Abstract: Described herein are mechanistic results showing that cis- and trans-RSV have opposite effects on TyrRS-regulated neuronal DNA repair and survival, mechanistically, only cis-RSV protected neurons against stress conditions by activating TyrRS-regulated neuronal DNA repair and resilient signaling; trans-RSV, conversely, facilitated the downregulation of TyrRS resulting in the accumulation of DNA damage and subsequent neurodegeneration. Knockdown of TyrRS blunted the neuroprotective effects of cis-RSV and exacerbated the neurotoxicity by trans-RSV, providing a potential molecular basis for the controversial effects of RSV in clinical studies.
Abstract: Described herein are systems, methods and devices for implementing a temperature-aware, multi-antenna scheduler that cools mmWave devices by preventing heat buildup via switching or distributing a data stream to other redundant antennas, allowing for dissipation of heat as well as providing reliable connectivity.
Type:
Application
Filed:
February 9, 2023
Publication date:
June 22, 2023
Applicant:
University of South Carolina
Inventors:
Sanjib Sur, Moh. S. Saadat, Srihari Nelakuditi
Abstract: Testing peptides in in vitro models of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Frontotemporal dementia, Amyotrophic lateral sclerosis, to evaluate systems and methods of treatment therefore.
Type:
Application
Filed:
November 18, 2022
Publication date:
June 22, 2023
Applicants:
University of South Carolina, Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.
Inventors:
Amar N. Kar, Pabitra Sahoo, Jeffery Twiss, Sean McGill, Eran Perlson, Topaz Altman, Ariel Razvan Ionescu, Tal Gradus-Pery, Amir Dori
Abstract: Described herein are methods and systems for the preparation of a brain targeted cerium oxide nanop article (CeNP) and its application in treating central neuronal system diseases. The brain targeted CeNP (T-CeNP) can effectively pass the blood brain barrier and specifically target brain tissue and exhibit anti-inflammatory and anti-oxidant effects.
Abstract: A new vibration test-cell that allows a static load to be applied simultaneously with lateral vibration coupled with in-situ microscopy that allows for the ability to open a fatigue crack up to a desired gap, as well as generate acoustic emission (AE) from vibration excitation, micro-fracture events are captured by the AE measurement while the physical observation of the crack faying surfaces is performed in-situ with an optical microscope embedded in the test cell.
Type:
Grant
Filed:
September 3, 2020
Date of Patent:
June 20, 2023
Assignee:
University of South Carolina
Inventors:
Victor Giurgiutiu, Yeasin Bhuiyan, Matthew Droghini
Abstract: Methods for forming a graphene film on a silicon carbide material are provided, along with the resulting coated materials. The method can include: heating the silicon carbide material to a growth temperature (e.g., about 1,000° C. to about 2,200° C.), and exposing the silicon carbide material to a growth atmosphere comprising a halogen species. The halogen species reacts with the silicon carbide material to remove silicon therefrom. The halogen species can comprise fluorine (e.g., SiF4, etc.), chlorine (e.g., SiCl4), or a mixture thereof.
Type:
Grant
Filed:
February 14, 2014
Date of Patent:
June 20, 2023
Assignee:
University of South Carolina
Inventors:
Tangali S. Sudarshan, Tawhid Rana, MVS Chandrashekhar
Abstract: The present disclosure provides methods and systems for flight velocimetry employing at least one bleaching laser, at least one detection laser, at least one dichroic mirror, an objective, a detection system, and a nano stage to bleach a dye to form a bleached blot in a flow pathway.
Abstract: The present disclosure is directed to hybrid multifunctional macromers that can self-assemble to form nanoparticles for on-demand and targeted release of morphogens. Embodiments of the disclosure can include the hybrid multifunctional macromers and peptide sequences incorporated therein, self-assembled nanoparticles including the hybrid multifunctional macromers, methods for producing the hybrid multifunctional macromers and peptide sequences, and methods for treating a disease by the on-demand and targeted delivery of a compound using the hybrid multifunctional macromers.
Abstract: A quartz crystal microbalance coated with functionalized nanoparticles used to detect molecule-nanoparticle interactions to assist with characterization of difficult to predict molecule-nanoparticle interactions for novel ligand chemistries and, particularly, mixed ligand nanoparticles exhibiting different ligand morphologies, in order to quantify nanoparticle-molecule interactions independently from more complex solvation requirements.
Abstract: Apparatuses, systems, and methods for transmitting and multiplexing chirp signals for communications are provided. An example apparatus includes an antenna, a radio, and processing circuitry. The radio may be configured to transmit and receive wireless communications via the antenna, and the processing circuitry configured to establish a wireless communications link with a receiving communications device. The signaling transmitted by the antenna via the radio as controlled by the processing circuitry may include a plurality of sequenced chirp signals within an orthogonal frequency division multiplexing (OFDM) framework.
Type:
Grant
Filed:
October 7, 2020
Date of Patent:
May 16, 2023
Assignee:
UNIVERSITY OF SOUTH CAROLINA
Inventors:
Alphan Sahin, David Matolak, Nozhan Hosseini
Abstract: The present subject matter relates to techniques for systems and methods for determining alpha phase in brain of subjects undergoing depressive disorder. The disclosed system for a closed-loop operation in simultaneous functional magnetic resonance imaging (fMRI)-electroencephalogram (EEG)-transcranial magnetic stimulation (TMS), can include a processor that be configured to receive and process a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and/or transcranial magnetic stimulation (TMS) pulse simultaneously.
Type:
Application
Filed:
November 10, 2022
Publication date:
May 11, 2023
Applicants:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, MEDICAL UNIVERSITY OF SOUTH CAROLINA
Inventors:
Paul Sajda, Truman R. Brown, Mark S. George, Robin Goldman, Josef Faller, Jaycee Doose, James McIntosh, Joshua B. Teves, Yida Lin, Golbarg T. Saber, Aidan Blankenship, Spiro P. Pantazatos, Xiaoxiao Sun
Abstract: The current disclosure determines if structural faults exist and extracts geometric features of the structural faults from acoustic emission waveforms, such as crack length and orientation, and can evaluate the structural faults online, during normal operation conditions.
Type:
Grant
Filed:
September 11, 2020
Date of Patent:
May 2, 2023
Assignee:
University of South Carolina
Inventors:
Victor Giurgiutiu, Jingjing Bao, Banibrata Poddar, Md Yeasin Bhuiyan
Abstract: Described herein are regenerative approaches with tunable cell-cell and cell-matrix interactions to enhance the ability to regenerate multiple zones within a construct with each zone possessing a unique, optimum, level of cell-cell and cell-matrix interaction.
Abstract: The present disclosure is directed to compositions and structures of supported metal catalysts for use in applications such as direct methanol fuel cells. Generally, implementations include supported metal catalysts that include Pt active sites that have been modified by addition or co-localization of a second metal such as Cu, Co, Ni, and/or other base metals to lower the inhibiting effect of strongly-adsorbed CO, an intermediate of methanol oxidation. An example aspect of the present disclosure includes catalyst compositions where the exterior metal sites in the supported catalyst include at least two metals: Pt and a competitive binder (e.g., a second metal).
Type:
Grant
Filed:
January 22, 2020
Date of Patent:
April 18, 2023
Assignee:
University of South Carolina
Inventors:
John R. Monnier, Gregory L. Tate, Wen Xiong, Benjamin H. Meekins
Abstract: Anti-CCL8 antibodies and antigen binding fragments thereof are described. Antibodies and fragments thereof can be used for prevention of migration of breast cancer cells. Methods include delivery of an anti-CCL8 antibody or an antigen binding fragment thereof to an area including the breast cancer cells, e.g., delivery to a subject in need thereof in an effective amount.
Abstract: Described herein are systems and methods for using artificial intelligence (AI) in real-time to assess the difficulty level of a patient being scanned and assigning an objective scanning difficulty level (SDL) to the patient to help inform medical personnel and educators of the difficulty of scanning said patient.
Type:
Application
Filed:
October 11, 2022
Publication date:
April 13, 2023
Applicant:
University of South Carolina
Inventors:
Richard Hoppmann, Floyd Bell, Robert Haddad, Keith Barron
Abstract: The present disclosure provides using ultrasound technology and artificial intelligence to enhance MSR assessment by making the assessment more objective, reproducible, and recordable to allow a more precise and/or personalized approach to the medical practice of individual patients via using multiple ultrasound functions and artificial intelligence to improve the accuracy and consistency of assessing reflexes and allowing MSR data to be combined with other patient medical information for improved diagnosis and management of a patient's condition.
Type:
Application
Filed:
December 13, 2022
Publication date:
April 13, 2023
Applicants:
University of South Carolina, Texas Tech University System
Abstract: An antenna assembly includes an antenna and a heatsink. The antenna may be configured to support radio communications and generate heat, and may include a forward antenna surface configured to transmit or receive communications signals and a rear antenna surface that is affixed to a substrate. The heatsink structure may be positioned to be within a forward electromagnetic field that is emitted from the forward antenna surface and away from the rear antenna surface. The heatsink structure may be configured to perform a convection operation between the antenna and a fluid to perform thermal dissipation of the heat from the antenna.
Abstract: Embodiments disclosed herein are directed to systems and methods for producing high quality 3-dimensional prints using various materials. Aspects of the present disclosure may provide particular advantages when used with high temperature thermoplastics (such as polyetherimide (PEI) polymers), such as when using continuous fibers impregnated with a high temperature thermoplastic, or when co-depositing a continuous fiber with a formation material containing a high temperature thermoplastic.
Type:
Grant
Filed:
August 13, 2019
Date of Patent:
April 4, 2023
Assignees:
University of South Carolina, TIGHITCO. Inc.
Inventors:
Wout De Backer, Michael Van Tooren, Arturs Bergs
Abstract: Structural health monitoring (SHM)/nondestructive evaluation (NDE) exists as a tool in conjunction with manufactured pieces. Presently disclosed subject matter integrates automated video with a structural health monitoring system. In conjunction with bridge monitoring, integration of such two systems automates determination of the effect or correlation of vehicular loading on SHM data from a subject bridge. Such correlations help to understand the sources of structural health monitoring data, particularly acoustic emission data, in bridges and other structures, such as dams and nuclear plants. Automation of the evaluation of bridges and other structures increases accuracy and minimizes risk to workers and the public. Assessing the structural condition of bridges and other structures as presently disclosed also facilitates automated asset management of transportation systems, such as by state departments of transportation and other bridge/structural owners.