Abstract: Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in humanized mice that express human HLA alleles associated with increased-risk of Type 1 diabetes.
Abstract: The present invention provides a method and a system for producing an image using an imaging system by weighting: i) the signals transmitted from at least one element of a transducer array to form limited diffraction transmitted beams or the transmitted beams are steered with linear time delay over transducer aperture; and, ii) weighting the echo signals received at the separate elements to form limited diffraction receive beams or doing Fourier transformations of the echo signals over the transducer aperture. Fourier transformations of the weighted or Fourier transformed signals form multi-dimensional k-space data sets which are used to interpolate into a rectilinear k-space of the object to be imaged. Inverse Fourier transformation along each dimension of the rectilinear k-space to produce an image.
Abstract: Epothilone analogues include a molecular scaffold which holds at least one segment of epothilone in a predetermined orientation and which rigidities a region between the macrolactone ring and the aromatic side-chain.
Type:
Grant
Filed:
July 20, 2006
Date of Patent:
February 22, 2011
Assignee:
University of Toledo
Inventors:
Viranga Tillekeratne, Richard D. Hudson, Mamoun Alhamadsheh
Abstract: A novel photovoltaic solar cell and method of making the same are disclosed. The solar cell includes: at least one absorber layer which could either be a lightly doped layer or an undoped layer, and at least a doped window-layers which comprise at least two sub-window-layers. The first sub-window-layer, which is next to the absorber-layer, is deposited to form desirable junction with the absorber-layer. The second sub-window-layer, which is next to the first sub-window-layer, but not in direct contact with the absorber-layer, is deposited in order to have transmission higher than the first-sub-window-layer.
Abstract: A method for synthesizing anti-leukemic epothilone analogues includes rigidifying a region between the macrolactone ring and the aromatic side-chain. The anti-leukemic compositions are non-naturally occurring epothilone analogue that are rigidified between the macrolactone ring and the aromatic side-chain.
Type:
Application
Filed:
March 20, 2008
Publication date:
December 23, 2010
Applicant:
The University of Toledo
Inventors:
Viranga Tillekeratne, Richard A. Hudson, Mamoun Alhamadsheh
Abstract: An integrated photoelectrochemical (PEC) cell generates hydrogen and oxygen from water while being illuminated with radiation. The PEC cell employs a liquid electrolyte, a multi-junction photovoltaic electrode, and a thin ion-exchange membrane. A PEC system and a method of making such PEC cell and PEC system are also disclosed.
Abstract: This trunk rotation device uses dynamic movement of one's body such as, shoulder, hip, knee, back, thigh, and abdominal musculature. The device provides a method for exercising the spinal column and the muscles of the torso, including those in the abdominal lumbar and thoracic regions involving rotational torque. In a preferred embodiment, the device is a golf exercise and flexibility apparatus. The golf exercise apparatus provides resistance to a golfer during a golf swing to strengthen and condition the muscles of the axial skeleton of the golfer in a functional posture.
Type:
Grant
Filed:
August 9, 2005
Date of Patent:
April 13, 2010
Assignees:
University of Toledo, The Turning Point LLC
Inventors:
Vijay K. Goel, Danny M. Pincivero, David Dick, John Jaegly, F. Alan Schultheis, Kathleen Herndon
Abstract: Dissolution, partial dissolution or softening of cellulose in an ionic liquid (IL) and its subsequent contact with anti-solvent produces regenerated cellulose more amorphous in structure than native cellulose, which can be separated from the IL/anti-solvent mixture by mechanical means such as simple filtration or centrifugation. This altered morphology of IL-treated cellulose allows a greater number of sites for enzyme adsorption with a subsequent enhancement of its saccharification. The IL-treated cellulose exhibits significantly improved hydrolysis kinetics with optically transparent solutions formed after about two hours of reaction. This provides an opportunity for separation of products from the catalyst (enzyme) easing enzyme recovery. With an appropriate selection of enzymes, initial hydrolysis rates for IL-treated cellulose were up to two orders of magnitude greater than those of untreated cellulose.
Type:
Grant
Filed:
February 23, 2007
Date of Patent:
March 9, 2010
Assignee:
The University of Toledo
Inventors:
Sasidhar Varanasi, Constance Ann Schall, Anantharam Prasad Dadi
Abstract: A control system for an electromagnetic rotary drive for bearingless motor-generators comprises a winding configuration comprising a plurality of individual pole pairs through which phase current flows, each phase current producing both a lateral force and a torque. A motor-generator comprises a stator, a rotor supported for movement relative to the stator, and a control system. The motor-generator comprises a winding configuration supported by the stator. The winding configuration comprises at least three pole pairs through which phase current flows resulting in three three-phase systems. Each phase system has a first rotor reference frame axis current that produces a levitating force with no average torque and a second rotor reference frame axis current that produces torque.
Type:
Grant
Filed:
October 30, 2008
Date of Patent:
February 23, 2010
Assignee:
The University of Toledo
Inventors:
Peter E. Kascak, Ralph H. Jansen, Timothy P. Dever
Abstract: A novel photovoltaic solar cell and method of making the same are disclosed. The solar cell includes: at least one absorber layer which could either be a lightly doped layer or an undoped layer, and at least a doped window-layers which comprise at least two sub-window-layers. The first sub-window-layer, which is next to the absorber-layer, is deposited to form desirable junction with the absorber-layer. The second sub-window-layer, which is next to the first sub-window-layer, but not in direct contact with the absorber-layer, is deposited in order to have transmission higher than the first-sub-window-layer.
Abstract: An energy storage system for a vehicle includes an ultracapacitor that is electrically coupled in parallel with a battery through a diode connected in series with the battery. The ultracapacitor delivers the energy required for all high current surges that occur during engine start, acceleration, and regeneration. The battery is used only to assist with longer duration, high energy loads, such as accessory loads when an engine of the vehicle is not running. In other words, the battery conducts only during longer and less-frequent pulses and, therefore, does not have to withstand high-power pulses.
Type:
Grant
Filed:
November 10, 2005
Date of Patent:
February 23, 2010
Assignees:
Chrysler Group LLC, University of Toledo
Abstract: Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in humanized mice that express human HLA alleles associated with increased-risk of Type 1 diabetes.
Abstract: The present invention is directed to methods and compositions for evaluating nucleic acids, methods of preparing such compositions, and applications and business methods employing such compositions and methods. In particular, the present invention provides business methods for operating a gene expression measurement service.
Type:
Application
Filed:
March 16, 2009
Publication date:
September 10, 2009
Applicants:
University of Toledo, Gene Express, Inc.
Inventors:
James C. Willey, Brad Austermiller, Erin L. Crawford, Charles Knight, Terry Osborn, Robert Zahorchak
Abstract: The present invention relates to a method of reprogramming plant development that allows flower buds and seeds to arise de novo, directly from a cotyledon or radicle explants or from shoots produced on a cotyledon or radicle. The present invention also provides for an improved culturing media that provide for in vitro flowering.
Type:
Grant
Filed:
May 27, 2005
Date of Patent:
June 16, 2009
Assignee:
University of Toledo
Inventors:
Sairam V. Rudrabhatla, Stephen L. Goldman
Abstract: The present invention relates to a method of reprogramming plant development that allows flower buds and seeds to arise de novo, directly from a cotyledon or radicle explants or from shoots produced on a cotyledon or radicle. The present invention also provides for an improved culturing media that provide for in vitro flowering.
Type:
Application
Filed:
October 17, 2008
Publication date:
February 26, 2009
Applicant:
University Of Toledo, A University Instrumentally Of The State Of Ohio
Inventors:
Sairam V. Rudrabhatla, Stephen L. Goldman
Abstract: A control system for an electromagnetic rotary drive for bearingless motor-generators comprises a winding configuration comprising a plurality of individual pole pairs through which phase current flows, each phase current producing both a lateral force and a torque. A motor-generator comprises a stator, a rotor supported for movement relative to the stator, and a control system. The motor-generator comprises a winding configuration supported by the stator. The winding configuration comprises at least three pole pairs through which phase current flows resulting in three three-phase systems. Each phase system has a first rotor reference frame axis current that produces a levitating force with no average torque and a second rotor reference frame axis current that produces torque.
Type:
Grant
Filed:
December 15, 2005
Date of Patent:
November 25, 2008
Assignee:
The University of Toledo
Inventors:
Peter E. Kascak, Ralph H. Jansen, Timothy P. Dever
Abstract: A circuit for charging a battery combined with a capacitor includes a power supply adapted to be connected to the capacitor, and the battery. The circuit includes an electronic switch connected to the power supply. The electronic switch is responsive to switch between a conducting state to allow current and a non-conducting state to prevent current flow. The circuit includes a control device connected to the switch and is operable to generate a control signal to continuously switch the electronic switch between the conducting and non-conducting states to charge the battery.
Abstract: A novel photovoltaic solar cell and method of making the same are disclosed. The solar cell includes: at least one absorber layer which could either be a lightly doped layer or an undoped layer, and at least a doped window-layers which comprise at least two sub-window-layers. The first sub-window-layer, which is next to the absorber-layer, is deposited to form desirable junction with the absorber-layer. The second sub-window-layer, which is next to the first sub-window-layer, but not in direct contact with the absorber-layer, is deposited in order to have transmission higher than the first-sub-window-layer.
Abstract: A photovoltaic electrolysis (IPE) cell has a photovoltaic component and an electrolysis component which integrated, through an interconnect design, into a single unit.