Abstract: Embodiments are provided for a compress and forward relaying scheme in joint multi-cell processing. A plurality of base stations receive similar combinations of user signals from a plurality of users, compress the signals using quantization, and relay the signals over respective backhaul links to a processor in the network for decoding the signal. The processor determines suitable quantization noise levels for the backhaul links according to a weighted sum-rate maximization function for optimizing the quantization noise levels, subject to a backhaul sum capacity constraint on the backhaul links. The determined quantization noise levels are sent to the base stations, which then quantize the received combinations of user signals according to the quantization noise levels and relay the quantized signals to the processor. The quantization is according to a Wyner-Ziv coding or a single user compression algorithm that excludes statistical correlations between the user signals at the base stations.

Abstract: The present invention relaters to a system and methods for automated vitrification of mammalian oocytes or embryos. The system and methods enable automated processing of oocytes or embryos in vitrification solutions; robotically moving vitrification devices that carry processed cells for freezing in liquid nitrogen; automated sealing of the frozen devices; and transferring the sealed devices to an automated storage system for long-term cryopreservation.

Abstract: Methods and apparatus are disclosed to provision virtual machine resources. An example method includes labeling a copy of memory associated with an established virtual machine with an execution status based on an architecture type associated with the copy, and constraining a fetch operation in response to a page fault to a labeled portion of the copy that matches an architecture type of a received processor instruction.

Abstract: Devices and methods for implementing cell-based assays and long-term cell culture. The device and method are based on digital microfluidics (DMF) which is used to actuate nanoliter droplets of reagents and cells on a planar array of electrodes. DMF method is suitable for assaying and culturing both cells in suspension and cells grown on surface (adherent cells). This method is advantageous for cell culture and assays due to the automated manipulation of multiple reagents in addition to reduced reagent use and analysis time. No adverse effects of actuation by DMF were observed in assays for cell viability, proliferation, and biochemistry. These results suggest that DMF has great potential as a simple yet versatile analytical tool for implementing cell-based assays and cell culture on the microscale.

Abstract: Contemplated methods and devices comprise performing electrochemical sample analysis in a multiplexed electrochemical detector having reduced electrical cross-talk. The electrochemical detector includes electrodes that share a common lead from a plurality of leads. The sample, which may be a liquid sample, is introduced into one or more sample wells and a signal is applied to at least one of the electrodes. A response signal is measured while simultaneously applying a substantially fixed potential to each of a remainder of the plurality of leads.

Abstract: The incorporation of polymeric excipients into an injectable hydrogel matrix, for example, methyl cellulose in the case of a hydrogel matrix comprising hyaluronan and methylcellulose (HAMC) has been found to increase the solubility of sparingly soluble hydrophobic drugs and tune their rate of release. The hydrogel matrix may also include other sparingly soluble hydrophobic food or cosmetic agents.

Abstract: The present invention relates to a composite hydrogel comprising a blend of an aqueous solution of an anionic polysaccharide or a derivative thereof, such as hyaluronan (also commonly referred to as hyaluronic acid) or a derivative thereof and an aqueous solution of methylcellulose or another water soluble cellulose derivative thereof, having dispersed polymeric particles, such as polymeric hydrophobic particles therein selected from micro particles and nanoparticles, and wherein the stability of the hydrogel is enhanced relative to the stability of the hydrogel alone. The polymeric particles may contain at least one therapeutic agent, in which case each therapeutic agent exhibits a linear sustained release rate that can be tuned or altered by selecting the appropriate polymer formulation of the micro particles and/or nanoparticles.

Abstract: There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an antimicrobial, and their method of use.

Abstract: A building structure in an outrigger configuration having a building core, at least one perimeter column, and at least one outrigger beam having a main body portion connected to the building core, an end portion distal from the building core in a direction of the at least one perimeter column and a vane portion extending from the end portion. At least one damper having a high-viscosity fluid container connected is connected to the at least one perimeter column and the vane portion extends into the high-viscosity fluid container to couple the building core to the at least one perimeter column, such that when the building structure is subjected to lateral loads and the building core is displaced with respect to the at least perimeter column, high-viscosity fluid within the high-viscosity fluid container is sheared by the vane to damp vibrations and provide coupling in the building structure.

Abstract: There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an anticancer compound, and their method of use.

Abstract: The present invention provides exchangeable, reagent pre-loaded carriers (10), preferably in the form of plastic sheets, which can be temporarily applied to an electrode array (16) on a digital microfluidic (DMF) device (14). The carrier (10) facilitates virtually un-limited re-use of the DMF devices (14) avoiding cross-contamination on the electrode array (16) itself, as well as enabling rapid exchange of pre-loaded reagents (12) while bridging the world-to-chip interface of DMF devices (14). The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications.

Abstract: A bio-adhesive supramacromolecular complex of the general formula: wherein R1 is independently selected from the group consisting of an alkane unsubstituted or substituted with alkoxy groups; R2 is independently selected from the group consisting of C1-6 alkyl; R3 and R4 are independently selected from the group consisting of optionally substituted aliphatic or aromatic alkyl; R5 is independently selected from the group consisting of H or C1-6 alkyl; W is a hydrogen-bond accepting functional group-containing entity; Y is a carboxylic acid ester or amide linkage; R is an independently selected peptide linking group; T1, T2, T3 and T4 are independently selected polymer residues; and m1, m2, m3, n1 and n2 are integers selected from at least 25; and wherein P has a molecular weight of about 1×103 to 1×107 and Q has a molecular weight of about 1×103 to 1×107. The complex provides controlled nitric oxide release over a longer period of time than prior art compounds in the locally delivery systems.

Abstract: This invention provides a polymer composition comprising at least one thermal gelling polymer and at least one anionic polymer for cell delivery applications. These injectable polymer compositions are shear-thinning, thixotropic and resorbable. More specifically there is described a hyaluronan (HA) and methylcellulose (MC) based thermogelling cell delivery system (HAMC) that promotes cell survival both in vitro and in vivo. Importantly, HAMC (relative to media alone) enhances survival of transplanted stem/progenitor cells in the injured CNS. HAMC provides a minimally-invasive cell delivery strategy where the microenvironment can be further defined and the differentiation and regenerative capacity further explored. This hydrogel system has applications for minimally-invasive cell delivery to other tissues/organs in the body as well.

Abstract: A recombination layer with a gradient work function is provided which increases the power-conversion efficiency of multijunction photovoltaic devices by reducing the energy barrier to charge carriers migrating between pairs of photovoltaic junctions thereby facilitating the optimal recombination of opposing electron and hole currents generated when the photovoltaic is illuminated.

Abstract: The present invention provides a system, method and computer program for anonymous localization. The location of a mobile device can be determined based on received signal strength (RSS) from one or more access points (APs) and a radio map. A radio map can be generated by measuring RSS at a set of fingerprints, which are a finite set of reference points within the area to be mapped.

Abstract: Provided herein is a method of treating Respiratory Syncytial Virus (RSV) infection in a cell. The method involves administering the guanosine-rich oligonucleotide (GRO) AS 1411 (5?-GGTGGTGGTGG TTGTGGTGGTGGTGG-3?—also known as GR026B and AGRO100) to the cell.

Abstract: There is provided an output coupler modulated laser. The laser includes an optical resonator for light to circulate within, a gain medium housed within the optical resonator and a pump. An output coupler included in the optical resonator is responsive to a control signal to generate a modulated optical signal at a laser output port, and a complementary signal at a through port to retain circulating light within the optical resonator. The output coupler and the pump are jointly controllable to maintain the power level of the circulating light substantially at a selected, steady state level, and to decouple the modulation response of the laser from the intrinsic response of the circulating light due to interaction with the gain medium. The output coupler is configurable for simple amplitude modulation, Phase-Shift Keying (PSK), Quadrature Amplitude Modulation (QAM), and is suitable for use with high-finesse, micron or millimeter scale resonators.

Abstract: The present disclosure relates to methods and uses of C-terminal peptides for inhibiting neuronal cell death or dysfunction, such as retinal ganglion cell death or dysfunction, treating retinal degenerative disorders, stroke, CNS and PNS insults. The disclosure also relates to the C-terminal peptides, fusion proteins and compositions thereof.

Abstract: The present invention addresses a need for improved treatments for filovirus infections.

Abstract: The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitro and antitumor response in vivo.