Abstract: This disclosure relates to cyclodextrin-based drug delivery agents that comprise a cyclodextrin moiety covalently linked to a moiety of a gemini surfactant. Pharmaceutical compositions comprising the drug delivery agent and a therapeutic agent are also disclosed.
Type:
Grant
Filed:
May 18, 2012
Date of Patent:
October 27, 2015
Assignee:
University of Saskatchewan
Inventors:
Ildiko Badea, Ronald Verrall, Peng Yang, Marianna Foldvari, Jackson Chitanda, Deborah Michel
Abstract: A new class of antennas and microwave components are introduced. In this approach a high-permittivity dielectric film is applied (i.e. printed) on a dielectric substrate, which may be grounded. By changing the shape of the high-permittivity film, different microwave devices (e.g. waveguides, filters, couplers, and antennas) are produced. By changing the size and permittivity of the high-permittivity film and dielectric substrate, these elements are designed at different frequencies for different applications. Highly-efficient microwave devices can result due to the absence of surface currents.
Type:
Application
Filed:
June 21, 2013
Publication date:
October 22, 2015
Applicants:
The University of Manitoba, The University of Saskatchewan
Inventors:
Atabak Rashidian, Lotfollah Shafai, David M. Klymyshyn, Mohammadreza Tayfeh Aligodarz
Abstract: The present application includes alkali metal-promoted trimetallic catalysts for higher alcohol synthesis from synthesis gas, the catalyst comprising a catalyst of Formula (1): A-M1-M2-M3.
Abstract: Compositions and methods are provided for modulating an immune response in a vertebrate subject. Compositions and methods can comprise administering a modified host defense peptide to the vertebrate subject in an amount effective to activate the immune response in the vertebrate subject, wherein the modified host defense peptide is inverted in amino acid sequence from an amino terminus to a carboxy terminus or modified to one or more D-amino acids, or both modifications, when compared to a host defense peptide. Compositions and methods are provided which comprise administering a modified host defense peptide to the vertebrate subject in an amount effective to modify an immune response in the vertebrate subject.
Type:
Grant
Filed:
June 27, 2008
Date of Patent:
August 11, 2015
Assignee:
University of Saskatchewan
Inventors:
Scott Kirk Napper, Kenneth Jason Kindrachuk, Samuel Kwadwo Attah-Poku
Abstract: Methods and apparatus for image processing suitable for use in wireless capsule endoscopy are provided. The image processing techniques exploit characteristic features of endoscopic images to enable low complexity compression. A color space conversion, coupled with lossless predictive coding and variable length coding are employed. Sub-sampling and clipping may also be used. The described image processing can be used both with both white-band imaging and narrow-band-imaging.
Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.
Type:
Grant
Filed:
October 15, 2009
Date of Patent:
June 23, 2015
Assignees:
University of Saskatchewan, Dalhousie University, International Vaccines Institute, University of British Columbia
Inventors:
Sylvia van Drunen Littel-van den Hurk, Volker Gerdts, Andrew Potter, Lorne Babiuk, Robert Hancock, Scott Halperin, Jennifer Kovacs-Nolan, George Mutwiri, Song Lee, Mi-Na Kweon, Jason Kindrachuk, Melissa Elliott
Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.
Type:
Grant
Filed:
April 23, 2009
Date of Patent:
June 16, 2015
Assignee:
University of Saskatchewan
Inventors:
Scott Napper, Peter Hedlin, Philip Griebel, Lorne Babiuk, Neil Cashman, Avijit Chakrabartty, Andrew Potter
Abstract: The present disclosure relates to functionalized nanodiamonds comprising at least one MALDI matrix covalently bonded to a nanodiamond and compositions comprising the same. The present disclosure also relates to methods of performing matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS), for example on small molecules, using matrices comprising at least one MALDI matrix covalently bonded to a nanodiamond.
Abstract: Methods are provided for determining whether or not a horse is genetically normal, is a carrier of, or is affected with or predisposed to Congenital Stationary Night Blindness and/or leopard complex spotting. The method is based on detection of an insertion in an intron in the horse Transient Receptor Potential Cation Channel, Subfamily M, Member 1 (TRPM1) gene.
Type:
Grant
Filed:
December 5, 2011
Date of Patent:
March 31, 2015
Assignees:
Cornell University, University of Saskatchewan
Inventors:
Rebecca Bellone, Heather Marie Holl, Samantha Ann Brooks, George Forsyth
Abstract: Apparatus, methods and systems for bridging between commercially available, high-speed image sensors and low cost, low power microcontrollers. An image sensor interface processor is provided for controlling an image sensor, and receiving and storing image data. A microcontroller (or other general purpose or image processor) can communicate with the image sensor interface processor, to access pixel data in a random access fashion through a parallel memory access interface at any speed desired by the microcontroller. Moreover, automatic power management of the image sensor can be provided by the image sensor interface processor. In some alternative embodiments, the described image sensor interface processor may be integrated into the image sensor itself, or a microcontroller, or some other intermediate device.
Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.
Type:
Application
Filed:
April 29, 2014
Publication date:
January 1, 2015
Applicant:
University of Saskatchewan
Inventors:
Kristen Marciniuk, Ryan Taschuk, Scott Napper, Andrew Potter, Neil Cashman
Abstract: Nucleic acid molecules from Cannabis sativa (cannabis, hemp, marijuana) have been isolated and characterized, and encode polypeptides having aromatic prenyltransferase activity. Specifically, the enzyme, CsPT1, is a geranylpyrophosphate olivetolate geranyltransferase, active in the cannabinoid biosynthesis step of prenylation of olivetolic acid to form cannabigerolic acid (CBGA). Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
Type:
Grant
Filed:
August 4, 2010
Date of Patent:
November 11, 2014
Assignees:
National Research Council of Canada, University of Saskatchewan
Abstract: The present application relates to functionalized nanodiamonds, to complexes comprising a functionalized nanodiamond reversibly bound to a nucleic acid and to compositions comprising such functionalized nanodiamonds and complexes. In particular, the functionalized nanodiamonds comprise at least one naturally occurring basic amino acid, or analogs or derivatives thereof, covalently linked to a nanodiamond. The present application also includes methods and uses of the complexes and compositions, for example for delivering a nucleic acid to a cell.
Type:
Application
Filed:
April 17, 2014
Publication date:
October 23, 2014
Applicant:
University of Saskatchewan
Inventors:
Ildiko Badea, Ronald Verrall, Jackson M. Chitanda, Randeep Kaur, Saniya Alwani
Abstract: The present disclosure relates to functionalized nanodiamonds comprising at least one MALDI matrix covalently bonded to a nanodiamond and compositions comprising the same. The present disclosure also relates to methods of performing matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS), for example on small molecules, using matrices comprising at least one MALDI matrix covalently bonded to a nanodiamond.
Abstract: Methods for recovery of recyclable water and/or fermentation co-products from thin stillage process streams. Microbial metabolites plant derivatives and/or plant extractives are removed from thin stillage after which water is recovered and recycled. Thin stillage is commingled with polar organic solvents or with oil to react microbial metabolites, plant derivatives and/or plant extractives. The reacted organic solvents are then separated from the processed thin stillage. Thin stillage may be commingled with an oil to re act with certain organic compounds, after which, the reacted oil is separated from the processed thin stillage is further extracted with one or more polar organic solvents. Alternatively, thin stillage may be first processed with one or more polar organic solvents, and then processed with an oil. Useful organic compounds may be recovered from the reacted oil and reacted organic solvents.
Type:
Grant
Filed:
June 2, 2009
Date of Patent:
September 16, 2014
Assignee:
University of Saskatchewan
Inventors:
Martin J. Reaney, Yunhua Jia, Jianheng Shen, Komsulee Ratanapariyanuch
Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.
Type:
Application
Filed:
February 15, 2013
Publication date:
September 4, 2014
Applicants:
University of Saskatchewan, International Vaccine Institute, Dalhousie University, The University of British Columbia
Inventors:
University of Saskatchewan, The University of British Columbia, Dalhousie University, International Vaccine Institute
Abstract: Methods of selectively detecting the presence of at least one compound in a gaseous medium. A silicon substrate can be exposed to the gaseous medium under conditions to adsorb the at least one compound to the silicon substrate to form a modified silicon substrate. The modified silicon substrate can be analyzed to determine if the at least one compound was present in the gaseous medium. The step of analyzing can include using X-ray spectroscopy.
Type:
Application
Filed:
January 29, 2013
Publication date:
July 31, 2014
Applicant:
University of Saskatchewan
Inventors:
Alexander Moewes, John Anderson McLeod, Ernst Zagidovich Kurmaev, Igor Anatolievich Levitsky, Petr Sushko, Teak Dagan Boyko
Abstract: The present invention relates to primers for the universal amplification and detection of Archaea, which primers are designed based on a multiple sequence alignment of Archaea Type II chaperonin (thermo-some) genes. For detection of Archaea having templates with a GC content of below 60%, primers are designed so that inosine residues are found at degenerate positions. For amplification of higher GC content templates, degenerate positions are replaced with specific nucleotide bases found in the high GC organism. The primers are useful for detecting, identifying and quantifying Archaea in a sample and for determining a phylogenetic relationship of a test Archaea organism.
Type:
Grant
Filed:
March 8, 2011
Date of Patent:
June 24, 2014
Assignee:
University of Saskatchewan
Inventors:
Janet Elizabeth Hill, Bonnie Laura Chaban
Abstract: A Coleus plant particularly distinguished by triangular leaves with many deep lobes and yellow-green leaves with purple margins, is disclosed.
Type:
Grant
Filed:
May 10, 2012
Date of Patent:
December 9, 2014
Assignee:
University of Saskatchewan Department of Plant Sciences
Abstract: The present invention is directed to lentil plants having increased resistance to an imidaizolinone herbicide. One such plant described herein is the RH44 lentil variety. The present invention also includes seeds produced by these lentil plants and methods of controlling weeds in the vicinity of these lentil plants.
Type:
Grant
Filed:
September 16, 2010
Date of Patent:
January 13, 2015
Assignee:
University of Saskatchewan
Inventors:
Al Slinkard, Albert Vandenberg, Frederick Holm