Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
Type:
Grant
Filed:
November 19, 2020
Date of Patent:
July 4, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Richard T. Lewis, Matthew Hamilton, William J. Ray, Fernando Alvarez, Naphtali Reyna, Jason Cross, Suyambu Kesava Vijayan Ramaswamy
Abstract: Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol.
Type:
Grant
Filed:
April 17, 2021
Date of Patent:
July 4, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Thomas J. Slaga, Jacob Junco, Huiyun Liang, Sara Reyna
Abstract: Provided herein are methods of detecting pancreatic cancer, particularly early stage pancreatic cancer, comprising measuring the expression of the biomarker panel TNC-FN III-C, TFPI, and CA19-9. The expression may be determined by an ELISA, such as a multiplex ELISA. Further provided herein are methods of treating subjects identified to have pancreatic cancer.
Type:
Grant
Filed:
February 23, 2018
Date of Patent:
July 4, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Ann McNeill Killary, Steven T. Lott, Nanyue Chen, Seetharaman Balasenthil
Abstract: The present disclosure provides pharmaceutical compositions for monoclonal antibodies, antibody-related products, therapeutic proteins, peptides and other biopharmaceuticals. The compositions provide initial and long term stability of the biopharmaceutical agent, rendering them suitable for parenteral, pulmonary, transdermal, topical, intradermal, intrascleral, intracorneal, ocular and other forms of delivery. The compositions and methods lead to higher yields in dilute solutions and reduce unwanted aggregation of the biopharmaceutical agent. The compositions and methods also allow for disaggregation of previously aggregated proteins and protection from aggregation upon dilution. Additionally, provided are non-aggregating antibody reagents for analytical immunoassays including ELISA methods. The invention provides compositions and methods for topical, enteral, parenteral, pulmonary and other forms of delivery of biologically active substances.
Type:
Grant
Filed:
September 25, 2017
Date of Patent:
July 4, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Edward R. Kraft, Steven Andrew Giannos, Bernard Godley
Abstract: Endolysosomal targeting conjugates that are engineered to deliver cargo molecules such as cytotoxic drugs or imaging labels with improved efficiency to late endosomes and/or lysosomes in target cells such as tumor cells are described. The endolysosomal targeting conjugate includes a targeting component and a cargo component. The targeting component is configured to bind to a cell surface molecule of a target cell and the cargo component includes a cargo molecule. The targeting component and the cargo component may be fused by a covalent bond or associated by a non-covalent bond. The targeting component may bind to the cell surface molecule or the cargo component with higher affinity in the extracellular space than in an endolysosomal compartment of the target cell.
Type:
Grant
Filed:
January 17, 2018
Date of Patent:
July 4, 2023
Assignees:
The Texas A&M University System, Board of Regents of the University of Texas System
Inventors:
Elizabeth Sally Ward Ober, Raimund Johannes Ober, Jeffrey Che-Wei Kang, Wei Sun, Ran Li
Abstract: A quad-polymer composition includes monomers of (a) acrylonitrile, (a) vinylimidazole, (c) methyl acrylate and (d) either acrylic acid or itaconic acid. Such quad-polymer compositions may be used to form fibers (such as by melt spinning) that may then be annealed, stabilized, and/or carbonized to produce carbon fibers. The quad-polymer composition may be used for supercapacitors, lithium battery electrodes once carbonized, and as synthesized, it may be used for wound healing fibers, fabrics, coatings, and films, and anti-bacterial/anti-microbial fibers, fabrics, coatings and films. The carbon fibers formed from the quad-polymer composition may be used for the fiber composites for automobile, aerospace structures, marine structures, military equipment/parts, sporting goods, robotics, furniture, and electronic parts.
Type:
Grant
Filed:
May 9, 2018
Date of Patent:
July 4, 2023
Assignees:
The Board of Regents of the University of Texas System
Inventors:
Min Hye Jung, Hyun Kyu Shin, Kyu Soon Park, Duck Joo Yang, Benjamin Batchelor, Samsuddin Mahmood
Abstract: A method of producing aluminum chlorohydrate comprises adding small form aluminum metal pellets to a reactant receiving space of a reactor tank to form a pellet bed; adding aqueous hydrochloric acid to the reactant receiving space of the reactor tank; and continuously circulating the aqueous hydrochloric acid through the pellet bed. In some embodiments, the continuously circulating aqueous hydrochloric acid dispels reaction gases from the pellet bed. Methods described herein can, in some cases, further comprise consecutively adding additional small form aluminum metal pellets to the reactant receiving space of the reactor tank as the small form aluminum metal pellets are consumed in the pellet bed.
Type:
Application
Filed:
February 20, 2023
Publication date:
June 29, 2023
Applicants:
C-KOE Mentals, L.P., Board of Regents, The University of Texas System
Inventors:
Chase McTaggart, Brian Hodges, Charles Koetting, Frederick M. MacDonnell, Brian Dennis, Mark Hulsizer
Abstract: Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.
Type:
Application
Filed:
February 11, 2023
Publication date:
June 29, 2023
Applicant:
Board of Regents, The University of Texas System
Inventors:
Jef De Brabander, Qiren Liang, Beth Levine, Wei-Chung Chiang
Abstract: Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol.
Type:
Grant
Filed:
April 17, 2021
Date of Patent:
June 27, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Thomas J. Slaga, Jacob Junco, Huiyun Liang, Sara Reyna
Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
Type:
Grant
Filed:
August 11, 2021
Date of Patent:
June 27, 2023
Assignee:
The Board of Regents of The University of Texas System
Abstract: Provided herein are tumor-antigen VGLL1 specific peptides. Also provided herein are methods of generating VGLL1-specific T cells and their use for the treatment of cancer. In addition, the VGLL1-specific peptides may be used as a vaccine.
Type:
Grant
Filed:
October 5, 2017
Date of Patent:
June 27, 2023
Assignee:
Board of Regents, The University of Texas System
Abstract: Methods and devices for the prevention, treatment and diagnosis of cancer include assessing and quantifying imperfect dsDNA break repair. The methods may include determining a deletion signal for a DNA-containing sample of a subject, wherein the deletion signal comprises distributions of deletions (frequencies) of deletions with microhomologies of different lengths at the deletion sites in a DNA sequence or genome of the subject or sample thereof. The method may further include decomposing the deletion signal into components corresponding to changes arising from: (1) DNA repair processes, (2) systematic effects due to mapping personal deletion variants to reference genomes, and (3) false positive deletions generated during sample preparation, sequencing, and analysis, and quantifying these components to produce mutational signatures of defective HRR.
Type:
Application
Filed:
February 13, 2023
Publication date:
June 22, 2023
Applicant:
Board of Regents, The University of Texas System
Abstract: DNA is sequenced by (a) independently sequencing first and second strands of a dsDNA to obtain corresponding first and second sequences; and (b) combining the first and second sequences to generate a consensus sequence of the dsDNA. By independently sequencing first and second strands the error probability of the consensus sequence approximates a multiplication of those of the first and second sequences.
Type:
Application
Filed:
December 26, 2022
Publication date:
June 22, 2023
Applicant:
Board of Regents, The University of Texas System
Abstract: Certain aspects are directed to a housing and cap to provide protection of medical devices having one or more percutaneous connection (e.g., a three-way stopcock or catheter port).
Type:
Grant
Filed:
November 13, 2018
Date of Patent:
June 20, 2023
Assignee:
Board of Regents, The University of Texas System
Abstract: Pressure modulating soft actuator array devices and related systems and methods. One example of the present systems comprises: a device having a body that defines a plurality of cavities; a pressure source configured to be in fluid communication with the plurality of cavities; a plurality of sensors configured to capture data indicative of pressure within the plurality of cavities; and one or more controllers configured to actuate the pressure source to move fluid toward and/or away from one or more of the plurality of cavities in response to data captured by the plurality of sensors; wherein the device is configured to be disposed between a user and a surface on which the user is seated upon.
Type:
Grant
Filed:
April 20, 2018
Date of Patent:
June 20, 2023
Assignee:
The Board of Regents of the University of Texas System
Abstract: The current disclosure provides for novel therapeutic methods by identifying cancer patient populations that may be treated effectively by immunotherapies. Accordingly, aspects of the disclosure relate to a method of treating cancer in a subject comprising administering to the subject immune checkpoint blockade (ICB) therapy after the subject has been determined to have increased expression of CXCL13 in a biological sample from the subject.
Type:
Application
Filed:
April 20, 2021
Publication date:
June 15, 2023
Applicant:
Board of Regents, The University of Texas System
Inventors:
Padmanee Sharma, James Allison, Sangeeta Goswami, Hao Zhao
Abstract: Provided herein are CD79b antibodies and CD79b-specific chimeric antigen receptors (CARs). Further provided herein are immune cells expressing the CD79b-specific CARs and methods of treating cancer by administering the CD79b-specific CAR immune cells.
Type:
Application
Filed:
April 30, 2021
Publication date:
June 15, 2023
Applicant:
Board of Regents, The University of Texas System
Inventors:
Fuliang CHU, Sattva S. NEELAPU, JingJing CAO, Jingwei LIU
Abstract: A novel lithium battery cathode, a lithium ion battery using the same and processes and preparation thereof are disclosed. The battery cathode is formed by force spinning. Fiber spinning allows for the formation of core-shell materials using material chemistries that would be incompatible with prior spinning techniques. A fiber spinning apparatus for forming a coated fiber and a method of forming a coated fiber are also disclosed.
Type:
Grant
Filed:
April 14, 2020
Date of Patent:
June 13, 2023
Assignees:
National Technology & Engineering Solutions of Sandia, LLC, The Board of Regents, The University of Texas System
Inventors:
Nelson S. Bell, Nancy A. Missert, Karen Lozano, Yatinkumar N. Rane
Abstract: In one embodiment, a gas foil thrust bearing includes multiple arcuate bearing pads, each bearing pad including a top foil and a compliant support element, each top foil having a leading edge, a trailing edge, and a top surface that extends from the leading edge to the trailing edge, the top surface having a taper-flat-recess configuration in which the top surface includes a taper region located near the leading edge, a flat land region located near the trailing edge, and a pocket recess defined by a base, opposed side walls, and an end wall.
Type:
Grant
Filed:
December 2, 2020
Date of Patent:
June 13, 2023
Assignee:
Board of Regents, The University of Texas System