-2 (PCV-2) is a recently identified agent wherein the potential spectrum of PCV-2-associated disease has been expanded by evidence of vertical and sexual transmission and associated reproductive failure in swine populations. PCV-2 was isolated from a litter of aborted piglets from a farm experiencing late term abortions and stillbirths. Severe, diffuse myocarditis was present in one piglet associated with extensive immunohistochemical staining for PCV-2 antigen. Variable amounts of PCV-2 antigen were also present in liver, lung and kidney of multiple fetuses.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: February 11, 2003
    Assignees: Merial, University of Saskatchewan, The Queen's University of Belfast
    Inventors: John Albert Ellis, Gordon Allan Moore, Brian Meehan, Edward Clark, Deborah Haines, Lori Hassard, John Harding, Catherine Elisabeth Charreyre, Gilles Emile Chappuis, George Steve Krakowka, Jean-Christophe Francis Audonnet, Francis McNeilly
  • Biologically active metal-containing nucleic acids
    Publication number: 20030013672
    Abstract: The invention relates to polymers comprising metal-containing nucleic acid duplexes. Methods of using the metal-containing nucleic acid duplexes to provoke physiological responses in a host animal are provided, such as immunological methods that produce antibodies in the host.
    Type: Application
    Filed: January 31, 2002
    Publication date: January 16, 2003
    Applicant: University of Saskatchewan Technologies, Inc.
    Inventors: Jeremy S. Lee, Palok Aich
  • Cloning and expression of Haemophilus somnus transferrin-binding proteins
    Publication number: 20030007981
    Abstract: Cloning and expression of genes encoding H. somnus transferrin-binding proteins are described. The transferrin-binding proteins can be used in vaccine compositions for the prevention and treatment of H. somnus infections, as well as in diagnostic methods for determining the presence of H. somnus infections.
    Type: Application
    Filed: March 13, 2002
    Publication date: January 9, 2003
    Applicant: University of Saskatchewan
    Inventors: Andrew A. Potter, Clement Rioux, Anthony B. Schryvers
  • Semicarbazones having CNS activity and pharmaceutical preparations containing same
    Patent number: RE38425
    Abstract: A compound of general formula I below useful as an anticonvulsant for disorders of the central nervous system: wherein: R1, R2, R3 and R4 may be the same or different and each represents a hydrogen or halogen atom, or a C1-9 alkyl, C3-9cycloalkyl, cyano, C1-9alkoxy or C6-10aryloxy group; R5 represents a hydrogen atom or a C1-9alkyl, C3-9cycloalkyl or C6-10aryl group; and X is oxygen or sulfur; or a pharmaceutically-acceptable salt thereof. The compound may be adimistered orally for treating convulsions in humans or animals.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: February 10, 2004
    Assignee: University of Saskatchewan Technologies, Inc.
    Inventors: Jonathan Richard Dimmock, Ramanan Narayan Puthucode