Abstract: A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.

Abstract: The disclosure relates to a composition comprising adrenocorticotropic hormone (ACTH) or a synthetic ACTH analogue for use in a diagnostic test for adrenal insufficiency. A method to conduct said diagnostic test; a combined diagnostic and method of treatment; and kits comprising the components for said test are also disclosed.

Abstract: An end effector for a robot having a threaded shaft; a motor coupled to the shaft and configured to rotate the shaft about its axis; a nut threaded onto the shaft; a feature for preventing the nut from rotating about the axis of the shaft; and an elongate member fixed at one end to the nut and extending from the nut in a direction parallel to the axis of the shaft. The end effector may further include a container for containing a fluid having an elongate body portion having an opening at one end; and a reciprocable plunger extending into an opposite end of the body portion. A second end of the elongate member may be coupled to the plunger.

Abstract: The disclosure relates to long acting parathyroid or parathyroid hormone like fusion polypeptides comprising a receptor polypeptide and its use in the treatment of hypoparathyroidism and osteoporosis.

Abstract: Examples relate to detectors for determining motion from visual cues, said determining being invariant to changes in at least one of temporal and spatial frequencies of said visual cues.

Abstract: A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.

Abstract: A polyurethane material for the detection or sensing of species or stimulus comprising a polyurethane network comprising immobilized therein, or modified by the immobilization therein of, a hydrophilic polymer comprising a ligand or moiety for the detection or sensing of species or stimulus and an indicator for indicating detection or sensing wherein species or stimulus is selected from chemical or biological species or stimulus; the material for medical, dental, hygiene, point of use sterilization, sanitation, personal care, biosurveillance or packaging use, the use thereof preferably for detecting and/or sensing or binding bacteria, or for detecting or sensing pH or for detection or scanning with use of a reader; a Kit and a device comprising the same; and a process for the preparation thereof.

Abstract: A thermal imaging device is provided, comprising: a detector for receiving radiation and outputting a detector signal corresponding thereto; a steerable mirror device arranged in relation to the detector; wherein the steerable mirror device is steerable to scan an entrance pupil over a plurality of locations such that the detector outputs respective detector signals indicative of temperatures of respective portions of the object corresponding to the locations of the entrance pupil, and wherein the thermal imaging device is configured to provide a substantially constant etendue for all of the entrance pupil locations of the plurality of entrance pupil locations.

Abstract: The present disclosure relates to antagonists that target Serine/Arginine-Rich Splicing Factor 1 (SRSF1); expression vectors comprising SRSF1 antagonists; and the use of such antagonists in therapy for the treatment of neurodegenerative disorders and cancer and screening methods that identify agents that inhibit the expression or activity of SRSF1.

Abstract: A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1). In some cases, the compound is peptide P32 or P59. Methods of recruiting ?-arrestin 2 in a cell, modulating C5a-induced ERK1/2 activation in a macrophage, selectively inhibiting the release of IL-6 from a macrophage, are also provided.

Abstract: A first multi phase niobium silicide alloy composition consists essentially of: from 15 to 24 at % of Si; from 0 to 25 at % of one or more sp outer electron configuration element which is not Si; from 1 to 26 at % of one or more sd outer electron configuration element which is not Nb; and a balance of Nb, interstitials and impurities. This alloy may be used to increase the creep resistance of an article, for example a gas turbine engine blade. A second multi phase niobium silicide alloy composition consists essentially of: from 1 to 24 at % of Si; from 0 to 34 at % of one or more sp outer electron configuration element which is not Si; from 19.5 to 48.5 at % of one or more sd outer electron configuration element which is not Nb or Cr; from 0.5 to 9 at % Cr; and a balance of Nb, interstitials and impurities. This alloy may be used to increase the creep resistance and/or to increase the oxidation resistance of an article, for example a gas turbine engine blade.

Abstract: The present invention relates to a medium for storing, preserving, culturing, and/or differentiating stem cells. The medium employs a synthetic thermo-responsive copolymer, dispersed in an aqueous vehicle, which allows the medium to be readily “switched” between a non-gelatinous (fluid) form and a gelatinous form by simply adjusting temperature across the gelling temperature of the medium. As such, stem cells can be easily captured within a 3D gel matrix by simply mixing the stem cells with the non-gelatinous/fluid form of the medium and then gelling the medium by adjusting the temperature across the gelling temperature of the medium. The stem cells encapsulated within the gelatinous form of the medium may then be preserved for a significant time period before either using the stem cells directly within the medium (e.g. in therapy, or in culturing, differentiation, and such like), or after their extraction from the medium.

Abstract: An electric machine comprising: a) a first means for providing a first magneto motive force comprising a first set of magneto motive force space harmonics comprising odd and even harmonic subsets, each harmonic in said first set of magneto motive force space harmonics having a respective amplitude, wherein one of said odd or even subsets of said first set of magneto motive force space harmonics comprises a dominant working harmonic and the other of said odd or even subsets of said first set of magneto motive force space harmonics comprises a dominant undesirable harmonic; and b) a second means for providing a second magneto motive force comprising a second set of magneto motive force space harmonics comprising odd and even harmonic subsets, each harmonic of said second set of magneto motive force space harmonics having a respective amplitude, wherein one of said odd or even subset of said second set of magneto motive force space harmonics comprises a dominant working harmonic and the other of said odd or e

Abstract: A laser structure comprising a first photonic crystal surface emitting laser (PCSEL), a second PCSEL, and a coupling region that extends between the first PCSEL and the second PCSEL along a longitudinal axis and that is electrically controllable so as to be capable of coherently coupling the first PCSEL to the second PCSEL. Each PCSEL include an active layer, a photonic crystal, and a two-dimensional periodic array distributed in an array plane parallel to the longitudinal axis within the photonic crystal where the two-dimensional periodic array is formed of regions having a refractive index that is different to the surrounding photonic crystal.

Abstract: A method of preparing a block copolymer of Formula (B) wherein P1 represents a substantially aqueously soluble polymeric component and P2 represents a substantially aqueously insoluble polymeric component, comprises admixing an aqueously soluble polymer macro-chain transfer agent comprising P1 with a monomer (M2) and initiating an aqueous dispersion-type radical addition fragmentation chain transfer (RAFT) polymerization. (P1) is derived from a monomer (M1) selected from monomers of the Formulae (M1A), (M1B) and/or (M1C) where R1, R10 and R11 represent a substituent of (M1A) or (M1C) which allows P1 to be at least partially aqueously soluble, R2 represents H, CH3 or CN, RS represents one or more substituents of the aromatic ring effective to allow P1 to be at least partially aqueously soluble, and monomer M2 is selected from: where R3 is a substituent of (M2) which allows P2 to be substantially aqueously insoluble, and R4 and R6 independently represent H or methyl.

Abstract: The invention relates to phosphohistidine analogues. The invention also relates to antibodies that specifically bind to the analogues and methods of generating said antibodies. In one embodiment of the invention there is provided a phosphohistidine analogue of Formula V: (V) wherein W is selected from H, CO2H or CONH2; and X is selected from CH or N.

Abstract: Apparatus, systems, and methods relate to use of a time-varying bias for application to an avalanche photodiode. Embodiments include systems and methods of determining an appropriate time-varying bias for application to an avalanche photodiode in linear mode. Avalanche photodiode having appropriate parameters may also be determined. Additional apparatus, systems, and methods are disclosed.

Abstract: The disclosure relates to agents that inhibit the activity of osteoprotegerin and their use in the treatment of pulmonary hypertension.

Abstract: The reinforced polymer composites from recycled plastic are polymer blends made from recycled polymers that are reinforced with glass fibers and mica. In particular, the reinforced polymer composites are blends of recycled low-density polyethylene (LDPE), high-density polyethylene (HDPE), and polypropylene (PP) with a mica filler that are reinforced with glass fibers, where the low-density polyethylene forms between 30 wt % and 35 wt % of the composite, the high-density polyethylene forms between 15 wt % and 17.5 wt % of the composite, the polypropylene forms between 15 wt % and 17.5 wt % of the composite, the glass fibers form between 15 wt % and 40 wt % of the composite, and the mica forms up to 15 wt % of the structural element. The resultant reinforced polymer composite has a relatively high heat deflection temperature, good mechanical properties (such as increased stiffness and strength), improved thermal stability, and is cost effective to manufacture.

Abstract: The present invention relates to a medium for storing, preserving, culturing, and/or differentiating stem cells. The medium employs a synthetic thermo-responsive copolymer, dispersed in an aqueous vehicle, which allows the medium to be readily “switched” between a non-gelatinous (fluid) form and a gelatinous form by simply adjusting temperature across the gelling temperature of the medium. As such, stem cells can be easily captured within a 3D gel matrix by simply mixing the stem cells with the non-gelatinous/fluid form of the medium and then gelling the medium by adjusting the temperature across the gelling temperature of the medium. The stem cells encapsulated within the gelatinous form of the medium may then be preserved for a significant time period before either using the stem cells directly within the medium (e.g. in therapy, or in culturing, differentiation, and such like), or after their extraction from the medium.