Patents Assigned to University of South Alabama
  • Porous nanocomposite and related method
    Patent number: 10947356
    Abstract: A nanocomposite including an array of extended length fibers with nanofibers oriented in transverse relation to the extended length fibers. The nanofibers are mechanically interlocked with the extended length fibers using a connecting agent concentrated at contact locations between the extended length fibers and the nanofibers without saturating the composite. The resultant composite of fibers and connecting agent is characterized by significant internal porosity with an internal void volume not occupied by the connecting agent.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: March 16, 2021
    Assignee: THE UNIVERSITY OF SOUTH ALABAMA
    Inventor: Kuang-Ting Hsiao
  • DERIVATIVES OF SULINDAC CAN PROTECT NORMAL CELLS AGAINST OXIDATIVE DAMAGE
    Publication number: 20200095184
    Abstract: The disclosure provides chemical compounds possessing therapeutic and/or protective properties against oxidative damage. Methods of making such therapeutic and/or protective compounds and associated compositions are also provided, as are methods for their use, which include protecting cells from oxidative damage and/or inhibiting production of ROS in a cell or subject, as well as preventing or reducing the extent of tissue damage caused by an ischemic event in a subject at elevated risk of such an event.
    Type: Application
    Filed: March 16, 2018
    Publication date: March 26, 2020
    Applicant: University of South Alabama
    Inventors: Gary Piazza, Xi Chen, Herbert Weissbach, Shailaja Kesraju Allani
  • Apparatus and method for directional alignment of nanofibers in a porous medium
    Patent number: 10556390
    Abstract: A method and apparatus for uniformly and directionally aligning and stretching nanofibers inside a porous medium is described. The nanofibers may include nanotubes, nanowires, long-chain polymer molecules or likewise. Porous medium may include a porous layer, fabric, or composite prepreg or likewise. According to one embodiment, an apparatus for directional alignment of nanofiber in a porous medium includes a fluid matrix with nanofibers. A porous medium is provided as well as a device for forcing the fluid matrix radially through the porous medium.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: February 11, 2020
    Assignee: University of South Alabama
    Inventor: Kuang-ting Hsiao
  • Spectral illumination device and method
    Patent number: 10393964
    Abstract: An illumination device and method including multiple illumination sources such as LEDs, lasing diodes or the like operatively connected to a multi-branch light guide adapted to collect and co-align beams from the illumination sources for delivery of high intensity, spatially uniform illumination.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: August 27, 2019
    Assignee: THE UNIVERSITY OF SOUTH ALABAMA
    Inventor: Silas Leavesley
  • Methods and compositions for detecting endometrial or ovarian cancer
    Patent number: 10126311
    Abstract: Some embodiments of the present invention relate to methods and compositions for assessing the absence, presence, progression, or stage of cancer. In particular, methods and compositions for detecting endometrial cancer or ovarian cancer are provided.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: November 13, 2018
    Assignee: UNIVERSITY OF SOUTH ALABAMA
    Inventors: Michael A. Finan, Rodney P. Rocconi, Lewis K. Pannell
  • Method for manufacturing nano-structurally aligned multi-scale composites
    Patent number: 10066065
    Abstract: A method whereby nanostructures aligned within a matrix material to define an aligned admixture are transferred into a receiving porous medium while substantially maintaining the nanostructure alignment such that the nanostructures may be aligned predominantly in a common direction within receiving porous medium. Resulting composite structures are also provided.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: September 4, 2018
    Assignee: THE UNIVERSITY OF SOUTH ALABAMA
    Inventors: Kuang-Ting Hsiao, Gregory Hickman
  • Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression
    Patent number: 10039764
    Abstract: Disclosed are methods for treating cancer and precancerous conditions with PDE10A specific inhibitors and diagnosis of neoplastic diseases based on elevated levels of PDE10A.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: August 7, 2018
    Assignee: University of South Alabama
    Inventor: Gary A. Piazza
  • FORMULATIONS INCLUDING SILVER NANOPARTICLES AND METHODS OF USING THE SAME
    Publication number: 20180193239
    Abstract: A method for reducing or inhibiting damage to skin is disclosed herein. In some embodiments, the damage is ultraviolet (UV) radiation-induced damage. In some embodiments, the method comprises applying to the skin prior to exposure to radiation damaging source, a formulation containing an effective amount of silver nanoparticles (AgNPs) A method for treating damaged skin, and formulations include AgNPs are also disclosed.
    Type: Application
    Filed: November 2, 2017
    Publication date: July 12, 2018
    Applicant: University of South Alabama
    Inventors: Ajay Pratap Singh, Sumit Arora, Seema Singh
  • Minimal piggyBac Vectors for Genome Integration
    Publication number: 20180195086
    Abstract: Disclosed are genetic delivery systems that utilize genetic elements of the piggyBac family transposon system, and methods of introducing nucleic acid into target cells using the genetic delivery systems.
    Type: Application
    Filed: December 11, 2017
    Publication date: July 12, 2018
    Applicant: University of South Alabama
    Inventors: Victor Solodushko, Brian Fouty, Vira Bitko
  • Process for the separation of carbon dioxide from flue gas
    Patent number: 9901863
    Abstract: A process and system for separating CO2 from a flue gas stream is disclosed. The process involves (a) contacting a flue gas stream containing water vapor and CO2 with an ionic absorbent under absorption conditions to absorb at least a portion of the CO2 from the flue gas stream and form a CO2-absorbent complex; wherein the ionic absorbent comprises a cation and an anion comprising an amine moiety; and (b) recovering a gaseous product having a reduced CO2 content.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: February 27, 2018
    Assignees: Chevron U.S.A. Inc., University of South Alabama
    Inventors: Daniel Chinn, Russell Evan Cooper, Zunqing He, James H. Davis, Jr., Kevin N. West, Hye Kyung Timken, Michael S. Driver
  • Minimal vectors for genome integration
    Patent number: 9840718
    Abstract: Disclosed are genetic delivery systems that utilize genetic elements of the piggyBac family transposon system, and methods of introducing nucleic acid into target cells using the genetic delivery systems.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: December 12, 2017
    Assignee: University of South Alabama
    Inventors: Victor Solodushko, Brian Fouty, Vira Bitko
  • Methods and compositions for ameliorating pancreatic cancer
    Patent number: 9827224
    Abstract: Embodiments of the present invention include methods and compositions for ameliorating cancer. Some embodiments include methods and compositions for ameliorating pancreatic cancer targeting the CXCR4 receptor and the CXCL12 ligand.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: November 28, 2017
    Assignee: University of South Alabama
    Inventors: Seema Singh, Ajay P. Singh
  • Combination therapy for treatment of cancer
    Patent number: 9827328
    Abstract: The present invention relates to methods and compositions for the treatment of cancer. Some embodiments include methods of treating cancer comprising administering a chemotherapeutic agent associated with albumin, administering a second chemotherapeutic agent; and administering a third chemotherapeutic agent.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: November 28, 2017
    Assignee: UNIVERSITY OF SOUTH ALABAMA
    Inventor: Hung T. Khong
  • Aqueous solutions of amine functionalized ionic compounds for carbon capture processes
    Patent number: 9751044
    Abstract: An aqueous ionic absorbent solution is disclosed containing (a) about 15 wt. % to about 80 wt. % of one or more diluents, based on the total weight of the aqueous ionic absorbent solution; and (b) an ionic absorbent containing a cation and an anion comprising an amine moiety.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: September 5, 2017
    Assignees: Chevron U.S.A. Inc., University of South Alabama
    Inventors: Daniel Chinn, Rusell Evan Cooper, Zunqing He, James H. Davis, Jr., Kevin N. West, Hye Kyung Timken, Michael S. Driver
  • Methods and compositions for the treatment of cancer
    Patent number: 9540647
    Abstract: Some embodiments of the present invention relate to methods and compositions for treating cancer. More embodiments include methods and compositions for modulating the activity of the Hedgehog pathway.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: January 10, 2017
    Assignee: University of South Alabama
    Inventors: Lalita Samant, Rajeev Samant, Shamik Das, Eddie Reed
  • Methods and compositions for the treatment of cancer
    Patent number: 9464291
    Abstract: Some embodiments of the present invention relate to agents and compositions for treating cancer. More embodiments include agents and compositions for modulating the activity of the Hedgehog pathway.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: October 11, 2016
    Assignee: University of South Alabama
    Inventors: Eddie Reed, Lalita Samant, Rajeev Samant
  • Methods and compositions for the diagnosis, classification, and treatment of cancer
    Patent number: 9458456
    Abstract: Some embodiments of the present technology relate to methods and compositions for the diagnosis and treatment of cancer. Some embodiments include methods and compositions for the diagnosis and treatment of castration-resistant prostate cancer. Some embodiments include methods and compositions for the diagnosis and treatment of pancreatic cancer.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: October 4, 2016
    Assignee: UNIVERSITY OF SOUTH ALABAMA
    Inventors: Ajay Pratap Singh, Sanjeev Srivastava, Seema Singh
  • FORMULATIONS INCLUDING SILVER NANOPARTICLES AND METHODS OF USING THE SAME
    Publication number: 20160235635
    Abstract: A method for reducing or inhibiting damage to skin is disclosed herein. In some embodiments, the damage is ultraviolet (UV) radiation-induced damage. In some embodiments, the method comprises applying to the skin prior to exposure to radiation damaging source, a formulation containing an effective amount of silver nanoparticles (AgNPs) A method for treating damaged skin, and formulations include AgNPs are also disclosed.
    Type: Application
    Filed: October 16, 2014
    Publication date: August 18, 2016
    Applicant: University of South Alabama
    Inventors: Ajay Pratap Singh, Sumit Arora, Seema Singh
  • Treatment of disease conditions via administration of DNA repair enzyme
    Patent number: 9404102
    Abstract: The present invention is directed to compositions and methods of preserving viability of islets of Langerhans for transplantation, and treating various disease and other abnormal or pathological conditions, including inflammatory bowel disease, ischemic heart disease, acute lung injury, acute respiratory distress syndrome and radiation-induced brain injury, with DNA repair enzymes that are directed to the mitochondria.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: August 2, 2016
    Assignee: University of South Alabama
    Inventors: Glenn Wilson, Susan Ledoux, Mikhail Alexeyev, Inna Shokolenko, Mark N. Gillespie
  • MINIMAL PIGGYBAC VECTORS FOR GENOME INTEGRATION
    Publication number: 20160160235
    Abstract: Disclosed are genetic delivery systems that utilize genetic elements of the piggyBac family transposon system, and methods of introducing nucleic acid into target cells using the genetic delivery systems.
    Type: Application
    Filed: July 11, 2014
    Publication date: June 9, 2016
    Applicant: University of South Alabama
    Inventors: Victor Solodushko, Brian Fouty, Vira Bitko