Patents Assigned to University of Utah Research Foundation
  • Lensless imaging device
    Patent number: 11373278
    Abstract: Technology is described for methods and systems for imaging an object (110). The method can include an image sensor (116) exposed to light (114) from an object (110) without passing the light through an image modification element. Light intensity of the light (114) can be stored as data in a medium. The image data can be analyzed at a processor (902) as a reconstructed image of the object (110).
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: June 28, 2022
    Assignee: University of Utah Research Foundation
    Inventors: Rajesh Menon, Ganghun Kim, Kyle Isaacson
  • CD229 CAR T cells and methods of use thereof
    Patent number: 11365252
    Abstract: Disclosed are chimeric antigen receptor (CAR) polypeptides comprising a CD229 antigen binding domain, a transmembrane domain, and an intracellular signaling domain. Disclosed are nucleic acid sequences capable of encoding a CAR polypeptide comprising a CD229 antigen binding domain, a transmembrane domain, and an intracellular signaling domain. Also disclosed are vectors and cells comprising one or both of the CAR polypeptides and nucleic acid sequences capable of encoding CAR polypeptides. Also disclosed are methods of treating.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: June 21, 2022
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Tim Luetkens, Djordje Atanackovic, Sabarinath Venniyil Radhakrishnan
  • Salivary Gland Cell Sheets and Methods for their Production and Use
    Publication number: 20220175847
    Abstract: The disclosure provides a salivary gland (SG) cell sheet comprising one or more layers of confluent SG cells (e.g. submandibular gland (SMG) cells). Methods of treating a wound in a salivary gland (SG), treating hyposalivation, and treating irradiation damage in an SG are also provided. The disclosure also provides a method for producing SG cell sheets comprising culturing SG cells in culture solution on a temperature-responsive polymer which has been coated onto a substrate surface of a cell culture support, wherein the temperature-responsive polymer has a lower critical solution temperature in water of 0-80° C.; adjusting the temperature of el the culture solution to below the lower critical solution temperature, whereby the substrate surface is made hydrophilic and adhesion of the cell sheet to the surface is weakened; and detaching the cell sheet from the culture support.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 9, 2022
    Applicant: University of Utah Research Foundation
    Inventors: Olga Baker, Teruo Okano, Kihoon Nam, Kyungsook Kim
  • High speed nucleic acid melting analysis
    Patent number: 11351545
    Abstract: A method and system have been provided to perform high speed nucleic acid melting analysis while still obtaining accurate melting curve sufficient for genotyping. This rapid ability to interrogate DNA should be useful whenever time to result is important, such as in molecular point of care testing. Specifically, microfluidics enables genotyping by melting analysis at rates up to 50° C./s, requiring less than is to acquire an entire melting curve. High speed melting reduces the time for melting analysis, decreases errors, and improves genotype discrimination of small amplicons.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: June 7, 2022
    Assignees: Canon U.S.A., Inc., University of Utah Research Foundation
    Inventors: Robert J. Pryor, Carl T. Wittwer, Scott O. Sundberg, Ivor T. Knight, Joseph T. Myrick, Robert A. Palais, Jeanette Y. Paek
  • Compositions and methods comprising a triaryl polyamine
    Patent number: 11352315
    Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In some aspects, the present invention relates to polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms. In some aspects, the present invention relates to compositions and methods comprising the polyamine compound. In some aspects, the compounds, compositions, and methods enhance wound healing.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: June 7, 2022
    Assignees: Curza Global, LLC, University of Utah Research Foundation
    Inventors: Ryan E. Looper, Dustin Williams, Paul R. Sebahar, Travis J. Haussener, Hariprasada R. Kanna Reddy
  • COUPLED TORSIONAL FIXATOR AND METHOD OF USE
    Publication number: 20220160398
    Abstract: An apparatus and method for external anteversion correction of an intact bone may include a first arcuate segment, a second arcuate segment rotatably coupled to the first arcuate segment, a first pin extending from the first arcuate segment to a proximal segment of the intact bone, a second pin extending from the second arcuate segment to a distal segment of the intact bone, and a control mechanism attached to the first and second arcuate segments. The control mechanism may rotate the first arcuate segment relative to the second arcuate segment to exert torsional force on the intact bone between the proximal and distal segments of the intact bone, thereby externally reducing anteversion of the intact bone.
    Type: Application
    Filed: February 13, 2022
    Publication date: May 26, 2022
    Applicant: University of Utah Research Foundation
    Inventor: Peter M. STEVENS
  • Temperature measurement in thermal therapy
    Patent number: 11337610
    Abstract: A method, system and article of manufacture is disclosed. The method includes providing a spatial navigator outside of a thermal therapy region; receiving a plurality of analog-to-digital conversion (ADC) readouts from an MRI device at a plurality of time points, wherein the ADC readouts comprise a first ADC readout acquired at a first time point, and one or more additional ADC readouts acquired at subsequent time points; processing the ADC readouts to obtain a frequency of the spatial navigator at each of the time points; obtaining a main magnetic field (B0) drift of the MRI device based on the frequency of the spatial navigator at a particular time point and the frequency of the spatial navigator at the first time point; and obtaining the temperature change at the particular time point based on the B0 drift.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: May 24, 2022
    Assignees: Siemens Healthcare GmbH, University of Utah Research Foundation
    Inventors: Sunil Goraksha Patil, Henrik Odeen, Bhat Himanshu, John Roberts, Dennis L. Parker
  • In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
    Patent number: 11337994
    Abstract: Described herein are in situ gelling compositions. The compositions include an anti-inflammatory polysaccharide and a gelling polymer, wherein the composition is a liquid prior to administration to a subject but converts to a gel upon administration to the subject. The compositions described herein have numerous applications with respect to the local treatment (reduction or prevention) of inflammation and/or tissue damage.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: May 24, 2022
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Hamidreza Ghandehari, Siam Oottamasathien, Mark Martin Jensen, Joseph Cappello, Wanjian Jia, Glenn D. Prestwich
  • Benzimidazoles and methods of using same
    Patent number: 11339173
    Abstract: The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus, respiratory syntactical virus (RSV), Rift Valley fever, Influenza virus, Tacaribe virus, Mayaro virus, West Nile virus, yellow fever virus, and coronavirus), and disorders of uncontrolled cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: May 24, 2022
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Darrell Davis, Shuanghu Liu
  • Methods and systems for multiple taxonomic classification
    Patent number: 11335436
    Abstract: Described herein are methods of identifying a plurality of polynucleotides, as well as detecting presence, absence, or abundance of a plurality of taxa in a sample. Also provided are systems for performing methods of the disclosure.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: May 17, 2022
    Assignee: University of Utah Research Foundation
    Inventors: Steven Flygare, Keith Simmon, Chase Miller, Yi Qiao, Karen Eilbeck, Gabor Marth, Mark Yandell, Robert Schlaberg
  • Medical device implant carrier for fragile medical implants
    Patent number: 11331499
    Abstract: A medical implant device (100) is disclosed that can protect and shield an implant (101) as the implant (101) moves through body tissue. The medical implant device (100) can comprise a main body portion (110) having a payload opening (111) to receive a payload (i.e., an implant). The medical implant device (100) can also comprise a tapered nose portion (120) at a front end (103a) of the medical implant device (100) extending from the main body portion (110) and configured to penetrate body tissue. In addition, the medical implant device (100) can comprise a payload coupling interface (130) configured to couple the implant (101) to the main body portion (110).
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: May 17, 2022
    Assignee: University of Utah Research Foundation
    Inventors: David Kluger, Gregory Clark, Douglas Hutchinson, David Page, Suzanne Wendelken
  • Nucleic acid melting analysis with saturation dyes
    Patent number: 11332779
    Abstract: Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: May 17, 2022
    Assignees: BIOFIRE DEFENSE, LLC, UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Luming Zhou, Carl T. Wittwer, Philip Seth Bernard, Virginie Dujols
  • NNIF and nNIF-related peptides and related methods
    Patent number: 11324801
    Abstract: Neonatal NET-inhibitory Factor (nNIF) and nNIF-Related Peptides (NRPs) are provided. Methods for the treatment of and prophylaxis against inflammatory disorders and cancer are also provided. Additionally, methods for the inhibition of metastasis in patients having cancer are provided. The methods can include administering nNIF and/or a NRP to patients having, or at risk of developing, an inflammatory disorder or a cancer.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: May 10, 2022
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Christian Con Yost, Guy A. Zimmerman, Andrew S. Weyrich, Joshua Schiffman
  • Methods of making red blood cells and platelets in vitro and uses thereof
    Patent number: 11319528
    Abstract: Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats; and, non-immunogenic bioconjugates comprising recombinant polypeptides comprising one or more homologous amino acid repeats and one or more therapeutic agents. Also, disclosed herein are pharmaceutical compositions including the recombinant polypeptides; and methods of administering the recombinant polypeptides to patients for the treatment of cancer or infections.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: May 3, 2022
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventor: Tara L. Deans
  • Active compression bone screw
    Patent number: 11317956
    Abstract: A bone screw may be insertable into a bone, and may have a proximal member, a distal member with bone-engaging threads, wherein the distal member is configured to slidably engage the proximal member such that a variable-length cavity is defined within the proximal member and the distal member, and a tension member residing at least partially within the variable-length cavity. The tension member may have a proximal end coupled to the proximal member and a distal end coupled to the distal member such that, in response to motion of the distal member away from the proximal member, the tension member elongates and urges the distal member to move toward the proximal member. The proximal member and the distal member may be interconnected to share bending loads at a bending transmission feature.
    Type: Grant
    Filed: August 26, 2021
    Date of Patent: May 3, 2022
    Assignee: University of Utah Research Foundation
    Inventors: Colin S. Gregersen, T. Wade Fallin, Charles L. Saltzman
  • Auto-scaling cloud-based memory-intensive applications
    Patent number: 11307895
    Abstract: Improved techniques for dynamically responding to a fluctuating workload. Resources are reactively scaled for memory-intensive applications and automatically adapted to in response to workload changes without requiring pre-specified thresholds. A miss ratio curve (MRC) is generated for an application based on application runtime statistics. This MRC is then modeled as a hyperbola. An area on the hyperbola is identified as satisfying a flatten threshold. A resource allocation threshold is then established based on the identified area. This resource allocation threshold indicates how many resources are to be provisioned for the application. The resources are scaled using a resource scaling policy that is based on the resource allocation threshold.
    Type: Grant
    Filed: January 8, 2020
    Date of Patent: April 19, 2022
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Joe H. Novak, Sneha K. Kasera, Ryan Stutsman
  • Imaging device with image dispersing to create a spatially coded image
    Patent number: 11300449
    Abstract: An image capturing device (202) can include a sensor array (210), a lens (230) positioned at a first distance from an intermediate image (235), and apolychromat (220) positioned at a second distance from the lens (230). The polychromat (220) can diffract the intermediate image (235) according to a transform function (207) to produce a dispersed sensor image (215) onto the sensor array (210). The dispersed sensor image (215) can represent a spatial code of the intermediate image (235).
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: April 12, 2022
    Assignee: University of Utah Research Foundation
    Inventors: Rajesh Menon, Peng Wang
  • Percutaneous osseointegrated implant assembly for use in supporting an exo-prosthesis
    Patent number: 11298231
    Abstract: An implant assembly for a long bone is adapted to support an exo-prosthesis. The assembly includes a stem, a subdermal component and a percutaneous post. The stem has a proximal end that is adapted to be received in a surgically prepared medullary canal of the long bone, and a distal end having a surface that is adapted to promote bone ingrowth. The subdermal component includes a proximal portion that is adapted for attachment to the distal end of the stem, and a fixation surface that is adapted to promote soft tissue fixation. The percutaneous post has a proximal end that is adapted to be attached to the subdermal component.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: April 12, 2022
    Assignees: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Kent N. Bachus, Sujee Jeyapalina, James Peter Beck, Roy Bloebaum, Jayant P. Agarwal, Joseph A. Longo, Erik Kubiak, Brian Mueller Holt
  • p53-BAD fusion proteins
    Patent number: 11299526
    Abstract: Disclosed are peptides comprising a p53 peptide and a BH3-only protein. In some aspects, wherein the BH3-only protein is BAD, BID, BIM, NOXA. Disclosed are nucleic acid sequences comprising a sequence capable of encoding a p53 peptide operably linked to a nucleic acid sequence capable of encoding a BH3-only protein. Disclosed are nucleic acid sequences comprising a sequence capable of encoding one or more of the peptides disclosed herein. Disclosed are vectors comprising a nucleic acid sequence, wherein the nucleic acid sequence is capable of encoding one or more of the peptides disclosed herein. Also disclosed are methods of using the disclosed peptides, nucleic acid sequences, and vectors.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: April 12, 2022
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Carol S. Lim, Phong Lu
  • Compositions for adjustable ribosome translation speed and methods of use
    Patent number: 11293028
    Abstract: The present invention relates to the effects of codon context and synonymous codon changes on mRNA translation and methods of increasing protein production.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: April 5, 2022
    Assignee: University of Utah Research Foundation
    Inventors: Kelly T. Hughes, Fabienne Chevance