Abstract: An ultrasound transducer probe holder device comprising a support piece; a base connected to the support piece; a cylindrical orifice within the support piece; a housing extending from the orifice and defining a cavity; a sleeve for insertion within the orifice; and an adjustment screw fitted in the housing for contact with the sleeve. The device supports and maintains the position of an ultrasound transducer probe to provide for a hands-free application of the device during different modalities of exercise required to instigate hyperemic conditions while providing x, y, z, positional adjustments of the probe relative to the patient.
Type:
Grant
Filed:
October 3, 2019
Date of Patent:
September 12, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Francisco Morales Acuna, Luis A. Ochoa, Alvaro N. Gurovich
Abstract: A photoreactor including a reservoir configured to hold water, the reservoir defining an inlet and an outlet, and a multiplicity of optical fiber assemblies positioned in the reservoir. Each optical fiber assembly includes one or more optical fibers coated with a composition comprising a photoresponsive polymer and a light source optically coupled to the one or more optical fibers. The photoresponsive polymer undergoes a change from an initial state to an irradiated state when irradiated with light from the light source, and photoresponsive polymer in the irradiated state is adapted to bind an ion from the water.
Type:
Grant
Filed:
November 21, 2019
Date of Patent:
September 12, 2023
Assignees:
Arizona Board of Regents on behalf of Arizona State University, Board of Regents; The University of Texas System
Inventors:
Paul K. Westerhoff, Shahnawaz Sinha, Juan Noveron
Abstract: The present disclosure describes the use of ectopic SOX2 to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease, by reprogramming non-nerve cells into neuronal cells. In particular, the disclosure provides for the use of SOX2 therapy, optionally combined with neurogenic growth factors, to treat nerve deficit conditions.
Type:
Application
Filed:
October 28, 2022
Publication date:
September 7, 2023
Applicant:
The Board of Regents of the University of Texas System
Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
Type:
Grant
Filed:
July 7, 2021
Date of Patent:
September 5, 2023
Assignee:
Board Of Regents, The University Of Texas System
Abstract: The present disclosure relates to sealed isocyanate resin compositions. The resin compositions may be used for additive manufacturing. One embodiment of the invention includes a photopolymerizable resin for additive manufacturing, the resin comprising: a blocked isocyanate; at least one monomer or oligomer; and a multifunctional nucleophile.
Type:
Grant
Filed:
November 25, 2020
Date of Patent:
August 29, 2023
Assignees:
Adaptive 3D Technologies, Board of Regents, The University of Texas System
Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
Type:
Grant
Filed:
November 5, 2021
Date of Patent:
August 29, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, Noah Giese, Nitesh Katta
Abstract: Provided herein are methods, compositions, and devices for occluding cavities or passageways in a patient, in particular cavities or passageways in the cardiovascular system of a patient, such as the LAA of a patient's heart. The methods, compositions, and devices can be used to percutaneously occlude the LAA, decreasing the risk of thromboembolic events associated with AF.
Type:
Grant
Filed:
May 26, 2022
Date of Patent:
August 29, 2023
Assignees:
Applied Cardiovascular Solutions, LLC, Board of Regents, The University of Texas System
Inventors:
F. Javier Otero, Joseph J. Beaman, Krishnendu Roy, Andrew Zimbroff
Abstract: The invention relates to a method of treating chronic granulomatous disease through Hematopoietic stem cell (HSC) transplantation. The method comprises the steps of administering stem cell mobilization agent to human such that the target stem cell population migrates from host niches into the subject's blood. The target stem cells are removed from blood and administering the therapeutic stem cells to human and said therapeutic stem cells are engineered to express gp91phox. The steps are repeated multiple times i.e. at least four times. The mobilization agents used in the invention are granulocyte-colony stimulating factor and AMD3100. The method of HSC transplantation is effective in treatment of chronic granulomatous disease.
Type:
Grant
Filed:
September 1, 2017
Date of Patent:
August 29, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Senlin Li, Robert A Clark, Cang Chen, Yang Li
Abstract: Antimicrobial catheters and medical devices are provided. In some aspects, a low durometer aliphatic polyether polyurethane may be impregnated with a first antimicrobial agent (e.g., minocycline and rifampin) and coated with a second antimicrobial agent (e.g., chlorhexidine, gendine, or gardine). The antimicrobial catheters may display improved flexibility and resistance to kinking. Methods of producing the antimicrobial catheters are also provided.
Type:
Grant
Filed:
July 8, 2020
Date of Patent:
August 29, 2023
Assignee:
Board of Regents, The University of Texas System
Abstract: Apparatus and methods for providing three-dimensional printed oral stents are provided for head and neck radiotherapy. Movement of the jaw of the patient is simulated via a computer processor. Simulating movement of the jaw of the patient comprises rotating and translating a mandible of the jaw. A digital negative impression is transformed into a digital oral stent by adding support structures to the digital negative impression. The support structures facilitate three-dimensional (3D) printing of the patient-specific oral stent.
Type:
Grant
Filed:
July 17, 2018
Date of Patent:
August 22, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Eugene Jon Koay, Caroline Chung, Christopher T. Wilke, Clifton David Fuller, Mohamed Zaid
Abstract: The present invention discloses a live attenuated strain of Zika virus (ZIKV) having a deletion in the 3? untranslated region (3?UTR) of the viral genome, which may affect viral RNA synthesis and sensitivity to type I interferon inhibition, but may not affect viral RNA translation. The present invention also discloses the use of these live attenuated ZIKV strains in the preparation of ZIKV vaccines and for providing immunoprotection against ZIKV infection and congenital ZIKV syndrome, particularly in pregnant females.
Type:
Grant
Filed:
February 14, 2018
Date of Patent:
August 22, 2023
Assignee:
Board of Regents, The University of Texas System
Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.
Type:
Grant
Filed:
October 5, 2017
Date of Patent:
August 22, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Rinat O. Esenaliev, Maria-Adelaide Micci, Donald S. Prough
Abstract: A shunt operable to be implanted on an eye is provided. The shunt includes a vein fluidic channel operable to be in fluid communication with an interior of the eye and operable to receive aqueous fluid from the interior of the eye. A body is fluidly coupled with the vein fluidic channel. A valve is disposed within the body and is operable to regulate intraocular pressure in the eye by opening and closing based on pressure from the aqueous fluid. A plurality of outlets are in fluid communication with the body opposite the vein fluidic channel in relation to the valve. The outlets are operable to release the aqueous fluid to the sclera of the eye.
Type:
Application
Filed:
June 4, 2021
Publication date:
August 17, 2023
Applicants:
The Board of Regents of The University of Texas System, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventors:
Karanjit S. KOONER, Michael A. MONG, Ghadeer AL-HUMIMAT, Jacob A. AWKAL, Hebah G. ABDALLAH, Nguyen L. LE, Jamasp AZARNOOSH, Peter Dirk Jan REYNTJENS, Jeremy L. WARREN
Abstract: Various embodiments provide for deep learning-based architectures and design methodologies for an orthogonal frequency division multiplexing (OFDM) receiver under the constraint of one-bit complex quantization. Single bit quantization greatly reduces complexity and power consumption in the receivers, but makes accurate channel estimation and data detection difficult. This is particularly true for OFDM waveforms, which have high peak-to average (signal power) ratio in the time domain and fragile subcarrier orthogonality in the frequency domain. The severe distortion for one-bit quantization typically results in an error floor even at moderately low signal-to-noise-ratio (SNR) such as 5 dB. For channel estimation (using pilots), various embodiments use novel generative supervised deep neural networks (DNNs) that can be trained with a reasonable number of pilots. After channel estimation, a neural network-based receiver specifically, an autoencoder jointly learns a precoder and decoder for data symbol detection.
Type:
Application
Filed:
February 3, 2023
Publication date:
August 17, 2023
Applicant:
Board of Regents, The University of Texas System
Abstract: Disclosed are systems and techniques for increasing heat transfer from a substrate to a working fluid. The systems may include a substrate comprising a plurality of grooves or cavities on at least one external surface. The system may also include an infusing liquid filling at least a majority of the plurality of grooves. The system may also include a working fluid configured to flow parallel to the external surface.
Type:
Application
Filed:
February 17, 2023
Publication date:
August 17, 2023
Applicants:
The Trustees of Princeton University, Board of Regents, The University of Texas System, KTH Royal Institute of Technology
Inventors:
Marcus Hultmark, Shervin Bagheri, Johan Sundin, Stefano Leonardi, Umberto Ciri
Abstract: The claimed invention is directed to the use of a composition for use as an antimicrobial comprising an antimicrobial agent. In certain embodiments, the composition is used for treating or ameliorating inflammation in a subject and comprises an anti-inflammatory agent. The anti-inflammatory agent may include an NSAID, such as ibuprofen or diclofenac. The composition may further include solvents, anti-bacterial agents, anti-fungal agents, anti-parasitic agents, anti-viral agents, and buffers. The composition may include particles that have been processed via jet milling to reduce a diameter of the particles and to improve a flowability of the particles.
Type:
Grant
Filed:
May 29, 2016
Date of Patent:
August 15, 2023
Assignees:
The Texas A&M University System, The Board of Regents of the University of Texas System
Inventors:
Carolyn L. Cannon, Parth N. Shah, Justin A. Smolen, Hugh D. Smyth, Ashkan K. Yazdi, Matthew J. Herpin
Abstract: Disclosed herein are methods preparing a purified, carrier-free 68Ga solution. Tire present disclosure also provides systems for preparing a purified, carrier-free 68Ga solution. The present disclosure also provides compositions comprising the purified, carrier-free 68Ga solutions disclosed herein. Also provided are methods of administering compositions of the present disclosure to a patient in need thereof, for example, for imaging a disease or disorder, such as cancer.
Type:
Grant
Filed:
August 2, 2019
Date of Patent:
August 15, 2023
Assignee:
Board of Regents, The University of Texas System
Abstract: The present invention relates to ethanediamine-heterocycle compounds that are able to act as inhibitors of PRMTs (protein arginine methyltransferases) for treating cancer and other diseases mediated by PRMTs.
Type:
Grant
Filed:
May 4, 2021
Date of Patent:
August 15, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Maria Emilia Di Francesco, Philip Jones, Timothy Joseph McAfoos
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
Type:
Grant
Filed:
April 15, 2021
Date of Patent:
August 15, 2023
Assignee:
The Board of Regents of The University of Texas System
Inventors:
Jinming Gao, Gang Huang, Tian Zhao, Xinpeng Ma, Yiguang Wang, Yang Li, Baran D. Sumer
Abstract: The disclosure provides methods and compositions for treating subject having cancers with abnormal WNT signaling, such as APC-deficient cancers. Accordingly, aspects of the disclosure relate to methods for treating APC-deficient cancers comprising administering an inhibitor of TDO2 or of a cytokine activated by TDO2. Additional aspects relate to methods for identifying a cancer as being sensitive to TDO2 inhibition comprising detecting a deficiency in an APC gene and/or measuring an expression level of TDO2.
Type:
Application
Filed:
February 26, 2021
Publication date:
August 10, 2023
Applicant:
Board of Regents, The University of Texas System