Patents Assigned to University of Texas Systems
  • Devices and methods for detecting analytes
    Patent number: 11369967
    Abstract: A cartridge comprises a housing; a sample mixing compartment disposed within the housing, the sample mixing compartment comprising: an activation pouch, and a sample collection region; and a gas transporter tube having a first end and a second end, the tube being disposed within the housing adjacent to the sample mixing compartment, wherein the sample mixing compartment is partially defined by a moveable door of the housing, the moveable door providing access to the sample mixing compartment when the door is in an open position and preventing access to the sample mixing compartment when the door is in a closed position; and wherein the door is configured to release contents of the activation pouch upon movement from the open position to the closed position.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: June 28, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Purnendu Dasgupta, Aditya Das
  • TUMOR MICROBIOME SIGNATURE AND THERAPEUTIC USE OF FECAL MICROBIOTA TRANSPLANTATION ON PANCREATIC CANCER PATIENTS
    Publication number: 20220196667
    Abstract: Provided herein are methods of predicting whether a pancreatic cancer patient will be a short-term or long-term survivor based on their intra-tumoral microbiota. Also provided are methods of treating pancreatic cancer patients using fecal microbial transfer from long-term pancreatic cancer survivors as well as pharmaceutical compositions comprising fecal microbiota obtained from long-term pancreatic cancer survivors.
    Type: Application
    Filed: April 1, 2020
    Publication date: June 23, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Florencia McALLISTER, Yu ZHANG, Erick RIQUELME
  • COMPOUNDS WITH ANTI-TUMOR ACTIVITY AGAINST CANCER CELLS BEARING TYROSINE KINASE INHIBITOR RESISTANT EGFR MUTATIONS
    Publication number: 20220193074
    Abstract: The present disclosure provides methods of treating cancer in a patient determined to have osimertinib resistant EGFR mutations by administering a second-generation quinazolinamine derivative tyrosine kinase inhibitor.
    Type: Application
    Filed: April 16, 2020
    Publication date: June 23, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jacqulyne ROBICHAUX, Monique NILSSON, John V. HEYMACH
  • Methods of manipulating particles on solid substrates via optothermally-gated photon nudging
    Patent number: 11367539
    Abstract: Disclosed herein are methods of manipulating particles on solid substrates via optothermally-gated photon nudging.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: June 21, 2022
    Assignee: Board of Trustees, The University of Texas System
    Inventors: Yuebing Zheng, Jingang Li
  • Heterocyclic inhibitors of tyrosine kinase
    Patent number: 11365189
    Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of HER2 or EGFR for the treatment or prevention of disease, including cancer.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: June 21, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: John Heymach, Jacqulyne Robichaux, Monique Nilsson, Philip Jones, Jason Cross, Jay Theroff
  • Compositions and methods for cancer therapy
    Patent number: 11365250
    Abstract: The present disclosure generally relates to compositions and methods for cancer immunotherapy, as well as hematopoietic recovery following cancer treatment such as chemotherapy or irradiation.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: June 21, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Bruce Beutler, Evan Nair-Gill, Xue Zhong, Jinglei Zhang, Pingping Wang
  • Hotend for additive manufacturing with an actuated rod in a heated chamber
    Patent number: 11358326
    Abstract: A hotend assembly for an additive manufacturing device. The hotend assembly comprises a heated chamber, a number of inlets configured to feed filament into the heated chamber, and an exit orifice from the heated chamber. An actuated rod extends into the heated chamber and is rotated by a motor, wherein the actuated rod is configured to impart mechanical energy to the filament inside the heated chamber prior to extrusion through the exit orifice.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: June 14, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Joshua T. Green, Roger V. Gonzalez
  • System and method for liquid crystal display system incorporating wire grid polarizers for large scale and large volume stereolithography
    Patent number: 11360348
    Abstract: The present disclosure relates to a liquid crystal display (LCD) system. The system in one example has a light source for generating unpolarized light, and an LCD screen arranged in a path of transmittance of the unpolarized light. First and second wire grid polarizers are arranged adjacent to the LCD screen and each have a plurality of nano-scale wires, with the first and second wire grid polarizers have differing polarizations. A pitch of each of the nano-scale wires is no larger than one-third a wavelength of the unpolarized light from the light source. The wire grid polarizers create, in connection with operation of the LCD screen, a 2D light mask suitable for initiating the polymerization of an optically curable material.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: June 14, 2022
    Assignees: Lawrence Livermore National Security, LLC, Board of Regents, The University of Texas System
    Inventors: Eric B. Duoss, James Oakdale, Nicholas Anthony Rodriguez, Hongtao Song, Richard Crawford, Carolyn Seepersad, Morgan Chen
  • Field programmable transistor arrays
    Patent number: 11362662
    Abstract: Illustrative embodiments provide a mixed programmable and application-specific integrated circuit, a method of using the mixed programmable and application-specific integrated circuit and a method of making the mixed programmable and application-specific integrated circuit. The mixed programmable and application-specific integrated circuit includes at least a portion of a programmable transistor array that is programed after fabrication. The programmable transistor array can include at least another portion that is mask programed during fabrication.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: June 14, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Carl Sechen, Georgios Makris, Thomas Broadfoot
  • COMBINATIONS OF TRANSCRIPTION INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS FOR TREATMENT OF DISEASE
    Publication number: 20220175744
    Abstract: Provided herein are methods of treating patients with a combination of a transcription inhibitor (e.g., a STAT3 inhibitor) and an immune checkpoint blockade therapy (e.g., anti-PD-1 therapy, anti-PD-L1 therapy, anti-CTLA-4 therapy). The patient may have a proliferative disease, such as cancer or psoriasis. The patient may have a pathogenic infection.
    Type: Application
    Filed: April 2, 2020
    Publication date: June 9, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Waldemar PRIEBE, Rafal ZIELINSKI, Michael CURRAN, Midan AI
  • HIPK INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20220177891
    Abstract: Method of treating cancer, such as a metastatic cancer, with inhibitors of homeodomain interacting protein kinase 4 (HIPK4) are provided. Related therapeutic compositions are also disclosed.
    Type: Application
    Filed: February 19, 2020
    Publication date: June 9, 2022
    Applicants: Board of Regents, The University of Texas System, Vibliome Therapeutics, LLC
    Inventors: Qiang SHEN, Gary A. FLYNN
  • COLORECTAL CANCER CONSENSUS MOLECULAR SUBTYPE CLASSIFIER CODESETS AND METHODS OF USE THEREOF
    Publication number: 20220180974
    Abstract: Provided herein is a consensus molecular subtype (CMS) classifier for colorectal cancer patients. Also provided are methods of using the classifier to identify a clinically beneficial therapeutic regime for each patient as well as methods of treating a patient accordingly Custom Nanostring code sets, which work on formalin-fixed, paraffin-embedded samples, are provide for use in determining the CMS for a colorectal cancer patient.
    Type: Application
    Filed: April 2, 2020
    Publication date: June 9, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jeffrey MORRIS, Scott KOPETZ, Dipen MARU, David G. MENTER
  • COMPOUNDS AGAINST CANCER BEARING TYROSINE KINASE INHIBITOR RESISTANT EGFR MUTATIONS
    Publication number: 20220175779
    Abstract: The present disclosure provides methods of treating cancer in a patient determined to have osimertinib resistant EGFR mutations by administering a third-generation tyrosine kinase inhibitor, such as poziotinib.
    Type: Application
    Filed: April 16, 2020
    Publication date: June 9, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jacqulyne ROBICHAUX, Monique NILSSON, John V. HEYMACH
  • LOW-COBALT AND COBALT-FREE, HIGH-ENERGY CATHODE MATERIALS FOR LITHIUM BATTERIES
    Publication number: 20220181618
    Abstract: Described herein are low or no-cobalt materials useful as electrode active materials in a cathode for lithium or lithium-ion batteries. For example, compositions of matter are described herein, such as electrode active materials that can be incorporated into an electrode, such as a cathode. The disclosed electrode active materials exhibit high specific energy and voltage, and can also exhibit high rate capability and/or long operational lifetime.
    Type: Application
    Filed: January 24, 2022
    Publication date: June 9, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Arumugam Manthiram, Wangda Li, Steven Lee
  • COMPOUNDS WITH ANTI-TUMOR ACTIVITY AGAINST CANCER CELLS BEARING HER2 EXON 21 INSERTIONS
    Publication number: 20220175778
    Abstract: The present disclosure provides methods of treating cancer in a patient determined to have an HER2 exon 21 mutation by administering a third-generation tyrosine kinase inhibitor, such as poziotinib.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 9, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jacqulyne ROBICHAUX, John V. HEYMACH
  • Catalyst influenced chemical etching for fabricating three-dimensional SRAM architectures
    Patent number: 11355397
    Abstract: A method for fabricating a three-dimensional (3D) static random-access memory (SRAM) architecture using catalyst influenced chemical etching (CICE). Utilizing CICE, semiconductor fins can be etched with no etch taper, smooth sidewalls and no maximum height limitation. CICE enables stacking of as many nanosheet layers a desired and also enables a 3D stacked architecture for SRAM cells. Furthermore, CICE can be used to etch silicon waveguides thereby creating waveguides with smooth sidewalls to improve transmission efficiency and, for photon-based quantum circuits, to eliminate charge fluctuations that may affect photon indistinguishability.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: June 7, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sidlgata V. Sreenivasan, Akhila Mallavarapu, Jaydeep Kulkarni, Michael Watts, Sanjay Banerjee
  • METHODS AND COMPOSITIONS FOR TUSC2 IMMUNOTHERAPY
    Publication number: 20220168388
    Abstract: A method of treating a subject having a cancer comprising administering a tumor suppressor therapy, such as a TUSC2 therapy, in conjunction with an immune checkpoint inhibitor. Kits and reagents for use in cancer therapy are also provided.
    Type: Application
    Filed: February 17, 2022
    Publication date: June 2, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jack A. ROTH, Lin JI
  • PASSIVE INFRARED SENSING AND DETECTION FOR TRAFFIC
    Publication number: 20220172610
    Abstract: The present disclosure relates to systems and methods for passive infrared sensing and detection of vehicular traffic. Vehicle parameters are detected using thermal detection states of pixels of an infrared array sensor. The vehicle parameters can include a velocity of a vehicle. A vehicle record that includes the vehicle parameters can be provided, for example, by a computing device in connection with the infrared array sensor.
    Type: Application
    Filed: April 8, 2020
    Publication date: June 2, 2022
    Applicant: The Board of Regents, The University of Texas System
    Inventors: Zachary Balcar, Ayetullah Baha Biten, Sara Ahmed, Samer Dessouky, Jerome Helffrich
  • NOVEL STAT3 INHIBITORS IDENTIFIED BY STRUCTURE-BASED VIRTUAL SCREENING INCORPORATING SH2 DOMAIN FLEXIBILITY
    Publication number: 20220168322
    Abstract: In one aspect, the present disclosure provides methods of inhibiting STAT3 in a cell comprising contacting the cell with a compound of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure provides methods of using of the compounds disclosed herein for the treatment of cancer.
    Type: Application
    Filed: July 19, 2019
    Publication date: June 2, 2022
    Applicants: Board of Regents, The University of Texas System, The Methodist Hospital dba Houston Methodist Hospital
    Inventors: David John TWEARDY, Ren KONG, Uddalak BHARADWAJ, Moses Makokha KASEMBELI, Stephen T. C. WONG
  • Stereognosis training system and method for patients with chronic stroke, spinal cord injury or neuropathy
    Patent number: 11344727
    Abstract: Provided is an effective stereognosis training system that integrates hardware and software to provide a simple, reliable, quantitative system to provide tactile rehabilitation and progress monitoring. The system can include an interactive device including a novel set of objects, that are combined with neuromodulatory systems such as wireless closed-loop vagus nerve stimulation to improve neural plasticity and expedite functional recovery. The system can send updates to therapists or clinicians to monitor progress and encourage compliance with prescribed therapy.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: May 31, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventor: Michael P. Kilgard