Abstract: We disclose a diagnostic test to determine suitable therapeutic intervention of subjects suffering from subclinical Cushing's syndrome [SCS] and also agents that antagonize the action of cortisol or inhibit excess cortisol production in the treatment of conditions such as SCS in the presence of an adrenal incidentaloma.

Abstract: A semiconductor device comprises three semiconductor layers. The semiconductor layers are arranged to form a 2DHG and a 2DEG separated by a polarization layer. The device comprises a plurality of electrodes: first and second electrodes electrically connected to the 2DHG so that current can flow between them via the 2DHG and a third electrode electrically connected to the 2DEG so that when a positive voltage is applied to the third electrode, with respect to at least one of the other electrodes, the 2DEG and the 2DHG will be at least partially depleted.

Abstract: A light beam collimated by illumination optics (4) from a radiation source (6) illuminates the surface of a wave front modulator (8) such as an Spatial Light Modulator (SLM) or Computer Generated Hologram photomask (CGH). The resulting wave travels via projection optics (10) to the substrate (12), passing through a projection lens assembly (14). The SLM (8) is programmed or CGH configured with a modulation pattern that is determined by the substrate (12) topography and desired pattern. The substrate topography is provided by Digital Holography (DH) surface profilometery performed by a DH microscope (18), which provides geometrical or topographical input to the CGH calculation routines (16). An arrangement for vertical or sloping surface patterning has a grating (22) superimposed onto the CGH pattern (24) to generate +1 and ?1 orders.

Abstract: The disclosure relates to an adjuvant polypeptide effective at enhancing the immune response to an antigen crosslinked to the adjuvant polypeptide.

Abstract: The present invention relates to the use of an agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break in the manufacture of a medicament for the treatment of diseases caused by a defect in a gene that mediates homologous recombination.

Abstract: A low-loss GaN-based semiconductor device is provided. The semiconductor device has the InzGa1-zN layer (where 0?z<1), the AlxGa1-xN layer (where 0<x<1), the InyGa1-yN layer (where 0?y<1) and the p-type InwGa1-wN layer (where 0?w<1) which are sequentially stacked on a base substrate of a C-plane sapphire substrate, etc. At a non-operating time, the two-dimensional hole gas is formed in the InyGa1-yN layer in the vicinity part of a hetero-interface between the AlxGa1-xN layer and the InyGa1-yN layer, and the two-dimensional electron gas is formed in the InzGa1-zN layer in the vicinity part of a hetero-interface between the InzGa1-zN layer and the AlxGa1-xN layer.

Abstract: An apparatus of a damper (46) for a bicycle comprising a housing defining a chamber, and a piston, movable in the chamber along a first direction. The apparatus further comprises a controllable means to vary the resistance to movement of the piston in the chamber, a sensor (62), and a controller (58) including a timer. Said sensor measures at least one dynamic quantity and produces an output signal based thereon. Said output signal is received by the controller, and said controller controls said controllable means based on said dynamic quantity as a function of time to control the level of damping. The invention further provides means for manually adjusting the level of rebound damping.

Abstract: A process for treating a non-ferrous metal component, comprising placing the component into a process chamber at an elevated temperature, biasing the component to have a potential capable of attracting ions, introducing oxygen into the chamber at a pressure such that a glow discharge comprising oxygen ions is generated, the process chamber additionally comprising a glow discharge ionization enhancing means, and activating the glow discharge ionization enhancing means thereby increasing charged species density of the glow discharge, the oxygen ions flowing towards the component and colliding the surface thereof at least some of which diffuse into the component.

Abstract: Embodiments of the present invention provided a method of fabricating a semiconductor light source structure. The method comprises providing a GaAs substrate; forming a lower cladding layer above the substrate, the lower cladding layer comprising an AIxGa1-xAs alloy; forming an active region above the lower cladding layer, the active region comprising a GaAs separate confinement heterostructure; and forming an upper cladding layer comprising an AIxGa1-xAs alloy above the active region in the form of an elongate stripe bounded on either side by an InGaP current-blocking layer, the elongate stripe defining an index-guided optical waveguide.

Abstract: We disclose antigenic polypeptides that induce the production of opsonins, in particular opsonic antibodies, and the use of said antigenic polypeptides in vaccines that are protective against bacterial animal pathogens in particular bacterial pathogens of agriculturally important animal species and companion animals and including zoonotic Gram negative bacterial species.

Abstract: A point of care diagnostic test, device and disposables for determining a patient risk for oral cancer in the same visit that a sample is collected.

Abstract: Provided are methods and compositions for improving the growth characteristics of plants.

Abstract: A power electronic package includes: first and second high thermal conductivity insulating non-planar substrates; and multiple semiconductor chips and electronic components between the substrates. Each substrate includes multiple electrical insulator layers and patterned electrical conductor layers connecting to the electronic components, and further includes multiple raised regions or posts, which are bonded together so that the substrates are mechanically and electrically connected. The number, arrangement, and shape of the raised regions or posts are adjusted to have mechanical separation between the substrates. The electrical conductor layers are separated and isolated one another so that multiple electric circuits are provided on at least one of the substrates.

Abstract: There is provided a method of detecting the presence of a substance comprising providing a cantilever (30) comprising a magnetostrictive material (34) and having an original resonant frequency. The method also comprises receiving the substance on the cantilever (30, 36) causing the resonant frequency of the cantilever (30) to change. The method also comprises applying a magnetic field to the cantilever (30) causing the resonant frequency to change to a reference resonant frequency and sensing when the resonant frequency becomes the reference resonant frequency.

Abstract: A machining tool comprises a frame mounting an extendable yoke slidable with respect to the frame in a first direction through one or more mounting pillars. A tool motor is mounted on the yoke. A drive mechanism for the yoke is also mounted in the frame, with a drive motor to drive the yoke drive mechanism. A belt is between pulleys on the drive motor and mechanism to transmit drive between them. A rotatable sleeve is around the tool motor and on which sleeve the belt engages on opposite sides of the tool motor, whereby the tool motor can extend between the drive motor and mechanism, thereby resulting in a compact arrangement of the tool.

Abstract: A multilayer light reflective, variable interlayer separation (d-spacing), cross-linked self-assembling block copolymer film or coating wherein a property of the reflected light can be changed by varying the interlayer separation (d-spacing) of the film or coating.

Abstract: Embodiments of the present invention relate to a system and method for analysing, designing and manufacturing a body to determine potential discontinuities within the body when subjected to an action.

Abstract: A power electronic package includes: first and second high thermal conductivity insulating non-planar substrates; and multiple semiconductor chips and electronic components between the substrates. Each substrate includes multiple electrical insulator layers and patterned electrical conductor layers connecting to the electronic components, and further includes multiple raised regions or posts, which are bonded together so that the substrates are mechanically and electrically connected. The number, arrangement, and shape of the raised regions or posts are adjusted to have mechanical separation between the substrates. The electrical conductor layers are separated and isolated one another so that multiple electric circuits are provided on at least one of the substrates.

Abstract: Apparatus for measuring the electrical impedance of a tissue sample comprises a probe and a sheath comprising an elongated tubular body having one closed end and one open end providing an internal cavity. The sheath is composed of a material which when contacted with a tissue sample is capable of providing a conductive path through the sheath between the electrodes and the tissue sample. The resistivity of the material forming the sheath when contacted with the tissue sample is greater than the resistivity of the tissue sample. The probe is received within the internal cavity of the sheath. The sheath is impervious to bacteria and viruses.

Abstract: A power electronic package includes: first and second high thermal conductivity insulating non-planar substrates; and multiple semiconductor chips and electronic components between the substrates. Each substrate includes multiple electrical insulator layers and patterned electrical conductor layers connecting to the electronic components, and further includes multiple raised regions or posts, which are bonded together so that the substrates are mechanically and electrically connected. The number, arrangement, and shape of the raised regions or posts are adjusted to have mechanical separation between the substrates. The electrical conductor layers are separated and isolated one another so that multiple electric circuits are provided on at least one of the substrates.