Abstract: A new methodology for detecting, localizing, tracking, and counting objects. The method for state/space estimation includes arranging in a space a first pair of radio frequency sensors in a network of nodes. The first pair of radio frequency sensors is calibrated to determine a first fading condition associated with the first pair of radio frequency sensors. A signal strength of at least one signal sent between the first pair of nodes is measured. A first likelihood model is determined based on the first fading condition. A first posterior distribution is estimated based on the signal strength of the at least one signal using the first likelihood model for purposes of determining object information within the space.

Abstract: Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on, a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter.

Abstract: A fluorescence based sensor (10) is disclosed and described. The sensor (10) can include nanofibril materials (12) fabricated from a linear carbazole oligomer and a fluorescence detector (14). The linear carbazole oligomer can have the formula (I) wherein n is 3 to 9, R are independently selected amine sidegroups, and at least one, but not all, R is a C1 to C14 alkyl. The carbazole-based fluorescence based sensors (10) can be particularly suitable for detection of explosives and volatile nitro compounds.

Abstract: The present invention provides methods and compositions for modulating x-ray attenuation, where the x-ray attenuation compound can comprise a molecule having at least two conformational states, a first k-edge atom attached to the molecule at a first position, and a second k-edge atom attached to the molecule at a second position, where the molecule changes from a first conformational state to a second conformational state in response to an external stimulus. Additionally, a first interatom distance between the first k-edge atom and the second k-edge atom in the first conformational state can be within a first harmonic error of 0 to about 0.2, and a second interatom distance between the first k-edge atom and the second k-edge atom in the second conformational state can be within a second harmonic error of about 0.8 to 1.0.

Abstract: A self-navigating technique designed to detect motion in segmented sequences is disclosed. Certain embodiments compare a plurality of segments containing adjacent sets of k-space lines and produce an aliased error function which corresponds to a correlation of the segments. A global shift of the aliased error function may indicate the presence of in-plane rigid-body translation while other types of motion are evident in the dispersion or breadth of the error function. Some embodiments may then replace motion corrupted data with reacquired data. Further, some embodiments may correct or remove corrupted data retrospectively.

Abstract: An ultrasonic thermometer for measuring a temperature profile along a measurement axis of a solid structure, comprising a continuous measurement pathway of a solid structure (310) having a longitudinal measurement axis and proximal (202) and distal ends (204), and at least two backscatterers (332) formed therein transverse to the longitudinal axis and separated by a predetermined separation distance.

Abstract: Systems and methods utilize a rotating magnetic field to drive a magnetically actuated device where the source of the rotating magnetic field is not constrained to a particular orientation with respect to the device. In one embodiment a rotating permanent magnet is utilized to actuate a magnetically actuated device where the magnet is not constrained to any position relative to the magnetically actuated device, such as the radial or axial position. Accordingly, the rotating permanent magnet may be directed in a manner to avoid collisions or other obstacles in a workspace while still effectively driving the magnetically actuated device.

Abstract: Disclosed herein is a non-human animal model of protein aggregation cardiomyopathy. Also disclosed are compositions and methods of treating or preventing a condition in a subject caused or exacerbated by reductive stress. Also disclosed are compositions and methods of predicting, detecting, or monitoring reductive stress in a subject.

Abstract: A method and system for scoring task information. Through the use of an electronic time management device, such as a cell phone or other portable digital computer based device programmed to support this method, a user enters a description of a task and when the task should be completed. This information is then communicated to a scoring system, and the information is scored without human intervention and points are given. Optionally, if the information cannot be automatically scored, it is scored by a person. These points can be banked and then be used toward a socially desirable reward, such as sending text messages or playing music or watching videos. This is particularly effective in teaching time management skills to young students who may have attention deficit hyperactivity disorder (ADHD).

Abstract: Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.

Abstract: A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.

Abstract: In one aspect, the invention relates to isolated compounds useful as antifungal agents, for example, compounds having a structure represented by a formula: wherein R1 is hydrogen or hydroxyl; wherein R2 is hydrogen or xylose; and wherein R3 and R4 are each hydrogen or together oxygen, or a pharmaceutically acceptable salt thereof; methods of isolating and purifying same; pharmaceutical compositions comprising same; agricultural compositions comprising same; and methods of treating and/or preventing fungal infections using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: An implant assembly for a long bone is adapted to support an exo-prosthesis. The assembly includes a stem, a subdermal component and a percutaneous post. The stem has a proximal end that is adapted to be received in a surgically prepared medullary canal of the long bone, and a distal end having a surface that is adapted to promote bone ingrowth. The subdermal component includes a proximal portion that is adapted for attachment to the distal end of the stem, and a fixation surface that is adapted to promote soft tissue fixation. The percutaneous post has a proximal end that is adapted to be attached to the subdermal component.

Abstract: An isolated, pure homogeneous population of mammalian astrocyte restricted precursor cells which is CD44 immunoreactive and which generate astrocytes but not oligodendrocytes is provided. Methods for isolating and using these mammalian astrocyte restricted precursor cells are also provided.

Abstract: A system and method are provided for removal of undesirable substances from a body of liquid. The system can include an aeration structure having a continuously inclined surface configured to provide an interaction of air bubbles against substantially an entire length of the continuously inclined surface while the air bubbles are moving toward a top of the body of liquid. The continuously inclined surface can be substantially submerged in the body of liquid. A bio-film of diverse bacteria colonies is disposed on the continuously inclined surface, and a high surface area-to-volume structure is located in proximity to the aeration structure, upon which a bio-film of bacteria colonies can be formed.

Abstract: The disclosure provides methods for repairing nerves and inhibiting atrophy of a muscle via a side-to side neurorraphy using a bridging element between a first epineurial window on a donor nerve and a second epineurial window on a recipient nerve.

Abstract: Systems, devices, and methods for measuring an under foot load profile of a patient during a period of partial weight bearing are described. The system may include a walking boot cast. A housing, including an inner surface and an upper surface that cooperate to define an inner cavity, may be oriented with respect to a patient's leg. The upper surface may be slidably received within the inner cavity in a piston and cylinder configuration or may be otherwise configured. The system may include a pressure sensor configured to monitor the load profile of a patient during the desired period of partial weight bearing. The pressure sensor may be located below the upper surface. The system may include a noncompressible force transmitter positioned within the inner cavity and at least partially encapsulating an upper portion of the pressure sensor to transmit pressure within the housing to the pressure sensor.

Abstract: Systems, devices, and methods for measuring an under foot load profile of a tibial fracture patient during a period of partial weight bearing are described. The system may include a walking boot cast. A housing, including an inner surface and an upper surface that cooperate to define an inner cavity, may be oriented with respect to a patient's tibia. The upper surface is slidably received within the inner cavity in a piston and cylinder configuration. The system may include a pressure sensor configured to monitor the load profile of a patient during the desired period of partial weight bearing. The pressure sensor may be located below the upper surface. The system may include a noncompressible force transmitter positioned within the inner cavity and at least partially encapsulating an upper portion of the pressure sensor to transmit pressure within the housing to the pressure sensor.

Abstract: A method of creating an analogous workflow is provided. A first workflow is received at a first device, the first workflow including a plurality of first modules that are connected. A second workflow is received at the first device, the second workflow including a plurality of second modules that are connected. A third workflow is received at the first device, the third workflow including a plurality of third modules that are connected. An analogy workflow is determined based on a difference between the received first workflow and the received second workflow. The determined analogy workflow is applied to the received third workflow to define a fourth workflow. A method of identifying a workflow of a plurality of workflows is provided. A query workflow includes a plurality of modules that are connected. A workflow is identified that at least partially matches the received query workflow.

Abstract: A system and method are provided for a parallel processing of the Hamilton-Jacobi equation. A numerical method is provided to solve the Hamilton-Jacobi equation that can be used with various parallel architectures and an improved Godunov Hamiltonian computation.