Patents Assigned to University of South Carolina
  • Patent number: 10494461
    Abstract: Nanoparticles having a plurality of PVP chains covalently bonded to a surface of the nanoparticle are provided, along with their methods of formation and the RAFT agents for the polymerization of the PVP chains. RAFT agents are generally provided, along with their methods of formation and use. Methods are also generally provided for grafting a PVP polymer onto a nanoparticle. In one embodiment, the method includes: polymerizing a plurality of monomers in the presence of a RAFT agent to form a polymeric chain covalently bonded to the nanoparticle.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: December 3, 2019
    Assignee: University of South Carolina
    Inventors: Lei Wang, Brian C. Benicewicz
  • Patent number: 10494610
    Abstract: Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: December 3, 2019
    Assignee: University of South Carolina
    Inventor: Esmaiel Jabbari
  • Patent number: 10492759
    Abstract: In one aspect, the present subject matter is directed to a barrier device. The barrier device has a generally flat base with a width and a length. The base has a top portion and an opposite bottom portion. A surface of the bottom portion includes adhesive. A barrier extends upwardly from the base, the barrier having a generally flat first side and an opposite generally flat second side. A width between the first side of the barrier and the second side of the barrier is less than the width of the base.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: December 3, 2019
    Assignee: University of South Carolina
    Inventors: Richard A. Hoppmann, Debra Krotish, Michael Riffle
  • Patent number: 10487309
    Abstract: Methods are generally disclosed for attaching a cell binding motif to a carboxy end of a coat protein of a Tobacco Mosaic Virus particle to form a modified-TMV particle; and attaching a cell to the cell binding motif of the modified-TMV particle. Methods are also disclosed for incorporated virus particles, e.g., TMV virus particles into hydrogels.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: November 26, 2019
    Assignee: University of South Carolina
    Inventors: Qian Wang, Lim Andrew Lee
  • Patent number: 10463631
    Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of a natural pimarane diterpenoid extract of Hymenocrater elegans, or a derivative, analogue, or homolog thereof. Compounds based upon this natural extract have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: November 5, 2019
    Assignee: University of South Carolina
    Inventors: Ehsan Jabbarzadeh, Sara Eslambolchimoghada
  • Patent number: 10456410
    Abstract: A dressing for wound healing is provided, wherein the dressing includes a hydrogen sulfide (H2S) donor compound. The dressing facilitates the delivery of H2S to a wound site in a controlled manner, which results in an improved wound healing process by stimulating angiogenesis and anti-inflammatory action. In some embodiments, the wound dressing can include an electrospun nanofiber dressing, a sponge dressing, or a hydrogel dressing.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: October 29, 2019
    Assignee: University of South Carolina
    Inventor: Qian Wang
  • Patent number: 10435801
    Abstract: A syngas generation system that combines a solid oxide electrolysis cell (SOEC) and a carbon gasification unit is described. On the cathode side of the SOEC, CO2 and H2O are electrochemically converted to syngas. At the anode side of the system, a second stream of syngas is produced through a carbon gasification process in which solid carbon is reacted with H2O/CO2. Oxygen ion transported across the SOEC electrolyte reacts at the anode with a portion of the syngas produced in the gasification process. This reaction product (H2O/CO2) can be fed back to the gasification unit.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: October 8, 2019
    Assignee: University of South Carolina
    Inventors: Libin Lei, Fanglin Chen, Yao Wang
  • Patent number: 10422093
    Abstract: Methods for restoring tidal areas adjacent to a tidal water area are provided. The method can comprise: pumping water from the tidal water area; and directing a high-pressure water stream, using the water pumped from the tidal water area, to the bottom surface of the tidal water area during an incoming tide period. The high-pressure water stream impacts the bottom surface of the tidal water area with sufficient force to dislodge sediment from the bottom surface into the tidal water area.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: September 24, 2019
    Assignee: University of South Carolina
    Inventor: James Morris
  • Patent number: 10418511
    Abstract: Methods are provided for forming AlInGaBN material. The method can include growing an AlInGaBN layer on a substrate; removing a portion of the AlInGaBN layer from the substrate to define a plurality of AlInGaBN islands on the substrate; and growing a highly doped-AlInGaBN layer on each of the AlInGaBN islands.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: September 17, 2019
    Assignee: University of South Carolina
    Inventor: Asif Khan
  • Patent number: 10400054
    Abstract: Disclosed are polymerization initiators as may be utilized for addition of polymers to a substrate surface. The initiators are azo-based initiators that include multi-functionality through addition of multiple anchoring agents to an inner azo group. Disclosed polymerization initiators can be utilized to form high density and high molecular weight polymers on a surface such as a particulate surface. Formed materials can be beneficial in one embodiment in fracking applications, providing composite proppant/polymer materials that can prevent leakage of polymers from a subterranean geologic formation.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: September 3, 2019
    Assignee: University of South Carolina
    Inventors: Anand Viswanath, Brian C. Benicewicz, Michael H. Bell
  • Patent number: 10386133
    Abstract: Microfluidic devices, along with methods of their fabrication, are provided. The microfluidic device can include a substrate defining a microchannel formed between a pair of side walls and a bottom surface and a plurality of nanotips positioned within the microchannel and proximate to each side wall such that a boundary layer is formed along each side wall between the plurality of nanotips and the side wall upon addition of a liquid into the microchannel.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: August 20, 2019
    Assignee: University of South Carolina
    Inventors: Chen Li, Fanghao Yang, Yan Tong
  • Patent number: 10381035
    Abstract: Methods for magnetic recording are provided. The method can include: assembling a plurality of nanoparticles into a pattern on a disc; applying a polymer composition onto the pattern of nanoparticles; curing the polymer composition to form a polymer film on the disc, wherein the plurality of nanoparticles are immobilized in the pattern within the polymer film upon curing; and removing the polymer film containing the plurality of nanoparticles in the pattern. Diffraction gratings are also provided that can include a polymeric film comprising a plurality of nanoparticles immobilized in a pattern, wherein the polymer film defines a curvature.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: August 13, 2019
    Assignee: University of South Carolina
    Inventors: Thomas M. Crawford, Longfei Ye, Jason Ryan Henderson
  • Publication number: 20190229388
    Abstract: An electrically tunable radio frequency phase shifter with compact 3-D structure that integrates both ferromagnetic and ferroelectric materials, and utilizes 3-D structure to increase the tuning efficiency and achieve miniaturization.
    Type: Application
    Filed: January 24, 2019
    Publication date: July 25, 2019
    Applicant: University of South Carolina
    Inventors: Tengxing Wang, Guoan Wang
  • Patent number: 10336944
    Abstract: A hydrocarbon generation system that combines a solid oxide electrolysis cell (SOEC) and a Fischer-Tropsch unit in a single microtubular reactor is described. This system can directly synthesize hydrocarbons from carbon dioxide and water. High temperature co-electrolysis of H2O and CO2 and low temperature Fischer-Tropsch (F-T) process are integrated in a single microtubular reactor by designation of a temperature gradient along the axial length of the microtubular reactor. The microtubular reactor can provide direct conversion of CO2 to hydrocarbons for use as feedstock or energy storage.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: July 2, 2019
    Assignee: University of South Carolina
    Inventors: Fanglin Chen, Libin Lei, Tong Liu, Shumin Fang
  • Patent number: 10336777
    Abstract: Compounds are generally provided, along with pharmaceutical compositions including such compounds. Methods are also generally provided for inhibiting ribose 5-phosphate isomerase in a human, such as via administering to the human the pharmaceutical composition that includes such a compound. Methods are also generally provided for treating a mammal that is infected by a parasitic organism, such as via administering to the mammal the pharmaceutical composition that includes such a compound. Methods are also generally provided for forming a pharmaceutical composition.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: July 2, 2019
    Assignee: University of South Carolina
    Inventor: Edward L. D'Antonio
  • Patent number: 10303923
    Abstract: Methods and systems for characterization of NETosis (Neutrophil Extracellular Traps) in neutrophils. In some examples, a method includes acquiring an image of a sample of neutrophils. The method includes classifying each neutrophil depicted in the image as having either a NETotic or non-NETotic nucleus using one or more processors executing a convolutional neural network (CNN) trained on training images of NETotic and non-NETotic neutrophil nuclei. The method includes generating output indicative of a number of neutrophils classified as having a NETotic nucleus and a number of neutrophil classified as having a non-NETotic nucleus.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: May 28, 2019
    Assignees: The University of North Carolina at Chapel Hill, The University of South Carolina
    Inventors: Leslie Victoria Parise, Noah Sciaky, Laila Elsherif, Joshua Nathan Cooper
  • Patent number: 10287236
    Abstract: A method i for forming an epoxidized polymer is provided. The method may include mixing an epoxidized plant oil with a synthetic epoxy resin and crosslinking the epoxidized plant oil and the synthetic epoxy resin using a curing agent. The epoxidized plant oil may be formed via: converting plant oil triglycerides to fatty amide alcohols via aminolysis using primary or secondary amines, converting the fatty amide alcohols to epoxidized fatty amide alcohols, and reacting the epoxidized fatty amide alcohols with vinyl monomers to obtain epoxidized plant oil monomers.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: May 14, 2019
    Assignee: University of South Carolina
    Inventors: Chuanbing Tang, Zhongkai Wang, Liang Yuan
  • Patent number: 10273339
    Abstract: Porous networks are described linked by boronates. Also described are processes for producing the porous networks. The porous networks are formed by reacting a polyboronic acid with itself or with a polydiol, a polydiamine, or a polyamino alcohol. The resulting boronate linkage is covalently bonded. The characteristics and properties of the resulting porous material can be varied and altered by changing the reactants and by incorporating functional groups into the reactants. Of particular advantage, the porous materials can be formed at or near atmospheric pressure and at low temperature in the presence of one or more solvents.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: April 30, 2019
    Assignee: University of South Carolina
    Inventors: John J. Lavigne, R. William Tilford
  • Patent number: 10266397
    Abstract: A microcantilever based photoacoustic sensor is generally provided. In one embodiment, the microcantilever includes: a substrate; a GaN layer on the substrate, wherein the GaN layer defines a cantilever extending beyond an edge of the substrate, with a base area of the cantilever defined by the area spanning the edge of the substrate; a heterojunction field effect transistor (HFET) deflection transducer positioned on the cantilever; a pair of electrical contacts, each electrically connected to the HFET deflection transducer; and a microfluidic channel in fluid communication with an analyte reservoir, wherein the analyte reservoir is positioned at the base of the cantilever. A sensing system is also generally provided.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: April 23, 2019
    Assignee: University of South Carolina
    Inventors: Goutam Koley, Abdul Talukdar
  • Patent number: 10260166
    Abstract: Methods for forming an epilayer on a surface of a substrate are generally provided. For example, a substrate can be positioned within a hot wall CVD chamber (e.g., onto a susceptor within the CVD chamber). At least two source gases can then be introduced into the hot wall CVD chamber such that, upon decomposition, fluorine atoms, carbon atoms, and silicon atoms are present within the CVD chamber. The epilayer comprising SiC can then be grown on the surface of the substrate in the presence of the fluorine atoms.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: April 16, 2019
    Assignee: University of South Carolina
    Inventors: Tangali S. Sudarshan, Tawhid Rana, Haizheng Song