Patents Assigned to University of Utah
  • Method of making induced pluripotent stem cells
    Patent number: 9920333
    Abstract: Systems, constructs, and methods for reprogramming cells are provided. In one aspect, for example, a transformation construct for generating iPS cells can include an expression vector having a plurality of reprogramming factors, each reprogramming factor being under control of a separate promoter.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: March 20, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Stefan M. Pulst, Sharan Paul, Warunee Dansithong
  • Adhesive complex coacervates and method of making and using thereof
    Patent number: 9913926
    Abstract: Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: March 13, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Russell J. Stewart, Hui Shao
  • In situ solidifying complex coacervates and methods of making and using thereof
    Patent number: 9913927
    Abstract: Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: March 13, 2018
    Assignee: University of Utah Research Foundation
    Inventor: Russell J. Stewart
  • High molecular weight arginine-grafted bioreducible polymers
    Patent number: 9907861
    Abstract: The polymeric carrier for delivering nucleic acid material to a cell is provided herein. The polymeric carrier can include a dendrimer group having 2 to 8 termini, each of the termini having an arginine-grafted bioreducible polymer attached thereto. In one embodiment, only a portion of the termini can have an arginine-grafted bioreducible polymer attached thereto.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: March 6, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Sung Wan Kim, Hye Yeong Nam, Kihoon Nam, David A. Bull
  • Ron inhibitors for use in preventing and treating bone loss
    Patent number: 9907791
    Abstract: Provided herein are methods for inhibiting osteolysis or treating osteoporosis in a subject in need thereof, the method including administering to the subject at least one RON inhibitor. The osteolysis may be caused by a condition selected from the group consisting of cancer, inflammation, and cyst. The condition may include a bone tumor or a tumor located in bone. The subject may have been diagnosed with bone cancer. The inhibitor may be ASLAN002. The inhibitor may be OSI-296. The inhibitor may be selective or specific for RON. The inhibitor may not depend on the function of RANKL or TGF?.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: March 6, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Alana L. Welm, Kelsi Kretschmann Andrade
  • MULTI-SEQUENCE CAPTURE SYSTEM
    Publication number: 20180057874
    Abstract: Systems, devices, and methods for capturing single source-specific biological material from a multi-source aggregate of biological material are disclosed and discussed. A capture system is generated using reversible chain-blocking to make capture substrates having substrate-linked populations of capture molecules specific for molecules of interest. Incubating such capture substrates in the presence of only a single source of biological material facilitates the association of molecules of interest from the same source. Capture substrate-specific barcode sequences coupled to the capture molecules allow multisource aggregate processing and subsequent grouping to retain the source-specific information following downstream processing.
    Type: Application
    Filed: July 14, 2017
    Publication date: March 1, 2018
    Applicant: University of Utah Research Foundation
    Inventors: John Phillips, William M. Hanson, Jennifer M. Heemstra
  • Methods and compositions for treating nephrogenic diabetes insipidus
    Patent number: 9901624
    Abstract: Disclosed are compositions and methods for treating nephrogenic diabetes insipidus and for induction of diuretic effect.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: February 27, 2018
    Assignees: The United States of America as represented by the Department of Veterans Affairs, The University of Utah
    Inventors: Bellamkonda K. Kishore, Noel G. Carlson, Donald E. Kohan, Raoul D. Nelson
  • Methods of sintering dense zeta-phase tantalum carbide
    Patent number: 9896384
    Abstract: A method of forming a sintered ?-phase tantalum carbide can include assembling a particulate mixture including a tantalum hydride powder and a carbon source powder. The particulate mixture can be sintered to form a tantalum carbide having at least 70 wt. % of a ?-phase with at least about 90% densification. After sintering, the tantalum carbide can be cooled to substantially retain the ?-phase.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: February 20, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Dinesh K. Shetty, Raymond A. Cutler, Michael Sygnatowicz
  • Implantable devices for bone or joint defects
    Patent number: 9889235
    Abstract: In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: February 13, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Amanda Brooks, David Grainger, Kristofer D. Sinclair, Benjamin Brooks
  • Apparatus, compositions, and methods for assessment of chronic obstructive pulmonary disease progression among rapid and slow decline conditions
    Patent number: 9885085
    Abstract: Methods are disclosed for generating and isolating an informative content repository of respiratory related biomarkers to accurately determine whether an individual has normal or abnormal pulmonary function. Specifically, methods are directed to determination of whether individuals have chronic obstructive pulmonary disease, and if so, whether the affected individuals experience rapid long decline or slow lung decline as a result of COPD. Also disclosed is an informative content repository of chronic obstructive pulmonary disease biomarkers, which when linked with other informative content provides a powerful tool for diagnosis, study, therapeutic discovery and development, condition management, health maintenance, and linking chronic obstructive pulmonary disease through pattern of life style, environmental exposure, and genetic susceptibility and inheritance.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: February 6, 2018
    Assignees: University of Utah Research Foundation, Lineagen, Inc.
    Inventors: John Hoidal, Mary Beth Scholand, Mark F. Leppert, Michael S. Paul, Robert Mark Gritz, Joel Gardner Pounds, Richard Dale Smith
  • Intraocular drug delivery device and associated methods
    Patent number: 9877973
    Abstract: An intraocular active agent delivery device can include an active agent homogenously combined with a biodegradable active agent matrix such that the entire delivery device is homogenous. The homogenous delivery device can have a shape and size to fit within a lens capsule or ciliary sulcus of an eye and provide a therapeutically effective amount of the active agent to the eye. The biodegradable active agent matrix can be formulated to provide sustained release of the therapeutically effective amount of the active agent during a release period. In some examples, the active agent can include dexamethasone.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: January 30, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Balamurali K. Ambati, Bruce K. Gale, Srinivas Rao Chennamaneni
  • Isolation, identification, and uses of antifungal compounds
    Patent number: 9879048
    Abstract: In one aspect, the invention relates to isolated compounds useful as antifungal agents, for example, compounds having a structure represented by a formula: wherein R1 is hydrogen or hydroxyl; wherein R2 is hydrogen, a-xylose or ?-xylose; and wherein R3 and R4 are each hydrogen or together oxygen, or a pharmaceutically acceptable salt thereof; methods of isolating and purifying same; pharmaceutical compositions comprising same; agricultural compositions comprising same; and methods of treating and/or preventing fungal infections using same. In one aspect, R2 is not hydrogen or ?-xylose when R1 is hydroxyl and R3 and R4 are together oxygen. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: January 30, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Eric W. Schmidt, Joseph O. Falkinham, Peter W. Jeffs
  • Prosthetic joint
    Patent number: 9872772
    Abstract: A prosthetic joint (100) comprises a first component (110) having a first interface portion (111). The prosthetic joint (100) further comprises a second component (120) having a second interface portion (121) with a textured surface (122) to interface with the first interface portion (111) and form a skeletal joint. The textured surface (122) can include a plurality of concave features (123). Each or the concave features (123) can be configured to compress a lubricant (140) to facilitate hydrodynamic lubrication between the first and second interface portions (111, 121) to minimize wear between the first interface portion (111) and the second interface portion (121) of the prosthetic joint (100).
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: January 23, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Bart Raeymaekers, Anthony Sanders
  • Radiopaque marking implement
    Patent number: 9861449
    Abstract: This disclosure provides marking implements for making radiopaque markings, and methods of using the same.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 9, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Kevin John O'Neill, III, Joseph Passman, Ting Ruan, Andrea Tiede, John Langell
  • Monitoring temperature with fluorescence
    Patent number: 9850549
    Abstract: Systems, methods, and kits are provided wherein a temperature-sensitive reagent that emits a luminescent signal is used to adjust the identification of the temperature of a sample or to control thermocycling. In various illustrative embodiments, the sample is a PCR mixture.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: December 26, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Lindsay N. Sanford, Carl T. Wittwer
  • Memory access methods and apparatus
    Patent number: 9846550
    Abstract: A disclosed example apparatus includes a row address register (412) to store a row address corresponding to a row (608) in a memory array (602). The example apparatus also includes a row decoder (604) coupled to the row address register to assert a signal on a wordline (704) of the row after the memory receives a column address. In addition, the example apparatus includes a column decoder (606) to selectively activate a portion of the row based on the column address and the signal asserted on the wordline.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: December 19, 2017
    Assignees: Hewlett Packard Enterprise Development LP, University of Utah
    Inventors: Naveen Muralimanohar, Aniruddha Nagendran Udipi, Niladrish Chatterjee, Rajeev Balasubramonian, Alan Lynn Davis, Norman Paul Jouppi
  • Enhanced sensitivity for analysis of ketosteroid compounds using mass spectrometry
    Patent number: 9834578
    Abstract: The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of increasing the sensitivity for detection of a carbonyl group-containing compound by mass spectrometry can comprise derivatizing the carbonyl group-containing compound with an O-substituted hydroxylamine thereby producing an oxime, resulting in enhanced sensitivity of detection by mass spectrometry, as compared to the underivatized carbonyl group-containing compound. Additionally, a method for assaying a carbonyl group-containing compound can comprise reacting the carbonyl group-containing compound in a sample with an O-substituted hydroxylamine to produce an oxime and performing analysis with mass spectrometric detection of the oxime by a mass spectrometry instrument.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: December 5, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Bingfang Yue, Alan L. Rockwood, Mark M. Kushnir
  • Substituted N-(3-pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
    Patent number: 9828376
    Abstract: In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: November 28, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Hariprasad Vankayalapati, Venkataswamy Sorna, Steven L. Warner, David J. Bearss, Sunil Sharma
  • Nanofibril materials for highly sensitive and selective sensing of amines
    Patent number: 9823193
    Abstract: A sensory material with high sensitivity, selectivity, and photostability has been developed for vapor probing of organic amines. The sensory material is a perylene-3,4,9,10-tetracarboxyl compound having amine binding groups and the following formula where A and A? are independently chosen from N—R1, N—R2, and O such that both A and A? are not O, and R1 through R10 are amine binding moieties, solubility enhancing groups, or hydrogen such that at least one of R1 through R10 is an amine binding moiety. This perylene compound can be formed into well-defined nanofibers. Upon deposition onto a substrate, the entangled nanofibers form a meshlike, highly porous film, which enables expedient diffusion of gaseous analyte molecules within the film matrix, leading to a milliseconds response for vapor sensing.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: November 21, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Ling Zang, Yanke Che
  • Powder metallurgy methods for the production of fine and ultrafine grain Ti and Ti alloys
    Patent number: 9816157
    Abstract: A process includes sintering hydrogenated titanium or titanium hydride (TiH2) and/or Ti metal in a dynamically controlled hydrogen atmosphere with hydrogen partial pressure greater than 0.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: November 14, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Zhigang Zak Fang, Pei Sun, James Paramore, Hongtao Wang, Mark Koopman, Lu Yang