Abstract: Computer implemented method for rendering an image of a three-dimensional scene on an image plane by encoding at least a luminosity in the image plane by a luminosity function. The value of the luminosity can be computed at substantially each point of the image plane by using a set of stored input data describing the scene. The method includes constructing the luminosity function as equivalent to a first linear combination involving the functions of a first set of functions, and computing at least the value of the coefficients of the first linear combination, by solving a first linear system, obtained by using at least the functions of the first linear combination, at least a subset of the first subset of the image plane, and the luminosity at the points of said subset. The method further includes storing the value of the coefficients of the first linear combination and at least the information needed to associate each coefficient to the function multiplying said coefficient in the first linear combination.

Abstract: Methods for treatment and diagnosis of neurological disorders such as autism and autism spectrum disorder are disclosed. Also disclosed are modulators of alternative splicing regulators SRRM4 and/or SRRM3 for treating neurological disorders. Further disclosed are agents that modulate the expression of at least one splice variant for treating neurological disorders. Mouse models of neurological disorders having increased or decreased expression of SRRM4 and/or SRRM3 are also disclosed.

Abstract: The present invention provides novel Ruthenium-based transition metal complex catalysts comprising specific ligands, their preparation and their use in hydrogenation processes. Such complex catalysts are inexpensive, thermally robust, and olefin selective.

Abstract: Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bin-probe. Further disclosed are suitable electrochemical reporter systems for use with the bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.

Abstract: A silicon photonic platform includes a substrate supporting a buried oxide layer, an active silicon layer deposited on the buried oxide layer, a first silicon nitride layer separated from the active silicon layer by a first spacer, the first silicon nitride layer and the active silicon layer constituting a first light-transferring interlayer transition and a second silicon nitride layer covered by a cladding and separated from the first silicon layer by a second spacer, the second silicon nitride layer and the first silicon nitride layer constituting a second light-transferring interlayer transition. The second silicon nitride layer passes over one or more waveguides in the active silicon layer to thereby define a waveguide crossing. The silicon nitride layers may be substituted with an equivalent dielectric with a similar refractive index and high optical transparency in the desired operating wavelength range.

Abstract: Contemplated methods and devices comprise performing electrochemical sample analysis in a multiplexed electrochemical detector having reduced electrical cross-talk. The electrochemical detector includes electrodes that share a common lead from a plurality of leads. The sample, which may be a liquid sample, is introduced into one or more sample wells and a signal is applied to at least one of the electrodes. A response signal is measured while simultaneously applying a substantially fixed potential to each of a remainder of the plurality of leads.

Abstract: Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

Abstract: Described herein are systems and methods for detecting a target analyte in a sample with electrodes, comprising a linker and an antibody attached to the linker, and measuring an electrocatalytic signal changes generated by binding of an analyte in the sample to the antibody. Also disclosed herein are kits for electrochemical detection of protein analytes.

Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.

Abstract: A method of fabricating a P-N junction in a semiconductor structure, e.g. silicon (Si) structure, is presented. The method may include several implantation steps performed at a single implantation angle with respect to the Si structure. In a first implantation step, a first dopant species is implanted over a first portion of the Si structure including a first edge of the Si structure. In a second implantation step, a second dopant species is implanted over a second portion of the Si structure including a second edge of the Si structure opposed to the first edge but excluding the first edge. The first portion and the second portion may overlap in a central portion of the Si structure between the first edge and the second edge, such that the second dopant species may be implanted below the first dopant species.

Abstract: GB1 peptidic compounds that specifically bind to a hemagglutinin target protein, and libraries that include the same, as well as methods of making and using the same, are provided. Also provided are methods and compositions for making and using the compounds. Also provided are hemagglutinin mimics and fragments and methods of using the same, including methods of screening for GB1 peptidic compounds and methods of using conjugates the mimics as influenza A vaccines. Aspects of the invention include methods of screening libraries of L-peptidic compounds for specific binding to a D-peptidic hemagglutinin target protein. Once a L-peptidic compound has been identified that specifically binds to the D-peptidic hemagglutinin target protein, the D-enantiomer of the selected L-peptidic compound may be produced. In some embodiments, the D-enantiomer of the selected L-peptidic compound binds to, and in some instances, neutralizes influenza virus particles.

Abstract: The present invention provides stable, cyclic bent allene metal complexes and methods of conducting chemical processes, preferably olefin hydrogenation, comprising contacting an olefin substrate, preferably an unsaturated polymer, with a cyclic bent allene metal complex as described herein, under hydrogenation conditions.

Abstract: Provided are methods for identifying or monitoring a subject having, or at risk of developing, impaired glucose homeostasis. Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) is shown to be a biomarker for impaired glucose homeostasis and/or conditions characterized by ?-cell dysfunction. Comparing a test level of CMPF in a subject to a control level identifies subjects having, or at risk of developing, impaired glucose homeostasis. Also provided are methods of causing impaired glucose homeostasis or ?-cell dysfunction and methods of screening for compounds that affect the activity of ?-cells. Also provided are methods for the treatment of ?-cell dysfunction by reducing the physiological levels of CMPF in a subject as well as the use of a OAT modulator for the treatment of ?-cell dysfunction.

Abstract: A method for assessing cell contraction includes adhering contractile cells to an oxidized and cellular adhesion activated surface of a biocompatible silicone elastomer film. The biocompatible silicone elastomer film allows the cells to contract and wrinkles when the cells contract. Wrinkles in the biocompatible silicone elastomer film formed by contraction of the contractile cells are analyzed to assess cell contraction.

Abstract: A dual active bridge (DAB) converter operates in a power conversion operation by controlling multiple bridge configured switches to charge a magnetization inductance from an input supply during a charge phase of a power cycle and to discharge the magnetization inductance into an output of the DAB during a discharge phase of the power cycle. The DAB converter includes an input converter connected to the input supply, an inductance connected to the input converter, a transformer comprising a primary and a secondary winding, and an output converter connected to the transformer. The input and output converters each include a first pair of switches forming a first circuit path, and a second pair of switches forming a second circuit path parallel to the first circuit path. The first and second circuit paths are both completed by a third circuit path including the inductance and the primary winding of the transformer.

Abstract: The invention features methods and diffraction-based devices for the detection of specific analytes. The devices of the invention contain a periodic dielectric multilayer, which allows for the propagation of Bloch surface waves (BSWs) at the surface of the multilayer, thereby increasing the sensitivity of the device.

Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.

Abstract: The present disclosure provides immunogenic compositions comprising the N-domain of carcinoembryonic antigen (CEA). These compositions are useful for inducing or enhancing an immune response, for inhibiting tumor cell growth and for treating cancer.

Abstract: Methods and systems for providing therapy related to urological disorders which relate to stimulation of the saphenous nerve (SAFN) either alone or in combination with the posterior tibial nerve (PTN), medial plantar nerve (MPN) or lateral planar nerve. In embodiments nerves are stimulated by percutaneous, transcutaneous, and/or implanted stimulators. In embodiments the SAFN is stimulated below the level of the knee or near the medial malleolus. Embodiments also disclose improving nerve stimulation, including SAFN stimulation, using systems and methods termed enhanced transcutaneous electrical stimulation (eTENS) since these enhance the excitation of neural tissue. In an embodiment, systems and methods are provided to increase the chance of providing the selective modulation of specific (targeted) neural substrate, while decreasing the risk of activation of adjacent (non-targeted) nervous tissue.

Abstract: The disclosure concerns quantum repeater network system that does not need any matter qubit. According to the quantum repeater network system for performing quantum communication between one transmitter/receiver and the other transmitter/receiver via transmission repeaters and reception repeaters, each of the transmission repeaters prepares quantum systems in an irreducibly entangled state, each of the quantum systems being associated with a reception repeater as a transmission destination, and transmits, to the associated reception repeater, each of the quantum systems in the irreducibly entangled state together with a quantum system entangled with the quantum system.