Patents Assigned to University of Texas Systems
  • Publication number: 20250256080
    Abstract: Tumor-Treating Fields elicit a conditional vulnerability to PARP inhibitors (e.g., Olaparib) in certain cancer cells such as non-small cell lung cancer (NSCLC) cell lines. This conditional vulnerability is exploited in a method of killing cancer cells that comprises delivering a PARP inhibitor to the cancer cells and applying an alternating 80-300 kHz electric field to the cancer cells. At least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. In some embodiments, an additional step of treating the cancer cells with a radiation therapy is added to the method. In some embodiments, the frequency of the alternating electric field is between 100 and 200 kHz.
    Type: Application
    Filed: April 1, 2025
    Publication date: August 14, 2025
    Applicant: Board of Regents of the University of Texas System
    Inventors: Michael STORY, Debabrata SAHA, Narasimha Kumar KARANAM
  • Patent number: 12383196
    Abstract: Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: August 12, 2025
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Board of Regents, The University of Texas System, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Amit Etkin, Madhukar Trivedi, Wei Wu
  • Patent number: 12387288
    Abstract: A method of conforming a periodic array to a surface is provided. The method comprises calculating, with a spatially-variant lattice algorithm, a pair of planar gratings across the surface, wherein the planar gratings are generated via reciprocal lattice vectors and summing the pair of planar gratings. Intersections produced by summing the gratings are scanned for maxima on the surface, and a periodic array of elements is located at the maxima on the surface. A normal vector is calculated at each maximum on the surface, and each element is rotated to match the direction of the respective normal vector at each maximum on the surface. The elements are then conformed to the surface via a shrink-wrap modifier operation.
    Type: Grant
    Filed: September 23, 2022
    Date of Patent: August 12, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Raymond C. Rumpf, Cesar Luis Valle, Gilbert T. Carranza
  • Patent number: 12378201
    Abstract: The present disclosure provides a new series of 8-hydroxyquinoline derivatives/analogs that are potent KDM4 inhibitors with high activity and selectivity against KDM4 enzymes. Also disclosed are the pharmaceutical compositions comprising such 8-hydroxyquinoline-based potent KDM4 inhibitors, or a pharmaceutically acceptable salt thereof, and method of use thereof, for treating cancer and neoplastic diseases and the like.
    Type: Grant
    Filed: June 20, 2020
    Date of Patent: August 5, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jer-Tsong Hsieh, Jung-Mo Ahn, Zhi-Ping Liu
  • Patent number: 12370370
    Abstract: An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: July 29, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jonathan W. Valvano, John A. Pearce, Marc D. Feldman, Kaarthik Rajendran, John Porterfield, Anil Kottam, Wes Johnson
  • Patent number: 12370379
    Abstract: A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.
    Type: Grant
    Filed: February 7, 2023
    Date of Patent: July 29, 2025
    Assignees: University Of Maryland, Baltimore, The Board of Regents of the University of Texas System, Broncus Medical Inc.
    Inventors: Amit Sawant, Robert Timmerman, Yulong Yan, Henky Wibowo, Esther Vicente, Arezoo Modiri
  • Publication number: 20250235399
    Abstract: Described herein are dry powder inhalation mixtures for pulmonary delivery and processes for making the same. A process for making a dry powder inhaler blend as described herein comprises introducing an active pharmaceutical ingredient, a lubricant, and a carrier into a multi-screw extruder; and continuously mixing the active pharmaceutical ingredient, the lubricant, and the carrier in the multi-screw extruder to form a dry powder inhaler blend. In this method, the active pharmaceutical ingredient, the lubricant, and the carrier are in the form of a powder.
    Type: Application
    Filed: April 7, 2023
    Publication date: July 24, 2025
    Applicant: Board of Regents, The University of Texas System
    Inventors: Hugh Smyth, Feng Zhang, Jamie Spahn
  • Patent number: 12364640
    Abstract: An embodiment includes an apparatus for coupling a user to a robot to provide robot-assisted physical therapy to the user. Other embodiments are described herein.
    Type: Grant
    Filed: April 14, 2021
    Date of Patent: July 22, 2025
    Assignees: Board of Regents, The University of Texas System, Harmonic Bionics, Inc.
    Inventors: Rohit John Varghese, William Wu
  • Patent number: 12365761
    Abstract: The present disclosure relates to degradable polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and have backbones which are capable of undergoing degradation in vivo. In some aspects, the disclosure also provides methods of using these degradable polymers for the delivery of a drug.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: July 22, 2025
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Jinming Gao, Xu Wang, Houliang Tang, Wei Li, Jonathan Wilhelm, Baran Sumer
  • Publication number: 20250228788
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Application
    Filed: January 16, 2025
    Publication date: July 17, 2025
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Qiang CHENG, Tuo WEI, Daniel J. SIEGWART
  • Patent number: 12357580
    Abstract: In some aspects, the present disclosure provides compositions of lipid nanoparticles useful for the delivery of large RNAs including mRNAs. These compositions may include a cationic ionizable lipid, a phospholipid, a PEGylated lipid, and a steroid including using less of a cationic ionizable lipid than compositions with shorter nucleic acids. These compositions may be used to treat a disease or disorder for which the delivery of an mRNA is therapeutically effective.
    Type: Grant
    Filed: June 14, 2024
    Date of Patent: July 15, 2025
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Daniel J. Siegwart, Qiang Cheng
  • Patent number: 12359204
    Abstract: The present invention includes compositions and methods for treating an autoimmune disorder or a cancer in a subject in need thereof, the method comprising: administering an effective amount of a composition comprising an oligonucleotide that specifically binds a complementary sequence of the Interleukin-7 receptor (IL7R) pre-mRNA that influences splicing of exon 6, wherein the SM-ASO increases or decreases inclusion of exon 6 in IL7R pre-mRNAs and respectively decreases or increases expression of the soluble isoform of IL7R (sIL7R). In certain embodiments, the oligonucleotide is an antisense oligonucleotide (ASO), or a splice-modulating antisense oligonucleotide (SM-ASO).
    Type: Grant
    Filed: November 6, 2023
    Date of Patent: July 15, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Mariano A. Garcia-Blanco, Gaddiel Galarza-Munoz, Shelton S. Bradrick
  • Patent number: 12359266
    Abstract: The present invention includes a method and kit for single-primer tiled sequencing comprising: reverse transcribing a target nucleic acid with multiple tiled primers spaced along the genome, each only targeting one annealing site to form amplicons in the presence of terminating 3? azido nucleotides to incorporate the terminating 3? azido nucleotides into the cDNA; click-ligating a downstream primer onto tire 3? azido terminated cDNA such that a second template-specific primer is not required; amplifying the click-ligated cDNA; and sequencing the amplicons.
    Type: Grant
    Filed: June 18, 2021
    Date of Patent: July 15, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Andrew Routh, Elizabeth Jaworski
  • Patent number: 12357682
    Abstract: The invention generally relates to the development of immunogenic compositions comprising a DNA copy of at least one live attenuated plus-sense single-stranded RNA virus genome, such as the genome of a live-attenuated Zika vims (ZIKV), Japanese encephalitis virus (JEV) or yellow fever vims (YFV). The immunogenic compositions can be used for treating or conferring protective immunity against diseases related to plus-sense single-stranded RNA viruses, e.g. for affording prolonged immunoprotection against such viruses and protective immunity is conferred at low diseases, e.g., as low as 300 or 500 ng after administration of a single pLAV dosage.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: July 15, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jing Zou, Xuping Xie, Pei-Yong Shi
  • Publication number: 20250226119
    Abstract: Disclosed are techniques for initiating and sustaining a transport barrier within a magnetically confined plasma in a plasma fusion device. For a toroidal magnetic configuration, a characteristic region of the magnetic field can be established by generating a current within the plasma or by other means. The location of the characteristic region can be controlled to be suitably close to the interior walls of the plasma fusion device to allow a quantity of particles to be injected into the plasma at or inside the characteristic region. The quantity of particles can augment the density of the plasma and create a density gradient within the characteristic region, resulting in the formation of a transport barrier at or inside the characteristic region.
    Type: Application
    Filed: March 31, 2023
    Publication date: July 10, 2025
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael Thomas Kotschenreuther, Swadesh Mahajan, David R. Hatch, Xing Liu, Gabriele Merlo
  • Publication number: 20250222179
    Abstract: Embodiments of the disclosure concern devices comprised of resorbable, shape-memory foam configured to allow for healing at a desired location. In particular embodiments, use of the device at the location utilizes the inherent environment at the location to allow expansion of the device, resulting in an improved fit for the device. In specific cases, the device is a vaginal stent configured for use for pediatric or adolescent populations.
    Type: Application
    Filed: April 4, 2023
    Publication date: July 10, 2025
    Applicants: Baylor College of Medicine, Board of Regents, The University of Texas System, The Texas A&M University System
    Inventors: Julie Hakim, Elizabeth Cosgriff-Hernandez, Melissa Grunlan
  • Patent number: 12351560
    Abstract: Procedures for inhibiting hormone receptor activation include administering to a subject in need of hormone receptor inhibition a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions. Procedures for treating prostate cancer or breast cancer include administering to a subject having prostate cancer or breast cancer a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions.
    Type: Grant
    Filed: March 27, 2023
    Date of Patent: July 8, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Marc Cox, Artem Cherkasov, Fuqiang Ban
  • Patent number: 12351609
    Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: July 8, 2025
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Eric N. Olson, Rhonda S. Bassel-Duby, Catherine A. Makarewich, Benjamin R. Nelson
  • Publication number: 20250215019
    Abstract: Disclosed herein are methods of synthesizing compounds of the formula wherein the variables are defined herein. Also provided are compounds produced using these methods. In some aspects, the methods provided herein may be used to create di- and tri-substituted BCPs.
    Type: Application
    Filed: March 17, 2023
    Publication date: July 3, 2025
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Yangyang YANG, Jet TSIEN, Tian QIN
  • Publication number: 20250205358
    Abstract: Photoactivatable nanoparticles for simultaneous PD-L1 immune checkpoint targeting and blocking are capable of modulating tumor stroma, promoting self-delivery, improving tumor growth inhibition, and improving survival outcomes even with just a single priming dose. Light activation of the nanoparticles disrupts tumor collagen, reduces tumor fibroblasts, and promotes their self-delivery in vitro and in vivo which correlates with overall survival in mice. This demonstrates their ability to overcome the most significant barrier in nanoparticle delivery in PDAC tumors.
    Type: Application
    Filed: December 17, 2024
    Publication date: June 26, 2025
    Applicant: Board of Regents, The University of Texas System
    Inventors: Girgis Obaid, Chanda Bhandari, Nimit Shah