Patents Assigned to University of Utah
  • CROSS-LINKING AGENTS AND ASSOCIATED METHODS
    Publication number: 20190083529
    Abstract: An ophthalmic composition or dosage form can include a therapeutically effective amount of a cross-linking agent and a pharmaceutically acceptable carrier. The composition or dosage form can be used to treat an ophthalmic condition by administering a therapeutically effective amount of the composition to an eye of a subject during a treatment period.
    Type: Application
    Filed: December 6, 2016
    Publication date: March 21, 2019
    Applicant: University of Utah Research Foundation
    Inventors: Balamurali K. Ambati, Hironori Uehara, Santosh Muddana
  • Nanoparticle light filtering method and apparatus
    Patent number: 10234608
    Abstract: Implementations of the present invention relate to apparatuses, systems, and methods for blocking, attenuating, or filtering neuroactive wavelengths of the visible light spectrum and reducing or preventing the symptoms affiliated with exposure to those wavelengths. Nanoparticles of a predetermined composition, size, and structure are dispersed in a host medium to create an optical notch filter, thereby attenuating only a narrow range of the visible spectrum.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: March 19, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Steven M. Blair, Pradeep Kasinadhuni, Steve McDaniel, Bradley Jay Katz
  • Elongate member reinforcement with a studded collar
    Patent number: 10227786
    Abstract: An elongate member reinforcement system and associated methods are disclosed. The system can include an elongate member, a collar secured about an end portion of the elongate member, a support layer surrounding the end portion of the elongate member, and a structural filler disposed between the support layer and the end portion of the elongate member. The collar can be disposed in the structural filler and can include a structural filler interface feature that mechanically couples the collar to the structural filler to facilitate transferring loads between the elongate member and the structural filler.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: March 12, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Chris P Pantelides, Lawrence D. Reaveley
  • Pharmaceutical compositions composed of low molecular weight sulfated hyaluronan
    Patent number: 10226481
    Abstract: Described herein are pharmaceutical compositions composed of low molecular weight sulfated hyaluronan.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: March 12, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Glenn D. Prestwich, Siam Oottamasathien, Wanjian Jia, Lindsi M. Roundy, Won Yong Lee
  • Implantable devices for bone or joint defects
    Patent number: 10207030
    Abstract: In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: February 19, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Amanda Elaine Brooks, David W. Grainger, Kristofer D. Sinclair, Benjamin Delbert Brooks
  • Omnidirectional electromagnet
    Patent number: 10199147
    Abstract: An omnidirectional electromagnet (100) is disclosed. The omnidirectional electromagnet (100) comprises a ferromagnetic core (110) and three orthogonal solenoids (120, 130, 140) disposed about the core (110). Each solenoid (120, 130, 140) is adapted to receive a current from a current source to control an orientation and a magnitude of a magnetic field generated by the omnidirectional electromagnet (100). One or more omnidirectional electromagnets (100) can be used as a single magnetic manipulation system. The magnetic field generated by the omnidirectional electromagnet system can be used to control at least one of a force, a torque, an orientation, and a position of an adjacent magnetic object.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: February 5, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Andrew J. Petruska, Jacob J. Abbott
  • Ebolavirus pre-hairpin intermediate mimics and methods of use
    Patent number: 10189878
    Abstract: Ebolavirus is a highly lethal filovirus that causes hemorrhagic fever in humans and non-human primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent unmet global health need. The design, biophysical characterization, and validation of peptide mimics of the ebolavirus N-trimer (“N-trimer mimics”) are described herein.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: January 29, 2019
    Assignees: University of Utah Research Foundation, Navigen, Inc., The United States of America—Air Force
    Inventors: Tracy R. Clinton, Michael Thomas Jacobsen, Matthew T. Weinstock, Brett D. Welch, Debra Muir Eckert, Michael S. Kay
  • Encapsulated porous proppant
    Patent number: 10190041
    Abstract: The present disclosure describes proppant materials encapsulated with a polymer encapsulation layer. Proppant particles are formed with a core having relatively larger inner pores and a shell having relatively smaller shell pores. The shell pores and/or inner pores can be loaded with a treatment product, such as a methanogenic microbial consortium capable of converting coal into methane. The polymer encapsulation layer surrounds the shell and provides for sustained time-release of the treatment product when the proppant material has been delivered to a subterranean formation.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: January 29, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Kyu-Bum Han, John Fuertez, John McLennan, Taylor D. Sparks
  • Producing a titanium product
    Patent number: 10190191
    Abstract: A method (400) for producing a titanium product is disclosed. The method (400) can include obtaining TiO2-slag (401), and producing a titanium product from the TiO2-slag using a metallic reducing agent (402) at a moderate temperature and a pressure to directly produce a titanium product chemically separated from metal impurities in the TiO2 slag (403). The titanium product can comprise TiH2 and optionally elemental titanium. Impurities in the titanium product can then removed (404) by leaching, purifying and separation to form a purified titanium product.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: January 29, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Zhigang Zak Fang, Peng Fan, Scott Middlemas, Jun Guo, Ying Zhang, Michael Free, Amarchand Sathyapalan, Yang Xia
  • Multidirectional controller with shear feedback
    Patent number: 10191549
    Abstract: A multidirectional control system with shear feedback, comprising at least one stationary body, a plurality of tactors disposed within the at least one movable body or the at least one stationary body. In some embodiments, a moveable body is included, such that the tactors have at least one degree of freedom of motion with respect to the stationary body or the moveable body within which they are disposed and are operable to engage target areas of a user's skin; and a plurality of actuators capable of moving the tactors.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: January 29, 2019
    Assignee: University of Utah Research Foundation
    Inventor: William R. Provancher
  • METHODS FOR MODULATING ATAXIN 2 EXPRESSION
    Publication number: 20190017047
    Abstract: Disclosed herein are methods for decreasing Ataxin 2 mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate Ataxin 2 associated diseases, disorders, and conditions. Such Ataxin 2 associated diseases include spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis (ALS), and parkinsonism.
    Type: Application
    Filed: May 7, 2018
    Publication date: January 17, 2019
    Applicants: Ionis Pharmaceuticals, Inc., University of Utah Research Foundation
    Inventors: C. Frank Bennett, Susan M. Freier, Stefan M. Pulst, Daniel R. Scoles, Gene Hung
  • Applications of partially and fully sulfated hyaluronan
    Patent number: 10179147
    Abstract: Described herein is the use of partially and fully sulfated hyaluronan or the pharmaceutically acceptable salt or ester thereof for therapeutic and cosmetic applications as well as the treatment of a number of systemic, dermatological, periodontal, ophthalmic, and urological inflammatory diseases.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: January 15, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Glenn D. Prestwich, Siam Oottamasathein, Thomas P. Kennedy
  • OPHTHALMIC COMPOSITIONS AND ASSOCIATED METHODS
    Publication number: 20190008837
    Abstract: Ophthalmic formulations and compositions employing pergolide to treat an ophthalmic or ocular condition are disclosed and described.
    Type: Application
    Filed: December 15, 2017
    Publication date: January 10, 2019
    Applicant: University of Utah Research Foundation
    Inventors: Balamurali K. Ambati, Santosh Muddana, Xiaohaui Zhang
  • Structure and methodology for a shadow mask having hollow high aspect ratio projections
    Patent number: 10172558
    Abstract: A high aspect ratio shadow mask and a method of making and using the high aspect ratio shadow mask can provide multiple conductive trace pathways along high aspect ratio electrodes. The high aspect ratio shadow mask can include a substantially planar base layer and a plurality of hollow high aspect ratio projections extending from the substantially planar base layer. The high aspect ratio shadow mask can further include a plurality of openings along the hollow projections which define trace deposition patterns.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: January 8, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Sandeep Negi, Rajmohan Bhandari, Mobashir Hasan Shandi
  • Macromolecular delivery systems for non-invasive imaging, evaluation and treatment of arthritis and other inflammatory diseases
    Patent number: 10172962
    Abstract: This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: January 8, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Dong Wang, Jindrich Kopecek, Scott C. Miller, Pavla Kopeckova
  • Reduced parameter space kinetic modeling systems and methods
    Patent number: 10175216
    Abstract: Systems, methods and devices are provided for fitting kinetic models to measurements of dynamic curves where the kinetic models give rise to nonlinear fitting equations in two or more unknowns that can be formulated so that they are linear in one or more of the unknown parameters and nonlinear in one or more of the unknown parameters. Such systems, methods and devices may be utilized to monitor and characterize the attributes of a given tracer such as a radioactive substance within a body, a drug within the body, a concentration of a substance within a particular medium, and the like.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: January 8, 2019
    Assignee: The University of Utah Research Foundation
    Inventors: Dan J. Kadrmas, Mehmet Bugrahan Oktay
  • Liquid level sensor measuring a characteristic indicative of inductive coupling
    Patent number: 10161779
    Abstract: A sensor for determining liquid level in a liquid reservoir can include a primary inductor and a secondary inductor to be associated with sides of the reservoir that changes shape as a volume of liquid changes or is displaced within the liquid reservoir. The sensor can include an electrical power source to inductively couple the primary inductor and the secondary inductor. The liquid level sensor can include an inductive coupling measurement device associated with the primary inductor and/or the secondary inductor to measure a characteristic indicative of the inductive coupling of the primary inductor and the secondary inductor (e.g., a distance between inductors). As liquid volume changes and the reservoir deforms, the inductors move relative to each other and a voltage change occurs to determine a liquid level in the reservoir. A sensor kit is provided.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: December 25, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Gianluca Lazzi, Dulce Altabella Lazzi, Anil Kumar Ram Rakhyani, Kyle Loizos
  • Interfacial nanofibril composite for selective alkane vapor detection
    Patent number: 10151720
    Abstract: A nanofiber composite sensor for detecting alkanes can include a network of contacting nanofibers having multiple contact points. Each contact point can form an interfiber interface of interdigitated alkyl chains. Alkanes can be adsorbed at the interfiber interface which results in an increased interfiber distance between first and second nanofibers and a decreased charge transfer efficiency. The detected alkanes can be in a vapor or liquid phase.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: December 11, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Chen Wang, Ling Zang, Benjamin Bunes
  • Skin stretch feedback devices, systems, and methods
    Patent number: 10152853
    Abstract: Embodiments of the present disclosure relate devices, systems, methods, and for displaying information about the direction and magnitude of position, movement, and/or resistive force experienced for an object. The present disclosure also provides a shear display device that can generate skin shear with one or more tactors. The movement of the tactors can represent to a user various information about an object.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: December 11, 2018
    Assignee: University of Utah Research Foundation
    Inventors: William R. Provancher, Markus N. Montandon, Andrew J. Doxon, Nathan A. Caswell, Landon T. Gwilliam
  • Tracheal intubation system including a laryngoscope
    Patent number: 10149957
    Abstract: A tracheal intubation system including a laryngoscope is disclosed. An endotracheal tube exchange system is also disclosed. In some examples, the system includes a laryngoscope, a stylet, and an endotracheal tube. In some examples the stylet is an articulating stylet. An endotracheal tube with one or more depth-assessment bands is also disclosed. An articulating stylet with one or more depth-assessment bands and an orientation mark is also disclosed. A method of positioning an endotracheal tube in a patient is also disclosed. A method of positioning a stylet for placement of an endotracheal tube is also disclosed. A method of performing an endotracheal tube exchange procedure is also disclosed.
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: December 11, 2018
    Assignee: University of Utah Research Foundation
    Inventor: Sean T. Runnels