Patents Assigned to University of Toledo
  • Electromagnetic Polymer Composite Material for Anti-Fouling Effect
    Publication number: 20140356228
    Abstract: The antifouling coating is a composite material consisting of fluorinated electroactive bipolymers and magnetic particles. This composite material is coated on a solid surface to make a smooth durable grassy coating. The coating generates electrical current when an electrolytic liquid flows over it, which prevents bacterial cells from attaching to the surface. It prevents virus and protein attachment. It also prevents chemical corrosion of a surface. The composite material itself, and the antifouling method that uses fluoride compounds and electrical current that is generated by the fluid flow are disclosed for a patent. The composite material can be applied to medical devices, biomedical devices, industrial equipment, ship's hulls, food processing equipment, food processors, drinking water distribution systems, and home electrical appliances.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 4, 2014
    Applicant: The University of Toledo
    Inventors: Dong-Shik Kim, Youngwoo Seo
  • Insertion assembly for minimally invasive spinal surgery
    Patent number: 8900248
    Abstract: A telescopic insertion assembly is configured to insert a pedicle screw into a vertebral body. The insertion assembly includes an attachment fixture having one end configured to mate with the pedicle screw and another end having a ridged portion. A center tube is provided having one end slidably attached to the attachment fixture and another end having an internally ridged portion. A telescoping member has one ridged end configured to slidably attach to the center tube and another end having a yoke. The telescoping member is configured to extend the yoke to different distances from the center tube. An alignment member is configured to hingeably attach to the yoke of the telescoping member. The alignment member is configured to rotate from a first position to a second position. The second position of the alignment member is above a top surface of a patient's skin.
    Type: Grant
    Filed: June 15, 2009
    Date of Patent: December 2, 2014
    Assignee: The University of Toledo
    Inventor: Ashok Biyani
  • Bioactive Fusion Device
    Publication number: 20140350608
    Abstract: In a first broad aspect, there is provided herein a bioactive device and system for fusion between two bones, two parts of a bony joint, or a bony defect, such as of the spine. The fusion device includes a screw having a head and a threaded shaft. The fusion device also includes a bone dowel having an internal bore of which at least a distal portion is threaded to engage the threads of the screw shaft. The bone dowel is made of a bone-like, biocompatible, or allograft material to provide a layer of bone-like, biocompatible, or allograft material between the screw and the spinal bone. The device is generally coaxial and is further described in the drawings and description herein.
    Type: Application
    Filed: January 31, 2013
    Publication date: November 27, 2014
    Applicant: The University of Toledo
    Inventors: Vijay K. Goel, Anand K. Agarwal
  • Methods for forming peptides and peptide conjugates and peptides and peptide conjugates compositions formed thereby
    Patent number: 8895696
    Abstract: Methods for building peptide chains containing sulfonyl modified amines at the N-terminus, or, within amino acid side chains, of a growing peptide in a solid-phase peptide synthesis are described. Further, compositions having a sulfonyl modified amine attached to the N-terminus, or within an amino acid side chain, of a polypeptide containing three or more amino acid residues are described.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: November 25, 2014
    Assignee: The University of Toledo
    Inventors: Steven J. Sucheck, Rommel S. Talan, Partha Karmakar
  • Method for Modifying Surfaces for Better Osseointegration
    Publication number: 20140308334
    Abstract: In one aspect, there is provided a method for preparing a biocompatible coated substrate. The method generally includes: depositing nucleation amorphous calcium phosphate sites on at least a portion of an outer surface of a substrate by: exposing at least the portion of the outer surface to a mixture having a favorable Ca/P molar ratio, and irradiating with microwave energy; and, stabilizing the deposited nucleation amorphous calcium phosphate sites on the portion of the outer surface. In another aspect, there is provided herein a method for preparing a biocompatible coated substrate.
    Type: Application
    Filed: October 31, 2012
    Publication date: October 16, 2014
    Applicant: The University of Toledo
    Inventors: Sarit B. Bhaduri, Vijay K. Goel, Huan Zhou
  • Cervical plate assembly
    Patent number: 8858604
    Abstract: A cervical plate assembly facilitates the fusion of cervical vertebrae by quickly and easily causing the vertebrae to exert a preloading force against a bone graft interposed therebetween. A cervical plate assembly also facilitates the installation of the cervical plate assembly in an orthopedic surgical procedure by providing both a locking mechanism that positively retains one or more fasteners thereto and a viewing window that results in an unobstructed view of the vertebrae and the bone graft.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 14, 2014
    Assignee: The University of Toledo
    Inventors: Ashok Biyani, Michael A. Rymer
  • Neural Network System and Uses Thereof
    Publication number: 20140304204
    Abstract: A multifunctional neural network system for prediction which includes memory components to store previous values of data within a network. The memory components provide the system with the ability to learn relationships/patterns existent in the data over time.
    Type: Application
    Filed: May 22, 2014
    Publication date: October 9, 2014
    Applicant: The University of Toledo
    Inventors: Brent D. Cameron, Scott M. Pappada
  • Non-invasive ocular analyte sensing system
    Patent number: 8845100
    Abstract: A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One example of such structure is the subject's iris.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: September 30, 2014
    Assignee: The University of Toledo
    Inventors: Brent D. Cameron, Anthony Webb
  • Materials and methods related to sodium/potassium adenosine triphosphase and cholesterol
    Patent number: 8835171
    Abstract: This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: September 16, 2014
    Assignee: The University of Toledo
    Inventors: Zi-Jian Xie, Yiliang Chen, Haojie Wang
  • Back contact buffer layer for thin-film solar cells
    Patent number: 8829342
    Abstract: A photovoltaic cell structure is disclosed that includes a buffer/passivation layer at a CdTe/Back contact interface. The buffer/passivation layer is formed from the same material that forms the n-type semiconductor active layer. In one embodiment, the buffer layer and the n-type semiconductor active layer are formed from cadmium sulfide (CdS). A method of forming a photovoltaic cell includes the step of forming the semiconductor active layers and the buffer/passivation layer within the same deposition chamber and using the same material source.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: September 9, 2014
    Assignee: The University of Toledo
    Inventors: Alvin D. Compaan, Victor V. Plotnikov
  • Core muscle strengthening
    Patent number: 8827880
    Abstract: The method and system of this invention provides for core muscle strengthening. The method comprises the step of: providing an apparatus (10) that provides resistance and assistance during core muscle training using dynamic therapeutic movement for chest, back, abdominal and leg musculature to strengthen and condition muscles of the axial skeleton and lower extremities of a performing user. In one embodiment, the method also is for non-invasive physical therapy.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: September 9, 2014
    Assignees: The University of Toledo, The Turning Point LLC
    Inventors: Vijay K. Goel, Kenneth Germano, F. Alan Schultheis, David Dick
  • Trunk rotation
    Patent number: 8790226
    Abstract: This trunk rotation device uses dynamic movement of one's body such as, shoulder, hip, knee, back, thigh, and abdominal musculature. The device provides a method for exercising the spinal column and the muscles of the torso, including those in the abdominal lumbar and thoracic regions involving rotational torque. In a preferred embodiment, the device is a golf exercise and flexibility apparatus. The golf exercise apparatus provides resistance to a golfer during a golf swing to strengthen and condition the muscles of the axial skeleton of the golfer in a functional posture.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: July 29, 2014
    Assignee: The University of Toledo
    Inventors: Vijay K. Goel, Danny M. Pincivero, David Dick, John Jaegly, F. Alan Schuitheis, Kathleen Herndon
  • Cancer risk biomarkers
    Patent number: 8771947
    Abstract: The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular cancer or predisposition to cancer.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: July 8, 2014
    Assignee: The University of Toledo
    Inventors: James C. Willey, Thomas M. Blomquist, Erin L. Crawford, D'Anna N. Mullins
  • Cancer risk biomarker
    Patent number: 8765368
    Abstract: The present disclosure relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular cancer or predisposition to cancer. Also provided are methods and compositions for identifying a greater risk for a cancer-related condition in an subject.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: July 1, 2014
    Assignee: The University of Toledo
    Inventors: James C. Willey, Thomas M. Blomquist, Erin L. Crawford, D'Anna N. Mullins
  • Neural network for glucose therapy recommendation
    Patent number: 8762306
    Abstract: A multifunctional neural network system for prediction which includes memory components to store previous values of data within a network. The memory components provide the system with the ability to learn relationships/patterns existent in the data over time.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: June 24, 2014
    Assignee: The University of Toledo
    Inventors: Brent D. Cameron, Scott M. Pappada
  • Removable anchoring pedicle screw
    Patent number: 8734497
    Abstract: A removable anchoring pedicle screw includes an implant mounting screw, an anchor screw, and a nose piece. The anchor screw is configured to be rotated relative to the implant mounting screw such that the nose piece engages an expandable anchor. The expandable anchor is disposed between the implant mounting screw and the nose piece such that rotation of the anchor screw relative to the implant mounting screw causes expansion of the expandable anchor.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: May 27, 2014
    Assignee: The University of Toledo
    Inventors: Vijay K. Goel, Aaron Matyas
  • Boron selective ionic liquids and polymeric ionic liquids, methods of making and methods of use thereof
    Patent number: 8734673
    Abstract: Boron selective ionic liquids and polymeric ionic liquids, methods of making and methods of using the same are disclosed.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: May 27, 2014
    Assignee: The University of Toledo
    Inventor: Jared L. Anderson
  • Method for selecting a treatment for non-small cell lung cancer using gene expression profiles
    Patent number: 8722331
    Abstract: The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased lung. The present invention also identifies and quantifies expression profiles which serve as useful diagnostic markers as well as markers that are useful to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: May 13, 2014
    Assignee: University of Toledo
    Inventors: Jeffrey P. Demuth, Erin L. Crawford, James C. Willey, David A. Weaver, Kristy A. Warner, Timothy G. Graves
  • Na/K-ATPase Ligand
    Publication number: 20140128356
    Abstract: Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described.
    Type: Application
    Filed: March 25, 2013
    Publication date: May 8, 2014
    Applicant: The University of Toledo
    Inventors: Zi-Jian Xie, Joseph I. Shapiro
  • Non-invasive polarimetric apparatus and method for analyte sensing in birefringent media
    Patent number: 8718734
    Abstract: A noninvasive polarimetric apparatus used to measure levels of a substance in a sample in the presence of dynamically changing sample birefringence is provided. A polarization system generates multiple states of polarized light which interact with the sample. An analyzer system receives a signal from the sample and generates a secondary signal. This signal is detected and then processed to measure levels of a substance in a sample that may be have time varying birefringent components.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: May 6, 2014
    Assignee: The University of Toledo
    Inventor: Brent D. Cameron