Patents Assigned to University of Texas Systems
  • Patent number: 11690850
    Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: July 4, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard T. Lewis, Matthew Hamilton, William J. Ray, Fernando Alvarez, Naphtali Reyna, Jason Cross, Suyambu Kesava Vijayan Ramaswamy
  • Patent number: 11690851
    Abstract: Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol.
    Type: Grant
    Filed: April 17, 2021
    Date of Patent: July 4, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Thomas J. Slaga, Jacob Junco, Huiyun Liang, Sara Reyna
  • Patent number: 11693007
    Abstract: Provided herein are methods of detecting pancreatic cancer, particularly early stage pancreatic cancer, comprising measuring the expression of the biomarker panel TNC-FN III-C, TFPI, and CA19-9. The expression may be determined by an ELISA, such as a multiplex ELISA. Further provided herein are methods of treating subjects identified to have pancreatic cancer.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: July 4, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ann McNeill Killary, Steven T. Lott, Nanyue Chen, Seetharaman Balasenthil
  • Patent number: 11692027
    Abstract: The present disclosure provides pharmaceutical compositions for monoclonal antibodies, antibody-related products, therapeutic proteins, peptides and other biopharmaceuticals. The compositions provide initial and long term stability of the biopharmaceutical agent, rendering them suitable for parenteral, pulmonary, transdermal, topical, intradermal, intrascleral, intracorneal, ocular and other forms of delivery. The compositions and methods lead to higher yields in dilute solutions and reduce unwanted aggregation of the biopharmaceutical agent. The compositions and methods also allow for disaggregation of previously aggregated proteins and protection from aggregation upon dilution. Additionally, provided are non-aggregating antibody reagents for analytical immunoassays including ELISA methods. The invention provides compositions and methods for topical, enteral, parenteral, pulmonary and other forms of delivery of biologically active substances.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: July 4, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Edward R. Kraft, Steven Andrew Giannos, Bernard Godley
  • Patent number: 11690919
    Abstract: Endolysosomal targeting conjugates that are engineered to deliver cargo molecules such as cytotoxic drugs or imaging labels with improved efficiency to late endosomes and/or lysosomes in target cells such as tumor cells are described. The endolysosomal targeting conjugate includes a targeting component and a cargo component. The targeting component is configured to bind to a cell surface molecule of a target cell and the cargo component includes a cargo molecule. The targeting component and the cargo component may be fused by a covalent bond or associated by a non-covalent bond. The targeting component may bind to the cell surface molecule or the cargo component with higher affinity in the extracellular space than in an endolysosomal compartment of the target cell.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: July 4, 2023
    Assignees: The Texas A&M University System, Board of Regents of the University of Texas System
    Inventors: Elizabeth Sally Ward Ober, Raimund Johannes Ober, Jeffrey Che-Wei Kang, Wei Sun, Ran Li
  • Patent number: 11692285
    Abstract: A quad-polymer composition includes monomers of (a) acrylonitrile, (a) vinylimidazole, (c) methyl acrylate and (d) either acrylic acid or itaconic acid. Such quad-polymer compositions may be used to form fibers (such as by melt spinning) that may then be annealed, stabilized, and/or carbonized to produce carbon fibers. The quad-polymer composition may be used for supercapacitors, lithium battery electrodes once carbonized, and as synthesized, it may be used for wound healing fibers, fabrics, coatings, and films, and anti-bacterial/anti-microbial fibers, fabrics, coatings and films. The carbon fibers formed from the quad-polymer composition may be used for the fiber composites for automobile, aerospace structures, marine structures, military equipment/parts, sporting goods, robotics, furniture, and electronic parts.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: July 4, 2023
    Assignees: The Board of Regents of the University of Texas System
    Inventors: Min Hye Jung, Hyun Kyu Shin, Kyu Soon Park, Duck Joo Yang, Benjamin Batchelor, Samsuddin Mahmood
  • Publication number: 20230202858
    Abstract: A method of producing aluminum chlorohydrate comprises adding small form aluminum metal pellets to a reactant receiving space of a reactor tank to form a pellet bed; adding aqueous hydrochloric acid to the reactant receiving space of the reactor tank; and continuously circulating the aqueous hydrochloric acid through the pellet bed. In some embodiments, the continuously circulating aqueous hydrochloric acid dispels reaction gases from the pellet bed. Methods described herein can, in some cases, further comprise consecutively adding additional small form aluminum metal pellets to the reactant receiving space of the reactor tank as the small form aluminum metal pellets are consumed in the pellet bed.
    Type: Application
    Filed: February 20, 2023
    Publication date: June 29, 2023
    Applicants: C-KOE Mentals, L.P., Board of Regents, The University of Texas System
    Inventors: Chase McTaggart, Brian Hodges, Charles Koetting, Frederick M. MacDonnell, Brian Dennis, Mark Hulsizer
  • Publication number: 20230203020
    Abstract: Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.
    Type: Application
    Filed: February 11, 2023
    Publication date: June 29, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Qiren Liang, Beth Levine, Wei-Chung Chiang
  • Patent number: 11684626
    Abstract: Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol.
    Type: Grant
    Filed: April 17, 2021
    Date of Patent: June 27, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Thomas J. Slaga, Jacob Junco, Huiyun Liang, Sara Reyna
  • Patent number: 11685710
    Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: June 27, 2023
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Daniel J. Siegwart, Jason B. Miller
  • Patent number: 11684657
    Abstract: Provided herein are tumor-antigen VGLL1 specific peptides. Also provided herein are methods of generating VGLL1-specific T cells and their use for the treatment of cancer. In addition, the VGLL1-specific peptides may be used as a vaccine.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: June 27, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Gregory Lizée, Cassian Yee, Janos Roszik
  • Publication number: 20230197277
    Abstract: Methods and devices for the prevention, treatment and diagnosis of cancer include assessing and quantifying imperfect dsDNA break repair. The methods may include determining a deletion signal for a DNA-containing sample of a subject, wherein the deletion signal comprises distributions of deletions (frequencies) of deletions with microhomologies of different lengths at the deletion sites in a DNA sequence or genome of the subject or sample thereof. The method may further include decomposing the deletion signal into components corresponding to changes arising from: (1) DNA repair processes, (2) systematic effects due to mapping personal deletion variants to reference genomes, and (3) false positive deletions generated during sample preparation, sequencing, and analysis, and quantifying these components to produce mutational signatures of defective HRR.
    Type: Application
    Filed: February 13, 2023
    Publication date: June 22, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zbyszek Otwinowski, Dominika Borek, Raquel Bromberg
  • Publication number: 20230193378
    Abstract: DNA is sequenced by (a) independently sequencing first and second strands of a dsDNA to obtain corresponding first and second sequences; and (b) combining the first and second sequences to generate a consensus sequence of the dsDNA. By independently sequencing first and second strands the error probability of the consensus sequence approximates a multiplication of those of the first and second sequences.
    Type: Application
    Filed: December 26, 2022
    Publication date: June 22, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zbyszek Otwinowski, Dominika Borek
  • Patent number: 11680067
    Abstract: Certain embodiments are directed to adenosine receptor antagonists that inhibit migration and growth of cancer cells.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: June 20, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventor: Jean X. Jiang
  • Patent number: 11679247
    Abstract: Certain aspects are directed to a housing and cap to provide protection of medical devices having one or more percutaneous connection (e.g., a three-way stopcock or catheter port).
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: June 20, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Luiz Maracaja, Edward Sako
  • Patent number: 11679047
    Abstract: Pressure modulating soft actuator array devices and related systems and methods. One example of the present systems comprises: a device having a body that defines a plurality of cavities; a pressure source configured to be in fluid communication with the plurality of cavities; a plurality of sensors configured to capture data indicative of pressure within the plurality of cavities; and one or more controllers configured to actuate the pressure source to move fluid toward and/or away from one or more of the plurality of cavities in response to data captured by the plurality of sensors; wherein the device is configured to be disposed between a user and a surface on which the user is seated upon.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: June 20, 2023
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Muthu Wijesundara, Wei Carrigan
  • Publication number: 20230184771
    Abstract: The current disclosure provides for novel therapeutic methods by identifying cancer patient populations that may be treated effectively by immunotherapies. Accordingly, aspects of the disclosure relate to a method of treating cancer in a subject comprising administering to the subject immune checkpoint blockade (ICB) therapy after the subject has been determined to have increased expression of CXCL13 in a biological sample from the subject.
    Type: Application
    Filed: April 20, 2021
    Publication date: June 15, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Padmanee Sharma, James Allison, Sangeeta Goswami, Hao Zhao
  • Publication number: 20230183371
    Abstract: Provided herein are CD79b antibodies and CD79b-specific chimeric antigen receptors (CARs). Further provided herein are immune cells expressing the CD79b-specific CARs and methods of treating cancer by administering the CD79b-specific CAR immune cells.
    Type: Application
    Filed: April 30, 2021
    Publication date: June 15, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Fuliang CHU, Sattva S. NEELAPU, JingJing CAO, Jingwei LIU
  • Patent number: 11677071
    Abstract: A novel lithium battery cathode, a lithium ion battery using the same and processes and preparation thereof are disclosed. The battery cathode is formed by force spinning. Fiber spinning allows for the formation of core-shell materials using material chemistries that would be incompatible with prior spinning techniques. A fiber spinning apparatus for forming a coated fiber and a method of forming a coated fiber are also disclosed.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: June 13, 2023
    Assignees: National Technology & Engineering Solutions of Sandia, LLC, The Board of Regents, The University of Texas System
    Inventors: Nelson S. Bell, Nancy A. Missert, Karen Lozano, Yatinkumar N. Rane
  • Patent number: 11674546
    Abstract: In one embodiment, a gas foil thrust bearing includes multiple arcuate bearing pads, each bearing pad including a top foil and a compliant support element, each top foil having a leading edge, a trailing edge, and a top surface that extends from the leading edge to the trailing edge, the top surface having a taper-flat-recess configuration in which the top surface includes a taper region located near the leading edge, a flat land region located near the trailing edge, and a pocket recess defined by a base, opposed side walls, and an end wall.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: June 13, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nguyen LaTray, Daejong Kim