Abstract: Disclosed herein are methods of treating a tumor or cancer in a subject whose tumor or cancer cells express low levels of asparagine synthetase (ASNS), and compounds and compositions useful in such treatment. Also disclosed herein are methods of evaluating whether to administer a compound that inhibits glutathione production or a glutaminase inhibitor to a subject with a tumor or cancer.
Type:
Grant
Filed:
September 6, 2023
Date of Patent:
June 24, 2025
Assignee:
Board of Regents, The University of Texas System
Inventors:
Timothy Heffernan, Jeffrey Kovacs, Nakia Spencer, Christopher Bristow
Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
Type:
Grant
Filed:
November 21, 2019
Date of Patent:
June 24, 2025
Assignees:
Rodeo Therapeutics Corporation, Case Western Reserve University, Board of Regents of the University of Texas System
Inventors:
Sanford Markowitz, Joseph Ready, Stephen L. Gwaltney, II, Monika Antczak
Abstract: The present invention relates to assays, methods, and kits to assess traumatic brain injury (TBI) in a subject. The present invention also relates to ultrasensitive assays for GFAP, tau, CKBB, IL-1?, IL-2, IL-6, IL-10, IL-22, IP-10, TNF?, TSLP, NFL, and/or NFH.
Type:
Grant
Filed:
March 8, 2019
Date of Patent:
June 24, 2025
Assignees:
Meso Scale Technologies, LLC., Georgetown University, The Board of Regents of the University of Texas System
Inventors:
Jeff Debad, Joshua Gatson, Mark Burns, Arianna Biesso
Abstract: Various embodiments of the present technology provide a novel deep learning-based error correction coding scheme for AWGN channels under the constraint of moderate to low bit quantization (e.g., one-bit quantization) in the receiver. Some embodiments of the error correction code minimize the probability of bit error can be obtained by perfectly training a special autoencoder, in which “perfectly” refers to finding the global minima of its cost function. However, perfect training is not possible in most cases. To approach the performance of a perfectly trained autoencoder with a suboptimum training, some embodiments utilize turbo codes as an implicit regularization, i.e., using a concatenation of a turbo code and an autoencoder.
Type:
Grant
Filed:
August 26, 2020
Date of Patent:
June 17, 2025
Assignee:
Board of Regents, The University of Texas System
Abstract: Modified hydrophilic carbon clusters (HCCs), poly(ethylene glycol)-hydrophilic carbon clusters (PEG-HCCs) and similarly structured materials like graphene quantum dots (GQDs), PEGylated GQDs, small molecule antioxidants, and PEGylated small molecule antioxidants. These materials have been modified with an iron chelating moiety, deferoxamine, or a similar chelating moiety. By exploiting common binding sites, the carbon nanostructure facilitates intracellular transport including in mitochondria, reduces oxidative breakdown of the chelator moiety prior to treatment, and reduces both the cause and consequences of metal induced oxidative stress within the body thus providing a novel form of therapy for a range of oxidative and metal-related toxicities. Graphenic materials can be used for the treatment of acute and chronic mitochondrial electron transport chain dysfunction.
Type:
Grant
Filed:
April 30, 2018
Date of Patent:
June 17, 2025
Assignees:
William Marsh Rice University, Board of Regents, The University of Texas System, Baylor College of Medicine, Houston Methodist Research Institute, The United States Government
Inventors:
James M. Tour, Lizanne Nilewski, William Sikkema, Kimberly Mendoza, Thomas Andrew Kent, William Dalmeida, Jr., Paul J. Derry, Ah-Lim Tsai, Muralidhar L. Hegde, Prakash Dharmalingam, Pavana Dixit Hegde, Sankar Mitra, Joy Mitra
Abstract: The present disclosure is directed to antibodies binding to PD-L1 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1.
Type:
Grant
Filed:
November 17, 2022
Date of Patent:
June 10, 2025
Assignee:
Board of Regents, The University of Texas System
Inventors:
Michael A. Curran, Carlo Toniatti, Ashvin R. Jaiswal, Dongxing Zha, Kui Voo, Bianka Prinz, Nadthakarn Boland
Abstract: Processes that determine transcriptional regulation from genetic sequence data are described. Generally, computational models are trained to predict transcriptional regulatory effects, which can be used in several downstream applications. Various methods further develop research tools, develop and perform diagnostics, and treat individuals based on identified variants.
Type:
Application
Filed:
June 21, 2022
Publication date:
June 5, 2025
Applicants:
The Trustees of Princeton University, The Simons Foundation, Inc., The Board of Regents of The University of Texas System
Inventors:
Olga G. Troyanskaya, Kathleen Chen, Jian Zhou
Abstract: The invention discloses a method for adhering a metal layer to a polymer substrate and device manufacture therefrom. The metal layer is deposited on a sacrificial substrate of a mold to form part of an interior surface of the mold, and a solution of monomers is deposited on the metal layer. The monomers are then polymerized together to form the polymer substrate on the metal layer. Then the polymer substrate is removed from the mold such that the metal layer is removed from the mold and adhered to the polymer substrate.
Type:
Grant
Filed:
April 19, 2021
Date of Patent:
June 3, 2025
Assignee:
Board of Regents, The University of Texas System
Abstract: The present disclosure relates to an electrolyte membrane for an alkali metal or an alkali metal ion battery, comprising: a composite membrane comprising an ionically conductive polymer; an alkali metal salt; and a filler comprising a carbon nitride nanosheet, an oxygenated carbon nitride nanosheet or a combination thereof.
Type:
Grant
Filed:
September 27, 2021
Date of Patent:
June 3, 2025
Assignees:
Enpower Greentech, Inc., Board of Regents, The University of Texas System
Inventors:
Henghui Xu, Yutao Li, Yong Che, John B. Goodenough
Abstract: Embodiments of the present disclosure provide robotic systems, apparatuses, and methods. One such robotic system comprises a robotic surgical tool; and a steering system configured to steer the robotic surgical tool based on motion angle commands along X and Y axes as the robotic surgical tool moves in an Z axis direction within a tubular passageway. The system further comprises a computing device that executes an artificial intelligence program configured to control the steering system by computing the motion angle commands based on a current position of the robotic surgical tool along planar axes of the tubular passageway and center positions of the passageway along the planar axes. Other systems and methods are disclosed.
Type:
Grant
Filed:
February 12, 2021
Date of Patent:
June 3, 2025
Assignee:
Board of Regents of the University of Texas System
Inventors:
Amir Jafari, Miltiadis Alamaniotis, Teja Guda, Dimitrios Miserlis
Abstract: An antibody, preferably a blocking antibody, and most preferably a monoclonal antibody (mAb), specific for human endothelial cell protein C receptor (EPCR) such as mAbs JRK 1494 or JRK 1535 is used to reduce or attenuate joint swelling, macrophage infiltration, iron deposition and/or blood vessel formation and to treat arthropathy in a hemophilic subject.
Type:
Grant
Filed:
September 5, 2019
Date of Patent:
June 3, 2025
Assignee:
Board of Regents, The University of Texas System
Inventors:
Vijaya M. Lella, Usha R. Pendurthi, Jhansi L. Magisetty
Abstract: Various embodiments generally relate to robotics and more specifically to tank seal inspections. In some embodiments, the robotic inspection device comprising a power supply, a body, a drive system, a camera, a navigational system, and/or one or more sensors. The drive system may include one or more surface engaging drivers to propel the robotic inspection device along a surface of a tank. The camera can be housed within the body to capture images and/or video of a seal. The navigational system can compute a route (or receive commands that route) and send commands to the drive system to navigate the robotic inspection device along the surface of the tank allowing the camera to capture the images or video of the seal. Some embodiments may use an artificial intelligence or machine learning engine to review the images or video of the seal and identify potential problems.
Type:
Grant
Filed:
February 28, 2020
Date of Patent:
June 3, 2025
Assignee:
Board of Regents, The University of Texas System
Inventors:
Mitchell Pryor, Andrew Zelenak, Robert Blake Anderson, Connor D. Crawford
Abstract: The present application provides BCMA targeting chimeric antigen receptor (CAR) comprising a BCMA binding region and an intracellular costimulatory domain derived from DAP10. Further provided are engineered immune effector cells (such as NK cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.
Type:
Grant
Filed:
April 17, 2024
Date of Patent:
May 27, 2025
Assignees:
Board of Regents, The University of Texas System, Takeda Pharmaceutical Company Limited
Inventors:
Katy Rezvani, Rafet Basar, Paul Lin, Michael David Curley, LeeAnn Talarico, Prashanth Vishwanath, James Wilson Meador, III
Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
Type:
Grant
Filed:
December 16, 2021
Date of Patent:
May 27, 2025
Assignees:
ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas System
Abstract: Classical computer systems can generate certified random bit strings using an untrusted quantum computer. The classical computer system can issue a sequence of challenges to the quantum computer, with each challenge involving execution of an apparently-random quantum circuit generated by the classical client. By executing the quantum circuits, the quantum computer can generate a high-entropy bit sequence, and the classical client can use the high-entropy bit sequence to generate sequences of random bits. The classical client can use models of quantum probability distributions for at least some of the challenges to verify that the bit sequence was generated by a quantum computer executing the quantum circuit generated by the classical client, thereby supporting certification of the randomness of the sequence of bits.
Type:
Grant
Filed:
February 7, 2020
Date of Patent:
May 27, 2025
Assignee:
Board of Regents, The University of Texas System
Abstract: A compound according to Formula (I) or a pharmaceutically acceptable salt thereof: is provided. X1 is N or C—Y; Y is H, halogen, NH2, OH, SH, alkyl, aryl, alkoxy, or aryloxy; A is O, NH, S, Se, or CH2, B is X2 is N or CH; and Z is NH, CH2, S, O, or Se.
Type:
Grant
Filed:
September 29, 2022
Date of Patent:
May 27, 2025
Assignees:
Chapman University, The Board of Regents of University of Texas System, Northeastern University
Inventors:
Miao Zhang, Keykavous Parang, Naglaa Ibrahim, Young Woo Nam, Ilya Bezprozvanny, Meng Cui
Abstract: In one aspect, a neuromodulation device is described herein. In some embodiments, a neuromodulation device comprises a chamber operable to receive a nerve, at least one electrode disposed in the chamber, and a channel defined by two walls. In some embodiments, the channel of the device is in fluid communication with an interior of the chamber and an external surface of the device. In another aspect, methods of neuromodulation are described herein. In some embodiments, methods described herein can use one or more neuromodulation devices described herein.
Type:
Grant
Filed:
May 16, 2019
Date of Patent:
May 27, 2025
Assignees:
Board of Regents, The University of Texas System, National Autonomous University of Mexico
Inventors:
Mario I. Romero-Ortega, Margarita Martinez-Gomez, Stuart F. Cogan, Aswini Kanneganti
Abstract: A system for generating objective assessment criteria of social skills, comprising a speech to text system receiving audio data and converting the audio data into text data for a first speaker and a second speaker, a dialog management system processing text data for the first speaker and text data for the second speaker generating a strategic attention score for the first speaker based on responsiveness of the text data of the first speaker to text data of the second speaker, and a response verification system generating a user control for the strategic attention score and receiving feedback data from the second speaker to accept or modify the strategic attention score.
Type:
Application
Filed:
January 17, 2024
Publication date:
May 15, 2025
Applicant:
Board of Regents, The University of Texas System
Abstract: A method of producing aluminum chlorohydrate comprises adding small form aluminum metal pellets to a reactant receiving space of a reactor tank to form a pellet bed; adding aqueous hydrochloric acid to the reactant receiving space of the reactor tank; and continuously circulating the aqueous hydrochloric acid through the pellet bed. In some embodiments, the continuously circulating aqueous hydrochloric acid dispels reaction gases from the pellet bed. Methods described herein can, in some cases, further comprise consecutively adding additional small form aluminum metal pellets to the reactant receiving space of the reactor tank as the small form aluminum metal pellets are consumed in the pellet bed.
Type:
Grant
Filed:
February 20, 2023
Date of Patent:
May 13, 2025
Assignees:
C-KOE Metals, L.P., Board of Regents, The University of Texas System
Inventors:
Chase McTaggart, Brian Hodges, Charles Koetting, Frederick M MacDonnell, Brian Dennis, Mark Hulsizer