Abstract: Systems, constructs, and methods for reprogramming cells are provided. In one aspect, for example, a transformation construct for generating iPS cells can include an expression vector having a plurality of reprogramming factors, each reprogramming factor being under control of a separate promoter.
Type:
Application
Filed:
August 23, 2013
Publication date:
June 19, 2014
Applicant:
University of Utah Research Foundation
Inventors:
Stefan M. Pulst, Sharan Paul, Warunee Dansithong
Abstract: Described herein are polymeric compositions that comprise at least one polymer residue and at least one crosslinking moiety, wherein the polymer residue is crosslinked by the crosslinking moiety and wherein the crosslinking moiety is formed from a reaction between a boronic acid moiety and a hydroxamic acid moiety. Also, described are methods of making and using such polymeric compositions.
Type:
Grant
Filed:
January 16, 2013
Date of Patent:
June 10, 2014
Assignee:
University of Utah Research Foundation
Inventors:
Kavita Gupta, Meredith R. Clark, Patrick F. Kiser, Julie I. Jay
Abstract: A gene-specific prediction tool for classifying and interpreting gene tests is described. The prediction tool includes a classifier trained and tested using databases of gene variants and their known phenotypes. The classifier uses differences between features of amino acids in obtaining attributes used to perform classification and generate predictions, including for benign and pathologic outcomes, for uncertain gene variants.
Abstract: Drug delivery models, displays, and systems may be configured to provide a clinician with readily intuitive information about the effects of one or more drugs on a subject. Interactive features may be included to provide a subject-specific model of the expected or predicted effects of one or more drugs on the subject. Additionally, interactive features that effect drug delivery to the subject may also be included. Drug delivery models, displays, and systems may be used in teaching, in advance of treatment, during treatment, or following treatment.
Type:
Grant
Filed:
January 27, 2012
Date of Patent:
June 3, 2014
Assignee:
University of Utah Research Foundation
Inventors:
Noah Syroid, Dwayne R. Westenskow, James Agutter, Talmage D. Egan, Kenward B. Johnson
Abstract: Methods, assays, and products for the detection of small molecules are provided. In one aspect, for example, a method of detecting a small molecule in a sample can include reacting together a first half of a DNA split aptamer having a first reactive group coupled thereto, a second half of a DNA split aptamer having a second reactive group coupled thereto, where the DNA split aptamer is selective for the small molecule, and a sample containing the small molecule. The first half and the second half bind to the small molecule and the first reactive group and the second reactive group react to form an aptamer ligation product of the first half and the second half. The method can also include assaying for the aptamer ligation product in order to detect the small molecule presence in the sample.
Abstract: The invention relates to relatively short peptides (termed ?-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
Type:
Grant
Filed:
June 6, 2013
Date of Patent:
May 27, 2014
Assignee:
The University of Utah Research Foundation
Inventors:
Maren Watkins, Baldomero M. Olivera, David R. Hillyard, J. Michael McIntosh
Abstract: Systems and methods which generate a sequence of images using turbo spin echo magnetic resonance imaging which are retrospectively correlated with periodic motion occurring within a subject being imaged are described. In one embodiment, k-space measurements (or the measurements from which images are formed) are captured during, and correlated with, different phases in a cardiac cycle of the subject. With this sequence, the images that are produced are able to show, and/or compensate for, motion correlated with the cardiac cycle of the subject.
Type:
Grant
Filed:
September 30, 2010
Date of Patent:
May 27, 2014
Assignee:
University of Utah Research Foundation
Inventors:
Dennis L. Parker, Jason K. Mendes, Jordan Hulet
Abstract: Nanoelectromechanical logic devices can include a plurality of flexible bridges having control and logic electrodes. Voltages applied to control electrodes can be used to control flexing of the bridges. The logic electrodes can provide logical functions of the applied voltages.
Abstract: The present disclosure describes systems, methods, and apparatus for reducing the frequency and/or severity of photophobic responses or for modulating circadian cycles by controlling light exposure to cells in the human eye in certain wavelengths, such as 480 nm and 620 nm, and a visual spectral response of the human eye. Embodiments of an optical filter are described. In one embodiment an optical filter may be configured to transmit less than a first amount of light in certain wavelengths, and to transmit more than a second amount of light weighted across the visual spectral response. Methods of use and methods of manufacturing optical filters are also described.
Abstract: Methods of controlling island size and density on an OMVPE growth film may comprise adding a surfactant at a critical concentration level, allowing a growth phase for a first period of time, and ending the growth phase when desired island size and density are achieved. For example, the island size and density of an OMVPE grown InGaN thin film may be controlled by adding an antimony surfactant at a critical concentration level.
Type:
Application
Filed:
October 25, 2013
Publication date:
May 15, 2014
Applicant:
The University of Utah
Inventors:
Jason Merrell, Feng Liu, Gerald B. Stringfellow
Abstract: A coaxial molecular stack (10) for transferring photocurrent generation in a device such as a solar cell (14) is disclosed. The device comprises a plurality of macrocyclic ?-conjugated planar molecules stackable through columnar self assembly to form a stack (10) having an axial channel (26) with an outer p-channel (22) of the nano-composite coaxial molecular stack (10). A plurality of C60 molecules are positioned coaxially within the axial channel of the stack (10) to form an inner n-channel (24) that forms a bulk heterojunction with the p-channel (22) to provide charge transport of photocurrent through the nano-composite coaxial molecular stack (10). A plurality of the stacks (16) are oriented orthogonally between first (18) and second electrodes (20) to form the device (14).
Abstract: Described herein is the synthesis and pharmacology of a series of ?-substituted methylene phosphonate analogs, in which the ?-CH2 moiety is replaced with CHCl or CHBr.
Type:
Grant
Filed:
June 13, 2008
Date of Patent:
May 13, 2014
Assignees:
University of Utah Research Foundation, University of Tennessee Research Foundation
Abstract: Methods and systems for determining travel history can be based on noninvasive analysis of stable isotope ratios in the body of an individual. A method for reconstructing a travel history for an individual can include collecting a sample of exhaled breath from the individual and analyzing the sample to obtain a breath isotope ratio. The breath isotope ratio can be transformed to a body water isotope ratio and compared to a map model correlating input isotope ratios to geographic locations so as to determine a travel origin for the individual.
Type:
Grant
Filed:
February 25, 2009
Date of Patent:
May 13, 2014
Assignee:
University of Utah Research Foundation
Inventors:
David W. Podlesak, James R. Ehleringer, Thure E. Cerling
Abstract: A method is described for correlating microscopy images from a number of modalities in a sub diffraction resolution environment. The method may include receiving a number of datasets that may represent microscopy captures from a number of different modalities. The microscopy captures may contain feature markers that may be used to register a number of data points contained in a dataset with data points from another dataset. Upon registering the data points of the datasets, a combined dataset may be produced and a visual image of the combined dataset may be provided.
Type:
Application
Filed:
March 18, 2013
Publication date:
May 8, 2014
Applicant:
University of Utah Research Foundation
Inventors:
Steven P. Callahan, Bryan W. Jones, Greg M. Jones, Erik Jorgensen, John Schreiner, Tolga Tasdizen, Shigeki Watanabe, Stan Kanarowski, Josh Cates
Abstract: A system and method are configured to provide a virtual application desktop and communication channel. The system includes a virtual machine executing on an operating system within which multiple applications can concurrently execute. A plurality of applications can each have a protected namespace and be configured to execute using the virtual machine. Each of the plurality of applications can have a request box. A centralized communication engine can be configured to control communications between each request box. In addition, the centralized communication engine can be configured to retrieve, transfer and distribute data between the request boxes of the plurality of applications in response to requests from the plurality of applications.
Type:
Grant
Filed:
March 13, 2007
Date of Patent:
May 6, 2014
Assignee:
University of Utah Research Foundation
Inventors:
Thanh N. Troung, Thomas Cook, Manohar Nayak
Abstract: Disclosed herein are compositions and methods for the identification of a subject at risk for developing microvascular complications associated with diabetes such as diabetic nephropathy and diabetic retinopathy. Also disclosed is a therapeutic target for the prevention and treatment of microvascular complications associated with diabetes.
Abstract: Systems and methods which utilize stress first and then rest imaging techniques to provide for improved medical imaging results are provided herein. One embodiment may administer a stress regime, such as exercise stress, and administer a tracer to a patient and retrieve a stress image. Then a second tracer is administered to a patient and a resting image is retrieved. Embodiments may implement this method with PET/CT scanning techniques. Additionally, embodiments may utilize a single CT scan when obtaining both the stress and rest images.
Type:
Application
Filed:
October 30, 2012
Publication date:
May 1, 2014
Applicants:
The University of Utah Research Foundation
Inventor:
The University of Utah Research Foundation
Abstract: A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
Type:
Grant
Filed:
March 30, 2012
Date of Patent:
April 29, 2014
Assignee:
University of Utah Research Foundation
Inventors:
Margot Mayer-Proschel, Mahendra S. Rao, Patrick A. Tresco, Darin J. Messina
Abstract: Described herein are nanoemulsions comprising (1) at least one fluoro ether and (2) a block copolymer comprising a hydrophilic block and hydrophobic block, wherein the nanoemulsion comprises a therapeutic agent in the nanoemulsion. The nanoemulsions are stable and are excellent drug delivery devices for ultrasound-mediated, image guided drug delivery. Also described herein are methods for using the nanoemulsions to treat tumors and cancers as well as using them as imaging agents.
Abstract: The present invention extends to methods, systems, and computer program products for representing polarized light in computer models. A rendering pipeline receives three dimensional modeling data (e.g., geometric primitives) for rendering a two dimensional image are received. The modeling data includes data representing a light source The light energy from the simulated transmission of particles at each pixel of the two dimensional image is calculated for any particles transmitted in an adjoint direction from a specified view point back to the light source. The light energies from each pixel are summed to calculate the total light energy present at the specified view point. The total light energy can be forwarded to other modules in rendering pipeline to more accurately render the two dimensional image, such as, for example, representing polarized light in the two dimensional image.
Type:
Grant
Filed:
February 7, 2008
Date of Patent:
April 29, 2014
Assignee:
The University of Utah Research Foundation
Inventors:
Peter Schuyler Shirley, Solomon Boulos, Jared Moroni Johnson, Austin Huff Robison